Abstract:
:Tick larvae (Boophilus microplus) were extracted, fractionated by gel filtration and ion-exchange chromatography, and the fractions assayed by enzyme-linked immunosorbent assay (ELISA) against sera from cattle immunized and protected by antigens from the mid-gut of adult ticks. Unfractionated, whole larval extracts and selected reactive components were used to vaccinate cattle; they decreased the number of ticks dropped after challenge, but the effect of treatment was not significant. Antigens purified from crude larval extracts by affinity chromatography, using immunoglobulin ligands from an immune steer vaccinated with tick mid-gut antigens, also failed to protect cattle. However, tick extracts from both larval and adult ticks, which were first separated into membrane-associated and soluble fractions and then purified by exposure to the affinity ligands, protected cattle greater than 80% against subsequent challenge with ticks.
journal_name
Immunologyjournal_title
Immunologyauthors
Opdebeeck JP,Wong JY,Dobson Csubject
Has Abstractpub_date
1989-07-01 00:00:00pages
388-93issue
3eissn
0019-2805issn
1365-2567journal_volume
67pub_type
杂志文章相关文献
IMMUNOLOGY文献大全abstract::Circulating CD4+ CD25+ regulatory T cells (Tregs) have been demonstrated to maintain immunotolerance and suppress the antigen-specific or antigen-non-specific T-cell responses, but their role in chronic hepatitis B (CHB) infection in humans has not been well characterized. In this study, we analysed the frequency and ...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1111/j.1365-2567.2007.02691.x
更新日期:2008-01-01 00:00:00
abstract::Substitution by lectins for the carrier-priming requirement in thymus-dependent, antigen-binding responses in Xenopus laevis has been examined. Concanavalin A (Con A) was found to substitute for carrier priming in control, early-thymectomized and adult-thymectomized animals, but not in animals given a single, high dos...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1984-08-01 00:00:00
abstract::There is much evidence to suggest that potentially immunogenic tumour cells can escape cytolytic immune destruction by loss of class I antigen expression. Many tumours are allele-specific class I negative and, in murine systems, reconstitution of class I expression by gene transfection leads to an increase in tumour i...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1991-02-01 00:00:00
abstract::Burkholderia pseudomallei is the causative agent of melioidosis, an infectious disease with high incidence and mortality in South East Asia and northern Australia. To date there is no protective vaccine and antibiotic treatment is prolonged and not always effective. Most people living in endemic areas have been expose...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1111/imm.12709
更新日期:2017-05-01 00:00:00
abstract::Epididymitis represents a serious threat to male fertility and usually develops following secondary bacterial infection of the epididymis such as urinary tract infections or sexually transmitted diseases. Surprisingly, very little is known about the innate host response triggered by bacterial infection in the male rep...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1111/j.1365-2567.2007.02763.x
更新日期:2008-06-01 00:00:00
abstract::Immununoelectron microscopy of human peripheral blood mononuclear cells enriched for the presence of antigen-presenting dendritic cells (DC) has revealed two morphologically distinct cell types both expressing DR and DQ major histocompatibility complex (MHC) class II antigens but lacking T, B, natural killer (NK) and ...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1991-03-01 00:00:00
abstract::The gut immune system and its modification by diet have been implicated in the pathogenesis of type 1 diabetes (T1D). Therefore, we investigated gut immune status in non-diabetes-prone LEW.1AR1 and diabetes-prone LEW.1AR1-iddm rats and evaluated the effect of a low antigen, hydrolysed casein (HC)-based diet on gut imm...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1111/imm.12457
更新日期:2015-07-01 00:00:00
abstract::The major site of B-cell genesis in the sheep is the ileal Peyer's patch (PP). The B cells in the ileal PP undergo both extensive proliferation and massive death in association with an ongoing diversification of the immunoglobulin repertoire by somatic hypermutation. Most, if not all, the B-cell death in the ileal PP ...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1995-03-01 00:00:00
abstract::alpha 1-Acid glycoprotein (AG), a serum component elevated during acute inflammation, has been implicated in the suppression of various immunological responses. Pretreatment of lymphoid cells with AG at a concentration commonly found in patients with acute inflammation results in the inhibition of mitogen induced lymp...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1984-03-01 00:00:00
