Requirement for B-lymphocyte alloantigen in the production of neutrophil migration inhibition factor from T lymphocytes (NIF-T).

abstract：:The functional avidity of a cytotoxic T lymphocyte (CTL) is known to be a critical determinant of the efficacy with which it clears pathogens. High avidity cells, which are by definition highly sensitive to peptide antigen, are superior for elimination of viruses and tumours. Our studies have established the ability o...

journal_title：Immunology

authors： Sharma SK,Alexander-Miller MA

更新日期：2011-07-01 00:00:00

abstract：:Monoclonal human anti-IgG preparations purified from mixed IgM-IgG cryoglobulins were tested for their antigenic specificity by haemagglutination-inhibition assay. A panel of fourteen IgG preparations of the four gamma chain subclasses were prepared from myeloma sera and used as inhibitors of haemagglutination. Each o...

journal_title：Immunology

authors： Johnston SL,Abraham GN

更新日期：1979-04-01 00:00:00

abstract：:Polysorbate 80 (PS80 or Tween-80) is often used as an additive to promote the rapid solubilization of pharmaceuticals in aqueous solutions. We investigated whether coinjection of a minimal amount of PS80 had a modulatory effect on the immunotherapeutic effects of Cry (Cryptomeria)-consensus peptide, a novel peptide de...

journal_title：Immunology

authors： Kozutsumi D,Tsunematsu M,Yamaji T,Murakami R,Yokoyama M,Kino K

更新日期：2006-07-01 00:00:00

abstract：:The immunological basis for the production of autoantibodies characteristic of systemic lupus erythematosus (SLE) against a wide range of antigens remains obscure. The specificity of (NZB x NZW)F1 (BWF1) or MRL/Mp-lpr/lpr (MRL/lpr) mouse monoclonal antibodies (mAb) was examined by immunofluorescence, immunoblotting an...

journal_title：Immunology

authors： Bronze-da-Rocha E,Machado C,Staines NA,Sunkel CE

更新日期：1992-12-01 00:00:00

abstract：:The association between three major spondyloarthritic diseases, ankylosing spondylitis, Reiter's syndrome, and reactive arthritis, and the major histocompatibility complex (MHC) class 1 antigen HLA-B27 is well documented. The hypothesis of cross-reactivity between HLA-B27 and the antecedent infection-causing Gram-nega...

journal_title：Immunology

authors： Kapasi K,Chui B,Inman RD

更新日期：1992-11-01 00:00:00

abstract：:The 'binding' of IgE to particulate preparations derived from sonicated purified rat mast cells was measured by the blocking of PCA titrations of the supernatant solutions from incubations with such preparations. It was found that the PCA blocking reaction was inhibited by the addition of calcium ion to the incubation...

journal_title：Immunology

authors： Bach MK,Brashler JR

更新日期：1976-01-01 00:00:00

abstract：:Immune synapse formation is critical for T lymphocyte activation, and mitochondria have a role in this process, by localizing close to the immune synapse, regulating intracellular calcium concentration, and providing locally required ATP. The interaction between antigen presenting cells (APCs) and T lymphocytes is a t...

journal_title：Immunology

authors： Bonifaz L,Cervantes-Silva M,Ontiveros-Dotor E,López-Villegas E,Sánchez-García F

更新日期：2014-09-23 00:00:00

abstract：:Purified human and murine monocytes can be activated in vitro by human recombinant IL-2 to secrete tumour necrosis factor (TNF). TNF mRNA is detected within 4 h of addition of IL-2. Signal transduction does not appear to require expression of the Tac peptide of the IL-2 receptor. IL-2 does, however, induce Tac mRNA an...

journal_title：Immunology

authors： Economou JS,McBride WH,Essner R,Rhoades K,Golub S,Holmes EC,Morton DL

更新日期：1989-08-01 00:00:00

abstract：:The recovery of the B-cell population in adult thymectomized, irradiated and bone marrow-reconstituted mice (T X BM mice was estimated at various times after bone marrow transplantation. The spleen cells to be tested were mixed with dexamethasone-resistant thymocytes (DRT) and sheep red blood cells (SRBC) and transfer...

journal_title：Immunology

authors： van Muiswinkel WB,van Beek JJ,van Soest PL

更新日期：1975-08-01 00:00:00

abstract：:The hepatic and splenic uptake of circulating, small-latticed immune complexes and the effect of these complexes on the hepatic mononuclear phagocyte system (MPS) were examined in mice. The small-latticed immune complexes were prepared at fifty-fold antigen excess. The clearance from circulation and uptake by the live...

