Abstract：
:Studies with gene-deficient and gnotobiotic mice have identified many host and microbial factors that contribute to induced colitis, but information on whether specific factors determine susceptibility under more physiological conditions is lacking. Using wild-type strains that differ in their IgA response but harbor a diverse gut microbiome, we found that the IgA-high strain CBA/CaJ (CBA) is resistant to acute colitis induced with dextran sodium sulfate (DSS), unlike the IgA-low strain C57BL/6 (B6). Resistance was associated with extensive IgA-coating of fecal bacteria, lower fecal bacterial loads and greater abundance of barrier-protective transcripts in colonic tissues under homeostatic conditions. Fecal microbial transplant (FT) experiments revealed that disease induction in B6 mice was associated with a cohort of bacteria that are not targeted by IgA. However, CBA mice continued to be resistant to colitis induction following FTs from B6 mice, indicating that they are able to contain such colitogenic members. In support of a role for bacterial exclusion in resistance, oral administration of immunoglobulins decreased DSS-induced disease in B6 mice. In F1 mice derived separately with CBA and B6 dams and in F1 mice backcrossed to the two parental strains, resistance segregated with the IgA response of the pups and not with barrier-associated transcripts or bacterial loads. Interestingly, B6 pups foster-nursed on CBA dams continued to be susceptible in later life, whereas CBA pups foster-nursed on B6 dams continued to be resistant. Together, the data indicate that a high-IgA response in adult life can protect against colitis and compensate for IgA deficiency in early life.
journal_name
Immunologyjournal_title
Immunologyauthors
Gupta S,Basu S,Bal V,Rath S,George Adoi
10.1111/imm.13091subject
Has Abstractpub_date
2019-09-01 00:00:00pages
19-34issue
1eissn
0019-2805issn
1365-2567journal_volume
158pub_type
杂志文章相关文献
IMMUNOLOGY文献大全abstract：:Mice injected in the footpad with carrageenin developed local inflammation which peaked at 48 hr. This delayed-type footpad swelling was significantly reduced in mice injected intraperitoneally (i.p.) with a specific nitric oxide (NO) synthase inhibitor, L-NGmonomethyl-arginine (L-NMMA). The draining lymph node (DLN) ...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1994-07-01 00:00:00
abstract：:T cells play a key role in the pathogenesis of type 1 diabetes, and targeting the CD3 component of the T-cell receptor complex provides one therapeutic approach. Anti-CD3 treatment can reverse overt disease in spontaneously diabetic non-obese diabetic mice, an effect proposed to, at least in part, be caused by a selec...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1111/imm.12729
更新日期：2017-06-01 00:00:00
abstract：:The fungus metabolite cyclosporin A is a small cyclic peptide acting as a novel antilymphocytic agent. It is effective following either parenteral or oral administration in mice, rats and guinea-pigs. The suppressive effect after short and prolonged treatment on plaque-forming cells, the inhibition of the secondary hu...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1977-06-01 00:00:00
abstract：:The decay-accelerating factor (DAF) contains four complement control protein repeats (CCPs) with a single N-linked glycan positioned between CCPs 1 and 2. In previous studies we found that the classical pathway regulatory activity of DAF resides in CCPs 2 and 3 while its alternative pathway regulatory activity resides...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1046/j.1365-2567.2000.00086.x
更新日期：2000-09-01 00:00:00
abstract：:During the immune response to H-2 and Mls alloantigens, murine lymphocytes showed altered sensitivity to polyclonal mitogens. The reactivity to the T-cell mitogen PHA followed a similar pattern in both H-2 and Mls-immunized mice while the reactivity to the B-cell mitogen LPS was contrasting in the two groups. In the f...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1979-08-01 00:00:00
abstract：:Natural cell-mediated cytotoxicity is mediated by a family of effector cells that express cytolytic activities distinct from those generally attributed to B cells, T cells and macrophages; it includes both natural killer (NK) and natural cytotoxic (NC) activities. There is now convincing evidence to show that NC activ...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1989-08-01 00:00:00
abstract：:Antigen-induced allergic airway inflammation is mediated by T helper type 2 (Th2) cells and their cytokines, but the mechanism that initiates the Th2 immunity is not fully understood. Recent studies show that basophils play important roles in initiating Th2 immunity in some inflammatory models. Here we explored the ro...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1111/imm.12240
