Abstract:
:Electron microscopic findings made on microsomal fractions of rat liver after treatment with microsomal antibodies obtained from the blood of patients diagnosed as having chronic aggressive hepatitis and liver cirrhosis and after incubation with peroxidase-labelled antihuman IgG are described and presented in this paper. Interpretation of these findings as the substrate of an antibody reaction directed against membranes of the endoplasmic reticulum of hepatocytes is discussed.
journal_name
Immunologyjournal_title
Immunologyauthors
Storch W,Cossel L,Dargel Rsubject
Has Abstractpub_date
1977-06-01 00:00:00pages
941-5issue
6eissn
0019-2805issn
1365-2567journal_volume
32pub_type
杂志文章相关文献
IMMUNOLOGY文献大全abstract::The fungus metabolite cyclosporin A is a small cyclic peptide acting as a novel antilymphocytic agent. It is effective following either parenteral or oral administration in mice, rats and guinea-pigs. The suppressive effect after short and prolonged treatment on plaque-forming cells, the inhibition of the secondary hu...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1977-06-01 00:00:00
abstract::Nasal carriage of Staphylococcus aureus is an important source of nosocomial infection and community-acquired methicillin-resistant S. aureus (MRSA). Previous studies by our laboratory revealed that nasal carriage of S. aureus is accompanied by subclinical inflammation, which is insufficient to prevent colonization, a...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1111/j.1365-2567.2007.02615.x
更新日期:2007-09-01 00:00:00
abstract::We have identified two components of human seminal plasma which suppress natural killer (NK) cell activity in vitro. Dialysis and gel filtration experiments have shown both components to be of low molecular weight. The first will suppress NK cells following a short period of pretreatment, but this suppression is depen...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1988-03-01 00:00:00
abstract::The association between three major spondyloarthritic diseases, ankylosing spondylitis, Reiter's syndrome, and reactive arthritis, and the major histocompatibility complex (MHC) class 1 antigen HLA-B27 is well documented. The hypothesis of cross-reactivity between HLA-B27 and the antecedent infection-causing Gram-nega...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1992-11-01 00:00:00
abstract::Serum antibodies to glucosyltransferase (GTF) of Streptococcus mutans serotype c were assayed sequentially by means of an enzyme inhibition radio-assay in twenty-six Rhesus monkeys immunized with S. mutans. Pre-immune and control sera had a GTP-enhancing effect which was shown also by albumin and non-immune immunoglob...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1976-05-01 00:00:00
abstract::The ability of preparations of cobra factor (CoF) to convert C3 via the properdin pathway (anticomplementary activity) has been demonstrated to be unrelated to its ascribed ability to convert a tolerogenic signal into an immunogenic stimulus (adjuvant activity). It has been shown that CoF preparations which have becom...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1976-03-01 00:00:00
abstract::From our experiments and those of others in which cells were cultured at a density of 100,000 cells per well, it has been suggested that autoantibody production against mouse bromelain-treated erythrocytes (mouse brom-RBC) was independent of T cells, and further, was enhanced by the removal of T cells from responsive ...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1987-06-01 00:00:00
abstract::The effect of corticosteroid administration on the redistribution of sirculating lymphocytes was studied in the guinea-pig, since this species closely resembles man in its relative resistance to the lymphopenic effect of corticosteroids. A single intravenous injection of hydrocortisone (either 10 mg or 100 mg/kg) cau...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1975-04-01 00:00:00
abstract::Immunohistological techniques have been used to study the stromal cells of the human placenta in both the chorionic villous mesenchyme and the connective tissue underlying the amnion. Throughout gestation many of these cells express an antigen (3C10) that is found on mononuclear phagocytes but not on dendritic cells o...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1986-05-01 00:00:00
abstract::Metabolism of ss-DNA in Swiss Webster mice and NZB/W mice was studied. The delay in intra-hepatic catabolism of ssDNA in old NZB/W female mice seems to correlate with the presence of increased anti-DNA antibodies; similar to effects produced in Swiss Webster mice that have been pretreated with a small dose of carbon b...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1977-03-01 00:00:00
abstract::We have produced a mouse anti-rabbit Ia monoclonal antibody (MAb) that detects an isotypic determinant on all rabbit Ia molecules. This MAb precipitates three polypeptide chains with molecular weights of 28,000, 31,000 and 35,000, corresponding to the Ia beta, Ii and alpha chains, respectively. The anti-Ia MAb inhibit...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1984-01-01 00:00:00
abstract::Rat mast cells with the properties of mucosal mast cells (MMC) proliferate in cultures of haemopoietic tissue in the presence of conditioned medium (CM) from antigen- or mitogen-activated T lymphocytes. The present study shows that recombinant rat interleukin-3 (rIL-3) both stimulated the development of MMC from bone ...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1988-10-01 00:00:00
abstract::When mice were homozygous for the Wf allele at W locus, the delayed-type hypersensitivity (DTH) reaction observed in mice primed i.v. or s.c. with optimal doses of sheep red blood cells was greatly decreased. The number of sensitized splenic cells able to transfer a delayed-type hypersensitivity reaction was identical...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1980-02-01 00:00:00
abstract::The effector CD8(+) T cells recognize major histocompatibility complex (MHC) class I binding altered self-peptides expressed in tumour cells. Although the requirement for CD4(+) T helper type 1 (Th1) cells in regulating CD8(+) T cells has been documented, their target epitopes and functional impact in antitumour respo...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1111/j.1365-2567.2005.02262.x
更新日期:2006-01-01 00:00:00
