Immunogenicity of lipid-conjugated antigens. I. The influence of chain length and degree of conjugation on induction of antibody in mice.

abstract：:The non-obese diabetic (NOD) mouse is a model for the study of insulin-dependent diabetes mellitus (IDDM). Recently transgenic NOD mice have been derived (NOD-E) that express the major histocompatibility complex (MHC) class II I-E molecule. NOD-E do not become diabetic and show negligible pancreatic insulitis. The pos...

journal_title：Immunology

authors： Parish NM,Acha-Orbea H,Simpson E,Qin SX,Lund T,Cooke A

更新日期：1993-04-01 00:00:00

abstract：:We performed a genomic study combining single-cell mRNA differential display and RNA subtractive hybridization to elucidate CD8 T-cell quiescence/ignorance. By comparing actively maintained quiescent CD8 T cells from liver tumour tumour-infiltrating lymphocytes (TILs) with quiescent T cells at the single-cell level, w...

journal_title：Immunology

authors： Zhang W,Ding J,Qu Y,Hu H,Lin M,Datta A,Larson A,Liu GE,Li B

更新日期：2009-05-01 00:00:00

abstract：:Basophils are implicated in the pathogenesis of the late-phase allergic reaction, but the mechanisms by which circulating basophils adhere to vascular endothelium and migrate to lesional sites remain unclear. In order to assess the biological similarity of the basophilic cell line KU-812 to normal human basophils, we ...

journal_title：Immunology

authors： Bacon KB,Flores-Romo L,Aubry JP,Wells TN,Power CA

更新日期：1994-07-01 00:00:00

abstract：:Rabbit IgG and its Fab, Fc and pFc' fragments, prepared by papain or peptic digestion, were assayed for binding to homologous peritoneal macrophages. The binding affinity of IgG for the peritoneal macrophages (Ka = 5.9 +/- 1.6 x 10(5) L/M) was comparable to that recorded with alveolar macrophages (7.6 +/- 1.8 x 10(5) ...

journal_title：Immunology

authors： Ganczakowski M,Leslie RG

更新日期：1979-03-01 00:00:00

abstract：:We aimed to establish a panel of MHC-peptide multimers suitable as a positive control in the detection of HLA A*0201 restricted antigen specific T cells (ASTC) by flow cytometry. MHC Dextramers were loaded with HLA A*0201 binding peptides from viral antigens and melanoma targets identified from a literature search and...

journal_title：Immunology

authors： Fløe A,Løppke C,Hilberg O,Wejse C,Brix L,Jacobsen K

更新日期：2017-10-01 00:00:00

abstract：:Homogenates from human lung contained a preformed slow reacting substance (pSRS). The pattern of contraction on the guinea-pig ileum by pSRS was indistinguishable from that of SRS-A. The activity of pSRS could not be attributed to the presence of K+, Na+, Ca2+ and Mg2+ ions, or any prostaglandin including PGF2 or its ...

journal_title：Immunology

authors： Turnbull LS,Jones DG,Kay AB

更新日期：1976-11-01 00:00:00

abstract：:Mice injected with rat erythrocytes developed anti-erythrocyte autoantibodies which reached a plateau at 4-12 weeks, then gradually declined until at about 24 weeks the majority of mice were negative. In such recovered mice re-challenge with rat erythrocytes produced an accelerated peak of autoantibody and a much more...

journal_title：Immunology

authors： Naysmith JD,Elson CJ,Dallman M,Fletcher E,Ortega-Pierres MG

更新日期：1980-04-01 00:00:00

abstract：:The linker protein LAT is expressed mainly in T and natural killer (NK) cells. LAT-deficient mice have an arrest of intrathymic T-cell development at the CD4+ CD8+ stage and lack mature T cells in the periphery. However, no gross abnormality in development and function of the B and NK cells has been described. Here we...

journal_title：Immunology

authors： Oya K,Wang J,Watanabe Y,Koga R,Watanabe T

更新日期：2003-07-01 00:00:00

abstract：:It has been reported that, in early pregnancy in mice, there is an increase in the number of immunoglobulin-secreting cells in the lymph nodes which drain the uterus. This paper describes the results of further investigations provoked by interest in these early changes. Increases in the numbers of immunoglobulin-secre...

journal_title：Immunology

authors： Hancock RJ,Popham AM,Faruki S,Dresser DW

更新日期：1985-06-01 00:00:00

abstract：:We studied proliferative responses of bovine T lymphocytes to foot-and-mouth disease virus (FMDV) serotypes A, O and C as well as to three peptides including the two major B-cell epitopes of FMDV (VP1[141-156] and VP1[200-213]). Peripheral blood mononuclear cells (PBMC) from cattle previously vaccinated with monovalen...

