Abstract:
:Young (15-week-old) CBA/Ca mice were injected intravenously with spleen cells from individual young (15-week-old) or old (18-24-month-old) CBA/T6T6 mice. Samples of peripheral blood were taken at monthly intervals and cultured with phytohaemagglutinin (PHA) to stimulate T lymphocytes into mitosis. In the recipients of young lymphocytes, the percentage of donor cells dividing in these cultures remained low throughout the experiment, but in the recipients of old spleen cells, after an initial period when the percentage of donor cells declined, there was a marked increase in the percentage of donor cells. The interval between the injection and the increase in the proportion of donor cells was very variable. Ten of the 12 recipients of old lymphocytes developed tumours involving the spleen and mesenteric lymph node. They resembled type B reticulum cell neoplasms as described by Dunn & Deringer (1968), and all but two were transplantable. In addition, one mouse that had no evidence of tumour on histological examination nevertheless gave rise to a transplantable tumour. The five tumours on which chromosomal analysis was carried out proved to be of old donor cell origin. Two out of the five recipients of young cells also eventually developed tumours, but these arose later than the others, had a more granulocytic character, and did not transplant.
journal_name
Immunologyjournal_title
Immunologyauthors
Wallis VJ,Chaudhuri M,Jacob MC,Valkova BA,Davies AJsubject
Has Abstractpub_date
1984-12-01 00:00:00pages
769-77issue
4eissn
0019-2805issn
1365-2567journal_volume
53pub_type
杂志文章相关文献
IMMUNOLOGY文献大全abstract::The MHC class I and II antigen processing and presentation pathways display peptides to circulating CD8+ cytotoxic and CD4+ helper T cells respectively to enable pathogens and transformed cells to be identified. Once detected, T cells become activated and either directly kill the infected / transformed cells (CD8+ cyt...
journal_title:Immunology
pub_type: 杂志文章,评审
doi:10.1111/imm.12675
更新日期:2017-01-01 00:00:00
abstract::Initial separation and concentration of Clq from fresh, normal equine serum was accomplished by precipitation in 0.02 M acetate buffer, pH 5.5, at 4 degrees for 24 h. The re-dissolved precipitate was clarified by centrifugation at 80,000 g for 1 h and then dialysed against Tris-HCl buffer (0.05 M, pH 8.0) containing 1...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1979-07-01 00:00:00
abstract::The uptake by human blood monocytes of sheep erythrocytes treated with rabbit anti-sheep antibody with or without mouse complement was assessed by a radioactive method to discover whether immune complexes would inhibit this reaction. It was found that sera from SLE patients inhibited uptake whereas normal sera enhance...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1977-07-01 00:00:00
abstract::Although lymphocyte traffic through the brain is normally low, this can increase dramatically in response to infection or an autoimmune reaction. We have studied the adhesion of lymphocytes to cerebral endothelium in vitro in an attempt to model the first step of the infiltration process--that is, the initial interact...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1988-08-01 00:00:00
abstract::Cytokines are the most important inducers of T helper (Th) cell differentiation. Interleukin-12 (IL-12) and interferon-alpha (IFN-alpha) are responsible for human Th1-cell differentiation, while IL-4 is the critical cytokine promoting Th2-cell development. These two subsets of cells co-ordinate immunological responses...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1111/j.1365-2567.2005.02201.x
更新日期:2005-09-01 00:00:00
abstract::The level of circulating thymic factor (FTS) tested by its action on spleen rosette-forming cells from adult thymectomized mice, has been shown to be stable in young animals. This stability suggests a regulatory mechanism. An approach of this regulation has been attempted by disrupting the FTS level either by neonatal...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1979-02-01 00:00:00
abstract::The selective cytotoxicity of the lysosomotropic methyl esters of leucine or its lysosomal condensation product leucyl-leucine has been used to investigate the effect of cytolytic cells on the clonal outgrowth, cellular proliferation and antibody secretion of Epstein-Barr virus (EBV)-transformed human B cells. Large g...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1989-04-01 00:00:00
