A human CD4+ T-cell line expresses functional CD64 (Fc gamma RI), CD32 (Fc gamma RII), and CD16 (Fc gamma RIII) receptors but these do not enhance the infectivity of HIV-1-IgG complexes.

abstract：:In order to study the precise localization pattern of anti-TNP antibody-forming cells (AFCs) during the early primary immune response against TNP conjugated TD (thymus-dependent) and TI-2 (thymus-independent type-2) antigens, rats received an intravenous injection with either TNP-keyhole limpet haemocyanin (KLH) or wi...

journal_title：Immunology

authors： Claassen E,Kors N,Dijkstra CD,Van Rooijen N

更新日期：1986-03-01 00:00:00

abstract：:Rabbits immunized with complexes of denatured calf thymus DNA and methylated bovine serum albumin (MBSA) produced only IgM antibodies to denatured DNA, confirming the results of previous studies. In contrast, both IgM and IgG antibodies were induced by MBSA complexes of Trypanosoma brucei DNA. A similar response was o...

journal_title：Immunology

authors： Kushimo JB

更新日期：1976-05-01 00:00:00

abstract：:Chlamydia trachomatis is a major cause of sexually transmitted disease, infertility and reactive arthritis in the Western world, and of trachoma in the developing world. There is evidence that the chronic inflammatory reaction seen in diseases associated with chlamydiae represents a delayed-type hypersensitivity respo...

journal_title：Immunology

authors： Hassell AB,Reynolds DJ,Deacon M,Gaston JS,Pearce JH

更新日期：1993-08-01 00:00:00

abstract：:Macrophage (MΦ) polarization is triggered during the innate immune response to defend against microbial pathogens, but can also contribute to disease pathogenesis. In a previous study, we found that interleukin-15 (IL-15) -derived classically activated macrophages (M1 MΦ) have enhanced antimicrobial activity, whereas ...

journal_title：Immunology

authors： Montoya D,Mehta M,Ferguson BG,Teles RMB,Krutzik SR,Cruz D,Pellegrini M,Modlin RL

更新日期：2019-02-01 00:00:00

abstract：:The guinea-pig (gp) CD4 protein was identified using the rat monoclonal antibody (mAb) H155 derived from an interspecies hybrid. The hybrid was obtained after immunization of rats with purified guinea-pig T lymphocytes and fusion to a mouse myeloma line. The mAb H155 reacted with a subpopulation (60-70%) of nylon-wool...

journal_title：Immunology

authors： Schäfer H,Burger R

更新日期：1991-02-01 00:00:00

abstract：:Interleukin-6 (IL-6) is an important B-cell growth and differentiation factor. IL-6 treatment of the human lymphoblastoid cell line, SKW6.4, leads to increased IgM production. We have previously shown that IL-6 induces activation of JAK1 and JAK2 in human B cell lines. A chimeric IL-6 receptor, comprised of the intrac...

journal_title：Immunology

authors： Faris M,Kokot N,Stahl N,Nel AE

更新日期：1997-03-01 00:00:00

abstract：:The effect on murine immunoglobulin G (IgG) glycosylation of altering IgG production in vivo was assessed in interleukin (IL)-6 transgenic and CD4 knockout mice. C57BL/6 mice carrying the IL-6 transgene showed increased levels of circulating IgG. This was associated with decreased levels of galactose on the IgG oligos...

journal_title：Immunology

authors： Jeddi P,Keusch J,Lydyard PM,Bodman-Smith KB,Chesnutt MS,Wofsy D,Hirota H,Taga T,Delves PJ

更新日期：1999-11-01 00:00:00

abstract：:The effector CD8(+) T cells recognize major histocompatibility complex (MHC) class I binding altered self-peptides expressed in tumour cells. Although the requirement for CD4(+) T helper type 1 (Th1) cells in regulating CD8(+) T cells has been documented, their target epitopes and functional impact in antitumour respo...

journal_title：Immunology

authors： Kikuchi T,Uehara S,Ariga H,Tokunaga T,Kariyone A,Tamura T,Takatsu K

更新日期：2006-01-01 00:00:00

abstract：:Human autologous-rosette-forming T cells (Tar cells) have many of the characteristics of post-thymic precursor cells. Thus, they bind to sheep erythrocytes but have neither receptors for the Fc portion of IgG nor for that of IgM. They include a subpopulation that binds peanut agglutinin which suggests that they are im...

journal_title：Immunology

authors： Palacios R,Alarcón-Segovia D,Llorente L,Ruíz-Arguelles A,Díaz-Jouanen E

更新日期：1981-01-01 00:00:00

abstract：:Staphylococcal enterotoxins (SE) are potent T-lymphocyte activators that stimulate T cells by directly cross-linking HLA-DR molecules on antigen-presenting cells with the V beta gene products of the T-cell receptor. The different SE activate all T cells expressing a given V beta, and, therefore, have been termed 'supe...

