Abstract：
:In comparison to primary immune responses after lung immunization, the level of antigen-specific antibody and the number of cells producing specific antibody are significantly increased after challenging the lungs with antigen. The response of immune memory cells in the lung to an antigen challenge could be responsible for this elevated immune response. However, increased numbers of antibody-producing cells, possibly produced in the lung-associated lymph nodes, are also found in the blood after an antigen challenge. Therefore, it is possible that both the response of immune memory cells in the lung, and the recruitment of antibody-producing cells from the blood, contribute to the elevated levels of antibody in the lung after an antigen challenge. This study compared the level of antibody produced in the lung by the response of pulmonary immune memory cells with the level of antibody produced by antibody-forming cells that enter the lung from blood after an antigen challenge. This comparison was made possible by immunizing and challenging two lung lobes of dogs with two antigens. The immune responses to both antigens were then evaluated in both lung lobes after primary immunization and challenge. Data from these evaluations showed that most antibody in the lung after an antigen challenge is produced by a localized anamnestic response of pulmonary immune memory cells. A significantly lower level of antibody entered the lung from the vasculature and/or was produced by antibody-forming cells that entered the lung from blood after an antigen challenge.
journal_name
Immunologyjournal_title
Immunologyauthors
Bice DE,Muggenburg BAdoi
10.1111/j.1365-2567.1996.tb00004.xsubject
Has Abstractpub_date
1996-06-01 00:00:00pages
191-7issue
2eissn
0019-2805issn
1365-2567journal_volume
88pub_type
杂志文章相关文献
IMMUNOLOGY文献大全abstract：:In order to analyse the molecular mechanism of lymphocyte activation defect in MRL/MP-lpr (MRL/1) mice, c-myc proto-oncogene expression was examined in MRL/1 lymph node cells stimulated by various agents. Since a transient increase of c-myc RNA in early hours is required for lymphocyte activation, detection of c-myc m...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1988-05-01 00:00:00
abstract：:Using cloned human helper T lymphocytes reactive with a 24 amino acid peptide (p20) of the carboxyl terminal of the HA-1 molecule of influenza haemagglutinin we have investigated the influence of antigen structure on the activation and in the induction of antigen specific unresponsiveness of T cells. For this analysis...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1986-03-01 00:00:00
abstract：:An experiments in mice with a range of human serum albumin (HSA) molecules acylated to various degrees with side-chains of 6--20 carbon atoms, the greatest antibody responses against HSA were induced by highly acylated HSA with side-chains of intermediate length (C10--14). Similar results were obtained in rats but in ...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1980-03-01 00:00:00
abstract：:Corneal allografts contain few or no Ia+ Langerhans' cells and consistently fail to elicit allospecific delayed-type hypersensitivity (DTH). The present study examined the hypothesis that the inability of corneal allografts to induce allospecific DTH was the result of active suppression. However, the results indicated...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1993-12-01 00:00:00
abstract：:Using mast cell-deficient mutant W/Wv mice and their normal counterpart we re-evaluated the significance of participation of mast cells in allergic inflammatory response. W/Wv mice developed immediate hypersensitivity (IH) footpad reaction (FPR) to a somewhat lesser degree than the normal mice, suggesting that the mas...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1993-03-01 00:00:00
abstract：:The in vitro frequency and proliferative capacity of B cells and B-cell precursors in old mice was assessed. The mitogenic response to the B-cell mitogens lipopolysaccharide (LPS) and dextran sulphate decline later and at a slower rate than the T-cell response to phytohaemagglutinin and concanavalin A. The response to...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1979-06-01 00:00:00
abstract：:T helper type 17 (Th17) cells and regulatory T (Treg) cells are two distinct T-cell subsets with opposite effects on immune functions. While Th17 cells are a key effector in the immune response and play critical roles in the development of autoimmunity and inflammation, Treg cells orchestrate the overall immune respon...
