Activation of an interleukin-4 mRNA-producing population of peripheral blood mononuclear cells after infection with Mycobacterium bovis or vaccination with killed, but not live, BCG.

abstract：:The effect of E. coli lipopolysaccharide (LPS) on the induction of both hapten-specific immunity and tolerance was studied in an in vivo system utilizing putative T-cell dependent (TD) or T-cell independent (TI) challenge antigens. The administration of LPS 1 day prior to challenge preempted the response of C3D2 mice ...

journal_title：Immunology

authors： Venkataraman M,Scott DW

更新日期：1979-11-01 00:00:00

abstract：:Evidence is accumulating that dietary iodine intake is an important modulator of autoimmune thyroid reactions. To study this role of iodine intake further, female Wistar rats were kept on an enriched iodine diet (EID, iodine intake 100 micrograms iodine/day) for a period of up to 18 weeks. Control rats were either on ...

journal_title：Immunology

authors： Mooij P,de Wit HJ,Drexhage HA

更新日期：1994-02-01 00:00:00

abstract：:Previous studies in our laboratory have shown that bone-marrow-derived mast cells (BMMC) could present immunogenic peptides, from soluble antigens endocytosed through fluid phase, only if they were subjected to a 48-hr treatment with interleukin-4 (IL-4) and granulocyte-macrophage colony-stimulating factor (GM-CSF). I...

journal_title：Immunology

authors： Tkaczyk C,Villa I,Peronet R,David B,Mécheri S

更新日期：1999-06-01 00:00:00

abstract：:Highly enriched bovine polymorphonuclear neutrophils (PMN) were able to destroy herpesvirus-infected cells in the presence of complement. Our results suggest that some viral antigens are capable of activating the alternate complement pathway directly which results in cytotoxicity however, the addition of PMN plus comp...

journal_title：Immunology

authors： Grewal AS,Babiuk LA

更新日期：1980-06-01 00:00:00

abstract：:All-trans retinoic acid (atRA), the main biologically active metabolite of vitamin A, has been implicated in immunoregulation and anti-cancer. A recent finding that vitamin A could decrease the risk of melanoma in humans indicates the beneficial role of atRA in melanoma. However, it remains unknown whether topical app...

journal_title：Immunology

authors： Yin W,Song Y,Liu Q,Wu Y,He R

更新日期：2017-10-01 00:00:00

abstract：:Much of the pathology of malaria may be due to the interactions of cytokines, especially tumour necrosis factor (TNF), with various cell types, including endothelial cells, with consequent widespread systemic effects. It has been shown previously that heat-stable exoantigens in the supernatants of blood-stage parasite...

journal_title：Immunology

authors： Bate CA,Taverne J,Davé A,Playfair JH

更新日期：1990-07-01 00:00:00

abstract：:The suppression of immune responsiveness to heterologous antigenic stimulation during concurrent infection with Nematospiroides dubius was reproduced using soluble antigens derived from adult parasites. Immunosuppression appeared to be selective in that the administration of equivalent quantities of an irrelevant hete...

journal_title：Immunology

authors： Pritchard DI,Ali NM,Behnke JM

更新日期：1984-04-01 00:00:00

abstract：:Runx1 transcription factor is highly expressed at a CD4/CD8-double-negative (DN) stage of thymocyte development but is down-regulated when cells proceed to the double-positive (DP) stage. In the present study, we examined whether the down-regulation of Runx1 is necessary for thymocyte differentiation from the DN to DP...

journal_title：Immunology

authors： Wong WF,Nakazato M,Watanabe T,Kohu K,Ogata T,Yoshida N,Sotomaru Y,Ito M,Araki K,Telfer J,Fukumoto M,Suzuki D,Sato T,Hozumi K,Habu S,Satake M

更新日期：2010-06-01 00:00:00

abstract：:The human primary and secondary IgG subclass antibody responses to keyhole limpet haemocyanin (KLH) have been measured by ELISA using IgG subclass-specific monoclonal antibodies. KLH-specific IgG1 and IgG2 antibodies were detected 3 weeks after primary immunization, and IgG1, IgG2 and IgG4 antibodies after secondary i...

journal_title：Immunology

authors： Bird P,Calvert JE,Amlot PL

更新日期：1990-03-01 00:00:00

abstract：:The ability of preparations of cobra factor (CoF) to convert C3 via the properdin pathway (anticomplementary activity) has been demonstrated to be unrelated to its ascribed ability to convert a tolerogenic signal into an immunogenic stimulus (adjuvant activity). It has been shown that CoF preparations which have becom...

