Abstract:
:HIV infection is associated with increased representation of T cells bearing an activated, memory (CD45RO+) phenotype. Although administration of antiretroviral agents and interleukin-2 (IL-2) augment depleted CD4+ T-cell numbers, such therapies have been preferentially beneficial for CD45RO+ T cells. Interleukin-15 (IL-15) exhibits many biological activities in common with IL-2, including promoting T-cell survival and proliferation. The present study found that these two cytokines differed in their ability to induce proliferation, enhance survival, and control apoptosis of CD45RO+ and CD45RO- T-cell populations of human immunodeficiency- (HIV) infected individuals. When used at equivalent concentrations in vitro, IL-15 was more potent than IL-2 in activating and stimulating proliferation of CD4+CD45RO+, CD8+CD45RO+ and CD8+CD45RO- cells, but failed to be more effective than IL-2 in reducing apoptosis. Poor activation of CD4+CD45RO- cells by IL-15 and to IL-2 appeared to be attributable to low expression of the beta receptor chain utilized by both cytokines. However, IL-15 was more effective than IL-2 in enhancing survival of the CD4+CD45RO- population, suggesting a greater protective effect of IL-15 for naive CD4+ T cells, which are preferentially lost in HIV-infected individuals.
journal_name
Immunologyjournal_title
Immunologyauthors
Naora H,Gougeon Mdoi
10.1046/j.1365-2567.1999.00807.xkeywords:
subject
Has Abstractpub_date
1999-06-01 00:00:00pages
181-7issue
2eissn
0019-2805issn
1365-2567pii
imm807journal_volume
97pub_type
杂志文章相关文献
IMMUNOLOGY文献大全abstract::Long-term bovine lymphocyte cultures were initiated by stimulation with alloantigens and maintained in continuous culture using medium containing recombinant human interleukin-2 (rh IL-2). The development of specific and lectin-dependent killing was monitored following primary alloantigen challenge. Cytolytic activity...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1986-01-01 00:00:00
abstract::Different kinds of IgM antibodies were tested for their activity in antibody-dependent cellular cytotoxicity (ADCC): firstly an anti-benzylpenicilloyl (BPO) IgM antibody from immune rabbit serum purified by affinity, ion exchange, and molecular-sieving chromatography, secondly two monoclonal rat anti-BPO IgM antibodie...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1981-05-01 00:00:00
abstract::BALB/c mice develop myasthenic symptoms after immunization with rodent acetylcholine receptor (AChR). After immunization with Torpedo AChR (TAChR), their CD4+ cells become strongly sensitized against a conserved region of the TAChR alpha subunit sequence (residues alpha 304-322), and cross-react vigorously with the ho...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1994-05-01 00:00:00
abstract::Drug abuse is a global problem of considerable concern to health. One such health concern stems from the fact that many drugs of abuse have immunosuppressive actions and consequently have the potential to increase susceptibility to infectious disease. This article is focused on the impact of the amphetamine derivative...
journal_title:Immunology
pub_type: 杂志文章,评审
doi:10.1111/j.0019-2805.2004.01847.x
更新日期:2004-04-01 00:00:00
abstract::Therapeutic vaccination using T-cell receptor (TCR) peptides from V genes commonly expressed by potentially pathogenic T cells remains an approach of interest for treatment of multiple sclerosis (MS) and other autoimmune diseases. We developed a trivalent TCR vaccine containing complementarity determining region (CDR)...
