Evidence that ultraviolet B radiation induces tolerance and impairs induction of contact hypersensitivity by different mechanisms.

abstract：:Interleukin-2 (IL-2) is a critical regulator of immune homeostasis through its non-redundant role in regulatory T (Treg) cell biology. There is major interest in therapeutic modulation of the IL-2 pathway to promote immune activation in the context of tumour immunotherapy or to enhance immune suppression in the contex...

journal_title：Immunology

authors： Huss DJ,Pellerin AF,Collette BP,Kannan AK,Peng L,Datta A,Wipke BT,Fontenot JD

更新日期：2016-07-01 00:00:00

abstract：:Lymphoid cells in decidualized uterine endometrium in early human pregnancy may be essential for successful implantation and placentation. Endometrial granulocytes are prominent in early pregnancy decidua and express some T-cell associated surface antigens (CD2+, CD7+), but little is known of their function. We report...

journal_title：Immunology

authors： Ritson A,Bulmer JN

更新日期：1987-10-01 00:00:00

abstract：:Levels of IgA and IgG antibodies were measured in uterine and vaginal secretions to examine the effect of uterine immunization on the genital tract humoral immune system. When ovariectomized animals were immunized on Day 0 and boosted 13 days later by placing sheep erythrocytes (SRBC) directly in the uterine lumen (UT...

journal_title：Immunology

authors： Wira CR,Sandoe CP

更新日期：1989-09-01 00:00:00

abstract：:The intestinal lamina propria (LP) contains antigen-presenting cells with features of dendritic cells and macrophages, collectively referred to as mononuclear phagocytes (MNPs). Association of MNPs with the epithelium is thought to play an important role in multiple facets of intestinal immunity including imprinting M...

journal_title：Immunology

authors： McDonald KG,Wheeler LW,McDole JR,Joerger S,Gustafsson JK,Kulkarni DH,Knoop KA,Williams IR,Miller MJ,Newberry RD

更新日期：2017-12-01 00:00:00

abstract：:Staphylococcus aureus is a major pathogen that can cause a broad spectrum of serious infections including skin infections, pneumonia and sepsis. Peritoneal mast cells have been implicated in the host response towards various bacterial insults and to provide mechanistic insight into the role of mast cells in intraperit...

journal_title：Immunology

authors： Rönnberg E,Johnzon CF,Calounova G,Garcia Faroldi G,Grujic M,Hartmann K,Roers A,Guss B,Lundequist A,Pejler G

更新日期：2014-10-01 00:00:00

abstract：:Marmosets are natural blood chimeras, this condition resulting from the high frequency of fraternal twinning and the consistent development of placental vasular anastomoses between the two embryos. Identification of chimerism by sex-chromosome analysis of cultured blood lymphocytes provided a means of determining the ...

journal_title：Immunology

authors： Niblack GD,Kateley JR,Gengozian N

更新日期：1977-02-01 00:00:00

abstract：:Suppressor T (Ts) cells specific for minor alloantigens can be generated by intravenous administration of high doses (10(8) cells) of alloantigenic spleen cells. Such Ts cells have previously been shown to inhibit the in vivo induction of CTL responses and are now shown to suppress in vitro proliferative responses to ...

journal_title：Immunology

authors： Nanda NK

更新日期：1989-10-01 00:00:00

abstract：:Membrane attack complexes of complement occur around thyroid follicles in Graves' disease and Hashimoto's thyroiditis. The lytic potential of such complexes is controlled by membrane-bound and fluid phase regulators and we have investigated the role of these in autoimmune thyroid disease. By immunohistochemical staini...

journal_title：Immunology

authors： Tandon N,Yan SL,Morgan BP,Weetman AP

更新日期：1994-04-01 00:00:00

abstract：:Simultaneous kinetic measurements have been made of basophil degranulation and of histamine release. Both antigen and ionophore A23187 were studied. Cells from the same donor under the same conditions undergo both reactions at a similar rate. Regression analysis indicated a statistically highly significant correlation...

journal_title：Immunology

authors： Pruzansky JJ,Zeiss CR,Patterson R

更新日期：1980-07-01 00:00:00

abstract：:The genes coding for the main molecules involved in the human immune system--immunoglobulins, human leucocyte antigen (HLA) molecules and killer-cell immunoglobulin-like receptors (KIR)--exhibit a very high level of polymorphism that reveals remarkable frequency variation in human populations. 'Genetic marker' (GM) al...

journal_title：Immunology

authors： Sanchez-Mazas A,Fernandez-Viña M,Middleton D,Hollenbach JA,Buhler S,Di D,Rajalingam R,Dugoujon JM,Mack SJ,Thorsby E

