Endometrial granulocytes in human decidua react with a natural-killer (NK) cell marker, NKH1.

abstract：:We have previously reported that human granulocyte-macrophage colony-stimulating factor (hGM-CSF) causes a stage-specific inhibition of T-cell receptor (TCR) alphabeta cell development in the thymus of transgenic mice constitutively expressing the hGM-CSF receptor. Since it has been reported that the addition of inter...

journal_title：Immunology

authors： Yasuda Y,Kaneko A,Nishijima I,Miyatake S,Arai K

更新日期：2002-06-01 00:00:00

abstract：:Loss of ζ-associated protein 70 (Zap70) results in severe immunodeficiency in humans and mice because of the critical role of Zap70 in T-cell receptor (TCR) signalling. Here we describe a novel mouse strain generated by N-ethyl-N-nitrosourea mutagenesis, with the reduced protein stability (rps) mutation in Zap70. The ...

journal_title：Immunology

authors： Cauwe B,Tian L,Franckaert D,Pierson W,Staats KA,Schlenner SM,Liston A

更新日期：2014-03-01 00:00:00

abstract：:The non-obese diabetic (NOD) mouse is an animal model for insulin-dependent diabetes that has many similarities to the human disease. NOD mice transgenic for the Ea gene, allowing expression of the E molecule, are protected from diabetes and rarely develop insulitis. An Ea transgene mutated in the promoter region, (De...

journal_title：Immunology

authors： Brenden N,Böhme J

更新日期：1998-09-01 00:00:00

abstract：:Humans and other mammals coexist with a diverse array of microbes colonizing the intestine, termed the microflora. The relationship is symbiotic, with the microbes benefiting from a stable environment and nutrient supply, and the host gaining competitive exclusion of pathogens and continuously maintenance of the gut i...

journal_title：Immunology

authors： Zeuthen LH,Fink LN,Frokiaer H

更新日期：2008-02-01 00:00:00

abstract：:Release of immunoglobulin-binding factors was induced from cultured human lymphoblastoid cells in a serum-free environment by incubation at 37 degrees. RPMI-8866 cells expressing Fc receptors for IgE (Fc epsilon R) and Daudi cells expressing Fc receptors for IgG (Fc gamma R) released IgE- and IgG-binding factors, resp...

journal_title：Immunology

authors： Jensen JR,Sand TT,Spiegelberg HL

更新日期：1984-09-01 00:00:00

abstract：:The 'binding' of IgE to particulate preparations derived from sonicated purified rat mast cells was measured by the blocking of PCA titrations of the supernatant solutions from incubations with such preparations. It was found that the PCA blocking reaction was inhibited by the addition of calcium ion to the incubation...

journal_title：Immunology

authors： Bach MK,Brashler JR

更新日期：1976-01-01 00:00:00

abstract：:MicroRNAs (miRNAs) regulate many aspects of helper T cell (Th) development and function. Here we found that they are required for the suppression of interleukin-9 (IL-9) expression in Th9 cells and other Th subsets. Two highly related miRNAs (miR-15b and miR-16) that we previously found to play an important role in re...

journal_title：Immunology

authors： Singh Y,Garden OA,Lang F,Cobb BS

更新日期：2016-09-01 00:00:00

abstract：:The in vitro migration activity of monocytic cells and the effect of lymphocytes in the delayed hypersensitivity (DH) reaction induced by intrapleural injection of PPD into FCA-sensitized guinea-pigs was investigated. The in vitro migration of exudate mononuclear cells was lower than that of comparable blood cells, an...

journal_title：Immunology

authors： Yamamoto S,Dunn CJ,Willoughby DA

更新日期：1976-04-01 00:00:00

abstract：:Intraepithelial lymphocytes (IEL) in normal human small intestine exhibit cytotoxicity. This study was undertaken to characterize the effector cells and their mode of action. Freshly isolated jejunal IEL and lamina propria lymphocytes (LPL), as well as IEL and LPL depleted of CD4+, CD8+ and T-cell receptor (TCR)-gamma...

journal_title：Immunology

authors： Melgar S,Bas A,Hammarström S,Hammarström ML

更新日期：2002-08-01 00:00:00

abstract：:The liver is where lymphocytes undergo activation-induced cell death (AICD) at the resolution phase of an immune response, which is crucial for homeostasis of the immune system and prevention of autoimmunity. Exploring the machinery of AICD in the liver, we found that a primary culture supernatant of murine hepatocyte...