abstract::CD45 is known to regulate signalling through many different surface receptors in diverse haemopoietic cell types. Here we report for the first time that CD45-/- bone marrow dendritic cells (BMDC) are more activated than CD45+/+ cells and that tumour necrosis factor (TNF) and interleukin-6 (IL-6) production by BMDC and...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1111/j.1365-2567.2006.02363.x
更新日期:2006-06-01 00:00:00
abstract::It has been reported that, in early pregnancy in mice, there is an increase in the number of immunoglobulin-secreting cells in the lymph nodes which drain the uterus. This paper describes the results of further investigations provoked by interest in these early changes. Increases in the numbers of immunoglobulin-secre...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1985-06-01 00:00:00
abstract::The classical acute phase reactant, C-reactive protein (CRP), appears in markedly elevated concentration in the sera of individuals undergoing reactions of acute inflammation and tissue degradation. We previously demonstrated that like IgG, appropriately purified CRP could be thermally modified (H-CRP) such that it en...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1982-09-01 00:00:00
abstract::Selective Alzheimer disease indicator-1 (seladin-1) is a broadly expressed oxidoreductase and is related to Alzheimer disease, cholesterol metabolism and carcinogenesis. The effect of lipopolysaccharide (LPS) on the expression of seladin-1 was examined using RAW 264.7 macrophage-like cells and murine peritoneal macrop...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1111/j.1365-2567.2010.03274.x
更新日期:2010-09-01 00:00:00
abstract::Mice fed a protein-deficient diet containing 2% ovalbumin for 6 weeks (PD) show a reduced spleen IgA plaque-forming cell (PFC) response after oral immunization with sheep red blood cells (SRBC), compared to the response of mice fed a control diet containing 20% ovalbumin (C). This reduced IgA PFC response was partiall...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1988-08-01 00:00:00
abstract::Within the lesions of inflammatory myopathies, muscle fibres and invading mononuclear cells express Fas and Fas ligand (FasL), respectively. However, the roles of the Fas/FasL interaction in the pathogenesis of inflammatory myopathies are not fully understood. In the present study, we investigated the roles of proinfl...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1111/j.1365-2567.2008.03039.x
更新日期:2009-09-01 00:00:00
abstract::The immunophenotypes of the HLA-DR-positive leucocyte populations in normal human skin were studied using an extensive panel of monoclonal antibodies, which included antibodies from the Third International Leucocyte Differentiation Antigen Workshop (3rd LDAW). Langerhans' cells (LC) in the epidermis stained with antib...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1988-12-01 00:00:00
abstract::The anti-C6 monoclonal antibody WU 6-4 was shown to be unequivocally native restricted since it neither binds to the terminal complement complex (TCC) nor to C5b6. In addition, it was shown to inhibit TCC formation by interfering with C5b6 generation. Using the pUEX expression system and C6 cDNA the WU 6-4 epitope was...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1995-06-01 00:00:00
abstract::LacZ (Gal)-reactive immune cells were transferred into athymic nu/nu mice inoculated with Gal-expressing syngeneic tumour cells (ESbL-Gal) in order to study tumour-protective T-cell memory. This transfer prevented tumour outgrowth in recipients and resulted in the persistence of a high frequency of Gal-specific CD8(+)...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1111/j.1365-2567.2005.02163.x
更新日期:2005-07-01 00:00:00
abstract::Humans and other mammals coexist with a diverse array of microbes colonizing the intestine, termed the microflora. The relationship is symbiotic, with the microbes benefiting from a stable environment and nutrient supply, and the host gaining competitive exclusion of pathogens and continuously maintenance of the gut i...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1111/j.1365-2567.2007.02687.x
更新日期:2008-02-01 00:00:00
abstract::Down-regulated chemerin expression has been reported to correlate with poor prognosis of several types of cancer including melanoma. All-trans retinoic acid (atRA) is a potent inducer of chemerin, and we previously reported that atRA inhibited murine melanoma growth through enhancement of anti-tumor T-cell immunity. H...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1111/imm.13065
更新日期:2019-07-01 00:00:00
abstract::Natural cell-mediated cytotoxicity is mediated by a family of effector cells that express cytolytic activities distinct from those generally attributed to B cells, T cells and macrophages; it includes both natural killer (NK) and natural cytotoxic (NC) activities. There is now convincing evidence to show that NC activ...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1989-08-01 00:00:00
