Marginal zone of the spleen and the development and localization of specific antibody-forming cells against thymus-dependent and thymus-independent type-2 antigens.

abstract：:In order to analyse the molecular mechanism of lymphocyte activation defect in MRL/MP-lpr (MRL/1) mice, c-myc proto-oncogene expression was examined in MRL/1 lymph node cells stimulated by various agents. Since a transient increase of c-myc RNA in early hours is required for lymphocyte activation, detection of c-myc m...

journal_title：Immunology

authors： Koizumi T,Nakao Y,Matsui T,Katakami Y,Mihara K,Takahashi R,Maeda S,Sugiyama T,Fujita T

更新日期：1988-05-01 00:00:00

abstract：:The subcutaneous (s.c.) injection of sheep red blood cells (SRBC) without adjuvant into mice preferentially induced delayed hypersensitivity (DH) reaction, as measured by footpad swelling, while intraperitoneal (i.p.) measured by the haemagglutinin test. Under these conditions, the properties of the helper activities...

journal_title：Immunology

authors： Tamura SI,Egashira Y

更新日期：1975-05-01 00:00:00

abstract：:The objective of the present study was to examine and to compare the impact of severe protein malnutrition during development, adulthood and ageing on secretory immune expression in the eye, mouth and small intestine. In addition, we sought to determine whether potential abrogation of mucosal immunity by protein depri...

journal_title：Immunology

authors： Sullivan DA,Vaerman JP,Soo C

更新日期：1993-02-01 00:00:00

abstract：:Studies with gene-deficient and gnotobiotic mice have identified many host and microbial factors that contribute to induced colitis, but information on whether specific factors determine susceptibility under more physiological conditions is lacking. Using wild-type strains that differ in their IgA response but harbor ...

journal_title：Immunology

authors： Gupta S,Basu S,Bal V,Rath S,George A

更新日期：2019-09-01 00:00:00

abstract：:Macrophage (MΦ) polarization is triggered during the innate immune response to defend against microbial pathogens, but can also contribute to disease pathogenesis. In a previous study, we found that interleukin-15 (IL-15) -derived classically activated macrophages (M1 MΦ) have enhanced antimicrobial activity, whereas ...

journal_title：Immunology

authors： Montoya D,Mehta M,Ferguson BG,Teles RMB,Krutzik SR,Cruz D,Pellegrini M,Modlin RL

更新日期：2019-02-01 00:00:00

abstract：:Following exposure of mice to contact sensitizing chemicals, dendritic cells (DC) rapidly accumulate in the draining lymph nodes. A proportion, at least, of the DC which arrive in the nodes bear significant amounts of antigen and are derived from epidermal Langerhans' cells (LC). It is of interest that although LC are...

journal_title：Immunology

authors： Cumberbatch M,Gould SJ,Peters SW,Kimber I

更新日期：1991-11-01 00:00:00

abstract：:The concentration of CXCL12/SDF-1 in the bloodstream is tightly regulated, given its central role in leucocyte and stem/progenitor cell egress from bone marrow and recruitment to sites of inflammation or injury. The mechanism responsible for this regulation is unknown. Here we show that both genetic deletion and pharm...

journal_title：Immunology

authors： Berahovich RD,Zabel BA,Lewén S,Walters MJ,Ebsworth K,Wang Y,Jaen JC,Schall TJ

更新日期：2014-01-01 00:00:00

abstract：:The immunosuppressive activity of serum from PVG rats following orthotopic transplantation of DA liver has been examined in vitro. Liver grafts in this combination are never rejected, but induce a state of specific transplantation tolerance in the recipient. Serum from such tolerant animals was able to inhibit prolife...

journal_title：Immunology

authors： Tsurufuji M,Ishiguro K,Shinomiya T,Uchida T,Kamada N

更新日期：1987-08-01 00:00:00

abstract：:During attempts to generate Sendai virus-specific T-cell hybridomas, a number of autoreactive T-cell hybridomas were produced. These hybrids secrete IL-2 in response to class II-positive syngeneic cells in the absence of added Sendai virus. Class II molecules on the stimulator cells are involved since monoclonal anti-...

journal_title：Immunology

authors： Pullen AM,Munro AJ

更新日期：1988-02-01 00:00:00

abstract：:The differentiation mechanisms that force thymocytes into the T-cell receptor (TCR)-alpha beta or TCR-gamma delta lineage are poorly understood, but rearrangement processes in the TCR-alpha/delta locus are likely to play an important role. It is assumed that the TCR-delta gene is deleted prior to V alpha-J alpha rearr...

