Natural autoantibodies against heat-shock proteins hsp70 and gp96: implications for immunotherapy using heat-shock proteins.

abstract：:Expression of CD45RO on intraepithelial lymphocytes (IEL) bearing the T-cell receptor (TcR) alpha/beta or gamma/delta was studied in situ by three-colour immunofluorescence on jejunal tissue sections from 21 patients with coeliac disease and eight controls. CD45RA-TcR alpha/beta+ IEL expressed CD45RO significantly mor...

journal_title：Immunology

authors： Halstensen TS,Farstad IN,Scott H,Fausa O,Brandtzaeg P

更新日期：1990-12-01 00:00:00

abstract：:Differences in the activity of monocytes/macrophages, important target cells of Mycobacterium tuberculosis, might influence tuberculosis progression. With the purpose of identifying candidate genes for tuberculosis susceptibility we infected monocytes from both healthy elderly individuals (a tuberculosis susceptibilit...

journal_title：Immunology

authors： Guerra-Laso JM,Raposo-García S,García-García S,Diez-Tascón C,Rivero-Lezcano OM

更新日期：2015-02-01 00:00:00

abstract：:The role of anti-idiotypic subclass-specific antibodies was analysed in the regulation of the immune response to BCG in the guinea-pig. The idiotypes to BCG were separated into subclasses and anti-idiotypes were carried out by immunizing with the purified IgG1 and IgG2 anti-idiotypes. The in vivo T cell response was r...

journal_title：Immunology

authors： Daus H,Hammer HJ,Rajki K,Mauch H

更新日期：1984-08-01 00:00:00

abstract：:Autoimmune diabetes is predominated by a T helper 1 (Th1) response at the expense of an impaired Th2 response. Although T cells producing Th2 cytokines are generally thought to counter a Th1 response, there have been reports of Th2 T-cell clones with pathogenic activity, including one previously reported by us in whic...

journal_title：Immunology

authors： He J,Haskins K

更新日期：2008-01-01 00:00:00

abstract：:Endothelial cell activation antigens may play important roles in immune responses and in inflammation. This report describes the identification and characterization of a monoclonal antibody, named EAA-B, which reacts specifically with human umbilical vein endothelial (HUVE) cells pre-treated with tumour necrosis facto...

journal_title：Immunology

authors： To SS,Magoulas T,Nicholson E,Schrieber L

更新日期：1992-08-01 00:00:00

abstract：:The results presented in this paper demonstrate that a mouse IgM monoclonal antibody (T-80) recognizes an antigen on cells of the T-lymphocyte lineage of sheep. However, this antibody does not identify all T cells, as 10-20% of thymocytes and some peripheral-blood T cells are negative. T-80- thymocytes reside in the m...

journal_title：Immunology

authors： Miyasaka M,Heron I,Dudler L,Cahill RN,Forni L,Knaak T,Trnka Z

更新日期：1983-07-01 00:00:00

abstract：:Adult normal mice and those mice which had been thymectomized, X-irradiated, and reconstituted either with bone marrow cells and thymus cells (TxXBT) or with bone marrow cells along (TxXB), were given varying amounts (0.1-5 mg) of deaggregated soluble bovine serum albumin (sBSA). They were challenged 10 days later wit...

journal_title：Immunology

authors： Muramatsu S,Amagai T,Katura Y

更新日期：1975-05-01 00:00:00

abstract：:Peritoneal macrophages from CBA mice incubated with recombinant murine tumour necrosis factor (TNF-alpha) are effective in killing the protozoa parasite Leishmania major in vitro. The leishmanicidal activity is directly correlated with the level of nitrite (NO2-) in the culture supernatants. The killing of intracellul...

journal_title：Immunology

authors： Liew FY,Li Y,Millott S

更新日期：1990-12-01 00:00:00

abstract：:The relationship between allograft rejection and the response in the one-way mixed leucocyte reaction (MLR) of the WBC of allograft recipients was investigated. The responses of the WBC were assessed prior to skin allografting and subsequent to rejection of the allograft. The optimal MLR response of the WBC from the a...

journal_title：Immunology

authors： Milthorp P,Belanger R,Richter M

更新日期：1979-01-01 00:00:00

abstract：:The migration of immune cells through the extracellular matrix (ECM) towards inflammatory sites is co-ordinated by receptors recognizing ECM glycoproteins, chemokines and proinflammatory cytokines. In this context, galectins are secreted to the extracellular milieu, where they recognize poly-N-acetyllactosamine chains...

