In vitro modulation of interleukin-1 beta secretion by cultured rat doxorubicin-stimulated whole glomeruli and dissociated mesangial glomerular cells.

abstract：:Cancer immune surveillance is considered to be an important host protection process to inhibit carcinogenesis and to maintain cellular homeostasis. In the interaction of host and tumour cells, three essential phases have been proposed: elimination, equilibrium and escape, which are designated the 'three E's'. Several ...

journal_title：Immunology

authors： Kim R,Emi M,Tanabe K

更新日期：2007-05-01 00:00:00

abstract：:Bovine Concanavalin A-induced suppressor cells were generated from lymphocytes which were non-adherent to anti-immunoglobulin coated dishes and cells possessing receptors for peanut agglutinin. Bovine lymphocytes, preincubated with 25 microgram/ml of Con A for 40-45 hr, could suppress the responses of autologous cells...

journal_title：Immunology

authors： Smith WG,Usinger WR,Splitter GA

更新日期：1981-05-01 00:00:00

abstract：:A panel of monoclonal antibodies was used to define the lymphocyte subpopulations in the sheep uterus at various stages of the oestrous cycle. A striking finding was that the majority of lymphocytes in the uterine and endometrial glandular epithelia belonged to a unique lymphocyte subpopulation that expressed the CD45...

journal_title：Immunology

authors： Lee CS,Gogolin-Ewens K,Brandon MR

更新日期：1988-01-01 00:00:00

abstract：:When spleen cells of C57BL/6 mice or mast cell-deficient W/Wv mice were cultured, their histidine decarboxylase (HDC) activity increased with increases in the histamine concentration in the cells and the medium. Addition of concanavalin A (Con A) or Escherichia coli lipopolysaccharide (LPS) enhanced the increase. The ...

journal_title：Immunology

authors： Aoi R,Nakashima I,Kitamura Y,Asai H,Nakano K

更新日期：1989-02-01 00:00:00

abstract：:Killer cell immunoglobulin-like receptors (KIRs) interact with polymorphic human leucocyte antigen (HLA) class I molecules, modulating natural killer (NK) cell functions and affecting both the susceptibility and outcome of immune-mediated diseases. The KIR locus is highly diverse in gene content, copy number and allel...

journal_title：Immunology

authors： Tao S,Kichula KM,Harrison GF,Farias TDJ,Palmer WH,Leaton LA,Hajar CGN,Zefarina Z,Edinur HA,Zhu F,Norman PJ

更新日期：2020-12-06 00:00:00

abstract：:We previously reported that FTY720 is an efficient inducer of apoptosis in lymphocytes and cultured cell lines. In the present study, HL-60 human promyerocytoma cells also induced apoptosis through in vitro treatment with the drug, demonstrating extensive DNA fragmentation 6 hr after incubation. The major target of FT...

journal_title：Immunology

authors： Shinomiya T,Li XK,Amemiya H,Suzuki S

更新日期：1997-08-01 00:00:00

abstract：:Herpes simplex virus (HSV) encodes a protein, glycoprotein C (gC), which binds to the third complement component, the central mediator of complement activation. In this study the structural and functional relationships of gC from HSV type 1 (HSV-1) and known human complement regulatory proteins factor H, properdin, fa...

journal_title：Immunology

authors： Huemer HP,Wang Y,Garred P,Koistinen V,Oppermann S

更新日期：1993-08-01 00:00:00

abstract：:Recently it has been shown that selective subconjunctival macrophage depletion reduced the incidence and severity of stromal herpes simplex virus (HSV) keratitis in mice. In this study, we examined the effect of conjunctival macrophage depletion on the corneal and systemic T-cell-mediated immune response. BALB/c mice ...

journal_title：Immunology

authors： Bauer D,Schmitz A,Van Rooijen N,Steuhl KP,Heiligenhaus A

更新日期：2002-09-01 00:00:00

abstract：:Antigenic encounter by T cells induces immunological synapse formation and T-cell activation. Using different concentrations of toxic shock syndrome toxin-1 (TSST-1) as stimulus, we examined the capacities of dendritic cells (DC) and macrophages (Mphi) to prime syngeneic naive T cells. DCs were, under all experimental...

journal_title：Immunology

authors： Rothoeft T,Gonschorek A,Bartz H,Anhenn O,Schauer U

更新日期：2003-12-01 00:00:00

abstract：:Bile acids (BAs) play important roles not only in lipid metabolism, but also in signal transduction. TGR5, a transmembrane receptor of BAs, is an immunomodulative factor, but its detailed mechanism remains unclear. Here, we aimed to delineate how BAs operate in immunological responses via the TGR5 pathway in human mon...