journal_title：Immunology

authors： Jimenez RA,Haakenstad AO,Mannik M

更新日期：1983-02-01 00:00:00

abstract：:This study investigates the effect of feeding fermented milks with Lactobacillus casei, Lactobacillus acidophilus and a mixture of both micro-organisms on the specific and non-specific host defence mechanisms in Swiss mice. Animals fed with fermented milk for 8 days (100 micrograms/day) showed an increase in both phag...

journal_title：Immunology

authors： Perdigón G,de Macias ME,Alvarez S,Oliver G,de Ruiz Holgado AP

更新日期：1988-01-01 00:00:00

abstract：:Using KOLT-2 monoclonal antibody (mAb) recognizing a 44,000 molecular weight (MW) T-cell activation antigen (CD28), we observed the co-expression of KOLT-2 (CD28) antigen and Tac (CD25) antigen, associated with a 55,000 MW chain of the interleukin-2 receptor (IL-2R) complex. IL-2R (p55), on several T-cell lines transf...

journal_title：Immunology

authors： Shindo T,Sugie K,Nakamura K,Tagaya Y,Maeda M,Uchiyama T,Sagawa K,Yokoyama M,Wada H,Hitomi S

更新日期：1990-09-01 00:00:00

abstract：:Several cloned, non-leukaemic mouse haemopoietic cell lines are believed to be uniquely dependent on interleukin-3 (IL-3) for their survival. All of these lines require the addition of WEHI-3B cell-conditioned medium for their growth. We have examined the growth requirements of four IL-3-dependent cell lines and found...

journal_title：Immunology

authors： Carron JA,Marshall-Clarke S

更新日期：1986-08-01 00:00:00

abstract：:Signaling by Kit has been extensively studied in hematopoietic cells and is essential for the survival, proliferation and maintenance of hematopoietic stem and progenitor cells. In addition to the activation of intrinsic signaling pathways, Kit has been shown to interact with lineage-restricted type I cytokine recepto...

journal_title：Immunology

authors： Sethumadhavan A,Mani M

更新日期：2020-04-01 00:00:00

abstract：:The expression of adhesion molecules in monocytes of patients with recent onset type I diabetes was analysed. Monocytes were identified as CD14-positive cells by flow cytometry. The percentage of monocytes expression LFA-1 alpha, ICAM-1 and HLA-DR was slightly lower in recent onset type I diabetes (n = 13) compared to...

journal_title：Immunology

authors： Martin S,Rothe H,Tschöpe D,Schwippert B,Kolb H

更新日期：1991-05-01 00:00:00

abstract：:The requirement for Ca2+, a divalent ion which plays a fundamental role in cell activation, has been analysed in cultures of PHA-stimulated human peripheral blood lymphocytes (PHA-PBL) from adult (range: 20-35 years) and old (over 70 years) subjects. For this purpose, increasing concentrations of Ca2+ chelators (EGTA ...

journal_title：Immunology

authors： Kennes B,Hubert C,Brohee D,Neve P

更新日期：1981-01-01 00:00:00

abstract：:The properties of IgA and IgG anti-gliadin antibodies from the serum of patients with coeliac disease have been compared. The antibodies were quantified by ELISA using microtitre plates coated with crude gliadin fractions. Their specificity was confirmed by immunoblotting. Heat-treated sera containing IgA antibodies s...

journal_title：Immunology

authors： Stewart WW,Kerr MA

更新日期：1991-08-01 00:00:00

abstract：:To determine the influence of anti-idiotypic antibodies on the complementary idiotype (Id), the clearance kinetics, tissue distribution and fate of idiotype-anti-idiotype complexes were investigated in mice. The complexes were prepared by mixing purified radiolabelled monomeric (mIgA) or polymeric IgA (pIgA) with mono...

journal_title：Immunology

authors： Rifai A,Wu CG

更新日期：1990-04-01 00:00:00

abstract：:The current study sought to delineate the gene expression profile of the host response in the caecum and colon during acute infection with Clostridium difficile in a mouse model of infection, and to investigate the nature of the unfolded protein response in this process. The infected mice displayed a significant up-re...

journal_title：Immunology

authors： Sadighi Akha AA,Theriot CM,Erb-Downward JR,McDermott AJ,Falkowski NR,Tyra HM,Rutkowski DT,Young VB,Huffnagle GB

更新日期：2013-09-01 00:00:00

abstract：:The purpose of this work was to determine if the fine specificity of T cells differed between mice immunized with an antigen in a T helper 1 (Th1) cytokine-dominated environment as compared with a T helper 2 (Th2) cytokine-dominated environment. It was found that splenic T cells from mice immunized with mycobacterial ...