journal_title：Immunology

authors： Rabinovich GA,Ariel A,Hershkoviz R,Hirabayashi J,Kasai KI,Lider O

更新日期：1999-05-01 00:00:00

abstract：:It has been suggested that tumour cell lysis by gamma-radiation induces a tumoral antigen release eliciting an immune response. It is not clear how a specific immune response in cervical cancer patients is developed after radiotherapy. This study is an attempt to investigate the role of the human papillomavirus type 1...

journal_title：Immunology

authors： Delgado FG,Martínez E,Céspedes MA,Bravo MM,Navas MC,Cómbita Rojas AL

更新日期：2009-04-01 00:00:00

abstract：:The liver is where lymphocytes undergo activation-induced cell death (AICD) at the resolution phase of an immune response, which is crucial for homeostasis of the immune system and prevention of autoimmunity. Exploring the machinery of AICD in the liver, we found that a primary culture supernatant of murine hepatocyte...

journal_title：Immunology

authors： Ikeda M,Yoshikawa H,Liu J,Nakajima Y,Akahane Y,Tasaka K

更新日期：2003-01-01 00:00:00

abstract：:Electron microscopic findings made on microsomal fractions of rat liver after treatment with microsomal antibodies obtained from the blood of patients diagnosed as having chronic aggressive hepatitis and liver cirrhosis and after incubation with peroxidase-labelled antihuman IgG are described and presented in this pap...

journal_title：Immunology

authors： Storch W,Cossel L,Dargel R

更新日期：1977-06-01 00:00:00

abstract：:Peripheral blood lymphocytes (PBL) from non-immunized rabbits or from rabbits immunized several months previously with a single dose of sheep red blood cells (SRBC) were cultured at several different cell densities in the presence of antigen for 5 days. The cells were then distributed in 10 microliter microcultures at...

journal_title：Immunology

authors： Luzzati AL,Giacomini E,Lefkovits I

更新日期：1985-12-01 00:00:00

abstract：:2B4 (CD244) is a member of the CD2 subset of the immunoglobulin superfamily and functions as a triggering molecule on natural killer (NK) cells. Previously, we have found that 2B4-mediated activation of NK cells involves complex interactions involving LAT, Ras, Raf, ERK and p38 and that cytolytic function and cytokine...

journal_title：Immunology

authors： Chuang SS,Lee JK,Mathew PA

更新日期：2003-07-01 00:00:00

abstract：:MCA44 is a monoclonal antibody (mAb) to guinea-pig decay-accelerating factor (DAF) and, using this mAb, tissue distribution of guinea-pig DAF was studied by immunofluorescence. Guinea-pig DAF was found to be expressed not only on the vascular endothelium but also on different types of cells, such as the tubular epithe...

journal_title：Immunology

authors： Nishikawa K,Matsuo S,Tamai H,Okada N,Okada H

更新日期：1998-10-01 00:00:00

abstract：:The IgE immune response was studied in female athymic, nude (Lewis rnu/rnu) and euthymic (Lewis +/+) rats infected with the nematode Nippostrongylus brasiliensis. During the course of the infection, serum IgE levels were followed using an enzyme-linked immunosorbent assay technique (ELISA), while the surface expressio...

journal_title：Immunology

authors： Chen XJ,Wiedermann U,Dahlgren U,Hanson LA,Enerbäck L

更新日期：1995-11-01 00:00:00

abstract：:Salmonella enterica serovar Typhimurium (S. typhimurium) causes a localized enteric infection and its elimination is dependent on a T helper type 1 immune response. However, the mechanism of the protective immune response against the pathogen in gut-associated lymphoid tissue (GALT) at an early stage of the infection ...

journal_title：Immunology

authors： Mayuzumi H,Inagaki-Ohara K,Uyttenhove C,Okamoto Y,Matsuzaki G

更新日期：2010-11-01 00:00:00

abstract：:Human β-defensin 3 (hBD-3) activates antigen-presenting cells through Toll-like receptors (TLRs) 1/2. Several TLR1/2 agonists have been identified but little is known about how they might differentially affect cellular activation. We compared the effects of hBD-3 with those of another TLR1/2 agonist, Pam(3) CSK(4) , i...

journal_title：Immunology

authors： Funderburg NT,Jadlowsky JK,Lederman MM,Feng Z,Weinberg A,Sieg SF

更新日期：2011-10-01 00:00:00

abstract：:Monocyte chemotactic protein-1 (MCP-1) is a proinflammatory cytokine that attracts and activates specific types of leucocytes. The purpose of this work was to analyse the generation of MCP-1 and mRNA transcript in a model of chronic inflammation using a granulomatous tissue induced by potassium permanganate (KMnO4; wa...

