Abstract：
:The haemolymph of the colonial ascidian Botrylloides leachii contains two haemagglutinins which have been termed HA-1 and HA-2 respectively. The HA-1 agglutinin is specific for guinea-pig erythrocytes, requires Ca2+ ions for its activity and has an apparent mol. wt. of about 200,000. It can be adsorbed by guinea-pig but not human, sheep, mouse or pigeon erythrocytes. The agglutination of guinea-pig cells is reversibly inhibited by various mono- and oligosaccharides, lactose and D-galactose being among the most effective of those tested. The HA-2 agglutinin is smaller (mol.wt. approximately 63,000) and agglutinates a variety of erythrocyte types, including those from the human, guinea-pig, mouse, sheep, pigeon and chicken. The agglutination of all these cells is inhibited by lactose. Data from sugar-inhibition and adsorption experiments indicate that the HA-2 agglutinins are homogeneous with respect to binding site specificity. Divalent cations are not required for activity.
journal_name
Immunologyjournal_title
Immunologyauthors
Schluter SF,Ey PL,Keough DR,Jenkin CRsubject
Has Abstractpub_date
1981-02-01 00:00:00pages
241-50issue
2eissn
0019-2805issn
1365-2567journal_volume
42pub_type
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