journal_title：Immunology

authors： Yoneno K,Hisamatsu T,Shimamura K,Kamada N,Ichikawa R,Kitazume MT,Mori M,Uo M,Namikawa Y,Matsuoka K,Sato T,Koganei K,Sugita A,Kanai T,Hibi T

更新日期：2013-05-01 00:00:00

abstract：:Experiments were designed to determine the in vivo cell-cycle phase of lymphocytes in secondary lymphoid follicles, and whether B-cell proliferation and apoptosis occur within follicular dendritic cell (FDC)-associated clusters. Using frozen serial sections of human tonsils, lymphoid follicles were stained to reveal h...

journal_title：Immunology

authors： Orui H,Yamakawa M,Imai Y

更新日期：1997-04-01 00:00:00

abstract：:The genes coding for the main molecules involved in the human immune system--immunoglobulins, human leucocyte antigen (HLA) molecules and killer-cell immunoglobulin-like receptors (KIR)--exhibit a very high level of polymorphism that reveals remarkable frequency variation in human populations. 'Genetic marker' (GM) al...

journal_title：Immunology

authors： Sanchez-Mazas A,Fernandez-Viña M,Middleton D,Hollenbach JA,Buhler S,Di D,Rajalingam R,Dugoujon JM,Mack SJ,Thorsby E

更新日期：2011-06-01 00:00:00

abstract：:Although the co-stimulatory interaction between B and T cells is well defined, recent evidence suggests that B cells also have a regulatory role. Here, we show that B cells activated using anti-IgD conjugated to dextran (α-δ-dex) directly inhibit TCR-induced CD4 T cell activation, proliferation and cytokine production...

journal_title：Immunology

authors： Preciado-Llanes L,Wing JB,Foster RA,Carlring J,Lees A,Read RC,Heath AW

更新日期：2014-09-20 00:00:00

abstract：:The major site of B-cell genesis in the sheep is the ileal Peyer's patch (PP). The B cells in the ileal PP undergo both extensive proliferation and massive death in association with an ongoing diversification of the immunoglobulin repertoire by somatic hypermutation. Most, if not all, the B-cell death in the ileal PP ...

journal_title：Immunology

authors： Motyka B,Reynolds JD

更新日期：1995-03-01 00:00:00

abstract：:Oral administration of antigen induces a state of tolerance that is associated with activation of CD8+ T cells that can transfer unresponsiveness to naïve syngeneic hosts. These T cells are not lytic, but they inhibit development of antibody, CD4+ T helper cell, and CD8+ cytotoxic T lymphocyte (CTL) responses upon ado...

journal_title：Immunology

authors： Kapp JA,Kapp LM,McKenna KC,Lake JP

更新日期：2004-02-01 00:00:00

abstract：:Interactions between heparin and protamine in normal human serum previously were found to activate the primary complement pathway and deplete the early-acting complement components. In the present investigation, the role of heparin-protamine complexes, immunoglobulins, C1q and C1-INH in this interaction was studied. H...

journal_title：Immunology

authors： Fiedel BA,Rent R,Myhrman R,Gewurz H

更新日期：1976-02-01 00:00:00

abstract：:Peroxisome proliferator activated receptor-gamma (PPARgamma) has been reported to exert anti-inflammatory properties in endotoxic shock and sepsis. One phenomenon that alters the inflammatory response to endotoxin [lipopolysaccharide (LPS)] is endotoxin tolerance, which is caused by previous exposure to endotoxin. Her...

journal_title：Immunology

authors： Zingarelli B,Fan H,Ashton S,Piraino G,Mangeshkar P,Cook JA

更新日期：2008-05-01 00:00:00

abstract：:Formation of osteoclasts and consequent joint destruction are hallmarks of rheumatoid arthritis (RA). Here we show that LIGHT, a member of the tumour necrosis factor (TNF) superfamily, induced the differentiation into tartrate-resistant acid phosphatase (TRAP)-positive multinucleated cells (MNCs) of CD14(+) monocytes ...

journal_title：Immunology

authors： Ishida S,Yamane S,Nakano S,Yanagimoto T,Hanamoto Y,Maeda-Tanimura M,Toyosaki-Maeda T,Ishizaki J,Matsuo Y,Fukui N,Itoh T,Ochi T,Suzuki R

更新日期：2009-09-01 00:00:00

abstract：:Virus-specific cytotoxic T-cell (Tc) clones can lyse target cells in vitro in the presence of their specific peptide epitopes. The lytic potency of murine influenza nucleoprotein (NP)-specific Tc clones was investigated after observing that target cell killing was reduced in the presence of high (greater than 0.2 micr...

