Abstract：
:Macrophages have the potential to recognize apoptotic neutrophils and phagocytose them while the same function for monocytes is uncertain. In fact, early findings indicated that monocytes started to phagocytose neutrophils on the third day of differentiation to macrophages. Here we show, using flow cytometry and confocal microscopy, that peripheral blood monocytes phagocytose apoptotic but not freshly isolated granulocytes. Recognition of apoptotic cells is predominantly connected with CD16(+) monocytes (CD14(high) CD16(+) and CD14(dim) CD16(+)) and requires CD36. Clearance of apoptotic polymorphonuclear leucocytes appears to be independent of the CD14 mechanism. Uptake of apoptotic Jurkat T cells by monocytes is CD14 and CD36 dependent. Liposomes containing phosphatidyl-l-serine reduce binding of apoptotic polymorphonuclear leucocytes. Lipopolysaccharide-activated subpopulations of monocytes while in contact with apoptotic cells produce more anti-inflammatory cytokine interleukin-10 whereas the production of pro-inflammatory cytokines, tumour necrosis factor-alpha and interleukin-1beta is reduced.
journal_name
Immunologyjournal_title
Immunologyauthors
Mikołajczyk TP,Skrzeczyńska-Moncznik JE,Zarebski MA,Marewicz EA,Wiśniewska AM,Dzieba M,Dobrucki JW,Pryjma JRdoi
10.1111/j.1365-2567.2009.03087.xsubject
Has Abstractpub_date
2009-09-01 00:00:00pages
103-13issue
1eissn
0019-2805issn
1365-2567pii
IMM3087journal_volume
128pub_type
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