Abstract：
:Lymph nodes (LN) are secondary lymphoid organs spread throughout the lymphatic system. They function to filter pathogenic material from the lymphatic fluid to maintain the health of the organism. Subcapsular sinus macrophages (SCSM) are among the first-responders within the LN due to their strategic location within the subcapsular sinus region. These macrophages aid the delivery of immune complexes to B cells and follicular dendritic cells (FDC) within the LN. Here we show an increase in SCSM and other macrophage populations within aged LN. However, immune complex uptake by macrophages within LN was not altered with age, nor was immune complex uptake by B cells. LN stromal cell populations, important in immune responses and the localization and survival of leucocytes, were altered in their representation and distribution in aged LN. In particular, FDC regions were decreased in size and had decreased chemokine CXCL13 expression. Furthermore, the retention of immune complexes by FDC was decreased in aged LN at 24 hr post-injection. As FDC are important in the maintenance of germinal centre responses, the decreased retention of immune complex in aged LN may contribute to the reduced germinal centre responses observed in aged mice.
journal_name
Immunologyjournal_title
Immunologyauthors
Turner VM,Mabbott NAdoi
10.1111/imm.12727subject
Has Abstractpub_date
2017-06-01 00:00:00pages
239-247issue
2eissn
0019-2805issn
1365-2567journal_volume
151pub_type
杂志文章相关文献
IMMUNOLOGY文献大全abstract：:Compared with adults, the circulating Vγ2Vδ2 T-cell population in cord blood is present at low levels and does not show the strong bias for Vγ2-Jγ1.2 rearrangements. These features may be a result of limited exposure to stimulatory phosphoantigens, lack of T-cell-derived interleukin-2 (IL-2) or both. In cord blood mon...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1111/imm.12039
更新日期：2013-04-01 00:00:00
abstract：:Veiled cells (VC), isolated from the thoracic duct of irradiated lymphadenectomized mice (MLNX) or peritoneal macrophages (PM phi were incubated with isotope-labelled hen egg lysozyme (HEL), purified protein derivative (PPD) or keyhole limpet haemocyanin (KLH) in vitro. About 2-10 times less antigen was associated wit...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1989-11-01 00:00:00
abstract：:Extracorporeal photochemotherapy (ECP) has been shown to be a potent activator of peripheral blood macrophages because it causes a marked release of macrophage-dependent proinflammatory cytokines, and it is therefore currently considered to be a safe and non-toxic immunomodulatory treatment. On this basis we studied t...
journal_title：Immunology
pub_type： 临床试验,杂志文章
doi：10.1046/j.1365-2567.1997.00325.x
更新日期：1997-09-01 00:00:00
abstract：:The guinea-pig (gp) CD4 protein was identified using the rat monoclonal antibody (mAb) H155 derived from an interspecies hybrid. The hybrid was obtained after immunization of rats with purified guinea-pig T lymphocytes and fusion to a mouse myeloma line. The mAb H155 reacted with a subpopulation (60-70%) of nylon-wool...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1991-02-01 00:00:00
abstract：:Doxorubicin-stimulated whole rat glomeruli and dissociated mesangial and resident glomerular macrophage cells produced the release of interleukin (IL)-1 beta cytokine. This activity increased after the addition of lipopolysaccharide (LPS) or LPS plus indomethacin to the cultures. In the presence of WEB2086 [platelet-a...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1994-01-01 00:00:00
abstract：:Cells subjected to nucleoside incorporation studies using radiolabelled materials may suffer radiation damage that can alter the results. We did scintimetric and cytofluorographic analysis to confirm this and to determine the optimal experimental doses of, and exposure times to, [3H]-TdR, in order to prevent or minimi...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1981-12-01 00:00:00
abstract：:Infection of susceptible mice with murine cytomegalovirus (MCMV) induces persistent inflammation, and the production of autoantibodies reactive with large numbers of proteins from all major organs. However the roles of polyclonal B-cell activation, autoreactive T-helper cells and host-virus cross-reactions in these ph...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1993-01-01 00:00:00
abstract：:Three-week-old chickens were given sheep erythrocytes or bovine serum albumin intravenously. Seven days later their tears and saliva possessed low levels of antibody to those antigens. Concurrent infection with lentogenic Newcastle disease virus (NDV) caused a significant increase in transuded antibody in those fluids...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1976-07-01 00:00:00
