Abstract：
:Rabbits immunized with complexes of denatured calf thymus DNA and methylated bovine serum albumin (MBSA) produced only IgM antibodies to denatured DNA, confirming the results of previous studies. In contrast, both IgM and IgG antibodies were induced by MBSA complexes of Trypanosoma brucei DNA. A similar response was observed by Gruenewald and Stollar (1973) to T2 bacteriophage DNA, in which the normal base cytosine is replaced by hydroxymethylcytosine. T2 bacteriophage DNA is known to have a high adenine+thymine (A + T) content. It is suggested that the 7S antibody response to MBSA complexes of T. brucei DNA might be linked to the high A + T content in the DNA (especially kinetoplast DNA) of the subgenus Trypanozoon.
journal_name
Immunologyjournal_title
Immunologyauthors
Kushimo JBsubject
Has Abstractpub_date
1976-05-01 00:00:00pages
635-9issue
5eissn
0019-2805issn
1365-2567journal_volume
30pub_type
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