abstract::Immunoglobulin E (IgE)-dependent mechanisms play a pivotal role in mediating allergic disease. Previously, VH-Cepsilon transcripts from blood or spleen of atopic asthmatics have been analysed for VH gene usage and patterns of somatic mutation. An over-representation of the minor VH5 family has been observed, consisten...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1046/j.1365-2567.1999.00910.x
更新日期:1999-12-01 00:00:00
abstract::Receptors for the Fc fragment of IgG (Fc gamma R) have a well-documented role in the generation of oxidative burst. It is tempting to speculate that the type of interaction with Fc gamma R could be a mechanism of regulation of this process. Here we report on a comparative study of the induction of oxidative burst in h...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1994-09-01 00:00:00
abstract::Interleukin-6 (IL-6) is a multifunctional cytokine with a broad range of activities and can affect a variety of target cells or systems in multiple ways. However, there is currently no consensus on how IL-6 directly affects the peripheral nervous tissue. We performed histopathological and immunohistochemical analyses ...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1046/j.1365-2567.1999.00808.x
更新日期:1999-08-01 00:00:00
abstract::Secretory proteins of Mycobacterium tuberculosis are the major immunomodulators of the host immune response. Open reading frame (ORF) Rv2626c, encoding a conserved hypothetical protein eliciting a strong humoral immune response in patients with tuberculosis (TB), was shown to be up-regulated upon infection in mice und...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1111/j.1365-2567.2009.03196.x
更新日期:2010-05-01 00:00:00
abstract::Clonal deletion of T cells capable of recognizing both host-type Mls and donor-type Mls occurred in the peripheral mature T-cell pool in radiation bone marrow chimeras of two H-2-compatible Mls-disparate strain combinations of AKR/J(H-2k,Thy-1.1,Mls-1a) and C3H/He(H-2k,Thy-1.2,Mls-1b). In order to determine further th...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1990-03-01 00:00:00
abstract::Eosinophil recruitment to the airways, including involvement of haemopoietic eosinophil-basophil progenitors (Eo/B-CFU), is primarily regulated by interleukin-5 (IL-5) and eotaxin. In this study, we investigated the haemopoietic mechanisms in upper and lower airway eosinophilic inflammation. Ovalbumin (OVA) sensitized...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1111/j.1365-2567.2005.02109.x
更新日期:2005-03-01 00:00:00
abstract::Cancer immune surveillance is considered to be an important host protection process to inhibit carcinogenesis and to maintain cellular homeostasis. In the interaction of host and tumour cells, three essential phases have been proposed: elimination, equilibrium and escape, which are designated the 'three E's'. Several ...
journal_title:Immunology
pub_type: 杂志文章,评审
doi:10.1111/j.1365-2567.2007.02587.x
更新日期:2007-05-01 00:00:00
abstract::It has been known for 15 years that the chicken epidermis contains ATPase+ and major histocompatibility complex class II-positive (MHCII+) dendritic cells. These cells were designated as Langerhans cells but neither their detailed phenotype nor their function was further investigated. In the present paper we demonstra...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1111/j.1365-2567.2006.02432.x
更新日期:2006-10-01 00:00:00
abstract::The fluorescence-activated cell sorter and a rosette-depletion technique were used to separate rat spleen lymphocytes and BCG-activated lymphocytes into subpopulations with and without the antigens defined by W3/13, W3/23 and OX8 monoclonal antibodies. The resultant populations were then tested for natural killer (NK)...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1982-01-01 00:00:00
abstract::Although it is well known that cases with silicosis exhibit various immunological abnormalities, the mechanisms involved in the occurrence of immuno-dysfunction or dysregulation induced by silica compounds have not yet been determined. Fas is a well-known cell surface molecule that is involved in the apoptosis pathway...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1046/j.1365-2567.1998.00509.x
更新日期:1998-06-01 00:00:00
abstract::The soluble cytoplasmic fraction of an homogenate from peritoneal rat mast cells, demonstrated a considerable amount of catalytic activity which promotes the transfer of phosphate from creatine phosphate to ADP. The plasma membrane, mitochondrial and microsomal fractions show negligible amounts of the catalyst. Enzyme...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1980-03-01 00:00:00
abstract::The MHC class I and II antigen processing and presentation pathways display peptides to circulating CD8+ cytotoxic and CD4+ helper T cells respectively to enable pathogens and transformed cells to be identified. Once detected, T cells become activated and either directly kill the infected / transformed cells (CD8+ cyt...
