Abstract:
:The immunomodulatory molecule cyclosporine was found to cause an early acceleration of the capping of mouse B-cell membrane immunoglobulin. This was most marked when the capping process was slightly retarded by keeping the cells at 32 degrees. This is a sign that the drug can cause B-cell membrane alterations. At lower drug doses they might not be as easily detected, but are nevertheless sufficient to inhibit the activation of some B cells by membrane immunoglobulin clustering.
journal_name
Immunologyjournal_title
Immunologyauthors
Mosbach-Ozmen L,Humez S,Koponen M,Fonteneau P,Loor Fsubject
Has Abstractpub_date
1986-04-01 00:00:00pages
573-7issue
4eissn
0019-2805issn
1365-2567journal_volume
57pub_type
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