journal_title：Immunology

authors： Pemberton RM,Wraith DC,Askonas BA

更新日期：1990-06-01 00:00:00

abstract：:The kinetics of anti-paternal alloantibody production in syngeneically and allogeneically mated mice previously immunized with allogenic spleen cells has been investigated. In allogeneically mated females, total and cytotoxic alloantibody levels increased during the final 3 days of pregnancy to reach maximal levels ar...

journal_title：Immunology

authors： Roe R,Bell SC

更新日期：1982-05-01 00:00:00

abstract：:GD3, a ganglioside expressed on melanoma, is the only tumour-associated glycolipid described to date that can induce a CD1d-restricted natural killer T (NKT)-cell response. We analysed the fine specificity of GD3-reactive NKT cells and discovered that immunization with GD3 induced two populations of GD3-reactive NKT c...

journal_title：Immunology

authors： Park JE,Wu DY,Prendes M,Lu SX,Ragupathi G,Schrantz N,Chapman PB

更新日期：2008-01-01 00:00:00

abstract：:The human histocompatibility leucocyte antigen (HLA) class II-associated invariant chain comprises at least four polypeptides. One of these is expressed as a membrane-bound subunit and has been designated as CD74. We investigated the expression of CD74 on B- and T-cell types utilizing monoclonal antibodies (mAb) speci...

journal_title：Immunology

authors： Wilson KM,Labeta MO,Pawelec G,Fernandez N

更新日期：1993-06-01 00:00:00

abstract：:Activation of lymph nodes by the T-cell mitogens PHA and Con A is correlated with a depletion of lymphatic mast cells. This result, and our earlier reports on the depletion of mast cells in lymph nodes stimulated by allogeneic and tumour cells, as well as on the elevation of mast cell number in thymus-less 'nude' mice...

journal_title：Immunology

authors： Włodarski K,Rychlik G,Mazur S

更新日期：1985-06-01 00:00:00

abstract：:The objective of the present study was to examine and to compare the impact of severe protein malnutrition during development, adulthood and ageing on secretory immune expression in the eye, mouth and small intestine. In addition, we sought to determine whether potential abrogation of mucosal immunity by protein depri...

journal_title：Immunology

authors： Sullivan DA,Vaerman JP,Soo C

更新日期：1993-02-01 00:00:00

abstract：:Male and female spleen cells were compared before and after culture for their cytotoxicity to autologous-embryo fibroblasts. Cultures of male cells developed significantly greater reactivity than cultures of female cells. Moreover, while the cytotoxicity derived from cultures of male cells was totally abolished by tre...

journal_title：Immunology

authors： Gorczynski RM

更新日期：1976-10-01 00:00:00

abstract：:To study the influence of macrophages on the migration and distribution of lymphocytes in the spleen, macrophages were eliminated from the spleen of mice by injection of liposomes in which DMDP was encapsulated. This leads to an elimination of macrophages in both the red pulp and marginal zone of the spleen within 1-2...

journal_title：Immunology

authors： Kraal G,Rodrigues H,Hoeben K,Van Rooijen N

更新日期：1989-10-01 00:00:00

abstract：:Environmental factors have significant effects on the development of autoimmune diseases. The ligand-activated transcription factor aryl hydrocarbon receptor (AHR) is controlled by endogenous and environmental small molecules. Hence, AHR provides a molecular pathway by which endogenous and environmental signals can in...

journal_title：Immunology

authors： Quintana FJ

更新日期：2013-03-01 00:00:00

abstract：:Ribonucleic acid (immune RNA, iRNA), extracted from the spleens of mice immunized with sheep red blood cells (SRBC), induced specific immunological memory. The humoral immune responses of iRNA-treated animals were compared with in vivo and in vitro primary and secondary responses, using the haemolytic plaque-forming c...

journal_title：Immunology

authors： Kodama K,Yoshida T,Shibiya T,Kurashige S,Mitsuhashi S

更新日期：1981-11-01 00:00:00

abstract：:A plasmid that contained the cytomegalovirus (CMV)-promoter-driven lacZ reporter gene (pCMV-lacZ) remained in the epaxial muscle of five of eight goldfish as covalently closed circles, the most functional form of plasmid, for at least 70 days at 22 degrees. It was not present in the gills or elsewhere by polymerase ch...

journal_title：Immunology

authors： Kanellos T,Sylvester ID,Ambali AG,Howard CR,Russell PH

更新日期：1999-02-01 00:00:00

abstract：:Recent studies in mice have highlighted the importance of polymorphic genetic loci such as the major histocompatibility complex (MHC) or minor lymphocyte-stimulating antigen (Mls) in determining the nature of the peripheral T-cell receptor (TcR) population. As our knowledge of the equivalent process in humans is incom...

journal_title：Immunology

authors： Loveridge JA,Rosenberg WM,Kirkwood TB,Bell JI

更新日期：1991-10-01 00:00:00