journal_title：Immunology

authors： Ikeda M,Yoshikawa H,Liu J,Nakajima Y,Akahane Y,Tasaka K

更新日期：2003-01-01 00:00:00

abstract：:Ly-49A is a member of the Ly-49 family of mouse natural killer cell receptors that inhibit cytotoxicity upon recognition of their ligands, the major histocompatibility complex (MHC) class I molecules, on the target cell surface. Although Ly-49A has an immunoreceptor tyrosine-based inhibition motif (ITIM) in its cytopl...

journal_title：Immunology

authors： Motoda K,Takata M,Kiura K,Nakamura I,Harada M

更新日期：2000-07-01 00:00:00

abstract：:The negative role exerted by cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) in the regulation of T-cell activity, as induced by T-cell receptor (TCR)/CD3 and CD28 costimulation, has been widely described. In the present work we investigated the role of CTLA-4 in the control of cell activation, as induced by cost...

journal_title：Immunology

authors： Gatta L,Calviello G,Di Nicuolo F,Pace L,Ubaldi V,Doria G,Pioli C

更新日期：2002-10-01 00:00:00

abstract：:The relationship between the IgA antibody response in serum (total and polymeric IgA) and intestinal secretions was examined in volunteers subjected to oral and parenteral typhoid vaccination. After oral vaccination (three doses of 10(11) live Ty21a vaccine given at 48-hr intervals), serum pIgA antibody to typhoid lip...

journal_title：Immunology

authors： Bartholomeusz RC,Forrest BD,Labrooy JT,Ey PL,Pyle D,Shearman DJ,Rowley D

更新日期：1990-02-01 00:00:00

abstract：:It has been known for 15 years that the chicken epidermis contains ATPase+ and major histocompatibility complex class II-positive (MHCII+) dendritic cells. These cells were designated as Langerhans cells but neither their detailed phenotype nor their function was further investigated. In the present paper we demonstra...

journal_title：Immunology

authors： Igyártó BZ,Lackó E,Oláh I,Magyar A

更新日期：2006-10-01 00:00:00

abstract：:Selective Alzheimer disease indicator-1 (seladin-1) is a broadly expressed oxidoreductase and is related to Alzheimer disease, cholesterol metabolism and carcinogenesis. The effect of lipopolysaccharide (LPS) on the expression of seladin-1 was examined using RAW 264.7 macrophage-like cells and murine peritoneal macrop...

journal_title：Immunology

authors： Khuda II,Koide N,Noman AS,Dagvadorj J,Tumurkhuu G,Naiki Y,Komatsu T,Yoshida T,Yokochi T

更新日期：2010-09-01 00:00:00

abstract：:Vitamins A and E and select flavonoids in the family of catechins are well-defined small molecules that, if proven to possess immunomodulatory properties, hold promise as vaccine adjuvants and various therapies. In an effort to determine the in vivo immunomodulatory properties of these molecules, we found that althoug...

journal_title：Immunology

authors： Patel S,Akalkotkar A,Bivona JJ 3rd,Lee JY,Park YK,Yu M,Colpitts SL,Vajdy M

更新日期：2016-08-01 00:00:00

abstract：:Systemic lupus erythematosus (SLE) is an autoimmune disease that can attack many different body organs; the triggering event is unknown. SLE has been associated with more than 100 different autoantibody reactivities - anti-dsDNA is prominent. Nevertheless, autoantibodies to dsDNA occur in only two-thirds of SLE patien...

journal_title：Immunology

authors： Fattal I,Shental N,Molad Y,Gabrielli A,Pokroy-Shapira E,Oren S,Livneh A,Langevitz P,Pauzner R,Sarig O,Gafter U,Domany E,Cohen IR

更新日期：2014-02-01 00:00:00

abstract：:Extracts produced from the seeds of Ulex europeus (European gorse) were found to contain an inhibitor of human and murine lymphocyte growth. Interference with lymphocyte growth was demonstrated in three test systems. (1) Ulex seed extracts (USE) prevented the uptake of tritiated thymidine by stimulated human T and B l...

journal_title：Immunology

authors： Pirofsky B,Beaulieu R,Davies GH

更新日期：1981-08-01 00:00:00

abstract：:Immunization of mice with cognate cancer-derived heat-shock protein (hsp) preparations leads to protection from cancer growth. As hsp used for vaccination or therapy are derived from autologous cancers, questions of pathological autoimmunity are of immense significance for the ongoing translation of this approach to t...

journal_title：Immunology

authors： Ménoret A,Chandawarkar RY,Srivastava PK

更新日期：2000-11-01 00:00:00

abstract：:The CTLL-2 bioassay is used frequently to determine interleukin-2 (IL-2) concentrations in experimental samples, including samples that contain reagents which affect the CD28-B7 interaction. We therefore evaluated whether the CD28-B7 pathway plays a role in the growth of CTLL-2 cells. Flow cytometry demonstrated that ...