journal_title：Immunology

authors： van Lierop MJ,van Maanen K,Meloen RH,Rutten VP,de Jong MA,Hensen EJ

更新日期：1992-03-01 00:00:00

abstract：:Lymph nodes (LN) are secondary lymphoid organs spread throughout the lymphatic system. They function to filter pathogenic material from the lymphatic fluid to maintain the health of the organism. Subcapsular sinus macrophages (SCSM) are among the first-responders within the LN due to their strategic location within th...

journal_title：Immunology

authors： Turner VM,Mabbott NA

更新日期：2017-06-01 00:00:00

abstract：:Primary contact sensitivity (CS) to Ox and non-specific unresponsiveness to other unrelated delayed-type hypersensitivity (DTH) containing CS were induced simultaneously by i.v. administration of oxazolone(Ox)-conjugated spleen cells. The subpopulation of spleen cells which serves as carriers for the induction of prim...

journal_title：Immunology

authors： Nakano Y,Nakano K

更新日期：1985-02-01 00:00:00

abstract：:Antibody plaque-forming cells (FC) to the somatic antigens of Vibrio cholerae were enumerated in the spleen of mice after primary and secondary immunization with a heat-killed vaccine prepared from the vibrios. Immunocytes releasing both high efficiency IgM and low efficiency IgG antibody were readily detected using a...

journal_title：Immunology

authors： Friedman H

更新日期：1975-08-01 00:00:00

abstract：:Interleukin 27 (IL-27) has been identified as a potent cytokine in the differentiation of type 1 regulatory T (Tr1) cells through interactions with several key elements, including transcription factors such as aryl hydrocarbon receptor and IL-21. Autocrine production of IL-21 is known to be important for maintaining I...

journal_title：Immunology

authors： Nadya NA,Tezuka H,Ohteki T,Matsuda S,Azuma M,Nagai S

更新日期：2017-11-01 00:00:00

abstract：:The locomotor capacity of human lymphocytes is cell cycle-related. Many small blood lymphocytes are non-motile but acquire locomotor capacity in G1 on appropriate activation with e.g. anti-CD3 antibody (aCD3) for T cells, or interleukin-4 (IL-4) for B cells. Once this capacity is acquired, the cells can then respond b...

journal_title：Immunology

authors： Wilkinson PC,Watson EA

更新日期：1990-11-01 00:00:00

abstract：:Human plasma kallikrein can replace factor D for the activation of the alternative pathway C3 convertase of human complement. The factor B cleavage patterns by factor D and kallikrein are indistinguishable. The ability of kallikrein to cleave factor B is influenced by the magnesium ion concentration and the C3b concen...

journal_title：Immunology

authors： DiScipio RG

更新日期：1982-03-01 00:00:00

abstract：:To evaluate the T-cell large-scale differential gene expression in systemic lupus erythematosus (SLE) patients presenting with glomerulonephritis we studied SLE patients before and after immunosuppressive treatment. Large-scale gene expression of peripheral blood mononuclear T cells was evaluated using cDNA microarray...

journal_title：Immunology

authors： Pereira E,Tamia-Ferreira MC,Cardoso RS,Mello SS,Sakamoto-Hojo ET,Passos GA,Donadi EA

更新日期：2004-09-01 00:00:00

abstract：:Loss of ζ-associated protein 70 (Zap70) results in severe immunodeficiency in humans and mice because of the critical role of Zap70 in T-cell receptor (TCR) signalling. Here we describe a novel mouse strain generated by N-ethyl-N-nitrosourea mutagenesis, with the reduced protein stability (rps) mutation in Zap70. The ...

journal_title：Immunology

authors： Cauwe B,Tian L,Franckaert D,Pierson W,Staats KA,Schlenner SM,Liston A

更新日期：2014-03-01 00:00:00

abstract：:The present study aimed to determine whether the frequency of double positive (DP) thymocytes expressing alphabeta T-cell receptor (TCR) clonotypes at the time of selection regulates peripheral CD4 T-cell compartment size. Scid recipients were inoculated with various ratios of TCR Calpha(0/0) and wild-type bone marrow...

journal_title：Immunology

authors： Reed AJ,Zarrabi Y,Perate AL,Jeganathan A,Naji A,Noorchashm H

更新日期：2005-11-01 00:00:00

abstract：:Among peripheral T cells, the expression of CD4 and CD8 is almost mutually exclusive. However, here we show, using flow cytometric analysis, that ex vivo approximately 6% of rat T cells stained for both CD4 and CD8. These double positive cells were also detected by confocal microscopy. Only around 50% of double positi...