abstract：:Rabbit spleen and mesenteric lymph node cells were treated with a monoclonal anti-rabbit T-lymphocyte antibody (MAb) and complement and the effect of the treatment on various lymphocyte functions was determined. Lysis of spleen and mesenteric lymph node cells reactive with this MAb, 9AE10, essentially eliminated their...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1981-08-01 00:00:00
abstract：:The secondary humoral response evoked in W/Fu rats by the weakly immunogenic soluble Gross cell surface antigen (GCSAa) extracted from the syngeneic (C58NT)D lymphoma can be enhanced when GCSAa is presented in liposomes, and this requires the antigen to be strongly associated with the phospholipid bilayers. In order t...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1986-07-01 00:00:00
abstract：:We have previously demonstrated that immunoglobulin A (IgA)(-/-) knockout (KO) mice exhibit levels of susceptibility to influenza virus infection that are similar to those of their normal IgA(+/+) littermates. To understand the mechanism of this apparent mucosal immunity without IgA, immunoglobulin isotype and T helpe...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1046/j.0019-2805.2001.01368.x
更新日期：2002-03-01 00:00:00
abstract：:T helper type 17 (Th17) cells and regulatory T (Treg) cells are two distinct T-cell subsets with opposite effects on immune functions. While Th17 cells are a key effector in the immune response and play critical roles in the development of autoimmunity and inflammation, Treg cells orchestrate the overall immune respon...
journal_title：Immunology
pub_type： 杂志文章,评审
doi：10.1111/imm.12994
更新日期：2018-12-01 00:00:00
abstract：:We have developed a thyroglobulin-specific haemolytic plaque assay and investigated potential sites of autoantibody synthesis in good and poor responder strains of rats immunized with thyroglobulin and in rats subjected to thymectomy and sub-lethal irradiation which subsequently develop thyroiditis spontaneously. The ...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1982-06-01 00:00:00
abstract：:The relationship between allograft rejection and the response in the one-way mixed leucocyte reaction (MLR) of the WBC of allograft recipients was investigated. The responses of the WBC were assessed prior to skin allografting and subsequent to rejection of the allograft. The optimal MLR response of the WBC from the a...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1979-01-01 00:00:00
abstract：:The contribution of gut-associated lymphoid tissue (GALT) to the local immune response in the respiratory mucosa of sheep has been investigated. Sheep were primed intraperitoneally (i.p.) with antigen in Freund's complete adjuvant, a procedure known to produce a large IgA-specific antibody-containing cell (ACC) respon...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1984-10-01 00:00:00
abstract：:In mice, the plasma cell (PC) niche in the bone marrow is close to the haematopoietic stem cell (HSC) niche. We investigated whether PCs can be mobilized into the peripheral blood (PB) in healthy donors receiving granulocyte colony-stimulating factor (G-CSF) for the induction of HSC mobilization into the PB. G-CSF inc...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1111/j.1365-2567.2010.03361.x
更新日期：2011-02-01 00:00:00
abstract：:The sensitivity of host (circulating) forms of T. cruzi to cell-mediated immunological destruction and requirements for the reaction were examined. Both human and mouse leucocytes were found to kill significant numbers of parasites in the presence of specific antibodies against the flagellates. Antibody involvement wa...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1980-05-01 00:00:00
abstract：:Trypanosoma cruzi, the causative agent of Chagas' disease, suppresses immune responses during the acute phase and has been shown to induce multiple cellular alterations in activated human T lymphocytes. However, no information is available regarding the effects of this parasite on human B cells. Using an in vitro cult...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1991-10-01 00:00:00
abstract：:Systemic lupus erythematosus (SLE) is an autoimmune disease that can attack many different body organs; the triggering event is unknown. SLE has been associated with more than 100 different autoantibody reactivities - anti-dsDNA is prominent. Nevertheless, autoantibodies to dsDNA occur in only two-thirds of SLE patien...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1111/imm.12200
更新日期：2014-02-01 00:00:00