更新日期：2014-06-01 00:00:00
abstract：:The role of anti-idiotypic subclass-specific antibodies was analysed in the regulation of the immune response to BCG in the guinea-pig. The idiotypes to BCG were separated into subclasses and anti-idiotypes were carried out by immunizing with the purified IgG1 and IgG2 anti-idiotypes. The in vivo T cell response was r...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1984-08-01 00:00:00
abstract：:Degradation of the extracellular matrix plays an important role in rheumatoid articular destruction. Rheumatoid synovial fibroblasts secrete a large amount of matrix-degrading metalloproteinases (MMPs), which initiate tissue damage by proteolytic degradation of collagens and proteoglycans. Cytokines, such as interleuk...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1046/j.1365-2567.1996.d01-789.x
更新日期：1996-12-01 00:00:00
abstract：:Soluble low-affinity receptors for IgG are known to inhibit immune complex (IC)-mediated inflammation, and expression by leukocytes is elevated in several inflammatory diseases. Immunoglobulin M (IgM) rheumatoid factors (RF), anti-Fc autoantibodies, are found in autoimmune diseases, such as rheumatoid arthritis (RA), ...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1046/j.1365-2567.2003.01652.x
更新日期：2003-06-01 00:00:00
abstract：:Porcine alveolar macrophages (AM) metabolize leukotriene D4 (LTD4) to leukotriene E4 (LTE4). In the present study, the ability of a fluid-phase AM stimulus (A23187) and a phagocytic stimulus (opsonized zymosan) to augment LTD4 metabolism was examined. Both stimuli increased the release of superoxide (O-2) anions. Howe...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1985-09-01 00:00:00
abstract：:To assess the role of the macrophage scavenger receptor type A (SRA) in immune activation by CpG DNA, cytokine induction and DNA uptake were tested in vitro and in vivo using SRA knockout (SRA-/-) and wild type (WT) mice. As a source of CpG DNA, Escherichia coli DNA (EC DNA) and a 20-mer phosphorothioate oligodeoxynuc...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1046/j.1365-2567.2001.01222.x
更新日期：2001-06-01 00:00:00
abstract：:BALB/c mice injected with lyophilized vaccine from Streptococcus pneumoniae R36a (Pn) predominantly responded with antibody molecules the vast majority of which expressed the public idiotype T15 and were directed to the immunodominant epitope phosphorylcholine (PC). However, after a single immunization with Pn vaccine...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1046/j.1365-2567.1996.d01-724.x
更新日期：1996-10-01 00:00:00
abstract：:We report that interleukin (IL)-4 and IL-10 can significantly up- or down-regulate CXC chemokine receptor 4 (CXCR4) expression on CD4+ T lymphocytes, respectively. Stromal cell-derived factor-1alpha (SDF-1alpha)-induced CD4+ T-lymphocyte chemotaxis was also correspondingly regulated by IL-4 and IL-10. IL-4 and IL-10 u...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1046/j.1365-2567.2000.00954.x
更新日期：2000-03-01 00:00:00
abstract：:Infection of susceptible mice with murine cytomegalovirus (MCMV) induces persistent inflammation, and the production of autoantibodies reactive with large numbers of proteins from all major organs. However the roles of polyclonal B-cell activation, autoreactive T-helper cells and host-virus cross-reactions in these ph...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1993-01-01 00:00:00
abstract：:Enriched CD4+CD8-/CD4-CD8-, CD4-CD8+/CD4-CD8- and CD4-CD8- cell suspensions were prepared from normal peripheral blood by selective immunomagnetic depletion of monoclonal antibody-defined lymphocyte populations. Subsequent examination of these modified cell fractions by two-colour flow cytometry provided a means of de...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1990-07-01 00:00:00
abstract：:Prior study has revealed that the expression of certain major histocompatibility complex (MHC) class I molecules on the membranes of normal or transformed cells can prevent natural killer (NK)-cell-mediated killing. This has been explained by either (1) the target interference model, or (2) the effector inhibition mod...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1994-09-01 00:00:00
abstract：:Virus-specific cytotoxic T-cell (Tc) clones can lyse target cells in vitro in the presence of their specific peptide epitopes. The lytic potency of murine influenza nucleoprotein (NP)-specific Tc clones was investigated after observing that target cell killing was reduced in the presence of high (greater than 0.2 micr...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1990-06-01 00:00:00
abstract：:Human autologous-rosette-forming T cells (Tar cells) have many of the characteristics of post-thymic precursor cells. Thus, they bind to sheep erythrocytes but have neither receptors for the Fc portion of IgG nor for that of IgM. They include a subpopulation that binds peanut agglutinin which suggests that they are im...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1981-01-01 00:00:00
