Increased proliferative response of lymphocytes from intestinal lymph during long chain fatty acid absorption.

Abstract:

:The effect of long chain and medium chain fatty acid absorption on transport and mitogen-induced blast transformation of lymphocytes in intestinal lymphatics was investigated. Intestinal lymph was collected from mesenteric lymph duct cannulated rats maintained in Bollman's cage. Following the intraduodenal administration of oleic acid (long chain fatty acid) or octanoic acid (medium chain fatty acid), only oleic acid produced a significant increase in lymphocyte flux and enhanced proliferative response of lymphocyte in intestinal lymph, without significant alteration of lymphocyte subsets. These changes appeared to be closely correlated with the appearance of radiolabelled oleic acid. Absorption of a medium chain fatty acid, octanoic acid, most of which appeared to be transported to portal blood, did not produce a significant elevation of lymphocyte flux or increased proliferative response of lymphocyte in intestinal lymph. Pluronic L-81, which is a potent inhibitor of the intracellular formation and secretion of chylomicron, significantly attenuated the increased lymphocyte flux and suppressed the enhancement of lymphocyte responsiveness to PHA in intestinal lymph after stimulation by oleic acid administration. There is a possibility that lymphocyte transport and proliferative response in intestinal lymph during oleic acid absorption are closely related to the process of chylomicron formation and secretion to lymphatics in the intestinal mucosa.

journal_name

Immunology

journal_title

Immunology

authors

Miura S,Imaeda H,Shiozaki H,Ohkubo N,Tashiro H,Serizawa H,Tsuchiya M,Tso P

subject

Has Abstract

pub_date

1993-01-01 00:00:00

pages

142-6

issue

1

eissn

0019-2805

issn

1365-2567

journal_volume

78

pub_type

杂志文章
  • Mouse hepatitis virus infection suppresses modulation of mouse spleen T-cell activation.

    abstract::Natural infection by mouse hepatitis virus (MHV) can affect interpretation of immunological studies in mice. MHV, a collective term describing a group of corona viruses, is found in natural infections in over 70% of laboratory mouse populations in the U.S.A. and Canada. Natural outbreaks of MHV in our animal colony af...

    journal_title:Immunology

    pub_type: 杂志文章

    doi:

    authors: Cook-Mills JM,Munshi HG,Perlman RL,Chambers DA

    更新日期:1992-03-01 00:00:00

  • The bovine lymphoid system. III. A monoclonal antibody specific for bovine cell surface and serum IgM.

    abstract::Mouse spleen cells from animals immunized with bovine peripheral blood lymphocytes were fused to X63 . Ag8 myeloma cells and the activity of one of the resulting myeloma hybrids was characterized. The product of this clone (B5/4.1.4) binds to pentameric bovine IgM isolated from serum but not to serum IgG1 or IgG2. Thi...

    journal_title:Immunology

    pub_type: 杂志文章

    doi:

    authors: Pinder M,Musoke AJ,Morrison WI,Roelants GE

    更新日期:1980-07-01 00:00:00

  • SHP-1/immunoreceptor tyrosine-based inhibition motif-independent inhibitory signalling through murine natural killer cell receptor Ly-49A in a transfected B-cell line.

    abstract::Ly-49A is a member of the Ly-49 family of mouse natural killer cell receptors that inhibit cytotoxicity upon recognition of their ligands, the major histocompatibility complex (MHC) class I molecules, on the target cell surface. Although Ly-49A has an immunoreceptor tyrosine-based inhibition motif (ITIM) in its cytopl...

    journal_title:Immunology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2567.2000.00046.x

    authors: Motoda K,Takata M,Kiura K,Nakamura I,Harada M

    更新日期:2000-07-01 00:00:00

  • Inhibition of T-cell responsiveness by nasal peptide administration: influence of the thymus and differential recovery of T-cell-dependent functions.

    abstract::We have previously demonstrated that intranasal (i.n.) administration of the major encephalitogenic peptide, Ac1-9 of myelin basic protein (MBP), inhibited T-cell responsiveness in vitro and induced tolerance in the H-2u mouse model of experimental autoimmune encephalomyelitis (EAE). The peptide analogue Ac1-9[4Y] wit...

