Monoclonal antibody to human basement membrane collagen type IV.

abstract：:We have used a number of in vitro and in vivo techniques to identify the molecules that can bind to the cytoplasmic tail of the Ly49A receptor. Affinity chromatography using peptides corresponding to the N-terminal 18 amino acids of Ly49A allowed the recovery of a number of proteins that bound preferentially to the ty...

journal_title：Immunology

authors： Daws MR,Eriksson M,Oberg L,Ullén A,Sentman CL

更新日期：1999-08-01 00:00:00

abstract：:IgM was purified from normal human colostrum and salivary secretions devoid of IgA. The isolated immunoglobulin was found to contain J chain, and showed a slight affinity for free secretory component (SC). In the secretions IgM was saturated with SC, but only 60--70 per cent of the molecules had retained the component...

journal_title：Immunology

authors： Brandtzaeg P

更新日期：1975-09-01 00:00:00

abstract：:Young (15-week-old) CBA/Ca mice were injected intravenously with spleen cells from individual young (15-week-old) or old (18-24-month-old) CBA/T6T6 mice. Samples of peripheral blood were taken at monthly intervals and cultured with phytohaemagglutinin (PHA) to stimulate T lymphocytes into mitosis. In the recipients of...

journal_title：Immunology

authors： Wallis VJ,Chaudhuri M,Jacob MC,Valkova BA,Davies AJ

更新日期：1984-12-01 00:00:00

abstract：:The in vitro migration activity of monocytic cells and the effect of lymphocytes in the delayed hypersensitivity (DH) reaction induced by intrapleural injection of PPD into FCA-sensitized guinea-pigs was investigated. The in vitro migration of exudate mononuclear cells was lower than that of comparable blood cells, an...

journal_title：Immunology

authors： Yamamoto S,Dunn CJ,Willoughby DA

更新日期：1976-04-01 00:00:00

abstract：:The aim of this study was to characterize the epitope specificity and the idiotype(s) of gp330-specific autoantibodies in active Heymann nephritis (HN). To study this, two monoclonal autoantibodies (mAb), 3D9B and 5B8C, derived from Lewis rats with HN, were generated. These antibodies bound to different epitopes on th...

journal_title：Immunology

authors： Specht Grijp-Glandorf RJ,De Heer E,Dekker-Nooren CC,Daha MR,Van Es LA

更新日期：1990-07-01 00:00:00

abstract：:The metabolic consequences of non-lethal complement-membrane attack in neutrophils have been investigated by the measurement of cellular ATP content and functional parameters, including chemotactic and phagocytic responses and the capacity to secrete reactive oxygen metabolites, in cells before and after attack. Immed...

journal_title：Immunology

authors： Morgan BP

更新日期：1988-01-01 00:00:00

abstract：:We previously described the processing of antibodies to CD74 (the major histocompatibility complex class II-associated invariant chain, Ii), by B-cell lymphoma cell lines. These cells expressed relatively low levels of Ii on the surface, but the molecules were rapidly internalized and replaced by new molecules, so tha...

journal_title：Immunology

authors： Ong GL,Goldenberg DM,Hansen HJ,Mattes MJ

更新日期：1999-10-01 00:00:00

abstract：:Mercuric chloride (HgCl2)-induced autoimmunity in Brown Norway rats is a spontaneously resolving autoimmune response driven by the activation of T helper type 2 lymphocytes (Th2 cells). Treatment with antibody to OX40-ligand (OX40-L) from the time of the first HgCl2 injection for 12 days had little effect. Delayed tre...

journal_title：Immunology

authors： MacPhee IA,Yagita H,Oliveira DB

更新日期：2006-03-01 00:00:00

abstract：:Class switching and plasma cell differentiation occur at a high level within all mucosa-associated lymphoid tissues. The different classes of membrane immunoglobulin heavy chains are associated with the Igα/Igβ heterodimer within the B-cell receptor (BCR). Whether BCR isotypes convey specific signals adapted to the co...

journal_title：Immunology

authors： Amin R,Carrion C,Decourt C,Pinaud E,Cogné M

更新日期：2012-05-01 00:00:00

abstract：:The role of gut-derived CD4+ T cells in clearance of Pseudomonas aeruginosa from the lung was studied by cell transfer experiments. Mesenteric lymph node cells from unimmunized rats, or rats orally immunized with either killed P. aeruginosa or Helicobacter pylori, were transferred to naive rats which were subsequently...

journal_title：Immunology

authors： Dunkley ML,Clancy RL,Cripps AW

更新日期：1994-11-01 00:00:00

abstract：:We established in previous studies that the binding of Salmonella lipopolysaccharide (LPS) to constitutive receptors of low affinity triggers the expression of the inducible LPS-binding molecule CD14 in bone marrow cells (BMC) of C3H/HeOU mice, but not in BMC from C3H/HeJ mice. We show in this study that BMC from C3H/...