abstract::Mice of the strains A.TH and A.TL were rendered neonatally tolerant to class II major histocompatibility complex (MHC) by the injection of (A.TH x A.TL)F1 spleen and bone marrow cells within 24 hr of birth. Spleen and thymus cells from adult tolerant mice bearing long-term surviving skin grafts were compared with thos...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1993-08-01 00:00:00
abstract::T cells from mice injected with picryl sulphonic acid (PSA) inhibit the expression of contact sensitivity to picryl chloride. Adult thymectomy (aTx) prevents the production of cells which inhibit the effector stage but cells from aTx mice are, however, still able to suppress the induction of contact sensitivity. These...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1981-01-01 00:00:00
abstract::Human blood monocytes were activated by bacterial lipopolysaccharide endotoxin (LPS) (10 ng/ml) for cytotoxicity of WEHI-164 mouse fibrosarcoma cells, determined by release of 51Cr from WEHI-164 tumour cells incubated with monocyte supernatants. The chemotactic peptide N-formylmethionyl-leucyl-phenylalanine (FMLP) aug...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1992-05-01 00:00:00
abstract::Neutrophil migration inhibition factor from T lymphocytes (NIF-T) is produced in response to mitogens as the result of cellular interactions between T and B lymphocytes. The requirement for B-cell alloantigen in this interaction process was indicated by (1) collaboration between peripheral blood T cells with various B...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1980-04-01 00:00:00
abstract::The effect of corticosteroid administration on the redistribution of sirculating lymphocytes was studied in the guinea-pig, since this species closely resembles man in its relative resistance to the lymphopenic effect of corticosteroids. A single intravenous injection of hydrocortisone (either 10 mg or 100 mg/kg) cau...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1975-04-01 00:00:00
abstract::The numbers of murine hepatocytes and Kupffer cells with receptors for human polymeric (pIgA) or monomeric IgA (mIgA) were determined by rosette formation with immunobeads coated with human pIgA or mIgA. About 63% of hepatocytes were found to express receptors for pIgA. Receptors for mIgA were also found in a signific...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1986-01-01 00:00:00
abstract::Adoptive transfer of T-cells is a promising therapy for many cancers. To enhance tumour recognition by T-cells, chimeric antigen receptors (CARs) consisting of signalling domains fused to receptors that recognize tumour-associated antigens can be expressed in T-cells. While CAR T-cells have shown clinical success for ...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1111/imm.13187
更新日期:2020-07-01 00:00:00
abstract::The purpose of this study was to investigate the effect of cyclophosphamide (CY) and 6-mercaptopurine (6-MP) on the production of the two IgG antibody subclasses in guinea-pigs. Following the intradermal application of dinitrophenylated bovine gamma globulin (DNP20-BGG) emulsified in Freund's incomplete adjuvant (FIA)...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1981-09-01 00:00:00
abstract::Trypanosoma cruzi, the aetiological agent of Chagas disease, has a highly efficient detoxification system to deal with the oxidative burst imposed by its host. One of the antioxidant enzymes involved is the cytosolic tryparedoxin peroxidase (c-TXNPx), which catalyses the reduction to hydrogen peroxide, small-chain org...
journal_title:Immunology
pub_type: 临床试验,杂志文章
doi:10.1111/imm.12979
更新日期:2018-11-01 00:00:00
abstract::Peripheral blood lymphocytes from patients with Hashimoto's thyroiditis have been cultured for 2--3 weeks in Marbrook flasks. During this period, readily detectable amounts of thyroglobulin and microsomal antibodies were synthesized by the cells and secreted into the culture medium. Gel filtration studies indicated th...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1979-01-01 00:00:00
abstract::We have shown that human endothelial cells (EC) are protected against complement-mediated injury by the inducible expression of decay-accelerating factor (DAF). To understand further the importance of DAF regulation, we characterized EC DAF expression on murine EC in vitro and in vivo using a model of glomerulonephrit...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1046/j.1365-2567.2003.01733.x
更新日期:2003-10-01 00:00:00