    journal_title:Immunology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2567.1999.00795.x

    authors: Metzler B,Wraith DC

    更新日期:1999-06-01 00:00:00

  • Spontaneous priming for anti-viral envelope cytotoxic T lymphocytes in mice transgenic for a murine leukaemia virus envelope gene (Fv4).

    abstract::Compared with non-transgenic controls, mice bearing an Fv4 murine retroviral env transgene resist infection and do not become immunosuppressed when inoculated with Friend virus (FV). When immunized with FV antigens in the absence of infectious virus, they make antibodies and cytotoxic lymphocytes (CTL) to FV comparabl...

    journal_title:Immunology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2567.1997.00157.x

    authors: Nihrane A,Silver J

    更新日期:1997-02-01 00:00:00

  • Preferential restriction of minor alloantigen-specific suppressor T cells to I-E rather than I-A molecules.

    abstract::Suppressor T (Ts) cells specific for minor alloantigens can be generated by intravenous administration of high doses (10(8) cells) of alloantigenic spleen cells. Such Ts cells have previously been shown to inhibit the in vivo induction of CTL responses and are now shown to suppress in vitro proliferative responses to ...

    journal_title:Immunology

    pub_type: 杂志文章

    doi:

    authors: Nanda NK

    更新日期:1989-10-01 00:00:00

  • Both kinetic data and epitope mapping provide clues for understanding the anti-coagulant effect of five murine monoclonal antibodies to human beta2-glycoprotein I.

    abstract::The interaction between five murine monoclonal antibodies (mAb) and beta2-glycoprotein I (beta2GPI) in the absence of phospholipids was studied using surface plasmon resonance-based biosensor technology. Two separate epitope regions were confirmed for the five mAb but epitopes of two mAb were shown to be overlapping b...

    journal_title:Immunology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2567.1999.00780.x

    authors: Regnault V,Arvieux J,Vallar L,Lecompte T

    更新日期:1999-07-01 00:00:00

  • Mast cells are activated by Staphylococcus aureus in vitro but do not influence the outcome of intraperitoneal S. aureus infection in vivo.

    abstract::Staphylococcus aureus is a major pathogen that can cause a broad spectrum of serious infections including skin infections, pneumonia and sepsis. Peritoneal mast cells have been implicated in the host response towards various bacterial insults and to provide mechanistic insight into the role of mast cells in intraperit...

    journal_title:Immunology

    pub_type: 杂志文章

    doi:10.1111/imm.12297

    authors: Rönnberg E,Johnzon CF,Calounova G,Garcia Faroldi G,Grujic M,Hartmann K,Roers A,Guss B,Lundequist A,Pejler G

    更新日期:2014-10-01 00:00:00

  • Mycobacterial antigen-specific human T-cell clones secreting macrophage activating factors.

    abstract::Macrophage activating factor (MAF) is produced by antigen-stimulated lymphocytes and activates macrophages for antimicrobial function. The capacity of individual microbial antigens to evoke and regulate this response has been explored using an affinity purified antigen (TB68) of Mycobacterium tuberculosis in combinati...

    journal_title:Immunology

    pub_type: 杂志文章

    doi:

    authors: Matthews R,Scoging A,Rees AD

    更新日期:1985-01-01 00:00:00

  • Distribution of Ia antigens and T lymphocyte subpopulations in rat lungs.

    abstract::In order to examine the mechanism of specific immunity in the lung, the distribution of Ia antigens and T lymphocyte populations was determined using immunoperoxidase-staining of cryostat sections of lungs from specific pathogen-free rats. BALT was found to be divided into three regions of lymphoid tissue. The central...

    journal_title:Immunology

    pub_type: 杂志文章

    doi:

    authors: Simecka JW,Davis JK,Cassell GH

    更新日期:1986-01-01 00:00:00

  • Immune response mediated by liposome-associated protein antigens. I. Potentiation of the plaque-forming cell response.

