Titration and circulation of cells mediating delayed type hypersensitivity in normal and cyclophosphamide treated mice during response to sheep red blood cells.

abstract：:There is increasing evidence that primitive progenitors migrate from the bone marrow (BM) via the peripheral circulation to tissue sites where they undergo in situ differentiation to provide a continued source of effector cells, such as eosinophils, during an allergic inflammatory response. To study mechanisms of prog...

journal_title：Immunology

authors： Sehmi R,Dorman S,Baatjes A,Watson R,Foley R,Ying S,Robinson DS,Kay AB,O'Byrne PM,Denburg JA

更新日期：2003-08-01 00:00:00

abstract：:Antisera were prepared against a variety of chicken tissues with a view to detecting antigens specific for subpopulations of T and B cells at different maturation stages. By appropriate absorption analysis, the following antigens were defined: (a) thymus organ-specific antigen (CTOA); (b) T lymphocyte-specific antigen...

journal_title：Immunology

authors： Boyd RL,Ward HA

更新日期：1978-01-01 00:00:00

abstract：:The induction of T-cell growth by the T-cell antigen receptor (TcR) is dependent on a co-ordinated process of phosphorylation and dephosphorylation of intracellular proteins. An intermediary in this signalling pathway is the serine kinase, p42 mitogen-activated protein kinase (p42MAPK), also known as microtubule-assoc...

journal_title：Immunology

authors： Amaral MC,Casillas AM,Nel AE

更新日期：1993-05-01 00:00:00

abstract：:Tick larvae (Boophilus microplus) were extracted, fractionated by gel filtration and ion-exchange chromatography, and the fractions assayed by enzyme-linked immunosorbent assay (ELISA) against sera from cattle immunized and protected by antigens from the mid-gut of adult ticks. Unfractionated, whole larval extracts an...

journal_title：Immunology

authors： Opdebeeck JP,Wong JY,Dobson C

更新日期：1989-07-01 00:00:00

abstract：:Control of resistance to cyst burden following per-oral infection with Toxoplasma gondii has been mapped previously to a region of mouse chromosome 17 of approximately 140 kb. This region is contiguous with and contains the class I gene, Ld. Resistance to development of toxoplasmic encephalitis has also been reported ...

journal_title：Immunology

authors： Brown CR,Hunter CA,Estes RG,Beckmann E,Forman J,David C,Remington JS,McLeod R

更新日期：1995-07-01 00:00:00

abstract：:Previous studies have highlighted the importance of CD4+ T cells in regulation of IgA responses and have indicated a functional heterogeneity among these cells between inductive (Peyer's patch) and effector (lamina propria) sites in the intestine. To determine whether these functional differences could be accounted fo...

journal_title：Immunology

authors： Bao S,Goldstone S,Husband AJ

更新日期：1993-12-01 00:00:00

abstract：:We have used in situ hybridization (ISH) and immunohistochemistry (IHC) to investigate the kinetics of the expression for Fc epsilon RI mRNA (alpha-, beta- and gamma-chains), the alpha-chain protein product, as well as the phenotype of the mRNA- or protein-positive cells in allergen-induced late-phase skin reactions i...

journal_title：Immunology

authors： Ying S,Barata LT,Meng Q,Grant JA,Barkans J,Durham SR,Kay AB

更新日期：1998-02-01 00:00:00

abstract：:Expression of CD45RO on intraepithelial lymphocytes (IEL) bearing the T-cell receptor (TcR) alpha/beta or gamma/delta was studied in situ by three-colour immunofluorescence on jejunal tissue sections from 21 patients with coeliac disease and eight controls. CD45RA-TcR alpha/beta+ IEL expressed CD45RO significantly mor...

journal_title：Immunology

authors： Halstensen TS,Farstad IN,Scott H,Fausa O,Brandtzaeg P

更新日期：1990-12-01 00:00:00

abstract：:Activated T cells, through the production of the receptor activator of NF-kappaB ligand (RANKL) cytokine, have been implicated in the osteoclast development and bone loss that are associated with autoimmune diseases such as rheumatoid arthritis. However, the cellular pathways that regulate the expression of RANKL and ...

journal_title：Immunology

authors： Gendron S,Boisvert M,Chetoui N,Aoudjit F

更新日期：2008-11-01 00:00:00

abstract：:Monocyte chemotactic protein-1 (MCP-1) is a proinflammatory cytokine that attracts and activates specific types of leucocytes. The purpose of this work was to analyse the generation of MCP-1 and mRNA transcript in a model of chronic inflammation using a granulomatous tissue induced by potassium permanganate (KMnO4; wa...

journal_title：Immunology

authors： Conti P,Reale M,Feliciani C,Frydas S,Trakatellis M,Placido FC,Cataldo I,Di Gioacchino M,Barbacane RC