journal_title：Immunology

authors： Conti P,Reale M,Feliciani C,Frydas S,Trakatellis M,Placido FC,Cataldo I,Di Gioacchino M,Barbacane RC

更新日期：1997-10-01 00:00:00

abstract：:Primary contact sensitivity (CS) to Ox and non-specific unresponsiveness to other unrelated delayed-type hypersensitivity (DTH) containing CS were induced simultaneously by i.v. administration of oxazolone(Ox)-conjugated spleen cells. The subpopulation of spleen cells which serves as carriers for the induction of prim...

journal_title：Immunology

authors： Nakano Y,Nakano K

更新日期：1985-02-01 00:00:00

abstract：:A critical role for leukotriene B(4) (LTB(4)) and/or platelet-activating factor (PAF) in regulating polymorphonuclear cell (PMN) trafficking to inflammatory sites has been reported in a number of experimental inflammatory models. In vitro, newly synthesized LTB(4) and PAF were shown to act in an autocrine/paracrine or...

journal_title：Immunology

authors： Bélanger C,Elimam H,Lefebvre J,Borgeat P,Marleau S

更新日期：2008-07-01 00:00:00

abstract：:The immunomodulatory molecule cyclosporine was found to cause an early acceleration of the capping of mouse B-cell membrane immunoglobulin. This was most marked when the capping process was slightly retarded by keeping the cells at 32 degrees. This is a sign that the drug can cause B-cell membrane alterations. At lowe...

journal_title：Immunology

authors： Mosbach-Ozmen L,Humez S,Koponen M,Fonteneau P,Loor F

更新日期：1986-04-01 00:00:00

abstract：:Collectins are a group of soluble proteins, each of which has collagenous and non-collagenous globular domains, and may be complement associated and/or have lectin activity. The complement protein C1q is structurally and functionally related to the collectins. Members of the collectin family are mannan-binding protein...

journal_title：Immunology

authors： Malhotra R,Willis AC,Lopez Bernal A,Thiel S,Sim RB

更新日期：1994-07-01 00:00:00

abstract：:When mice were homozygous for the Wf allele at W locus, the delayed-type hypersensitivity (DTH) reaction observed in mice primed i.v. or s.c. with optimal doses of sheep red blood cells was greatly decreased. The number of sensitized splenic cells able to transfer a delayed-type hypersensitivity reaction was identical...

journal_title：Immunology

authors： Marchal G,Milon G,Guénet JL

更新日期：1980-02-01 00:00:00

abstract：:The fate of allogeneic lymphocytes (AO or DA) transferred to non-immune PVG recipients was studied in the light of previous evidence (Heslop & McNeilage, 1983; Rolstad & Ford, 1983) that allogeneic lymphocytes can be rapidly destroyed in certain strain combinations of rats and mice by a mechanism that is distinct from...

journal_title：Immunology

authors： Rolstad B,Fossum S,Bazin H,Kimber I,Marshall J,Sparshott SM,Ford WL

更新日期：1985-01-01 00:00:00

abstract：:Large doses of hydrocortisone, cyclophosphamide, and methotrexate injected subcutaneously, and whole-body irradiation (500 rads) caused a reduction in the number of peritoneal cells (PE cells) obtained after intraperitoneal injection of the treated mice with proteose-peptone. The same dose of cyclophosphamide and irra...

journal_title：Immunology

authors： Gadeberg OV,Rhodes JM,Larsen SO

更新日期：1975-01-01 00:00:00

abstract：:Various strains of anaerobic coryneforms and the closely related Propionibacteria have been compared in vivo with respect to their anti-tumour activity. Their effectiveness has been correlated with their serological relationship and to some extent with their ability to stimulate the lymphoreticular system. Organisms b...

journal_title：Immunology

authors： McBride WH,Dawes J,Dunbar N,Ghaffar A,Woodruff MF

更新日期：1975-01-01 00:00:00

abstract：:Preincubation of macrophages with immune complexes suppresses the interferon-gamma (IFN-gamma) induction of tumouricidal activity and Ia surface expression. The studies reported in this manuscript were designed to test if immune complexes alter the interaction of IFN-gamma with macrophages. The binding of IFN-gamma to...

journal_title：Immunology

authors： Celada A

更新日期：1988-06-01 00:00:00

abstract：:Over the past years, increasing numbers of distinct subsets have been discovered and identified for a T lymphocytes' entity. Differentiation and function of each T cell subset are controlled by a specific master transcription factor. Importantly, Runt-related transcription factors, particularly Runx1 and Runx3, interp...

journal_title：Immunology

authors： Wong WF,Kohu K,Chiba T,Sato T,Satake M

更新日期：2011-02-01 00:00:00