    abstract::Mice, immunized with liposome-associated bovine serum albumin (LSM-BSA), showed a significantly higher BSA-specific plaque-forming cell (PFC) response than did mice injected with fluid BSA (fBSA). Physical association between the liposome carrier and the protein antigen is imperative for potentiating the PFC response,...

    journal_title:Immunology

    pub_type: 杂志文章

    doi:

    authors: Shek PN,Sabiston BH

    更新日期:1982-02-01 00:00:00

  • An interferon-inducible molecule on brain endothelium which controls lymphocyte adhesion mediated by integrins.

    abstract::We undertook a search for cytokine-inducible molecules present on brain endothelium and which are involved in the control of lymphocyte adhesion. We screened 39 monoclonal antibodies (mAb) against rat brain endothelium in vitro, and identified five recognizing cytokine-inducible molecules. None of the 39 antibodies bl...

    journal_title:Immunology

    pub_type: 杂志文章

    doi:

    authors: Male D,Rahman J,Linke A,Zhao W,Hickey W

    更新日期:1995-03-01 00:00:00

  • Human small intestinal mucosa harbours a small population of cytolytically active CD8+ alphabeta T lymphocytes.

    abstract::Intraepithelial lymphocytes (IEL) in normal human small intestine exhibit cytotoxicity. This study was undertaken to characterize the effector cells and their mode of action. Freshly isolated jejunal IEL and lamina propria lymphocytes (LPL), as well as IEL and LPL depleted of CD4+, CD8+ and T-cell receptor (TCR)-gamma...

    journal_title:Immunology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2567.2002.01461.x

    authors: Melgar S,Bas A,Hammarström S,Hammarström ML

    更新日期:2002-08-01 00:00:00

  • Murine CD8 lymphocyte expansion in vitro by artificial antigen-presenting cells expressing CD137L (4-1BBL) is superior to CD28, and CD137L expressed on neuroblastoma expands CD8 tumour-reactive effector cells in vivo.

    abstract::The ability to expand tumour-infiltrating lymphocytes in vitro has been greatly enhanced by the use of antigen-independent mechanisms of immune cell costimulation. We have produced human, using the K562 cell line, and murine, using YAC-1 cells, artificial antigen presenting cells (aAPC) and demonstrate that these cell...

    journal_title:Immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2567.2004.01853.x

    authors: Yan X,Johnson BD,Orentas RJ

    更新日期:2004-05-01 00:00:00

  • Primary cytotoxic T-cell responses to bovine respiratory syncytial virus in calves.

    abstract::Bovine respiratory syncytial virus (RSV) is a major cause of respiratory disease in young calves. Recent studies in calves, in which different T-cell subsets were depleted, have shown that CD8+ T cells play a central role in recovery from RSV infection. The present study demonstrates that RSV-specific, major histocomp...

    journal_title:Immunology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2567.1996.d01-667.x

    authors: Gaddum RM,Cook RS,Thomas LH,Taylor G

    更新日期:1996-07-01 00:00:00

  • Creatine phosphokinase in rat mast cells.

    abstract::The soluble cytoplasmic fraction of an homogenate from peritoneal rat mast cells, demonstrated a considerable amount of catalytic activity which promotes the transfer of phosphate from creatine phosphate to ADP. The plasma membrane, mitochondrial and microsomal fractions show negligible amounts of the catalyst. Enzyme...

    journal_title:Immunology

    pub_type: 杂志文章

    doi:

    authors: Magro AM

    更新日期:1980-03-01 00:00:00

  • No impairment of local intestinal immune response to keyhole limpet haemocyanin in the absence of Peyer's patches.

    abstract::The role of Peyer's patches in the local intestinal and serum antibody responses to keyhole limpet haemocyanin (KLH) was studied in rabbits with chronically isolated ileal loops. Four weekly doses of 400 microgram KLH were administered into loops prepared with and without Peyer's patches. Isotype-specific IgA and IgG ...