abstract：:In lipopolysaccharide (LPS)-hyporesponsive C3H/HeJ mice, alveolar macrophages (AMphi) produce much more tumour necrosis factor-alpha than peritoneal macrophages (PMphi) when stimulated with LPS (10 microgram/ml), but the induction of inducible nitric oxide synthase (iNOS) gene expression and production of nitric oxide...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1046/j.1365-2567.1999.00908.x
更新日期：1999-12-01 00:00:00
abstract：:The influence of intact influenza virus and purified detergent solubilized haemagglutinin (HA) subunits from these viruses on human natural killer (NK) cell activity was examined. Effector cells incubated with whole influenza virus for 18 hr initiated the production of alpha interferon which was associated with the en...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1984-08-01 00:00:00
abstract：:Osteopontin (OPN) is a secreted phosphoprotein found in body fluids (e.g. plasma, urine, milk) and in mineralized tissues. Its expression is increased in many transformed cells and in normal cells exposed to various cytokines. When stimulated with the inflammatory mediators lipopolysaccharide and interferon-gamma, mou...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1046/j.1365-2567.1996.d01-691.x
更新日期：1996-08-01 00:00:00
abstract：:Oral administration of antigen induces a state of tolerance that is associated with activation of CD8+ T cells that can transfer unresponsiveness to naïve syngeneic hosts. These T cells are not lytic, but they inhibit development of antibody, CD4+ T helper cell, and CD8+ cytotoxic T lymphocyte (CTL) responses upon ado...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1111/j.0019-2805.2003.01793.x
更新日期：2004-02-01 00:00:00
abstract：:The discovery of host-encoded gene products that sense molecular patterns in infectious microbes, and the demonstration of their role in triggering innate and adaptive immune responses, has been a key milestone in our understanding of immunology. Twenty-three years after Janeway first outlined the fundamental concepts...
journal_title：Immunology
pub_type： 杂志文章,评审
doi：10.1111/j.1365-2567.2012.03587.x
更新日期：2012-08-01 00:00:00
abstract：:Young (15-week-old) CBA/Ca mice were injected intravenously with spleen cells from individual young (15-week-old) or old (18-24-month-old) CBA/T6T6 mice. Samples of peripheral blood were taken at monthly intervals and cultured with phytohaemagglutinin (PHA) to stimulate T lymphocytes into mitosis. In the recipients of...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1984-12-01 00:00:00
abstract：:Histamine not only mediates immediate allergic reactions, it also regulates cellular immune responses. H4R is the most recently identified histamine receptor (HR). In the present study, we examined the in vitro effect of histamine and H4R agonists on the responses of human T cells to purified protein derivative from M...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1111/j.1365-2567.2007.02574.x
更新日期：2007-06-01 00:00:00
abstract：:The vitamin D receptor (VDR) is a nuclear receptor expressed in a number of different cells of the immune system. This study was performed to determine the effect of VDR deficiency on immune function and inflammation of the gastrointestinal tract in a model of inflammatory bowel disease, namely interleukin-10 (IL-10) ...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1111/j.1365-2567.2005.02290.x
更新日期：2006-03-01 00:00:00
abstract：:In order to identify and characterize the sheep major histocompatibility complex (MHC) class II molecules, a panel of 19 monoclonal antibodies (mAb) has been raised following immunization of mice with a variety of class II antigen preparations. Antibodies were selected by ELISA using immunopurified sheep class II as a...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1990-05-01 00:00:00
abstract：:Infection of nude mice with Mesocestoides corti results in spleen enlargement, with a decrease in percentage positive, but overall increase in Thy-1 positive cells. A low frequency of both parasite antigen-specific and alloantigen-reactive T-cell clones were isolated from the spleen, mesenteric lymph nodes, peritoneal...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1985-02-01 00:00:00
abstract：:Therapeutic vaccination using T-cell receptor (TCR) peptides from V genes commonly expressed by potentially pathogenic T cells remains an approach of interest for treatment of multiple sclerosis (MS) and other autoimmune diseases. We developed a trivalent TCR vaccine containing complementarity determining region (CDR)...
journal_title：Immunology
pub_type： 临床试验,杂志文章
doi：10.1111/j.1365-2567.2007.02703.x
更新日期：2008-01-01 00:00:00