journal_title：Immunology

authors： Duan X,Nerl C,Janssen O,Kabelitz D

更新日期：1992-03-01 00:00:00

abstract：:Polysorbate 80 (PS80 or Tween-80) is often used as an additive to promote the rapid solubilization of pharmaceuticals in aqueous solutions. We investigated whether coinjection of a minimal amount of PS80 had a modulatory effect on the immunotherapeutic effects of Cry (Cryptomeria)-consensus peptide, a novel peptide de...

journal_title：Immunology

authors： Kozutsumi D,Tsunematsu M,Yamaji T,Murakami R,Yokoyama M,Kino K

更新日期：2006-07-01 00:00:00

abstract：:The hepatic and splenic uptake of circulating, small-latticed immune complexes and the effect of these complexes on the hepatic mononuclear phagocyte system (MPS) were examined in mice. The small-latticed immune complexes were prepared at fifty-fold antigen excess. The clearance from circulation and uptake by the live...

journal_title：Immunology

authors： Jimenez RA,Haakenstad AO,Mannik M

更新日期：1983-02-01 00:00:00

abstract：:Bacterial superantigens bind to major histocompatibility complex (MHC) class II and subsequently activate both CD4+ and CD8+ T lymphocytes expressing certain T-cell receptor (TCR)-Vbeta chains. In response to superantigen exposure these subsets proliferate, produce large amounts of proinflammatory cytokines and in add...

journal_title：Immunology

authors： Sundstedt A,Grundström S,Dohlsten M

更新日期：1998-09-01 00:00:00

abstract：:Fifty-seven serum samples positive for antibodies to double-stranded DNA (dsDNA), single-stranded DNA (ssDNA) or small nuclear ribonucleoproteins (snRNP) selected from patients with systemic lupus erythematosus and mixed connective tissue disease, were examined for the IgG subclass distribution of these autoantibodies...

journal_title：Immunology

authors： Zouali M,Jefferis R,Eyquem A

更新日期：1984-03-01 00:00:00

abstract：:The composition of the microbiome in health and disease has only recently become a major research focus. Although it is clear that an imbalance or dysbiosis in the microbiota is associated with disease, its interrelatedness to disease penetrance is largely unknown. Inflammatory bowel disease (IBD) is an excellent dise...

journal_title：Immunology

authors： Ray A,Dittel BN

更新日期：2015-11-01 00:00:00

abstract：:The relationship between allograft rejection and the response in the one-way mixed leucocyte reaction (MLR) of the WBC of allograft recipients was investigated. The responses of the WBC were assessed prior to skin allografting and subsequent to rejection of the allograft. The optimal MLR response of the WBC from the a...

journal_title：Immunology

authors： Milthorp P,Belanger R,Richter M

更新日期：1979-01-01 00:00:00

abstract：:The association between three major spondyloarthritic diseases, ankylosing spondylitis, Reiter's syndrome, and reactive arthritis, and the major histocompatibility complex (MHC) class 1 antigen HLA-B27 is well documented. The hypothesis of cross-reactivity between HLA-B27 and the antecedent infection-causing Gram-nega...

journal_title：Immunology

authors： Kapasi K,Chui B,Inman RD

更新日期：1992-11-01 00:00:00

abstract：:T cells play a key role in the pathogenesis of type 1 diabetes, and targeting the CD3 component of the T-cell receptor complex provides one therapeutic approach. Anti-CD3 treatment can reverse overt disease in spontaneously diabetic non-obese diabetic mice, an effect proposed to, at least in part, be caused by a selec...

journal_title：Immunology

authors： Wallberg M,Recino A,Phillips J,Howie D,Vienne M,Paluch C,Azuma M,Wong FS,Waldmann H,Cooke A

更新日期：2017-06-01 00:00:00

abstract：:The IgE immune response was studied in female athymic, nude (Lewis rnu/rnu) and euthymic (Lewis +/+) rats infected with the nematode Nippostrongylus brasiliensis. During the course of the infection, serum IgE levels were followed using an enzyme-linked immunosorbent assay technique (ELISA), while the surface expressio...

journal_title：Immunology

authors： Chen XJ,Wiedermann U,Dahlgren U,Hanson LA,Enerbäck L

更新日期：1995-11-01 00:00:00

abstract：:Memory CD8(+) T cells regain function during a recall response, but the requirement of signals in addition to antigen during a secondary immune response is unknown. In this study, the ability of interleukin-7 (IL-7) to enhance memory CD8(+ ) CD45RA(- ) CD127(+) T-cell responses in health and in human immunodeficiency ...

