Abstract：
:Immunoglobulin E is quantitatively a minor immunoglobulin class in serum, but nevertheless the major class of antibody mediating type I hypersensitivity reactions and hence, type I allergic phenomena. The bovine epsilon gene is one of the as yet uncharacterized mammalian immunoglobulin genes. We have therefore cloned and determined the cDNA sequence and genomic organization of the gene. It contains four constant region domain-encoding exons (CH1 to CH4) with a high homology to sheep C epsilon (87%) and to a lower degree to dog (62%), horse (58%), chimpanzee, orangutan, human (55%), mouse (52%) and rat (52%) C epsilon genes. Southern blot analysis of bovine genomic DNA, revealed the existence of a single C epsilon gene with a presence of allelic restriction fragment length polymorphism (RFLP).
journal_name
Immunologyjournal_title
Immunologyauthors
Mousavi M,Rabbani H,Hammarström Ldoi
10.1046/j.1365-2567.1997.00352.xsubject
Has Abstractpub_date
1997-11-01 00:00:00pages
369-73issue
3eissn
0019-2805issn
1365-2567journal_volume
92pub_type
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