journal_title:Immunology
pub_type: 临床试验,杂志文章
doi:10.1111/j.1365-2567.2007.02703.x
更新日期:2008-01-01 00:00:00
abstract::The tumour microenvironment is complex containing not only neoplastic cells but also a variety of host cells. The heterogeneous infiltrating immune cells include subsets of cells with opposing functions, whose activities are mediated either directly or through the cytokines they produce. Systemic delivery of cytokines...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1111/imm.12037
更新日期:2013-03-01 00:00:00
abstract::Radiation chimaeras, prepared from NIH (rapid-responder) mice or from the F1 progeny of a cross between H-2 compatible B10.G (slow-responder) and NIH mice, were tested for their ability to respond to infection with the intestinal nematode parasite Trichinella spiralis. Mice reconstituted with bone marrow (BM) from NIH...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1981-08-01 00:00:00
abstract::Haemolytic assays were used to compare alternative and classical complement (C) pathway activities in sera obtained from neonatal pigs reared on porcine colostrum, bovine colostrum or an immunoglobulin-free synthetic diet. Dramatic increases in immunoglobulin concentrations were noted in the colostrum-fed animals duri...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1980-09-01 00:00:00
abstract::Although it is well known that cases with silicosis exhibit various immunological abnormalities, the mechanisms involved in the occurrence of immuno-dysfunction or dysregulation induced by silica compounds have not yet been determined. Fas is a well-known cell surface molecule that is involved in the apoptosis pathway...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1046/j.1365-2567.1998.00509.x
更新日期:1998-06-01 00:00:00
abstract::This study describes a subtractive hybridization analysis to identify differences in gene expression between sibling Th memory clones, elicited by virus infection and expressing identical T-cell receptor (TCR)-alphabeta rearrangements but distinct lymphokine phenotype: clone Bpp9 secretes interleukin (IL)-4, IL-5 and ...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1111/j.1365-2567.2004.01953.x
更新日期:2004-10-01 00:00:00
abstract::The mechanisms of action and the nature of the co-operating cells (CC) controlling human T-lymphocyte-colony formation were investigated. Media conditioned by PHA-stimulated blood mononuclear cells (MC) were tested for their capacity to induce T-colony formation in the effluent cell population, obtained after anti (Fa...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1982-02-01 00:00:00
abstract::We have isolated, characterized and quantified the immunocompetent cells present in the extravascular hepatic compartment at various stages after Plasmodium yoelii malaria infection with sporozoites. Cytological analyses revealed a predominantly lymphoid population. In mice with a primary infection, the predominant ce...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1994-08-01 00:00:00
abstract::Mercuric chloride (HgCl2)-induced autoimmunity in Brown Norway rats is a spontaneously resolving autoimmune response driven by the activation of T helper type 2 lymphocytes (Th2 cells). Treatment with antibody to OX40-ligand (OX40-L) from the time of the first HgCl2 injection for 12 days had little effect. Delayed tre...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1111/j.1365-2567.2005.02314.x
更新日期:2006-03-01 00:00:00
abstract::A model of immediate-type hypersensitivity (ITH) in the dog using keyhole limpet haemocyanin (KLH) as the antigen was studied. Long-lasting ITH was induced in fifteen of sixteen dogs by the i.v. (Kepron & Tse, 1975), intradermal (Rockey, Schwartzmann & Halliwell, 1971), inhalation (Patterson & Kelley, 1974) and i.d. p...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1977-01-01 00:00:00
abstract::The haemolymph of the colonial ascidian Botrylloides leachii contains two haemagglutinins which have been termed HA-1 and HA-2 respectively. The HA-1 agglutinin is specific for guinea-pig erythrocytes, requires Ca2+ ions for its activity and has an apparent mol. wt. of about 200,000. It can be adsorbed by guinea-pig b...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1981-02-01 00:00:00
abstract::Initial separation and concentration of Clq from fresh, normal equine serum was accomplished by precipitation in 0.02 M acetate buffer, pH 5.5, at 4 degrees for 24 h. The re-dissolved precipitate was clarified by centrifugation at 80,000 g for 1 h and then dialysed against Tris-HCl buffer (0.05 M, pH 8.0) containing 1...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1979-07-01 00:00:00
abstract::It has been known for 15 years that the chicken epidermis contains ATPase+ and major histocompatibility complex class II-positive (MHCII+) dendritic cells. These cells were designated as Langerhans cells but neither their detailed phenotype nor their function was further investigated. In the present paper we demonstra...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1111/j.1365-2567.2006.02432.x
更新日期:2006-10-01 00:00:00