abstract：:Both lipopolysaccharide (LPS) and phorbol 12-myristate 13-acetate (PMA) impeded monocyte to macrophage differentiation with respect to typical phenotypic modulation and certain phagocyte-related processes. The down-regulation of the porcine monocyte marker SWC1, and up-regulation of the SWC9 macrophage marker were ret...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1046/j.1365-2567.2001.01266.x
更新日期：2001-08-01 00:00:00
abstract：:When cultured on a collagen matrix at a density of 7 X 10(4) cells/cm2 for 48 hr, 80 +/- 10% of unfractionated and 70 +/- 14% of T-enriched human blood lymphocytes from eight healthy individuals developed a motile morphology defined as the presence of lamellar surface activity and cytoplasmic flattening. During cultur...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1986-07-01 00:00:00
abstract：:2B4 (CD244) is a member of the CD2 subset of the immunoglobulin superfamily and functions as a triggering molecule on natural killer (NK) cells. Previously, we have found that 2B4-mediated activation of NK cells involves complex interactions involving LAT, Ras, Raf, ERK and p38 and that cytolytic function and cytokine...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1046/j.1365-2567.2003.01662.x
更新日期：2003-07-01 00:00:00
abstract：:6-Sulpho LacNAc dendritic cells (slanDC) are a major population of human blood DC that are highly pro-inflammatory, as characterized by their outstanding capacity to produce tumour necrosis factor-α and interleukin-12 (IL-12) and to prime antigen-specific T-cell responses. SlanDC were found to be present in inflamed t...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1111/j.1365-2567.2010.03336.x
更新日期：2011-01-01 00:00:00
abstract：:The localization of Thy-1, MRC OX 2 and Ia antigens as defined by monoclonal antibodies MRC OX 7, MRC OX 2 and MRC OX 6 was determined by an indirect immunoperoxidase technique on cryostat sections of rat ovaries. Thy-1 antigen was present significantly in the theca interna of growing antral follicles. Developing corp...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1983-03-01 00:00:00
abstract：:In this study we aimed to elucidate the physiological role of gammadelta intraepithelial lymphocytes (IEL) in the mouse intestine. For this purpose, we used T-cell receptor (TCR) Vgamma4/Vdelta5 transgenic mice (KN 6 Tg: BALB/c background, H-2d), and compared the immunological and physiological characteristics of the ...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1046/j.1365-2567.1999.00735.x
更新日期：1999-05-01 00:00:00
abstract：:Experimental protocols have been devised to deliniate the importance of T-cell subsets in immunity to Moloney sarcoma virus-induced tumours using the surface antigens L3T4 and Lyt-2 as markers of helper and cytotoxic cells, respectively. Because the monoclonal antibodies used have been shown to deplete T-cell subsets ...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1987-07-01 00:00:00
abstract：:Some plasmacytomas produce myeloma proteins with known antibody specificities and the secretion of these proteins by individual tumour cells can be determined using haemolytic plaque assay. After a 3 day culture of mouse plasmacytoma cells in medium containing 10% normal mouse serum, the number of plaques was reduced ...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1980-10-01 00:00:00
abstract：:Basophils are implicated in the pathogenesis of the late-phase allergic reaction, but the mechanisms by which circulating basophils adhere to vascular endothelium and migrate to lesional sites remain unclear. In order to assess the biological similarity of the basophilic cell line KU-812 to normal human basophils, we ...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1994-07-01 00:00:00
abstract：:Mitogen-activated protein/ERK kinase kinase 3 (MEKK3) is a Ser/Thr protein kinase belonging to the MEKK/STE11 subgroup of the MAP3K family. Recently, we found that MEKK3 plays a critical role in interleukin-1 (IL-1) receptor and Toll-like receptor 4 signalling using established primary mouse embryonic fibroblast (MEF)...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1111/j.1365-2567.2006.02495.x
更新日期：2007-02-01 00:00:00
abstract：:Bovine respiratory syncytial virus (RSV) is a major cause of respiratory disease in young calves. Recent studies in calves, in which different T-cell subsets were depleted, have shown that CD8+ T cells play a central role in recovery from RSV infection. The present study demonstrates that RSV-specific, major histocomp...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1046/j.1365-2567.1996.d01-667.x
更新日期：1996-07-01 00:00:00