更新日期：1997-10-01 00:00:00

abstract：:Systemic lupus erythematosus (SLE) is an autoimmune disease in which abnormal immune responses are mediated by tissue-binding autoantibodies and immune complex deposition. Because most SLE patients are women of child-bearing age, oestrogen has been suggested to play an important role in SLE pathogenesis. One proposed ...

journal_title：Immunology

authors： Lee J,Shin EK,Lee SY,Her YM,Park MK,Kwok SK,Ju JH,Park KS,Kim HY,Cho ML,Park SH

更新日期：2014-08-01 00:00:00

abstract：:Although it is clear that the CD45 tyrosine phosphatase is required for efficient T-cell activation and T-cell development, the factors that regulate CD45 function remain uncertain. Previous data have indicated that there is an association of CD45 with CD4 and the T-cell receptor (TCR) complex controlled by the variab...

journal_title：Immunology

authors： Leitenberg D,Falahati R,Lu DD,Takeda A

更新日期：2007-08-01 00:00:00

abstract：:Oral tolerance promotes a generalized decrease in specific immune responsiveness to proteins previously encountered via the oral route. In addition, parenteral immunization with a tolerated protein also triggers a significant reduction in the primary responsiveness to a second unrelated antigen. This is generally expl...

journal_title：Immunology

authors： Ramos GC,Rodrigues CM,Azevedo GM Jr,Pinho V,Carvalho CR,Vaz NM

更新日期：2009-03-01 00:00:00

abstract：:The cellular prion protein (PrPc) is a glycosyl-phosphatidylinositol (GPI)-linked cell surface protein, which is expressed at high density on nervous tissues and at lower levels on most other solid-organ tissues. It is also expressed on peripheral blood mononuclear cells (PBMC) of all lineages. In lymphocytes, its lev...

journal_title：Immunology

authors： Morelon E,Dodelet V,Lavery P,Cashman NR,Loertscher R

更新日期：2001-02-01 00:00:00

abstract：:Interleukin-8 (IL-8) is a pro-angiogenic cytokine associated with aggressive prostate cancer (CaP). We detected high levels of IL-8 in sera from patients with CaP compared with healthy controls and patients with benign prostatic hypertrophy. This study examines the role of IL-8 in the pathogenesis of metastatic prosta...

journal_title：Immunology

authors： Aalinkeel R,Nair B,Chen CK,Mahajan SD,Reynolds JL,Zhang H,Sun H,Sykes DE,Chadha KC,Turowski SG,Bothwell KD,Seshadri M,Cheng C,Schwartz SA

更新日期：2016-08-01 00:00:00

abstract：:Alveolar macrophages (AM) present antigen poorly to CD4+ T cells and respond weakly to interferon-gamma (IFN-gamma) for up-regulation of major histocompatibility complex (MHC) class II and costimulatory molecule expression. In atopic asthma, however, AM exhibit enhanced antigen-presenting cell (APC) activity. Since gr...

journal_title：Immunology

authors： Caulfield JJ,Fernandez MH,Sousa AR,Lane SJ,Lee TH,Hawrylowicz CM

更新日期：1999-09-01 00:00:00

abstract：:Glucosamine (GlcN) has been reported to possess several biomedical properties, and currently a great deal of attention has been focused on improving the functional properties of GlcN for different applications. Therefore, this study was conducted to introduce a carboxybutyryl functional group to GlcN and to find out t...

journal_title：Immunology

authors： Rajapakse N,Kim MM,Mendis E,Kim SK

更新日期：2008-03-01 00:00:00

abstract：:In this study, we describe the ability of hybrid mouse monoclonal antibody (mAb) to induce monocyte-mediated cytotoxicity towards human IgA1-coated E (HuIgA1-E), and the effect of mAb binding valency on Fc gamma RI-mediated ADCC. All hybrid monospecific (ms) anti-HuIgA1 and bispecific (bs) anti-HuIgA1/HRP mAb were cap...

journal_title：Immunology

authors： Koolwijk P,Van de Winkel JG,Otten I,Bast BJ

更新日期：1992-02-01 00:00:00

abstract：:The effects of anti-Ia antibodies and cyclosporin A (CsA) on phenotypic differentiation of murine thymocytes were assessed in organ-cultured fetal thymuses. Both agents specifically abrogated the generation of CD4+8- thymocytes. Immunohistochemical studies revealed that Ia antigen on the organ-cultured thymic epitheli...

journal_title：Immunology

authors： Takeuchi Y,Habu S,Okumura K,Suzuki G

更新日期：1989-03-01 00:00:00

abstract：:Soluble low-affinity receptors for IgG are known to inhibit immune complex (IC)-mediated inflammation, and expression by leukocytes is elevated in several inflammatory diseases. Immunoglobulin M (IgM) rheumatoid factors (RF), anti-Fc autoantibodies, are found in autoimmune diseases, such as rheumatoid arthritis (RA), ...