journal_title：Immunology

authors： Belani R,Weiner GJ

更新日期：1996-02-01 00:00:00

abstract：:The distribution of T lymphocytes expressing the different polypeptides of the leucocyte common antigen (LCA) family detected by CD45R and UCHL1 antibodies has been studied in normal lymphoid tissues. In the thymus most cortical thymocytes express UCHL1 and co-express CD4 and CD8. The more mature membrane CD3+ (mainly...

journal_title：Immunology

authors： Janossy G,Bofill M,Rowe D,Muir J,Beverley PC

更新日期：1989-04-01 00:00:00

abstract：:Electron microscopic findings made on microsomal fractions of rat liver after treatment with microsomal antibodies obtained from the blood of patients diagnosed as having chronic aggressive hepatitis and liver cirrhosis and after incubation with peroxidase-labelled antihuman IgG are described and presented in this pap...

journal_title：Immunology

authors： Storch W,Cossel L,Dargel R

更新日期：1977-06-01 00:00:00

abstract：:Haemolytic assays were used to compare alternative and classical complement (C) pathway activities in sera obtained from neonatal pigs reared on porcine colostrum, bovine colostrum or an immunoglobulin-free synthetic diet. Dramatic increases in immunoglobulin concentrations were noted in the colostrum-fed animals duri...

journal_title：Immunology

authors： Renshaw HW,Gilmore RJ

更新日期：1980-09-01 00:00:00

abstract：:Apoptosis of macrophages infected with pathogenic mycobacteria is an alternative host defence capable of removing the environment supporting bacterial growth. In this work the influence of virulence and bacterial load on apoptosis of alveolar macrophages during the initial phase of infection by Mycobacterium bovis was...

journal_title：Immunology

authors： Rodrigues MF,Barsante MM,Alves CC,Souza MA,Ferreira AP,Amarante-Mendes GP,Teixeira HC

更新日期：2009-09-01 00:00:00

abstract：:Natural cell-mediated cytotoxicity is mediated by a family of effector cells that express cytolytic activities distinct from those generally attributed to B cells, T cells and macrophages; it includes both natural killer (NK) and natural cytotoxic (NC) activities. There is now convincing evidence to show that NC activ...

journal_title：Immunology

authors： Patek PQ,Lin Y

更新日期：1989-08-01 00:00:00

abstract：:Specific IgE and IgG responses to highly purified Ambrosia (ragweed) allergens, Amb a V, Amb t V and Amb p V from the artemisiifolia (short), trifida (giant) and psilostachya (western) species are strongly associated with HLA-DR2 and Dw2 (DR2.2) in allergic Caucasoid individuals. To investigate the molecular basis of ...

journal_title：Immunology

authors： Huang SK,Marsh DG

更新日期：1991-07-01 00:00:00

abstract：:Suppressor T (Ts) cells specific for minor alloantigens can be generated by intravenous administration of high doses (10(8) cells) of alloantigenic spleen cells. Such Ts cells have previously been shown to inhibit the in vivo induction of CTL responses and are now shown to suppress in vitro proliferative responses to ...

journal_title：Immunology

authors： Nanda NK

更新日期：1989-10-01 00:00:00

abstract：:Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by chronic, synovial inflammation affecting multiple joints, finally leading to extra-articular lesions for which limited effective treatment options are currently available. Interleukin-34 (IL-34), recently discovered as the second colony-stimul...

journal_title：Immunology

authors： Zhou RP,Wu XS,Xie YY,Dai BB,Hu W,Ge JF,Chen FH

更新日期：2016-12-01 00:00:00

abstract：:In our earlier studies we have observed that T lymphocytes of dengue type 2 virus (DV)-infected mouse spleen produce a cytotoxic factor (CF). In the present study it has been observed that CF induces mouse spleen and peritoneal macrophages to produce a cytotoxin (CF2) as has been revealed by DEAE-cellulose chromatogra...

journal_title：Immunology

authors： Gulati L,Chaturvedi UC,Mathur A

更新日期：1983-05-01 00:00:00

abstract：:We have studied the adhesion of human CD4+ lymphocytes to cultured human retinal vascular endothelial cells (EC) and human retinal pigment epithelial cells (RPE), both of which comprise the cellular components of the blood-retina barrier. We have observed differences in the lymphocyte-RPE and the lymphocyte-EC interac...

journal_title：Immunology

authors： Liversidge J,Sewell HF,Forrester JV

更新日期：1990-11-01 00:00:00