Abstract：
:Random-bred TO mice have been selectively bred into two lines on the basis of the relative affinity (KR) of antibody produced to protein antigens, one line producing high and the other low KR antibody. After four generations of selective breeding the difference in KR between the two lines was highly significant (P less than 0-001). The selection on the basis of KR did not result in a corresponding selection for antibody levels (Abt), which were not significantly different in the two lines. These results indicate that antibody affinity is a genetically controlled parameter of the immune response. Furthermore, this control appears to be expressed by a mechanism which is independent of the amount of antibody produced.
journal_name
Immunologyjournal_title
Immunologyauthors
Katz FE,Steward MWkeywords:
subject
Has Abstractpub_date
1975-09-01 00:00:00pages
543-8issue
3eissn
0019-2805issn
1365-2567journal_volume
29pub_type
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