journal_title：Immunology

authors： Wines BD,Gavin A,Powell MS,Steinitz M,Buchanan RR,Mark Hogarth P

更新日期：2003-06-01 00:00:00

abstract：:The contribution of B7 molecules to the induction and maintenance of the T-cell response to the human pathogenic fungus Cryptococcus neoformans was investigated. T-cell activation by C. neoformans was regulated by B7 molecules. This costimulatory signal was necessary for initiation and maintenance of the T-cell respon...

journal_title：Immunology

authors： Monari C,Kozel TR,Casadevall A,Pietrella D,Palazzetti B,Vecchiarelli A

更新日期：1999-09-01 00:00:00

abstract：:Studies of tuberculosis have suggested a shift in dominance from a T helper type 1 (Th1) towards a Th2 immune response that is associated with suppressed cell-mediated immune (CMI) responses and increased humoral responses as the disease progresses. In this study a natural host disease model was used to investigate th...

journal_title：Immunology

authors： Welsh MD,Cunningham RT,Corbett DM,Girvin RM,McNair J,Skuce RA,Bryson DG,Pollock JM

更新日期：2005-01-01 00:00:00

abstract：:The results presented in this paper demonstrate that a mouse IgM monoclonal antibody (T-80) recognizes an antigen on cells of the T-lymphocyte lineage of sheep. However, this antibody does not identify all T cells, as 10-20% of thymocytes and some peripheral-blood T cells are negative. T-80- thymocytes reside in the m...

journal_title：Immunology

authors： Miyasaka M,Heron I,Dudler L,Cahill RN,Forni L,Knaak T,Trnka Z

更新日期：1983-07-01 00:00:00

abstract：:Microglia cells, the resident innate immune cells in the brain, are highly active, extending and retracting highly motile processes through which they continuously survey their microenvironment for 'danger signals' and interact dynamically with surrounding cells. Upon sensing changes in their central nervous system mi...

journal_title：Immunology

authors： Giunti D,Parodi B,Cordano C,Uccelli A,Kerlero de Rosbo N

更新日期：2014-03-01 00:00:00

abstract：:Peripheral blood lymphocytes (PBL) from non-immunized rabbits or from rabbits immunized several months previously with a single dose of sheep red blood cells (SRBC) were cultured at several different cell densities in the presence of antigen for 5 days. The cells were then distributed in 10 microliter microcultures at...

journal_title：Immunology

authors： Luzzati AL,Giacomini E,Lefkovits I

更新日期：1985-12-01 00:00:00

abstract：:We have produced a mouse anti-rabbit Ia monoclonal antibody (MAb) that detects an isotypic determinant on all rabbit Ia molecules. This MAb precipitates three polypeptide chains with molecular weights of 28,000, 31,000 and 35,000, corresponding to the Ia beta, Ii and alpha chains, respectively. The anti-Ia MAb inhibit...

journal_title：Immunology

authors： Lobel SA,Knight KL

更新日期：1984-01-01 00:00:00

abstract：:The activation of macrophages by various stimuli leading to chemotactic migration and phagocytosis is known to be mediated by an increase in intracellular Ca2+ concentration ([Ca2+]i). We measured changes in [Ca2+]i using a Ca2+ imaging method in individual human macrophages differentiated from freshly prepared periph...

journal_title：Immunology

authors： Oshimi Y,Miyazaki S,Oda S

更新日期：1999-10-01 00:00:00

abstract：:Porcine alveolar macrophages (AM) metabolize leukotriene D4 (LTD4) to leukotriene E4 (LTE4). In the present study, the ability of a fluid-phase AM stimulus (A23187) and a phagocytic stimulus (opsonized zymosan) to augment LTD4 metabolism was examined. Both stimuli increased the release of superoxide (O-2) anions. Howe...

journal_title：Immunology

authors： Paterson NA,McIver DJ,Schurch S

更新日期：1985-09-01 00:00:00

abstract：:The amount and relative affinity of antibodies to tetanus toxoid were measured, following immunization, in patients with chronic or recurrent acute chest infections and in healthy controls. The responding patients and controls produced similar amounts of antibody and, although antibody affinity was higher in the contr...

journal_title：Immunology

authors： Devey ME,Bleasdale KM,French MA,Harrison G

更新日期：1985-07-01 00:00:00

abstract：:This study has examined the stimuli required for secretion of regulated upon activation, normal T-cell expressed, presumed secreted (RANTES) from T lymphocytes and found that stimuli such as phorbol 12-myristate 13-acetate (PMA), which are unable to support T-cell proliferation and interleukin-2 (IL-2) production, are...

journal_title：Immunology

authors： Sotsios Y,Blair PJ,Westwick J,Ward SG

更新日期：2000-09-01 00:00:00