journal_title：Immunology

authors： Siew LK,Beech JT,Thompson SJ,Elson CJ

更新日期：1998-04-01 00:00:00

abstract：:In this study, we describe the ability of hybrid mouse monoclonal antibody (mAb) to induce monocyte-mediated cytotoxicity towards human IgA1-coated E (HuIgA1-E), and the effect of mAb binding valency on Fc gamma RI-mediated ADCC. All hybrid monospecific (ms) anti-HuIgA1 and bispecific (bs) anti-HuIgA1/HRP mAb were cap...

journal_title：Immunology

authors： Koolwijk P,Van de Winkel JG,Otten I,Bast BJ

更新日期：1992-02-01 00:00:00

abstract：:HIV infection is associated with increased representation of T cells bearing an activated, memory (CD45RO+) phenotype. Although administration of antiretroviral agents and interleukin-2 (IL-2) augment depleted CD4+ T-cell numbers, such therapies have been preferentially beneficial for CD45RO+ T cells. Interleukin-15 (...

journal_title：Immunology

authors： Naora H,Gougeon M

更新日期：1999-06-01 00:00:00

abstract：:Virus plaque assay (VPA) was utilized for the quantitative evaluation of activated lymphocytes. We examined what types of cells, especially which of activated T and non-T lymphocytes, were detected as infective centres after infection with vesicular stomatitis virus. Marked increases in DNA synthesis and in virus-plaq...

journal_title：Immunology

authors： Kasahara T,Shioiri-Nakano K,Sugiura A

更新日期：1977-06-01 00:00:00

abstract：:As the burden of infectious diseases becomes reduced in many countries, a remarkable increase in the incidence of allergies has occurred. The basis for the rise in atopic disorders as a correlate of the decline in infectious diseases has not been defined. In the present study, we tested experimentally whether prior sy...

journal_title：Immunology

authors： Yang X,Wang S,Fan Y,Zhu L

更新日期：1999-11-01 00:00:00

abstract：:We have previously reported that placental macrophages of fetal origin have a decreased ability to present antigen. To clarify the underlying mechanism for this deficiency, we have generated primary fetal macrophage cell lines. Our data show that despite their defective antigen-presenting ability, fetal macrophages do...

journal_title：Immunology

authors： Khalili H,Deshpande R,Chang MY

更新日期：1997-12-01 00:00:00

abstract：:The ultimate outcome of T-cell recognition of peptide-major histocompatibility complex (MHC) complexes is determined by the molecular context in which antigen presentation is provided. The paradigm is that, after exposure to peptides presented by steady-state dendritic cells (DCs), inhibitory signals dominate, leading...

journal_title：Immunology

authors： Konkel JE,Frommer F,Leech MD,Yagita H,Waisman A,Anderton SM

更新日期：2010-05-01 00:00:00

abstract：:The induction of T-cell growth by the T-cell antigen receptor (TcR) is dependent on a co-ordinated process of phosphorylation and dephosphorylation of intracellular proteins. An intermediary in this signalling pathway is the serine kinase, p42 mitogen-activated protein kinase (p42MAPK), also known as microtubule-assoc...

journal_title：Immunology

authors： Amaral MC,Casillas AM,Nel AE

更新日期：1993-05-01 00:00:00

abstract：:Fifty-seven serum samples positive for antibodies to double-stranded DNA (dsDNA), single-stranded DNA (ssDNA) or small nuclear ribonucleoproteins (snRNP) selected from patients with systemic lupus erythematosus and mixed connective tissue disease, were examined for the IgG subclass distribution of these autoantibodies...

journal_title：Immunology

authors： Zouali M,Jefferis R,Eyquem A

更新日期：1984-03-01 00:00:00

abstract：:We have investigated the potential of CD4+ T cells isolated from Peyer's patches and mesenteric lymph nodes (mucosa-associated lymphoid tissues) and from spleens and peripheral lymph nodes (systemic lymphoid tissues) to secrete a variety of lymphokines. The results show several pronounced differences in the kinetics o...

journal_title：Immunology

authors： Tonkonogy SL,Swain SL

更新日期：1993-12-01 00:00:00

abstract：:Induction of autoimmune antibodies against antigens of glomerular basement membrane (GBM) was studied in nine inbred strains of rats each with a different major histocompatibility complex H-1. Brown-Norway (BN) (H-1n), Lewis (H-1(1)), PVG/c (H-1c), AS2 (H-1f), AVN (H-1a), BD V (H-1d), DA (H-1a) and F344 (H-1(1)) rats ...

journal_title：Immunology

authors： Stuffers-Heiman M,Günther E,van Es LA

更新日期：1979-04-01 00:00:00