journal_title：Immunology

authors： Pedron T,Girard R,Jeyaretnam B,Carlson RW,Chaby R

更新日期：2000-10-01 00:00:00

abstract：:Monocyte chemotactic protein-1 (MCP-1) is a proinflammatory cytokine that attracts and activates specific types of leucocytes. The purpose of this work was to analyse the generation of MCP-1 and mRNA transcript in a model of chronic inflammation using a granulomatous tissue induced by potassium permanganate (KMnO4; wa...

journal_title：Immunology

authors： Conti P,Reale M,Feliciani C,Frydas S,Trakatellis M,Placido FC,Cataldo I,Di Gioacchino M,Barbacane RC

更新日期：1997-10-01 00:00:00

abstract：:B-lymphocyte maturation is considered to be independent of the thymus. However, there is circumstantial evidence suggesting that it may be impaired in nude animals that lack the thymus. Our study shows that the proportion of immature B-lymphocyte subsets (CD90(high) IgM(high) and CD90(high) IgM(low)) was significantly...

journal_title：Immunology

authors： Milićević NM,Nohroudi K,Milićević Z,Hedrich HJ,Westermann J

更新日期：2005-11-01 00:00:00

abstract：:In this paper we report that treatment with 17 beta-oestradiol depresses cutaneous delayed-type hypersensitivity (DTH) to oxazolone (OXA) in female oophorectomized NZB/W mice. Analysis of the parental strains revealed that this oestrogen-induced inhibition of DTH mice is a trait inherited from the healthy NZW and not ...

journal_title：Immunology

authors： Carlsten H,Holmdahl R,Tarkowski A,Nilsson LA

更新日期：1989-06-01 00:00:00

abstract：:Studies of tuberculosis have suggested a shift in dominance from a T helper type 1 (Th1) towards a Th2 immune response that is associated with suppressed cell-mediated immune (CMI) responses and increased humoral responses as the disease progresses. In this study a natural host disease model was used to investigate th...

journal_title：Immunology

authors： Welsh MD,Cunningham RT,Corbett DM,Girvin RM,McNair J,Skuce RA,Bryson DG,Pollock JM

更新日期：2005-01-01 00:00:00

abstract：:Passive transfer of immunity to Taenia taeniaeformis was achieved with serum taken 14, 21, 49 and 63 days after infection. The protective capacity of serum collected at 14 and 21 days resided in the 7Sgamma2 immunoglobulins and appeared to be partics the infection progressed the range of chromatographic fractions show...

journal_title：Immunology

authors： Musoke AJ,Williams JF

更新日期：1975-11-01 00:00:00

abstract：:The influence of antigens of the major histocompatibility complex (MHC) on the production of interferon (IFN) alpha or IFN gamma by human peripheral blood leucocytes (PBL) in vitro has been studied. Synthesis of IFN gamma by PBL stimulated with purified phytohaemagglutinin (PHA-P) or protein A of Staphylococcus aureus...

journal_title：Immunology

authors： Abb J,Zander H,Abb H,Albert E,Deinhardt F

更新日期：1983-06-01 00:00:00

abstract：:Macrophages have the potential to recognize apoptotic neutrophils and phagocytose them while the same function for monocytes is uncertain. In fact, early findings indicated that monocytes started to phagocytose neutrophils on the third day of differentiation to macrophages. Here we show, using flow cytometry and confo...

journal_title：Immunology

authors： Mikołajczyk TP,Skrzeczyńska-Moncznik JE,Zarebski MA,Marewicz EA,Wiśniewska AM,Dzieba M,Dobrucki JW,Pryjma JR

更新日期：2009-09-01 00:00:00

abstract：:The effect of long chain and medium chain fatty acid absorption on transport and mitogen-induced blast transformation of lymphocytes in intestinal lymphatics was investigated. Intestinal lymph was collected from mesenteric lymph duct cannulated rats maintained in Bollman's cage. Following the intraduodenal administrat...

journal_title：Immunology

authors： Miura S,Imaeda H,Shiozaki H,Ohkubo N,Tashiro H,Serizawa H,Tsuchiya M,Tso P

更新日期：1993-01-01 00:00:00

abstract：:Gene transfer to create tumour epitope-specific cytolytic T cells for adoptive immunotherapy of cancer remains an area of active inquiry. When the Mart-127-35 -specific DMF5 T-cell receptor (TCR) is transferred into peripheral human CD4(+) T cells, the reprogrammed cells exhibit a T helper type 1 (Th1) phenotype with ...

