Nanotherapy silencing the interleukin-8 gene produces regression of prostate cancer by inhibition of angiogenesis.

abstract：:C57BL/6 mice were injected with different doses of human T-cell receptor (TCR) V beta 8.1 CDR1 peptide at different times after murine retrovirus (LP-BM5) infection. Injection with TCR V beta 8.1 CDR1 peptide largely prevented the retrovirus-induced reduction in B- and T-cell proliferation, and T-helper 1 (Th1) cytoki...

journal_title：Immunology

authors： Liang B,Ardestani S,Marchalonis JJ,Watson RR

更新日期：1996-02-01 00:00:00

abstract：:Stimulation of human polymorphonuclear granulocytes with the calcium-ionophore A23187 and opsonized zymosan leads to the release of leukotrienes. The cell-free supernatants of the stimulated cells revealed gamma-glutamyl-transpeptidase and dipeptidase activity which induced the metabolism of exogeneously added LTC4 an...

journal_title：Immunology

authors： Raulf M,Stüning M,König W

更新日期：1985-05-01 00:00:00

abstract：:We report the cloning of cDNA encoding the pig homologue of human integrin-associated protein (IAP or CD47). A pig CD47-specific probe was generated by polymerase chain reaction (PCR) amplification of pig leucocyte cDNA, using primers based on consensus regions among the known sequences of CD47 from different species....

journal_title：Immunology

authors： Shahein YE,de Andrés DF,Pérez de la Lastra JM

更新日期：2002-08-01 00:00:00

abstract：:We have studied the antibody response in vitro of spleen cells from C57BL/6 mice kept on a protein deficient (D) or a normal diet (N). Short or long term protein restriction initiated after weaning led to increased plaque forming cell (PFC) responses to sheep red blood cells (SRBC), TNP-ficoll and TNP lipopolysacchari...

journal_title：Immunology

authors： Pocino M,Malavé I

更新日期：1981-06-01 00:00:00

abstract：:The effect of different macrophage populations and supernatants derived from these macrophages on Con-A induced lymphocyte activation in macrophage depleted lymph node cells has been investigated. All macrophage populations tested were able to restore the lymphocytic response to Con A. Macrophages of different origin ...

journal_title：Immunology

authors： Knop J

更新日期：1980-10-01 00:00:00

abstract：:Using cloned human helper T lymphocytes reactive with a 24 amino acid peptide (p20) of the carboxyl terminal of the HA-1 molecule of influenza haemagglutinin we have investigated the influence of antigen structure on the activation and in the induction of antigen specific unresponsiveness of T cells. For this analysis...

journal_title：Immunology

authors： Lamb JR,Feldmann M,Green N,Lerner RA

更新日期：1986-03-01 00:00:00

abstract：:A large proportion of intestinal intraepithelial lymphocytes (IEL) comprises alpha beta and gamma delta T-cell receptor (TcR)-bearing T cells. The numbers of alpha beta and gamma delta IEL are reported to be very different between germ-free and conventional microbial conditions. In this study, we investigated the kine...

journal_title：Immunology

authors： Umesaki Y,Setoyama H,Matsumoto S,Okada Y

更新日期：1993-05-01 00:00:00

abstract：:Examples suggesting that all or part of the V(H) segment of a rearranged V(H)DJ(H) may be replaced by all or part of another V(H) have been appearing since the 1980s. Evidence has been presented of two rather different types of replacement. One of these has gained acceptance and has now been clearly demonstrated to oc...

journal_title：Immunology

authors： Darlow JM,Stott DI

更新日期：2005-02-01 00:00:00

abstract：:It has previously been demonstrated that a gene on chromosome 1 in or near Mls-1 controls, on the surface of B cells, the mobility and aggregability of major histocompatibility complex (MHC) class II molecules but not the mobility or aggregability of other B-cell molecules, such as immunoglobulin (Ig) and class I anti...

journal_title：Immunology

authors： Mecheri S,Dannecker G,Dennig D,Hoffmann MK

更新日期：1991-12-01 00:00:00

abstract：:Mouse models and a recent vaccine trial have indicated the importance of T-cell immunity to the circumsporozoite protein (CSP) of malaria sporozoites. One of the major impediments for the development of a CSP-based vaccine is that human T-cell epitopes, identified on the CSP, span regions of significant point mutation...

journal_title：Immunology

authors： Zevering Y,Khamboonruang C,Good MF

更新日期：1998-07-01 00:00:00

abstract：:This study has examined the stimuli required for secretion of regulated upon activation, normal T-cell expressed, presumed secreted (RANTES) from T lymphocytes and found that stimuli such as phorbol 12-myristate 13-acetate (PMA), which are unable to support T-cell proliferation and interleukin-2 (IL-2) production, are...