journal_title：Immunology
pub_type： 杂志文章,评审
doi：10.1111/imm.12994
更新日期：2018-12-01 00:00:00
abstract：:Serum antibodies to glucosyltransferase (GTF) of Streptococcus mutans serotype c were assayed sequentially by means of an enzyme inhibition radio-assay in twenty-six Rhesus monkeys immunized with S. mutans. Pre-immune and control sera had a GTP-enhancing effect which was shown also by albumin and non-immune immunoglob...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1976-05-01 00:00:00
abstract：:Successful elimination of the hepatitis C virus (HCV) during acute infection has been linked to strong HCV-specific in vitro T-cell proliferation, whereas T cells from patients with chronic hepatitis C respond only weakly to HCV antigens. Lipid-coupled peptides are immunostimulants, which might provide a basis for nov...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1046/j.1365-2567.2001.01209.x
更新日期：2001-04-01 00:00:00
abstract：:To determine whether the availability of either B cells or T cells regulates the number and size of germinal centres observed following antigenic challenge, irradiated PVG rats were reconstituted with limiting numbers of thoracic duct B cells (with excess T cells) or with limiting numbers of thoracic duct CD4+ cells (...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1990-03-01 00:00:00
abstract：:The L2C leukaemia is a B-lymphocytic neoplasm of strain 2 guinea-pigs, maintained by passaging in vivo. It synthesizes mu and lambda immunoglobulin chains. These combines to form monomeric (7S) IgM molecules which are inserted into the plasma membranes. From here they are shed as monomeric IgM and as a species of high...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1978-05-01 00:00:00
abstract：:The role of endogenously mediated fever and exogenous hyperthermia as modulators of immune functions remains poorly understood. It is known that fever is mediated by several cytokines, including interleukin-1 alpha and interleukin-1 beta (IL-1 alpha and IL-1 beta), interleukin-6 (IL-6), tumour necrosis factor-alpha (T...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1991-07-01 00:00:00
abstract：:Experimental protocols have been devised to deliniate the importance of T-cell subsets in immunity to Moloney sarcoma virus-induced tumours using the surface antigens L3T4 and Lyt-2 as markers of helper and cytotoxic cells, respectively. Because the monoclonal antibodies used have been shown to deplete T-cell subsets ...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1987-07-01 00:00:00
abstract：:Antibody-dependent cellular cytotoxicity (ADCC) and Fc receptor-mediated phagocytosis were determined with human monocytes, monocyte-derived macrophages and activated macrophages, using rabbit IgG-covered sheep red blood cells (EAs) and anti-D-treated human erythrocytes (EAhu) as target cells. Monocyte and macrophage-...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1988-03-01 00:00:00
abstract：:Memory CD8(+) T cells regain function during a recall response, but the requirement of signals in addition to antigen during a secondary immune response is unknown. In this study, the ability of interleukin-7 (IL-7) to enhance memory CD8(+ ) CD45RA(- ) CD127(+) T-cell responses in health and in human immunodeficiency ...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1111/j.1365-2567.2010.03325.x
更新日期：2010-12-01 00:00:00
abstract：:Loss of ζ-associated protein 70 (Zap70) results in severe immunodeficiency in humans and mice because of the critical role of Zap70 in T-cell receptor (TCR) signalling. Here we describe a novel mouse strain generated by N-ethyl-N-nitrosourea mutagenesis, with the reduced protein stability (rps) mutation in Zap70. The ...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1111/imm.12199
更新日期：2014-03-01 00:00:00
abstract：:Mice injected in the footpad with carrageenin developed local inflammation which peaked at 48 hr. This delayed-type footpad swelling was significantly reduced in mice injected intraperitoneally (i.p.) with a specific nitric oxide (NO) synthase inhibitor, L-NGmonomethyl-arginine (L-NMMA). The draining lymph node (DLN) ...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1994-07-01 00:00:00
abstract：:A major role has been recently ascribed to the neutrophil in the resistance to infection by Listeria monocytogenes (L. monocytogenes). Here we evaluated whether such neutrophils played a role in the non-specific resistance to listeriosis that develops in hosts infected by mycobacteria. We found that the depletion of n...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1046/j.1365-2567.1996.d01-758.x
更新日期：1996-11-01 00:00:00
abstract：:Infection of nude mice with Mesocestoides corti results in spleen enlargement, with a decrease in percentage positive, but overall increase in Thy-1 positive cells. A low frequency of both parasite antigen-specific and alloantigen-reactive T-cell clones were isolated from the spleen, mesenteric lymph nodes, peritoneal...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1985-02-01 00:00:00
abstract：:Cytokines and their receptors represent key targets for therapeutic intervention. Ligands are being used to supplement cell numbers that become depleted as a result of disease (organ failure, infection) or subsequent disease treatments (i.e. chemotherapy). Conversely, the inhibition of target cell binding by cytokines...