journal_title：Immunology

authors： Jha SS,Chakraborty NG,Singh P,Mukherji B,Dorsky DI

更新日期：2015-05-01 00:00:00

abstract：:Co-expression of EP2 and EP3 subtypes of prostaglandin E2 (PGE2) receptors (R) by U937 human monocytic cells permitted comparative studies of desensitization of each subtype. Specific binding of [3H]PGE2 to membranes of U937 cells showed a Kd of 2.9 +/- 0.3 nM (mean +/- SEM) and a Bmax of 40.5 +/- 1.0 fmol/mg protein,...

journal_title：Immunology

authors： Zeng L,An S,Goetzl EJ

更新日期：1995-12-01 00:00:00

abstract：:A suppressive B-cell factor (SBF)-producing hybridoma termed TS-4.44 was established by fusion of B cells which possessed receptors for the Fc portion of IgG (FcR gamma + B cells) and thymidine kinase defective fibroblasts, 3T3-4E cells. The biological properties of hybridoma-produced SBF (Hyb-SBF) are almost the same...

journal_title：Immunology

authors： Suzuki T,Miyama-Inaba M,Masuda T,Uchino H,Ishii K

更新日期：1983-12-01 00:00:00

abstract：:T cells from mice injected with picryl sulphonic acid (PSA) inhibit the expression of contact sensitivity to picryl chloride. Adult thymectomy (aTx) prevents the production of cells which inhibit the effector stage but cells from aTx mice are, however, still able to suppress the induction of contact sensitivity. These...

journal_title：Immunology

authors： Thomas WR,Watkins MC,Asherson GL

更新日期：1981-01-01 00:00:00

abstract：:Human β-defensin 3 (hBD-3) activates antigen-presenting cells through Toll-like receptors (TLRs) 1/2. Several TLR1/2 agonists have been identified but little is known about how they might differentially affect cellular activation. We compared the effects of hBD-3 with those of another TLR1/2 agonist, Pam(3) CSK(4) , i...

journal_title：Immunology

authors： Funderburg NT,Jadlowsky JK,Lederman MM,Feng Z,Weinberg A,Sieg SF

更新日期：2011-10-01 00:00:00

abstract：:The effect of corticosteroid administration on the redistribution of sirculating lymphocytes was studied in the guinea-pig, since this species closely resembles man in its relative resistance to the lymphopenic effect of corticosteroids. A single intravenous injection of hydrocortisone (either 10 mg or 100 mg/kg) cau...

journal_title：Immunology

authors： Fauci AS

更新日期：1975-04-01 00:00:00

abstract：:An investigation was made of the properties of cytotoxic T cells induced by Con A and exposure to LCM virus-infected cells. As a basis for such studies, the optimal conditions for in vitro Con A stimulation of in vivo LCM virus-primed C3H mouse splenocytes were determined. The most potent cytotoxicity was obtained whe...

journal_title：Immunology

authors： Marker O,Andersen GT

更新日期：1979-10-01 00:00:00

abstract：:The binding of 125I-BSA-anti-BSA immune complexes (IC) formed in the presence of complement (nascent IC) and those that reacted with complement after their formation (preformed IC) to human erythrocytes was studied. The effect of antigen-antibody ratios and serum dilutions on IC binding to red blood cells (RBC) were a...

journal_title：Immunology

authors： Varga L,Thiry E,Füst G

更新日期：1988-07-01 00:00:00

abstract：:Cancer immune surveillance is considered to be an important host protection process to inhibit carcinogenesis and to maintain cellular homeostasis. In the interaction of host and tumour cells, three essential phases have been proposed: elimination, equilibrium and escape, which are designated the 'three E's'. Several ...

journal_title：Immunology

authors： Kim R,Emi M,Tanabe K

更新日期：2007-05-01 00:00:00

abstract：:Tick larvae (Boophilus microplus) were extracted, fractionated by gel filtration and ion-exchange chromatography, and the fractions assayed by enzyme-linked immunosorbent assay (ELISA) against sera from cattle immunized and protected by antigens from the mid-gut of adult ticks. Unfractionated, whole larval extracts an...

journal_title：Immunology

authors： Opdebeeck JP,Wong JY,Dobson C

更新日期：1989-07-01 00:00:00

abstract：:We investigated the individual CD8+ populations with natural killer (NK) cell markers (NK-type T cell); CD56 single positive (CD56)-T cells, CD56/CD57 double positive (DP)-T cells and CD57 single positive (CD57)-T cells in the peripheral blood. All NK-type T-cell populations expressed CD122 and intermediate levels of ...

journal_title：Immunology

authors： Takayama E,Koike Y,Ohkawa T,Majima T,Fukasawa M,Shinomiya N,Yamaguchi T,Konishi M,Hiraide H,Tadakuma T,Seki S

更新日期：2003-02-01 00:00:00