abstract::Trinitrophenyl (TNP)-specific humoral response was tested after immunization with TNP-protein conjugates composed of either native proteins or proteins modified by chlorination. Significant enhancement of the hapten-specific response was observed as a result of carrier chlorination. This effect was dose dependent and ...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1992-07-01 00:00:00
abstract::Membrane attack complexes of complement occur around thyroid follicles in Graves' disease and Hashimoto's thyroiditis. The lytic potential of such complexes is controlled by membrane-bound and fluid phase regulators and we have investigated the role of these in autoimmune thyroid disease. By immunohistochemical staini...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1994-04-01 00:00:00
abstract::Donor mice were painted on the skin of the abdomen with the contact sensitizing agent, oxazolone. One day later 2-5 x 10(6) cells from the regional lymph nodes were injected into the footpads of recipient mice. Contact sensitivity was detected 6 days later by challenging the ears of the recipients and measuring the in...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1979-05-01 00:00:00
abstract::The gut immune system and its modification by diet have been implicated in the pathogenesis of type 1 diabetes (T1D). Therefore, we investigated gut immune status in non-diabetes-prone LEW.1AR1 and diabetes-prone LEW.1AR1-iddm rats and evaluated the effect of a low antigen, hydrolysed casein (HC)-based diet on gut imm...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1111/imm.12457
更新日期:2015-07-01 00:00:00
abstract::Activation of human eosinophils by platelet-activating factor (PAF) involves multiple signal transduction pathways. Among these, protein kinase C has been demonstrated both to mediate respiratory burst and to suppress an alternative pathway of activation of respiratory burst and arachidonic acid metabolism in eosinoph...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1046/j.1365-2567.2000.00037.x
更新日期:2000-06-01 00:00:00
abstract::Silica, or silicon dioxide, has been shown to be toxic for macrophages. This is probably because it damages phagolysosomal membranes, allowing lysosomal enzymes to disrupt the cell. Neutrophils also take up particles such as silica and in addition they contain lysosomes. The purpose of this study was to determine whet...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1986-12-01 00:00:00
abstract::We have previously demonstrated that immunoglobulin A (IgA)(-/-) knockout (KO) mice exhibit levels of susceptibility to influenza virus infection that are similar to those of their normal IgA(+/+) littermates. To understand the mechanism of this apparent mucosal immunity without IgA, immunoglobulin isotype and T helpe...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1046/j.0019-2805.2001.01368.x
更新日期:2002-03-01 00:00:00
abstract::This study addresses the question of whether human peripheral CD4+ CD45RA+ T cells possess antigen-specific immune memory. CD4+ CD45RA+ T cells were isolated by a combination of positive and negative selection. Putative CD4+ CD45RA+ cells expressed CD45RA (98.9%) and contained < 0.1% CD4+ CD45RO+ and < 0.5% CD4+ CD45R...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1046/j.1365-2567.1997.00274.x
更新日期:1997-07-01 00:00:00
abstract::Neuropeptides can influence immune effector cell function at both systemic and mucosal immune sites. We examined the ability of substance P (SP) to modulate the natural killer (NK) activity of intestinal intraepithelial leucocytes (IEL). Yac-1 killing by IEL but not splenic cells was increased after either 18 hr prein...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1990-10-01 00:00:00
abstract::Spleen cells from LAF1 mice primed with photo-oxidized antigen B exhibit helper T-cell activity when assayed in an adoptive transfer system with spleen cells from mice primed with timothy pollen extract and treated with anti-thy 1.2 serum and complement. These helper cells, when placed in culture with antigen B, secre...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1981-10-01 00:00:00
abstract::Osteopontin (OPN) is important for the function of fibroblasts, macrophages and lymphocytes during inflammation and wound healing. In recent studies of experimental colitis we demonstrated exacerbated tissue destruction in OPN-null mice, associated with reduced tumour necrosis factor-alpha expression and increased mye...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1111/j.1365-2567.2007.02682.x
更新日期:2007-12-01 00:00:00
abstract::The synthetic antigen denoted P2-A--L, comprising the fragment P2 of the coat protein of MS-2 coliphage attached to multichain poly-DL-alanine, served for the immunization of guinea-pigs. Immunization was carried out either in phosphate buffered saline (PBS) or in Freund's incomplete adjuvant (FIA) in the presence or ...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1978-10-01 00:00:00
abstract::Macrophage (MΦ) polarization is triggered during the innate immune response to defend against microbial pathogens, but can also contribute to disease pathogenesis. In a previous study, we found that interleukin-15 (IL-15) -derived classically activated macrophages (M1 MΦ) have enhanced antimicrobial activity, whereas ...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1111/imm.13013
更新日期:2019-02-01 00:00:00