journal_title：Immunology

authors： Morrison DC,Louis JA,Weigle WO

更新日期：1976-03-01 00:00:00

abstract：:Toll-like receptor 2 (TLR2) is a key mediator of the immune response to mycobacterial infections, and mutations in TLR2 have been shown to confer susceptibility to infection with mycobacteria. This study investigated the profiles of cytokines, such as interferon (IFN)-gamma, interleukin (IL)-10, IL-12 and tumour necro...

journal_title：Immunology

authors： Kang TJ,Yeum CE,Kim BC,You EY,Chae GT

更新日期：2004-08-01 00:00:00

abstract：:Co-stimulation of highly purified peripheral T lymphocytes from healthy blood donors with the adhesion molecules CD2 and CD28 in association with recombinant interleukin-7 (rIL-7) induced T-cell proliferation, multiple cytokine secretion and IL-2 receptivity. We demonstrated that rIL-7 is as potent as rIL-2 in inducin...

journal_title：Immunology

authors： Costello R,Brailly H,Mallet F,Mawas C,Olive D

更新日期：1993-11-01 00:00:00

abstract：:Thoracic duct lymphocytes (TDL) from (AS2 x AS)F1 rats previously injected with human serum albumin (HSA) were transferred to 900 r irradiated syngeneic recipients which were challenged with various doses of soluble HSA (s-HSA). TDL from partially tolerant rats, which were deficient in high avidity B cells, produced a...

journal_title：Immunology

authors： Bell EB,Shand FL

更新日期：1977-10-01 00:00:00

abstract：:Experimental protocols have been devised to deliniate the importance of T-cell subsets in immunity to Moloney sarcoma virus-induced tumours using the surface antigens L3T4 and Lyt-2 as markers of helper and cytotoxic cells, respectively. Because the monoclonal antibodies used have been shown to deplete T-cell subsets ...

journal_title：Immunology

authors： Bateman WJ,Jenkinson EJ,Owen JJ

更新日期：1987-07-01 00:00:00

abstract：:The development of improved vaccines and vaccination strategies against Mycobacterium tuberculosis has been hindered by a limited understanding of the immune correlates of anti-tuberculosis protective immunity. Simple measurement of interferon-γ frequency or production per se does not provide adequate prediction of im...

journal_title：Immunology

authors： Kang H,Yuan Q,Ma H,Hu ZD,Han DP,Wu K,Lowrie DB,Fan XY

更新日期：2014-12-01 00:00:00

abstract：:We have isolated, characterized and quantified the immunocompetent cells present in the extravascular hepatic compartment at various stages after Plasmodium yoelii malaria infection with sporozoites. Cytological analyses revealed a predominantly lymphoid population. In mice with a primary infection, the predominant ce...

journal_title：Immunology

authors： Faure P,Marussig M,Goossens P,Miltgen F,Mazier D

更新日期：1994-08-01 00:00:00

abstract：:Virus plaque assay (VPA) was utilized for the quantitative evaluation of activated lymphocytes. We examined what types of cells, especially which of activated T and non-T lymphocytes, were detected as infective centres after infection with vesicular stomatitis virus. Marked increases in DNA synthesis and in virus-plaq...

journal_title：Immunology

authors： Kasahara T,Shioiri-Nakano K,Sugiura A

更新日期：1977-06-01 00:00:00

abstract：:The aim of this study was to characterize the epitope specificity and the idiotype(s) of gp330-specific autoantibodies in active Heymann nephritis (HN). To study this, two monoclonal autoantibodies (mAb), 3D9B and 5B8C, derived from Lewis rats with HN, were generated. These antibodies bound to different epitopes on th...

journal_title：Immunology

authors： Specht Grijp-Glandorf RJ,De Heer E,Dekker-Nooren CC,Daha MR,Van Es LA

更新日期：1990-07-01 00:00:00

abstract：:Purified cleavage products of the guinea-pig complement component C3, namely C3b and C3a, interact with guinea-pig and mouse macrophages in culture to induce a dose- and time dependent release of lysosmal enzymes into the medium. In the case of C3b the selectivity of the release of hydrolases, which occurs without cel...

journal_title：Immunology

authors： Schorlemmer HU,Allison AC

更新日期：1976-11-01 00:00:00

abstract：:Using KOLT-2 monoclonal antibody (mAb) recognizing a 44,000 molecular weight (MW) T-cell activation antigen (CD28), we observed the co-expression of KOLT-2 (CD28) antigen and Tac (CD25) antigen, associated with a 55,000 MW chain of the interleukin-2 receptor (IL-2R) complex. IL-2R (p55), on several T-cell lines transf...

journal_title：Immunology

authors： Shindo T,Sugie K,Nakamura K,Tagaya Y,Maeda M,Uchiyama T,Sagawa K,Yokoyama M,Wada H,Hitomi S

