Abstract：
:Jacalin, a lectin(s) extracted from the seeds of Artocarpus integrifolia (Jackfruit), was shown to induce the production of gamma interferon (IFN gamma) in human peripheral blood mononuclear cells (PBMC) and human T-lymphocyte cultures. The amount of IFN gamma produced was enhanced in the presence of mezerein, a phorbol ester derivative. Fusion of jacalin stimulated T lymphocytes with the SH9 T-cell line resulted in the formation of T-cell hybridomas which spontaneously secreted IFN gamma. The spontaneous production of IFN gamma by T-cell hybridomas was not influenced by the presence of jacalin, although significant enhancement of production was observed when the cells were cultured in the presence of mezerein.
journal_name
Immunologyjournal_title
Immunologyauthors
Crane I,Leung H,Barwick S,Parti S,Meager Asubject
Has Abstractpub_date
1984-12-01 00:00:00pages
855-9issue
4eissn
0019-2805issn
1365-2567journal_volume
53pub_type
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