journal_title：Immunology
pub_type： 杂志文章,评审
doi：10.1111/j.1365-2567.2004.01886.x
更新日期：2004-06-01 00:00:00
abstract：:We have established lines and clones of helper T cells specific for the antigen fowl gamma globulin (FGG) and maintained these cells in continuous proliferation in vitro for up to 8 months. During this period the specific helper activity was assessed in vitro in T cell-dependent anti-hapten responses. These pure popul...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1981-07-01 00:00:00
abstract：:In this paper we report that treatment with 17 beta-oestradiol depresses cutaneous delayed-type hypersensitivity (DTH) to oxazolone (OXA) in female oophorectomized NZB/W mice. Analysis of the parental strains revealed that this oestrogen-induced inhibition of DTH mice is a trait inherited from the healthy NZW and not ...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1989-06-01 00:00:00
abstract：:Fc-gamma receptor III (Fc gamma RIII, CD16) type A is expressed on natural killer cells, on a small subset of peripheral blood monocytes and on mature macrophages. Along with differentiation into macrophages, monocytes will express Fc gamma RIII when cultured with transforming growth factor-beta (TGF-beta). In view of...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1996-01-01 00:00:00
abstract：:The non-precipitating guinea-pig IgG1 and IgG2 antibodies, produced by administration of an excessive dose of hen ovalbumin (OA), were capable of forming only certain soluble complexes having molar ratios of antibody to antigen lower than 1-5:1, which were lower than the minimum ratio of 2-5:1 shown by anti-OA antibod...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1976-07-01 00:00:00
abstract：:Soluble low-affinity receptors for IgG are known to inhibit immune complex (IC)-mediated inflammation, and expression by leukocytes is elevated in several inflammatory diseases. Immunoglobulin M (IgM) rheumatoid factors (RF), anti-Fc autoantibodies, are found in autoimmune diseases, such as rheumatoid arthritis (RA), ...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1046/j.1365-2567.2003.01652.x
更新日期：2003-06-01 00:00:00
abstract：:The cellular elements of an antigen-specific suppressor system for secondary antibody responses have been identified, using positive cell-selection techniques in the fluorescence-activated cell sorter. In a double-adoptive transfer of memory cells for a thymus-dependent antigen, from one irradiated recipient to anothe...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1983-10-01 00:00:00
abstract：:The influence of the synthetic corticosteroid dexamethasone sodium phosphate (DEXA) upon mouse B cells was studied. This was done by in vivo treatment of mice with a single or multiple injection of DEXA, and by culturing murine spleen cells and bone marrow cells in vitro in the presence of different concentrations of ...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1987-10-01 00:00:00
abstract：:We studied the generation and metabolism of leukotrienes (LTs) in human lung macrophages obtained from lung tissue of patients with central bronchial carcinoma. By counterflow centrifugation macrophages were enriched with a purity of more than 95-100%. A time and dose dependent generation of LTB4 and LTC4 was determin...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1988-12-01 00:00:00
abstract：:In tumour (fibrosarcoma)-inoculated mice, alterations of host resistance to Listeria monocytogenes following tumour growth were examined. Non-immune macrophage-mediated antibacterial resistance was severely suppressed up to day 4 or so after tumour inoculation, but was enhanced thereafter. On the other hand, T cell-me...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1981-10-01 00:00:00
abstract：:The immunophenotypes of the HLA-DR-positive leucocyte populations in normal human skin were studied using an extensive panel of monoclonal antibodies, which included antibodies from the Third International Leucocyte Differentiation Antigen Workshop (3rd LDAW). Langerhans' cells (LC) in the epidermis stained with antib...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1988-12-01 00:00:00