更新日期：1990-09-01 00:00:00

abstract：:The anti-C6 monoclonal antibody WU 6-4 was shown to be unequivocally native restricted since it neither binds to the terminal complement complex (TCC) nor to C5b6. In addition, it was shown to inhibit TCC formation by interfering with C5b6 generation. Using the pUEX expression system and C6 cDNA the WU 6-4 epitope was...

journal_title：Immunology

authors： Würzner R,Mewar D,Fernie BA,Hobart MJ,Lachmann PJ

更新日期：1995-06-01 00:00:00

abstract：:Studies of tuberculosis have suggested a shift in dominance from a T helper type 1 (Th1) towards a Th2 immune response that is associated with suppressed cell-mediated immune (CMI) responses and increased humoral responses as the disease progresses. In this study a natural host disease model was used to investigate th...

journal_title：Immunology

authors： Welsh MD,Cunningham RT,Corbett DM,Girvin RM,McNair J,Skuce RA,Bryson DG,Pollock JM

更新日期：2005-01-01 00:00:00

abstract：:Macrophage activating factor (MAF) is produced by antigen-stimulated lymphocytes and activates macrophages for antimicrobial function. The capacity of individual microbial antigens to evoke and regulate this response has been explored using an affinity purified antigen (TB68) of Mycobacterium tuberculosis in combinati...

journal_title：Immunology

authors： Matthews R,Scoging A,Rees AD

更新日期：1985-01-01 00:00:00

abstract：:Cells subjected to nucleoside incorporation studies using radiolabelled materials may suffer radiation damage that can alter the results. We did scintimetric and cytofluorographic analysis to confirm this and to determine the optimal experimental doses of, and exposure times to, [3H]-TdR, in order to prevent or minimi...

journal_title：Immunology

authors： Ruiz-Arguelles A,Llorente L,Díaz-Jouanen E,Alarcón-Segovia D

更新日期：1981-12-01 00:00:00

abstract：:T-cell-mediated immunity to a virulent strain of Plasmodium berghei NK65 (Pb NK65) and to an attenuated derivative (Pb XAT) of the strain were examined in CBA mice by the administration of monoclonal antibodies against T-cell subsets or interferon-gamma (IFN-gamma). The injection of anti-CD8+ or anti-IFN-gamma delayed...

journal_title：Immunology

authors： Waki S,Uehara S,Kanbe K,Ono K,Suzuki M,Nariuchi H

更新日期：1992-04-01 00:00:00

abstract：:Receptors for the Fc fragment of IgG (Fc gamma R) have a well-documented role in the generation of oxidative burst. It is tempting to speculate that the type of interaction with Fc gamma R could be a mechanism of regulation of this process. Here we report on a comparative study of the induction of oxidative burst in h...

journal_title：Immunology

authors： Casado JA,Merino J,Cid J,Subira ML,Sanchez-Ibarrola A

更新日期：1994-09-01 00:00:00

abstract：:The subcutaneous (s.c.) injection of sheep red blood cells (SRBC) without adjuvant into mice preferentially induced delayed hypersensitivity (DH) reaction, as measured by footpad swelling, while intraperitoneal (i.p.) measured by the haemagglutinin test. Under these conditions, the properties of the helper activities...

journal_title：Immunology

authors： Tamura SI,Egashira Y

更新日期：1975-05-01 00:00:00

abstract：:The immunosuppressive effect of cyclosporin A (CS-A) was investigated in RIC-Sprague-Dawley rats. In vivo, CS-A totally abolished the formation of antibodies to the hapten dinitrophenyl (DNP) in rats immunized with DNP-keyhole limpet haemocyanin. In vitro, the effect of CS-A was investigated in spleen cell cultures st...

journal_title：Immunology

authors： Burckhardt JJ,Guggenheim B

更新日期：1979-04-01 00:00:00

abstract：:Antibody response to a T-cell dependent antigen, sheep erythrocytes and to a B-cell mitogen, purified lipopolysaccharide (LPS), has been studied in mice kept on protein deficient (2 and 4 per cent casein) diets. The number of plaque-forming cells (PFC) to SRBC were 20-5 +/- 7-7 per million spleen cells in protein-defi...

journal_title：Immunology

authors： Narayanan RB,Nath I,Bhuyan UN,Talwar GP

更新日期：1977-03-01 00:00:00

abstract：:We have developed a hybridoma cell line which secretes monoclonal antibody to human basement membrane type IV collagen. The monoclonal antibody secreted by this hybridoma has been obtained in large amounts by either concentrating it from culture supernatants or from the ascites fluid of mice bearing the hybridoma tumo...

journal_title：Immunology

authors： Sundarraj N,Willson J

更新日期：1982-09-01 00:00:00