    journal_title:Immunology

    pub_type: 杂志文章

    doi:

    authors: Hamilton SR,Keren DF,Yardley JH,Brown G

    更新日期:1981-03-01 00:00:00

  • Lymphocyte chemotaxis in inflammation. VII. Isolation and purification of chemotactic factors for T lymphocytes from PPD-induced delayed hypersensitivity skin reaction site in the guinea-pig.

    abstract::Four types of lymphocyte chemotactic factor (LCF-a, -b, -c and -d) could be isolated from extract of 24-hr-old delayed-type hypersensitivity (DTH) skin reaction sites induced with purified protein derivative (PPD) in guinea-pigs by gel filtration on Sephadex G-100 followed by chromatography with DEAE-Sephadex. Partial...

    journal_title:Immunology

    pub_type: 杂志文章

    doi:

    authors: Shimokawa Y,Harita S,Hayashi H

    更新日期:1984-02-01 00:00:00

  • The Toll-like receptor 1/2 agonists Pam(3) CSK(4) and human β-defensin-3 differentially induce interleukin-10 and nuclear factor-κB signalling patterns in human monocytes.

    abstract::Human β-defensin 3 (hBD-3) activates antigen-presenting cells through Toll-like receptors (TLRs) 1/2. Several TLR1/2 agonists have been identified but little is known about how they might differentially affect cellular activation. We compared the effects of hBD-3 with those of another TLR1/2 agonist, Pam(3) CSK(4) , i...

    journal_title:Immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2567.2011.03475.x

    authors: Funderburg NT,Jadlowsky JK,Lederman MM,Feng Z,Weinberg A,Sieg SF

    更新日期:2011-10-01 00:00:00

  • Cellular immune response in rnu/rnu rats. I. Lectin responsiveness and IL-2 production kinetics of natural cytotoxicity and spleen-cell surface marker expression.

    abstract::Several functional parameters and surface markers were studied serially in rnu/rnu rats and compared to rnu/+ controls. Expressed as a percentage of labelled splenocytes, rnu/rnu animals had decreased W3/13 (P less than 0.01) and W3/25 (P less than 0.01) positive cells. Both W3/13 and W3/25 antigens peaked at Week 16 ...

    journal_title:Immunology

    pub_type: 杂志文章

    doi:

    authors: Sfaksi A,Bonneville M,Soulillou JP

    更新日期:1985-08-01 00:00:00

  • Titration and circulation of cells mediating delayed type hypersensitivity in normal and cyclophosphamide treated mice during response to sheep red blood cells.

    abstract::The delayed-type-hypersensitivity (DTH) reaction observed in mice primed i.v. with low doses of sheep red blood cells is not detectable after priming with large doses. Estimation of the number of DTH mediating cells (DTH-C) was performed by titration (D50 determination) using local adoptive transfer of these cells mix...

    journal_title:Immunology

    pub_type: 杂志文章

    doi:

    authors: Marchal G,Milon G,Hurtrel B,Lagrance PH

    更新日期:1978-12-01 00:00:00

  • Influence of subclass-specific anti-idiotypic antibodies on the kinetics of the immune response to BCG.

    abstract::The role of anti-idiotypic subclass-specific antibodies was analysed in the regulation of the immune response to BCG in the guinea-pig. The idiotypes to BCG were separated into subclasses and anti-idiotypes were carried out by immunizing with the purified IgG1 and IgG2 anti-idiotypes. The in vivo T cell response was r...

    journal_title:Immunology

    pub_type: 杂志文章

    doi:

    authors: Daus H,Hammer HJ,Rajki K,Mauch H

    更新日期:1984-08-01 00:00:00

  • In vitro macrophage chemotactic generation from serum immunoglobulin G by neutrophil neutral seryl protease.

    abstract::A neutral protease with a molecular weight of about 14,00 was separated at acid pH from rabbit neutrophils and then partially purified by elution on DEAE-Sephadex, CM-Sephadex and Sephadex G-75 in that order. This enzyme was inactivated by diisopropyl fluorophosphate (DFP), phenylmethyl sulphonylfluoride (PMSF), soybe...