journal_title：Immunology

authors： Kenny E,Mason D,Pombo A,Ramírez F

更新日期：2000-10-01 00:00:00

abstract：:Epidermal keratinocytes are induced to express MHC class II molecules in a variety of disease states associated with immune activity. To investigate the mechanism of this process we have exposed murine and rat keratinocytes to a variety of lymphokines and monitored changes in their MHC molecule expression. Murine cult...

journal_title：Immunology

authors： Yeoman H,Anderton JG,Stanley MA

更新日期：1989-01-01 00:00:00

abstract：:Recent studies involving T cells that express gamma delta T-cell receptor (gamma delta TcR) have raised the possibility that Qa-1/Tla region class I major histocompatibility complex (MHC)-like molecules are antigen-presenting molecules for gamma delta TcR. In this report, cytotoxic T lymphocyte (CTL) clones specific f...

journal_title：Immunology

authors： Germana S,Shinohara N

更新日期：1991-12-01 00:00:00

abstract：:Cancer immune surveillance is considered to be an important host protection process to inhibit carcinogenesis and to maintain cellular homeostasis. In the interaction of host and tumour cells, three essential phases have been proposed: elimination, equilibrium and escape, which are designated the 'three E's'. Several ...

journal_title：Immunology

authors： Kim R,Emi M,Tanabe K

更新日期：2007-05-01 00:00:00

abstract：:BLT mice, constructed by surgical implantation of human fetal thymus-liver tissues and intravenous delivery of autologous CD34+ haematopoietic stem cells into adult non-obese diabetic/severe combined immunodeficiency mice, were evaluated for vaccine-induced humoral immune responses. Following engraftment, these mice d...

journal_title：Immunology

authors： Biswas S,Chang H,Sarkis PT,Fikrig E,Zhu Q,Marasco WA

更新日期：2011-12-01 00:00:00

abstract：:The uptake by human blood monocytes of sheep erythrocytes treated with rabbit anti-sheep antibody with or without mouse complement was assessed by a radioactive method to discover whether immune complexes would inhibit this reaction. It was found that sera from SLE patients inhibited uptake whereas normal sera enhance...

journal_title：Immunology

authors： Temple A,Loewi G

更新日期：1977-07-01 00:00:00

abstract：:Canine cutaneous histiocytoma is a benign epidermal neoplasm of Langerhans cell origin, which usually displays spontaneous regression. Based on the degree of lymphocytic infiltration, 30 histiocytomas were classified into four groups representing different stages of tumour regression. To elucidate further the mechanis...

journal_title：Immunology

authors： Kaim U,Moritz A,Failing K,Baumgärtner W

更新日期：2006-08-01 00:00:00

abstract：:The functional avidity of a cytotoxic T lymphocyte (CTL) is known to be a critical determinant of the efficacy with which it clears pathogens. High avidity cells, which are by definition highly sensitive to peptide antigen, are superior for elimination of viruses and tumours. Our studies have established the ability o...

journal_title：Immunology

authors： Sharma SK,Alexander-Miller MA

更新日期：2011-07-01 00:00:00

abstract：:Immunoglobulin E is quantitatively a minor immunoglobulin class in serum, but nevertheless the major class of antibody mediating type I hypersensitivity reactions and hence, type I allergic phenomena. The bovine epsilon gene is one of the as yet uncharacterized mammalian immunoglobulin genes. We have therefore cloned ...

journal_title：Immunology

authors： Mousavi M,Rabbani H,Hammarström L

更新日期：1997-11-01 00:00:00

abstract：:In our efforts to identify products that might be used for active immunotherapy in human immunodeficiency virus (HIV) infection, we have studied synthetic peptides derived from the CD4 attachment site of gp120. Two peptides have emerged with particularly interesting properties. The first (B138) is linear and spans the...

journal_title：Immunology

authors： Morrow WJ,Williams WM,Whalley AS,Ryskamp T,Newman R,Kang CY,Chamat S,Köhler H,Kieber-Emmons T

更新日期：1992-04-01 00:00:00

abstract：:Forssman antiserum produced in rabbits immunized with sheep erythrocyte stromata was found to contain an IgG antibody which inhibited both passive anaphylactic sensitization of guinea-pig lung and also histamine-releasing activity of soluble immune complexes. This Forssman antibody did not itself cause histamine rele...

journal_title：Immunology

authors： Duravetz J,Baumal R,Broder I

更新日期：1976-01-01 00:00:00