journal_title：Immunology

authors： Verschuren MC,Wolvers-Tettero IL,Breit TM,van Dongen JJ

更新日期：1998-02-01 00:00:00

abstract：:Preparations of ECF-A derived from anaphylactic guinea-pig lung diffusates were subjected to a variety of enzymatic degradations. The enzymes employed had specificityonly for their appropiate subtstates. No effect was found following treatmentwith relatively high doses of trypsin, alpha-chymotrypsin, pronase, alkali...

journal_title：Immunology

authors： Bach MK,Jones DG,Kay AB

更新日期：1975-04-01 00:00:00

abstract：:Cells of the female reproductive tract (FRT) can present antigen to naive and memory T cells. However, the effects of oestrogen, known to modulate immune responses, on antigen presentation in the FRT remain undefined. In the present study, DO11.10 T-cell antigen receptor transgenic mice specific for the class II MHC-r...

journal_title：Immunology

authors： Ochiel DO,Rossoll RM,Schaefer TM,Wira CR

更新日期：2012-01-01 00:00:00

abstract：:Salmonella enterica serovar Typhimurium (S. typhimurium) causes a localized enteric infection and its elimination is dependent on a T helper type 1 immune response. However, the mechanism of the protective immune response against the pathogen in gut-associated lymphoid tissue (GALT) at an early stage of the infection ...

journal_title：Immunology

authors： Mayuzumi H,Inagaki-Ohara K,Uyttenhove C,Okamoto Y,Matsuzaki G

更新日期：2010-11-01 00:00:00

abstract：:The plaque-forming cell (PFC) responses to sheep red blood cell (SRBC) dinitrophenyl-lysine-Ficoll (DNP-lys-Ficoll), and dinitrophenylated bovine serum albumin (DNP-BSA) have been studied in both germ-free and conventionally reared ICR mice. In germ-free mice, the IgG response to SRBC and the IgM and IgG responses to ...

journal_title：Immunology

authors： Ohwaki M,Yasutake N,Yasui H,Ogura R

更新日期：1977-01-01 00:00:00

abstract：:The negative role exerted by cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) in the regulation of T-cell activity, as induced by T-cell receptor (TCR)/CD3 and CD28 costimulation, has been widely described. In the present work we investigated the role of CTLA-4 in the control of cell activation, as induced by cost...

journal_title：Immunology

authors： Gatta L,Calviello G,Di Nicuolo F,Pace L,Ubaldi V,Doria G,Pioli C

更新日期：2002-10-01 00:00:00

abstract：:Predisposition to autoimmune disorder in Lewis rats has been associated with abnormal hypothalamic regulation of circulating steroids, leading to inadequate suppression of T helper 1 (Th1) cell-mediated inflammatory reactions. In addition, autoimmune syndromes can be triggered within formerly resistant animals, follow...

journal_title：Immunology

authors： Downing JE,Virag L,Jones IW

更新日期：1998-09-01 00:00:00

abstract：:The requirement for activity of the enzyme ADP-ribosyl transferase (ADPRT) and changes in single-strand DNA breaks were assessed during the initial stimulation of quiescent murine splenic lymphocytes with mitogen alone, the stimulation of activated blasts with IL-2-containing medium and, for comparison, the serum stim...

journal_title：Immunology

authors： Johnstone AP,Darling D

更新日期：1985-08-01 00:00:00

abstract：:Soluble low-affinity receptors for IgG are known to inhibit immune complex (IC)-mediated inflammation, and expression by leukocytes is elevated in several inflammatory diseases. Immunoglobulin M (IgM) rheumatoid factors (RF), anti-Fc autoantibodies, are found in autoimmune diseases, such as rheumatoid arthritis (RA), ...

journal_title：Immunology

authors： Wines BD,Gavin A,Powell MS,Steinitz M,Buchanan RR,Mark Hogarth P

更新日期：2003-06-01 00:00:00

abstract：:This study examines the expression of mRNA for the Th2 cytokine, interleukin-4 (IL-4). Peripheral blood mononuclear cells from deer infected with Mycobacterium bovis or vaccinated with live or killed M. bovis bacillus Calmette-Guérin (BCG) were cultured with mycobacterial antigens. IL-4 mRNA production was assayed usi...

journal_title：Immunology

authors： Hook S,Griffin F,Mackintosh C,Buchan G

更新日期：1996-06-01 00:00:00

abstract：:Syngeneic (CB20) thymus and spleen T cells transferred to SCID mice, and shown to be present by flow cytometric analysis and functional by their ability to reject third-party skin grafts, do not lead to a detectable failure of syngeneic or allogeneic pregnancy. Unless the small number of B cells contaminating the T-ce...