journal_title：Immunology

authors： Sotsios Y,Blair PJ,Westwick J,Ward SG

更新日期：2000-09-01 00:00:00

abstract：:Toll-like receptors (TLRs) are key receptors of the innate immune system and show cell subset-specific expression. We investigated the messenger RNA (mRNA) expression of TLR genes in human haematopoietic stem cells (HSC), in naïve B cells, in memory B cells, in plasma cells from palatine tonsils and in plasma cells fr...

journal_title：Immunology

authors： Dorner M,Brandt S,Tinguely M,Zucol F,Bourquin JP,Zauner L,Berger C,Bernasconi M,Speck RF,Nadal D

更新日期：2009-12-01 00:00:00

abstract：:This study examines the expression of mRNA for the Th2 cytokine, interleukin-4 (IL-4). Peripheral blood mononuclear cells from deer infected with Mycobacterium bovis or vaccinated with live or killed M. bovis bacillus Calmette-Guérin (BCG) were cultured with mycobacterial antigens. IL-4 mRNA production was assayed usi...

journal_title：Immunology

authors： Hook S,Griffin F,Mackintosh C,Buchan G

更新日期：1996-06-01 00:00:00

abstract：:Mitogen-activated protein/ERK kinase kinase 3 (MEKK3) is a Ser/Thr protein kinase belonging to the MEKK/STE11 subgroup of the MAP3K family. Recently, we found that MEKK3 plays a critical role in interleukin-1 (IL-1) receptor and Toll-like receptor 4 signalling using established primary mouse embryonic fibroblast (MEF)...

journal_title：Immunology

authors： Kim K,Duramad O,Qin XF,Su B

更新日期：2007-02-01 00:00:00

abstract：:It is now well accepted that sex hormones have immunoregulatory activity and may prevent exacerbations in multiple sclerosis during pregnancy. Our previous studies demonstrated that oestrogen (17β-oestradiol; E(2) ) protection against experimental autoimmune encephalomyelitis (EAE) is mediated mainly through oestrogen...

journal_title：Immunology

authors： Bodhankar S,Vandenbark AA,Offner H

更新日期：2012-12-01 00:00:00

abstract：:Natural infection by mouse hepatitis virus (MHV) can affect interpretation of immunological studies in mice. MHV, a collective term describing a group of corona viruses, is found in natural infections in over 70% of laboratory mouse populations in the U.S.A. and Canada. Natural outbreaks of MHV in our animal colony af...

journal_title：Immunology

authors： Cook-Mills JM,Munshi HG,Perlman RL,Chambers DA

更新日期：1992-03-01 00:00:00

abstract：:Monocyte chemotactic protein-1 (MCP-1) is a proinflammatory cytokine that attracts and activates specific types of leucocytes. The purpose of this work was to analyse the generation of MCP-1 and mRNA transcript in a model of chronic inflammation using a granulomatous tissue induced by potassium permanganate (KMnO4; wa...

journal_title：Immunology

authors： Conti P,Reale M,Feliciani C,Frydas S,Trakatellis M,Placido FC,Cataldo I,Di Gioacchino M,Barbacane RC

更新日期：1997-10-01 00:00:00

abstract：:In lipopolysaccharide (LPS)-hyporesponsive C3H/HeJ mice, alveolar macrophages (AMphi) produce much more tumour necrosis factor-alpha than peritoneal macrophages (PMphi) when stimulated with LPS (10 microgram/ml), but the induction of inducible nitric oxide synthase (iNOS) gene expression and production of nitric oxide...

journal_title：Immunology

authors： Wang MJ,Jeng KC,Shih PC

更新日期：1999-12-01 00:00:00

abstract：:Human β-defensin 3 (hBD-3) activates antigen-presenting cells through Toll-like receptors (TLRs) 1/2. Several TLR1/2 agonists have been identified but little is known about how they might differentially affect cellular activation. We compared the effects of hBD-3 with those of another TLR1/2 agonist, Pam(3) CSK(4) , i...

journal_title：Immunology

authors： Funderburg NT,Jadlowsky JK,Lederman MM,Feng Z,Weinberg A,Sieg SF

更新日期：2011-10-01 00:00:00

abstract：:Autoimmune diabetes is predominated by a T helper 1 (Th1) response at the expense of an impaired Th2 response. Although T cells producing Th2 cytokines are generally thought to counter a Th1 response, there have been reports of Th2 T-cell clones with pathogenic activity, including one previously reported by us in whic...