journal_title:Immunology
pub_type: 杂志文章,评审
doi:10.1111/imm.12675
更新日期:2017-01-01 00:00:00
abstract::Class switching and plasma cell differentiation occur at a high level within all mucosa-associated lymphoid tissues. The different classes of membrane immunoglobulin heavy chains are associated with the Igα/Igβ heterodimer within the B-cell receptor (BCR). Whether BCR isotypes convey specific signals adapted to the co...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1111/j.1365-2567.2012.03557.x
更新日期:2012-05-01 00:00:00
abstract::A panel of four mimotopes of the epitope recognized by the highly protective monoclonal antibody against Schistosoma mansoni (152-66-9B) was obtained by screening a solid-phase 8mer random peptide library. Three of the four mimotopes (p28, p29 and p30) were efficiently recognized in an in vitro radioimmunoassay by the...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1046/j.1365-2567.2000.00139.x
更新日期:2000-12-01 00:00:00
abstract::CD45 is known to regulate signalling through many different surface receptors in diverse haemopoietic cell types. Here we report for the first time that CD45-/- bone marrow dendritic cells (BMDC) are more activated than CD45+/+ cells and that tumour necrosis factor (TNF) and interleukin-6 (IL-6) production by BMDC and...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1111/j.1365-2567.2006.02363.x
更新日期:2006-06-01 00:00:00
abstract::Stimulation of human polymorphonuclear granulocytes with the calcium-ionophore A23187 and opsonized zymosan leads to the release of leukotrienes. The cell-free supernatants of the stimulated cells revealed gamma-glutamyl-transpeptidase and dipeptidase activity which induced the metabolism of exogeneously added LTC4 an...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1985-05-01 00:00:00
abstract::Post-translational modifications of histone proteins are major mechanisms that modify chromatin structure and regulate gene expression in eukaryotes. Activation of histone acetyltransferases or inhibition of histone deacetylases (HDACs) is generally believed to allow chromatin to assume a more open state, permitting t...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1111/j.1365-2567.2007.02678.x
更新日期:2007-12-01 00:00:00
abstract::Ligation of T-cell receptor (TCR) causes mature T cells to proliferate or, on re-exposure to antigen, can cause them to die by activation-induced cell death (AICD). In proliferative responses, costimulatory and adhesive interactions are required and activation of protein kinase C (PKC) has been shown to be essential. ...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1046/j.1365-2567.1996.515580.x
更新日期:1996-04-01 00:00:00
abstract::The present study aimed to determine whether the frequency of double positive (DP) thymocytes expressing alphabeta T-cell receptor (TCR) clonotypes at the time of selection regulates peripheral CD4 T-cell compartment size. Scid recipients were inoculated with various ratios of TCR Calpha(0/0) and wild-type bone marrow...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1111/j.1365-2567.2005.02240.x
更新日期:2005-11-01 00:00:00
abstract::Studies have demonstrated that the anti-tumour effect of natural killer (NK) cells is successful for patients with several cancers. Although interleukin-32 (IL-32) is endogenously expressed in NK cells, cytolytic function of NK cells against cancer cells has not been fully demonstrated. In the present study, we found ...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1111/j.1365-2567.2011.03513.x
更新日期:2012-01-01 00:00:00
abstract::Leukotriene B4 (LTB4 ) is a lipid mediator that is rapidly generated in inflammatory sites, and its functional receptor, BLT1, is mostly expressed on immune cells. Contact dermatitis is a common inflammatory skin disease characterized by skin oedema and abundant inflammatory infiltrates, primarily including neutrophil...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1111/imm.12478
更新日期:2015-09-01 00:00:00