更新日期：2011-06-01 00:00:00

abstract：:Synthesis of interferon (IFN)-gamma by natural killer (NK) cells is an important pro-inflammatory event with interleukin (IL)-12 and IL-18 playing major inductive roles. However, other temporal events are likely to regulate such processes and as prostaglandin E2 (PGE2) is ubiquitous during inflammation this study test...

journal_title：Immunology

authors： Walker W,Rotondo D

更新日期：2004-03-01 00:00:00

abstract：:The role of oral-associated lymphoid tissues during induction of oral tolerance still remains elusive. Therefore, the aim was to compare T-cell activation and induction of tolerance to ovalbumin (OVA) presented through either of two routes; deposited into the oral cavity, or the stomach, thereby bypassing the oral cav...

journal_title：Immunology

authors： Bankvall M,Östberg AK,Jontell M,Wold A,Östman S

更新日期：2016-09-01 00:00:00

abstract：:Using immunohistological techniques, class 1 products of the major histocompatibility complex (MHC) have been demonstrated on various forms of human extra-villous trophoblast in placental tissues taken from first, second and third trimester pregnancies. This contrasts with the absence of class 1 MHC antigens on all fo...

journal_title：Immunology

authors： Redman CW,McMichael AJ,Stirrat GM,Sunderland CA,Ting A

更新日期：1984-07-01 00:00:00

abstract：:The effect of E. coli lipopolysaccharide (LPS) on the induction of both hapten-specific immunity and tolerance was studied in an in vivo system utilizing putative T-cell dependent (TD) or T-cell independent (TI) challenge antigens. The administration of LPS 1 day prior to challenge preempted the response of C3D2 mice ...

journal_title：Immunology

authors： Venkataraman M,Scott DW

更新日期：1979-11-01 00:00:00

abstract：:Myelin oligodendrocyte glycoprotein (MOG), a minor protein of the central nervous system myelin, is recognized as a potential target in multiple sclerosis and neuromyelitis optica. The extracellular domain of MOG is commonly used in a wide range of mouse strains and other animals to induce experimental autoimmune ence...

journal_title：Immunology

authors： Delarasse C,Smith P,Baker D,Amor S

更新日期：2013-12-01 00:00:00

abstract：:Interleukin-31 (IL-31) is a novel T-helper-lymphocyte-derived cytokine that plays an important role in allergic skin inflammation and atopic dermatitis. It has recently been implicated in bronchial inflammation. We investigated the functions and mechanisms of IL-31-induced activation of human bronchial epithelial cell...

journal_title：Immunology

authors： Ip WK,Wong CK,Li ML,Li PW,Cheung PF,Lam CW

更新日期：2007-12-01 00:00:00

abstract：:The influence of antigens of the major histocompatibility complex (MHC) on the production of interferon (IFN) alpha or IFN gamma by human peripheral blood leucocytes (PBL) in vitro has been studied. Synthesis of IFN gamma by PBL stimulated with purified phytohaemagglutinin (PHA-P) or protein A of Staphylococcus aureus...

journal_title：Immunology

authors： Abb J,Zander H,Abb H,Albert E,Deinhardt F

更新日期：1983-06-01 00:00:00

abstract：:Bisphenol A (BPA) and p-nonylphenol (NP) are representative endocrine disruptors (EDs) that may have adverse effects on human health. The influence of these compounds on allergic immune responses remains unclear. In this study, we have examined the effects of BPA and NP on production of interleukin-4 (IL-4), a pro-inf...

journal_title：Immunology

authors： Lee MH,Chung SW,Kang BY,Park J,Lee CH,Hwang SY,Kim TS

更新日期：2003-05-01 00:00:00

abstract：:Anti-proteinase 3 antibodies are implicated in the pathogenesis of small vessel vasculitis. These are primarily immunoglobulin G (IgG), with different subclasses predominating at different stages of disease. However, little is known of their respective roles in pathogenesis. We have previously shown that patient IgG4 ...

journal_title：Immunology

authors： Hussain A,Pankhurst T,Goodall M,Colman R,Jefferis R,Savage CO,Williams JM

更新日期：2009-10-01 00:00:00

abstract：:Bone-marrow-derived macrophages are divided into two phenotypically and functionally distinct subsets, M1 and M2 macrophages. Recently, it was shown that adoptive transfer of M2-polarized peritoneal macrophages reduced the severity of experimental colitis in mice. However, it is still unclear whether peritoneal macrop...

