Cyclosporine facilitates B-cell membrane immunoglobulin capping.

Abstract:

:The immunomodulatory molecule cyclosporine was found to cause an early acceleration of the capping of mouse B-cell membrane immunoglobulin. This was most marked when the capping process was slightly retarded by keeping the cells at 32 degrees. This is a sign that the drug can cause B-cell membrane alterations. At lower drug doses they might not be as easily detected, but are nevertheless sufficient to inhibit the activation of some B cells by membrane immunoglobulin clustering.

journal_name

Immunology

journal_title

Immunology

authors

Mosbach-Ozmen L,Humez S,Koponen M,Fonteneau P,Loor F

subject

Has Abstract

pub_date

1986-04-01 00:00:00

pages

573-7

issue

4

eissn

0019-2805

issn

1365-2567

journal_volume

57

pub_type

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