    journal_title:Immunology

    pub_type: 杂志文章

    doi:

    authors: Ishida M,Honda M,Hayashi H

    更新日期:1978-07-01 00:00:00

  • The genetic contribution to human T-cell receptor repertoire.

    abstract::Recent studies in mice have highlighted the importance of polymorphic genetic loci such as the major histocompatibility complex (MHC) or minor lymphocyte-stimulating antigen (Mls) in determining the nature of the peripheral T-cell receptor (TcR) population. As our knowledge of the equivalent process in humans is incom...

    journal_title:Immunology

    pub_type: 杂志文章

    doi:

    authors: Loveridge JA,Rosenberg WM,Kirkwood TB,Bell JI

    更新日期:1991-10-01 00:00:00

  • Functional studies of rabbit T lymphocytes.

    abstract::Rabbit spleen and mesenteric lymph node cells were treated with a monoclonal anti-rabbit T-lymphocyte antibody (MAb) and complement and the effect of the treatment on various lymphocyte functions was determined. Lysis of spleen and mesenteric lymph node cells reactive with this MAb, 9AE10, essentially eliminated their...

    journal_title:Immunology

    pub_type: 杂志文章

    doi:

    authors: McNicholas JM,Watkins JR,Johnson AD,Knight KL

    更新日期:1981-08-01 00:00:00

  • Complement activation by interaction of polyanions and polycations.

    abstract::Interactions between heparin and protamine in normal human serum previously were found to activate the primary complement pathway and deplete the early-acting complement components. In the present investigation, the role of heparin-protamine complexes, immunoglobulins, C1q and C1-INH in this interaction was studied. H...

    journal_title:Immunology

    pub_type: 杂志文章

    doi:

    authors: Fiedel BA,Rent R,Myhrman R,Gewurz H

    更新日期:1976-02-01 00:00:00

  • Clonal deletion as the mechanism of abrogation of immunological memory following liver grafting in rats.

    abstract::In the rat strain combination of DA into PVG, an orthotopic liver graft has the ability to abrogate an existing state of sensitization against donor (DA) antigens. Fifty-four percent of PVG rats sensitized against DA by skin grafting accepted a DA liver graft permanently, and about half of these became systemically to...

    journal_title:Immunology

    pub_type: 杂志文章

    doi:

    authors: Kamada N,Shinomiya T

    更新日期:1985-05-01 00:00:00

  • Production and functional analysis of rat CD59 and chimeric CD59-Crry as active soluble proteins in Pichia pastoris.

    abstract::Crry (CR1-related gene/protein) is a rodent complement regulator that inhibits C3 convertases. CD59 is a conserved protein inhibitor active towards C8 and C9. We have previously produced rat Crry as a recombinant soluble (rs) protein in Pichia pastoris. In this study we produced functionally active rat rsCD59 and a ch...

    journal_title:Immunology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2567.2000.00945.x

    authors: Quigg RJ,He C,Hack BK,Alexander JJ,Morgan BP

    更新日期:2000-01-01 00:00:00

  • Local immunity in the respiratory tract of the chicken. I. Transudation of circulating antibody in normal and virus-infected birds.

    abstract::Three-week-old chickens were given sheep erythrocytes or bovine serum albumin intravenously. Seven days later their tears and saliva possessed low levels of antibody to those antigens. Concurrent infection with lentogenic Newcastle disease virus (NDV) caused a significant increase in transuded antibody in those fluids...

    journal_title:Immunology

    pub_type: 杂志文章

    doi:

    authors: Aitken ID,Parry SH

    更新日期:1976-07-01 00:00:00

  • Characterization of E-selectin-binding epitopes expressed by skin-homing T cells.

    abstract::The glycoprotein counter-receptors for E-selectin borne on skin-homing T cells are poorly defined. In this study we have used flow cytometry to investigate the surface expression of potential carbohydrate ligands for E-selectin on HUT78, a skin-homing cutaneous T-cell lymphoma. These cells possessed high surface expre...

    journal_title:Immunology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2567.1998.00551.x

    authors: Priest R,Bird MI,Malhotra R

    更新日期:1998-08-01 00:00:00