abstract::Membrane attack complexes of complement occur around thyroid follicles in Graves' disease and Hashimoto's thyroiditis. The lytic potential of such complexes is controlled by membrane-bound and fluid phase regulators and we have investigated the role of these in autoimmune thyroid disease. By immunohistochemical staini...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1994-04-01 00:00:00
abstract::Allergic diseases are frequently exacerbated between midnight and early morning, suggesting a role for the biological clock. Mast cells (MC) and eosinophils are the main effector cells of allergic diseases and some MC-specific or eosinophil-specific markers, such as tryptase or eosinophil cationic protein, exhibit cir...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1111/imm.12157
更新日期:2013-12-01 00:00:00
abstract::A plasmid that contained the cytomegalovirus (CMV)-promoter-driven lacZ reporter gene (pCMV-lacZ) remained in the epaxial muscle of five of eight goldfish as covalently closed circles, the most functional form of plasmid, for at least 70 days at 22 degrees. It was not present in the gills or elsewhere by polymerase ch...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1046/j.1365-2567.1999.00688.x
更新日期:1999-02-01 00:00:00
abstract::Human haematopoietic progenitor/stem cells (HPCs) differentiate into functional T cells in the thymus through a series of checkpoints. A convenient in vitro system will greatly facilitate the understanding of T-cell development and future engineering of therapeutic T cells. In this report, we established a lentiviral ...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1111/j.1365-2567.2008.03013.x
更新日期:2009-09-01 00:00:00
abstract::In the present study we have investigated whether bovine erythrocytes (Eb) specifically sensitized with human polyclonal IgA1 (Eb-IgA1) are able to bind to resident adherent rat peritoneal cells (PM phi). Rat PM phi formed rosettes with Eb-IgA1 at room temperature and at 37 degrees. The formation of these rosettes cou...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1988-06-01 00:00:00
abstract::Tumour-associated macrophages (TAMs) represent a predominant population of inflammatory cells that present in solid tumours. TAMs are mostly characterized as alternatively activated M2-like macrophages and are known to orchestrate nearly all stages of tumour progression. Experimental investigations indicate that TAMs ...
journal_title:Immunology
pub_type: 杂志文章,评审
doi:10.1111/imm.12023
更新日期:2013-02-01 00:00:00
abstract::We report that interleukin (IL)-4 and IL-10 can significantly up- or down-regulate CXC chemokine receptor 4 (CXCR4) expression on CD4+ T lymphocytes, respectively. Stromal cell-derived factor-1alpha (SDF-1alpha)-induced CD4+ T-lymphocyte chemotaxis was also correspondingly regulated by IL-4 and IL-10. IL-4 and IL-10 u...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1046/j.1365-2567.2000.00954.x
更新日期:2000-03-01 00:00:00
abstract::Surface receptors on peripheral blood neutrophils and monocytes from normal and immunodeficient horses have been studied. Sheep erythrocytes (SRBC) coated with IgG, IgM, and complement but not IgG(T), readily bound to normal equine monocytes and neutrophils. More than 4000 molecules of IgG were required to sensitize e...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1975-03-01 00:00:00
abstract::The anti-C6 monoclonal antibody WU 6-4 was shown to be unequivocally native restricted since it neither binds to the terminal complement complex (TCC) nor to C5b6. In addition, it was shown to inhibit TCC formation by interfering with C5b6 generation. Using the pUEX expression system and C6 cDNA the WU 6-4 epitope was...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1995-06-01 00:00:00
abstract::The kinetics of anti-paternal alloantibody production in syngeneically and allogeneically mated mice previously immunized with allogenic spleen cells has been investigated. In allogeneically mated females, total and cytotoxic alloantibody levels increased during the final 3 days of pregnancy to reach maximal levels ar...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1982-05-01 00:00:00
abstract::Herpes simplex virus (HSV) encodes a protein, glycoprotein C (gC), which binds to the third complement component, the central mediator of complement activation. In this study the structural and functional relationships of gC from HSV type 1 (HSV-1) and known human complement regulatory proteins factor H, properdin, fa...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1993-08-01 00:00:00
abstract::Circulating CD4+ CD25+ regulatory T cells (Tregs) have been demonstrated to maintain immunotolerance and suppress the antigen-specific or antigen-non-specific T-cell responses, but their role in chronic hepatitis B (CHB) infection in humans has not been well characterized. In this study, we analysed the frequency and ...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1111/j.1365-2567.2007.02691.x
更新日期:2008-01-01 00:00:00
abstract::Although lymphocyte traffic through the brain is normally low, this can increase dramatically in response to infection or an autoimmune reaction. We have studied the adhesion of lymphocytes to cerebral endothelium in vitro in an attempt to model the first step of the infiltration process--that is, the initial interact...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1988-08-01 00:00:00
abstract::In the study described here, the effect of human tears and purified lactoferrin was investigated on the deposition of complement components on solid-phase bound immune complexes. After incubating immune complexes with fresh normal human serum, the deposition of complement components (C3, C4 and C5) was measured with a...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1985-03-01 00:00:00
abstract::Expression of Fc gamma receptors on human placental trophoblast was investigated by immunostaining and immunoblotting using a panel of Fc gamma receptor monoclonal antibodies (mAb). Fc gamma receptors typical of other cell types were not detected on syncytiotrophoblast in term placentae when transplacental IgG transpo...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1993-11-01 00:00:00
abstract::Induction of expression of adhesion molecules is a crucial step in inflammation. The role of interleukin-18 (IL-18) in induction of various adhesion molecules was investigated in freshly isolated peripheral blood mononuclear cells and human monocyte and T-cell lines. IL-18 selectively up-regulated intercellular adhesi...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1046/j.1365-2567.2003.01747.x
更新日期:2003-11-01 00:00:00