journal_title：Immunology

authors： O'Connor AM,Crawley AM,Angel JB

更新日期：2010-12-01 00:00:00

abstract：:Two phenotypically distinct subpopulations of dendritic cells (SIRPalpha+ CC81Ag- DC and SIRPalpha- CC81Ag+ DC) have previously been identified in bovine afferent lymph which show functional differences when assayed in vitro. The purpose of this study was to investigate whether differences in cytokine production betwe...

journal_title：Immunology

authors： Stephens SA,Brownlie J,Charleston B,Howard CJ

更新日期：2003-09-01 00:00:00

abstract：:A model of immediate-type hypersensitivity (ITH) in the dog using keyhole limpet haemocyanin (KLH) as the antigen was studied. Long-lasting ITH was induced in fifteen of sixteen dogs by the i.v. (Kepron & Tse, 1975), intradermal (Rockey, Schwartzmann & Halliwell, 1971), inhalation (Patterson & Kelley, 1974) and i.d. p...

journal_title：Immunology

authors： Schatz M,Patterson R,Sommers HM,Harris KE,Suszko IM,Roberts M

更新日期：1977-01-01 00:00:00

abstract：:CD4 T cells help immune responses, but knowledge of how memory CD4 T cells are regulated and how they regulate adaptive immune responses and induce immunopathology is limited. Using adoptive transfer of virus-specific CD4 T cells, we show that naive CD4 T cells undergo substantial expansion following infection, but ca...

journal_title：Immunology

authors： Bhattacharyya M,Madden P,Henning N,Gregory S,Aid M,Martinot AJ,Barouch DH,Penaloza-MacMaster P

更新日期：2017-10-01 00:00:00

abstract：:B-lymphocyte maturation is considered to be independent of the thymus. However, there is circumstantial evidence suggesting that it may be impaired in nude animals that lack the thymus. Our study shows that the proportion of immature B-lymphocyte subsets (CD90(high) IgM(high) and CD90(high) IgM(low)) was significantly...

journal_title：Immunology

authors： Milićević NM,Nohroudi K,Milićević Z,Hedrich HJ,Westermann J

更新日期：2005-11-01 00:00:00

abstract：:Age-related macular maculopathy (ARM) and age-related macular degeneration (AMD) are the leading causes of blindness in the Western world. Despite the magnitude of this clinical problem, very little is known about the pathogenesis of the disease. In this study, we analysed the sera (using indirect immunohistochemistry...

journal_title：Immunology

authors： Patel N,Ohbayashi M,Nugent AK,Ramchand K,Toda M,Chau KY,Bunce C,Webster A,Bird AC,Ono SJ,Chong V

更新日期：2005-07-01 00:00:00

abstract：:Basophils are implicated in the pathogenesis of the late-phase allergic reaction, but the mechanisms by which circulating basophils adhere to vascular endothelium and migrate to lesional sites remain unclear. In order to assess the biological similarity of the basophilic cell line KU-812 to normal human basophils, we ...

journal_title：Immunology

authors： Bacon KB,Flores-Romo L,Aubry JP,Wells TN,Power CA

更新日期：1994-07-01 00:00:00

abstract：:Induction of all forms of protective immunity by oral immunization with subunit vaccines is an ideal goal for the development of novel vaccines, but creates several theoretical problems from the point of view of antigen processing mechanisms. We show here that incorporation of the protein antigen ovalbumin (OVA) in li...

journal_title：Immunology

authors： Mowat AM,Donachie AM,Reid G,Jarrett O

更新日期：1991-03-01 00:00:00

abstract：:Bursal and splenic lymphocytes in developing chick embryos were examined for the number of antigen binding cells (ABC) which could form rosettes with red blood cells from sheep, guinea-pig, rabbit or dinitrophenylated sheep red blood cells (DNP-SRBC). The kinetics of the development of bursal ABC to rabbit red blood c...

journal_title：Immunology

authors： Moriya O,Ichikawa Y

更新日期：1979-08-01 00:00:00

abstract：:The amount and relative affinity of antibodies to tetanus toxoid were measured, following immunization, in patients with chronic or recurrent acute chest infections and in healthy controls. The responding patients and controls produced similar amounts of antibody and, although antibody affinity was higher in the contr...

journal_title：Immunology

authors： Devey ME,Bleasdale KM,French MA,Harrison G

更新日期：1985-07-01 00:00:00

abstract：:T-cell mediated immunity (CMI) is crucial for protection against genital chlamydial infection in mice. To define the underlying molecular mechanism for this protection, several T-cell clones generated against the Chlamydia trachomatis agent of mouse pneumonitis (MoPn) were analysed in an in vitro model of the mucosal ...

journal_title：Immunology

authors： Igietseme JU

更新日期：1996-01-01 00:00:00