journal_title：Immunology

authors： Oishi S,Takano R,Tamura S,Tani S,Iwaizumi M,Hamaya Y,Takagaki K,Nagata T,Seto S,Horii T,Osawa S,Furuta T,Miyajima H,Sugimoto K

更新日期：2016-11-01 00:00:00

abstract：:T. brucei infection in mice causes generalized immunosuppression with multiple changes in the cells of the lymphoid tissue. Loss of B cell responsiveness to antigens and mitogens, and the induction of suppressive T-cells and macrophages, have been previously reported (Hudson, Byner, Freeman & Terry, 1976; Corsini, Cla...

journal_title：Immunology

authors： Askonas BA,Corsini AC,Clayton CE,Ogilvie BM

更新日期：1979-02-01 00:00:00

abstract：:Class switching and plasma cell differentiation occur at a high level within all mucosa-associated lymphoid tissues. The different classes of membrane immunoglobulin heavy chains are associated with the Igα/Igβ heterodimer within the B-cell receptor (BCR). Whether BCR isotypes convey specific signals adapted to the co...

journal_title：Immunology

authors： Amin R,Carrion C,Decourt C,Pinaud E,Cogné M

更新日期：2012-05-01 00:00:00

abstract：:The liver is a front-line immune tissue that plays a major role in the detection, capture and clearance of pathogens and foreign antigens entering the bloodstream, especially from the gut. Our largest internal organ maintains this immune barrier in the face of constant exposure to external but harmless antigens throug...

journal_title：Immunology

authors： Stamataki Z,Swadling L

更新日期：2020-06-01 00:00:00

abstract：:The absence of complement receptor 1 (CR1) related gene/protein y (Crry) leads to embryonic lethality as a result of unrestricted complement activation and concomitant neutrophil infiltration. Here we used Crry(-/-)C3(+/-) mice to investigate the role of Crry in the pathogenesis of immune complex glomerulonephritis (G...

journal_title：Immunology

authors： Bao L,Wang Y,Chen P,Sarav M,Haas M,Minto AW,Petkova M,Quigg RJ

更新日期：2009-09-01 00:00:00

abstract：:The process by which naive T cells become activated, differentiate into effector cells and ultimately generate long-lived memory cells is dependent upon a number of factors, including the costimulatory signals received by the T cell. To best understand the multiple events involved, it is important to understand the po...

journal_title：Immunology

authors： Kohlmeier JE,Chan MA,Benedict SH

更新日期：2006-08-01 00:00:00

abstract：:The IgG and IgA subclass distribution of anti-carbohydrate antibodies in normal and immunodeficient donors was investigated. In normal donors, the specific anti-dextran antibodies were mainly of the IgG2 and IgA2 subclass, although substantial amounts of antibodies could also be of the IgG1 subclass. In children, IgG1...

journal_title：Immunology

authors： Hammarström L,Persson MA,Smith CI

更新日期：1985-04-01 00:00:00

abstract：:Human autologous-rosette-forming T cells (Tar cells) have many of the characteristics of post-thymic precursor cells. Thus, they bind to sheep erythrocytes but have neither receptors for the Fc portion of IgG nor for that of IgM. They include a subpopulation that binds peanut agglutinin which suggests that they are im...

journal_title：Immunology

authors： Palacios R,Alarcón-Segovia D,Llorente L,Ruíz-Arguelles A,Díaz-Jouanen E

更新日期：1981-01-01 00:00:00

abstract：:Although lymphocyte traffic through the brain is normally low, this can increase dramatically in response to infection or an autoimmune reaction. We have studied the adhesion of lymphocytes to cerebral endothelium in vitro in an attempt to model the first step of the infiltration process--that is, the initial interact...

journal_title：Immunology

authors： Hughes CC,Male DK,Lantos PL

更新日期：1988-08-01 00:00:00

abstract：:Haemolymph of the American lobster, Homarus americanus, contains several lectins. One of these, lobster agglutinin 1 (LAg1) is specific for N-acetylneuraminic acid and agglutinates mouse and human erythrocytes. In addition, this lectin agglutinates peripheral T cells and cortisone-resistant thymocytes, but agglutinate...

journal_title：Immunology

authors： Campbell PA,Hartman AL,Abel CA

更新日期：1982-01-01 00:00:00

abstract：:We have studied the adhesion of human CD4+ lymphocytes to cultured human retinal vascular endothelial cells (EC) and human retinal pigment epithelial cells (RPE), both of which comprise the cellular components of the blood-retina barrier. We have observed differences in the lymphocyte-RPE and the lymphocyte-EC interac...

journal_title：Immunology

authors： Liversidge J,Sewell HF,Forrester JV

更新日期：1990-11-01 00:00:00