journal_title：Immunology

authors： Hetherington CM,Dresser DW

更新日期：1990-11-01 00:00:00

abstract：:The microfibrillar protein (MFP) of foetal bovine ligamentum nuchae elastic fibres was prepared and used to produce a monospecific antiserum. Indirect immunofluorescence studies employing the specific antiserum demonstrated its selectivity for MFP associated with elastic fibres. The antiserum was demonstrated to react...

journal_title：Immunology

authors： Kewley MA,Steven FS,Williams G

更新日期：1977-09-01 00:00:00

abstract：:The effect of invasive bacteria on the release of proinflammatory mediators (oxygen radicals, leukotriene release) from human polymorphonuclear neutrophils was studied. Bacterial stimuli were used including genetically cloned invasive Yersinia enterocolitica strains 108-P (bearing the phagocytosis-resistance plasmid) ...

journal_title：Immunology

authors： Gröne M,Scheffer J,König W

更新日期：1992-11-01 00:00:00

abstract：:Haemolymph of the American lobster, Homarus americanus, contains several lectins. One of these, lobster agglutinin 1 (LAg1) is specific for N-acetylneuraminic acid and agglutinates mouse and human erythrocytes. In addition, this lectin agglutinates peripheral T cells and cortisone-resistant thymocytes, but agglutinate...

journal_title：Immunology

authors： Campbell PA,Hartman AL,Abel CA

更新日期：1982-01-01 00:00:00

abstract：:Purified cleavage products of the guinea-pig complement component C3, namely C3b and C3a, interact with guinea-pig and mouse macrophages in culture to induce a dose- and time dependent release of lysosmal enzymes into the medium. In the case of C3b the selectivity of the release of hydrolases, which occurs without cel...

journal_title：Immunology

authors： Schorlemmer HU,Allison AC

更新日期：1976-11-01 00:00:00

abstract：:To investigate the effect of carbohydrate on activation of the alternative pathway of complement by IgA immune complexes, aglycosylated monoclonal IgA was made biosynthetically in the presence of tunicamycin. When immune complexes were incubated with normal human serum (NHS), the aglycosylated IgA immune complexes cau...

journal_title：Immunology

authors： Zhang W,Lachmann PJ

更新日期：1994-01-01 00:00:00

abstract：:Memory CD8(+) T cells regain function during a recall response, but the requirement of signals in addition to antigen during a secondary immune response is unknown. In this study, the ability of interleukin-7 (IL-7) to enhance memory CD8(+ ) CD45RA(- ) CD127(+) T-cell responses in health and in human immunodeficiency ...

journal_title：Immunology

authors： O'Connor AM,Crawley AM,Angel JB

更新日期：2010-12-01 00:00:00

abstract：:We performed a genomic study combining single-cell mRNA differential display and RNA subtractive hybridization to elucidate CD8 T-cell quiescence/ignorance. By comparing actively maintained quiescent CD8 T cells from liver tumour tumour-infiltrating lymphocytes (TILs) with quiescent T cells at the single-cell level, w...

journal_title：Immunology

authors： Zhang W,Ding J,Qu Y,Hu H,Lin M,Datta A,Larson A,Liu GE,Li B

更新日期：2009-05-01 00:00:00

abstract：:Tuberculin-active peptide-reactive T-cell lines were established from the popliteal lymph node of BALB/cA mice immunized with heat-killed Mycobacterium tuberculosis to investigate the cellular mechanisms in the protective immunity of tuberculosis. These T-cell lines, consisting mainly of L3T4 surface antigen-positive ...

journal_title：Immunology

authors： Yamamoto S,Iwai H,Ueda K

更新日期：1989-10-01 00:00:00

abstract：:Systemic lupus erythematosus (SLE) is an autoimmune disease that can attack many different body organs; the triggering event is unknown. SLE has been associated with more than 100 different autoantibody reactivities - anti-dsDNA is prominent. Nevertheless, autoantibodies to dsDNA occur in only two-thirds of SLE patien...

journal_title：Immunology

authors： Fattal I,Shental N,Molad Y,Gabrielli A,Pokroy-Shapira E,Oren S,Livneh A,Langevitz P,Pauzner R,Sarig O,Gafter U,Domany E,Cohen IR

更新日期：2014-02-01 00:00:00

abstract：:An experiments in mice with a range of human serum albumin (HSA) molecules acylated to various degrees with side-chains of 6--20 carbon atoms, the greatest antibody responses against HSA were induced by highly acylated HSA with side-chains of intermediate length (C10--14). Similar results were obtained in rats but in ...

journal_title：Immunology

authors： Stark JM,Locke J,Heatley RV

更新日期：1980-03-01 00:00:00