journal_title：Immunology

authors： He J,Haskins K

更新日期：2008-01-01 00:00:00

abstract：:The intestine immune response in rats following immunization with horseradish peroxidase (HRP) was studied morphologically. Various routes of immunization (intraperitoneal, intravenous, intraenteric and intra-Peyer's patch) were tested. Single injections did not evoke any specific antibody-containing (anti-HRP) cells ...

journal_title：Immunology

authors： Sminia T,Delemarre F,Janse EM

更新日期：1983-09-01 00:00:00

abstract：:Mercuric chloride (HgCl2)-induced autoimmunity in Brown Norway rats is a spontaneously resolving autoimmune response driven by the activation of T helper type 2 lymphocytes (Th2 cells). Treatment with antibody to OX40-ligand (OX40-L) from the time of the first HgCl2 injection for 12 days had little effect. Delayed tre...

journal_title：Immunology

authors： MacPhee IA,Yagita H,Oliveira DB

更新日期：2006-03-01 00:00:00

abstract：:Conjugates carrying a single 2-carboxy-4,6-dinitrophenyl hapten and as auxiliary group various thiazolidine substituents related to penicilloyl, were prepared and studied in guinea-pig passive cutaneous anaphylaxis (PCA). Included are monohaptenic model conjugates with discrete hydrocarbon auxiliary groups. One of the...

journal_title：Immunology

authors： Guenin R,Schneider CH

更新日期：1984-05-01 00:00:00

abstract：:Dogs with immunoglobulin E (IgE) allergy for ragweed that are sensitized by intrapulmonary exposure to ragweed can be used to study the pulmonary immune response that is important in allergic asthma. Using this model, we tested the hypothesis that T lymphocytes are activated locally in the airways shortly after allerg...

journal_title：Immunology

authors： Out TA,Wang SZ,Rudolph K,Bice DE

更新日期：2002-04-01 00:00:00

abstract：:The biochemical analysis of murine Fc gamma RI has been difficult because this receptor is co-expressed with other Fc receptors on the cell surface of myeloid cells and all precipitate together with immune complexes. To overcome this problem and to study cells which expressed Fc gamma RI and only this Fc receptor, sta...

journal_title：Immunology

authors： Quilliam AL,Osman N,McKenzie IF,Hogarth PM

更新日期：1993-03-01 00:00:00

abstract：:Immune synapse formation is critical for T lymphocyte activation, and mitochondria have a role in this process, by localizing close to the immune synapse, regulating intracellular calcium concentration, and providing locally required ATP. The interaction between antigen presenting cells (APCs) and T lymphocytes is a t...

journal_title：Immunology

authors： Bonifaz L,Cervantes-Silva M,Ontiveros-Dotor E,López-Villegas E,Sánchez-García F

更新日期：2014-09-23 00:00:00

abstract：:The uptake by human blood monocytes of sheep erythrocytes treated with rabbit anti-sheep antibody with or without mouse complement was assessed by a radioactive method to discover whether immune complexes would inhibit this reaction. It was found that sera from SLE patients inhibited uptake whereas normal sera enhance...

journal_title：Immunology

authors： Temple A,Loewi G

更新日期：1977-07-01 00:00:00

abstract：:The effect on murine immunoglobulin G (IgG) glycosylation of altering IgG production in vivo was assessed in interleukin (IL)-6 transgenic and CD4 knockout mice. C57BL/6 mice carrying the IL-6 transgene showed increased levels of circulating IgG. This was associated with decreased levels of galactose on the IgG oligos...

journal_title：Immunology

authors： Jeddi P,Keusch J,Lydyard PM,Bodman-Smith KB,Chesnutt MS,Wofsy D,Hirota H,Taga T,Delves PJ

更新日期：1999-11-01 00:00:00

abstract：:Cholera toxin (CT) or its subunits were given orally to mice and division of intestinal intraepithelial lymphocytes (IEL) in vivo measured by double immunofluorescence using 5-bromo-2'-deoxyuridine (BRdU) and membrane alpha beta T-cell receptors (TCR) or gamma delta TCR staining in frozen sections. Cholera toxin (10 m...

journal_title：Immunology

authors： Penney I,Kilshaw PJ,MacDonald TT

更新日期：1996-09-01 00:00:00

abstract：:The epigenetic regulation of transcription factor genes is critical for T-cell lineage specification. A specific methylation pattern within a conserved region of the lineage specifying transcription factor gene FOXP3, the Treg-specific demethylated region (TSDR), is restricted to regulatory T (Treg) cells and is requi...

journal_title：Immunology

authors： Kehrmann J,Tatura R,Zeschnigk M,Probst-Kepper M,Geffers R,Steinmann J,Buer J

更新日期：2014-07-01 00:00:00