Abstract：
:Extracorporeal photochemotherapy (ECP) has been shown to be a potent activator of peripheral blood macrophages because it causes a marked release of macrophage-dependent proinflammatory cytokines, and it is therefore currently considered to be a safe and non-toxic immunomodulatory treatment. On this basis we studied the function of peripheral blood mononuclear cells (PBMC) in eight patients with early stage (Ib) cutaneous T-cell lymphoma (CTCL), before and 1 year after ECP, together with their clinical and histological responses. In particular we evaluated in vitro phytohaemagglutinin (PHA)-stimulated proliferation and production of interleukin-4 (IL-4) and interferon-gamma (IFN-gamma) as well as lipopolysaccharide (LPS)-induced production of IL-12. Before treatment we observed that PBMC of patients produced significantly higher levels of IL-4 and lower levels of IFN-gamma and IL-12 than those of healthy control subjects. After 1 year of ECP, IL-4, IFN-gamma and IL-12 production no longer differed from that of control subjects. Moreover, we observed a good clinical result matched by histological response. Our data confirm that early-stage CTCL patients show a predominantly type-2 immune response that might be responsible for several immunological abnormalities found in this disease. We have demonstrated that ECP reverses the T-helper type 1/T-helper type 2 (Th1/Th2) imbalance and may therefore be considered an efficient biological response modifier.
journal_name
Immunologyjournal_title
Immunologyauthors
Di Renzo M,Rubegni P,De Aloe G,Paulesu L,Pasqui AL,Andreassi L,Auteri A,Fimiani Mdoi
10.1046/j.1365-2567.1997.00325.xsubject
Has Abstractpub_date
1997-09-01 00:00:00pages
99-103issue
1eissn
0019-2805issn
1365-2567journal_volume
92pub_type
临床试验,杂志文章相关文献
IMMUNOLOGY文献大全abstract：:Virus plaque assay (VPA) was utilized for the quantitative evaluation of activated lymphocytes. We examined what types of cells, especially which of activated T and non-T lymphocytes, were detected as infective centres after infection with vesicular stomatitis virus. Marked increases in DNA synthesis and in virus-plaq...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1977-06-01 00:00:00
abstract：:Acquisition of T-cell central tolerance involves distinct pathways of self-antigen presentation to thymocytes. One pathway termed indirect presentation requires a self-antigen transfer step from thymic epithelial cells (TECs) to bone marrow-derived cells before the self-antigen is presented to thymocytes. The role of ...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1111/imm.12904
更新日期：2018-07-01 00:00:00
abstract：:B-lymphocyte maturation is considered to be independent of the thymus. However, there is circumstantial evidence suggesting that it may be impaired in nude animals that lack the thymus. Our study shows that the proportion of immature B-lymphocyte subsets (CD90(high) IgM(high) and CD90(high) IgM(low)) was significantly...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1111/j.1365-2567.2005.02226.x
更新日期：2005-11-01 00:00:00
abstract：:Despite extensive investigation of the signals required for development of T helper type 1 (Th1) and type 2 (Th2) immune responses, the mechanisms involved are still not well-defined. A critical role for Epstein-Barr virus-induced gene 3 (EBI3) in these responses has been proposed. EBI3, initially discovered as a tran...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1111/j.1365-2567.2010.03401.x
更新日期：2011-04-01 00:00:00
abstract：:Mice sensitized with optimal doses of 2,4-dinitrofluorobenzene (DNFB) develop maximum delayed hypersensitivity in 4-5 days; the intensity of this reaction declines rapidly 14 days after sensitization. In the serum of mice 14 days after sensitization, an anti-receptor antibody has been described. It has been suggested ...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1985-06-01 00:00:00
abstract：:Thioglycollate-stimulated, adherence and density gradient-enriched peritoneal exudate cells were used for the preparation of a specific, highly active antimacrophage reagent. After absorption with mouse lymphoid cells, an antimacrophage globulin (AMG) fraction was shown to be cytotoxic for peritoneal exudate macrophag...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1976-01-01 00:00:00
abstract：:Previous studies have highlighted the importance of CD4+ T cells in regulation of IgA responses and have indicated a functional heterogeneity among these cells between inductive (Peyer's patch) and effector (lamina propria) sites in the intestine. To determine whether these functional differences could be accounted fo...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1993-12-01 00:00:00
abstract：:The activity of Nocardia water-soluble mitogen (NWSM) and LPS were compared in several experimental systems, since both compounds are B-cell mitogens and polyclonal activators in vitro. The results reported here demonstrated that NWSM like LPS also has a strong adjuvant activity in vivo if administered in saline with ...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1977-06-01 00:00:00
abstract：:We quantified immunoglobulin E (IgE) on peritoneal mast cells of interleukin-4 (IL-4)-gene knockout (-/-) mice and wild-type (+/+) controls using a cytofluorometric method, and examined the expression of IgE receptors, estimated by quantifying the total binding of IgE on the mast cells of IL-4 (-/-) mice. The mast cel...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1046/j.1365-2567.1999.00727.x
更新日期：1999-04-01 00:00:00
abstract：:Prostaglandins are some of the main mediators which control parturition, and their production by intrauterine tissues can be up-regulated by pro-inflammatory cytokines. Anti-inflammatory cytokines may oppose these effects, and in this study we have investigated how two such cytokines affected fetal membrane function. ...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1046/j.1365-2567.2000.00942.x
更新日期：2000-01-01 00:00:00
abstract：:We established in previous studies that the binding of Salmonella lipopolysaccharide (LPS) to constitutive receptors of low affinity triggers the expression of the inducible LPS-binding molecule CD14 in bone marrow cells (BMC) of C3H/HeOU mice, but not in BMC from C3H/HeJ mice. We show in this study that BMC from C3H/...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1046/j.1365-2567.2000.00107.x
更新日期：2000-10-01 00:00:00
abstract：:Plasma fibronectin (FN) has been demonstrated to serve as an opsonin involved in the ingestion of foreign particles by phagocytes. This study concerns the effect of FN exposure on the respiratory burst of normal human peripheral phagocytes, using a luminol-dependent chemiluminescence (CL) assay for measurement of reac...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1988-10-01 00:00:00
abstract：:The non-obese diabetic (NOD) mouse is an animal model for insulin-dependent diabetes that has many similarities to the human disease. NOD mice transgenic for the Ea gene, allowing expression of the E molecule, are protected from diabetes and rarely develop insulitis. An Ea transgene mutated in the promoter region, (De...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1046/j.1365-2567.1998.00580.x
更新日期：1998-09-01 00:00:00
abstract：:Susceptibility to collagen-induced arthritis (CIA), a murine model of autoimmune arthritis, is strongly linked to only two major histocompatibility complex (MHC) haplotypes, H-2q and H-2r. In order to identify the determinants of type II collagen (CII) required to induce arthritis in H-2r-bearing mice, B10.RIII mice w...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1995-04-01 00:00:00
abstract：:Random-bred TO mice have been selectively bred into two lines on the basis of the relative affinity (KR) of antibody produced to protein antigens, one line producing high and the other low KR antibody. After four generations of selective breeding the difference in KR between the two lines was highly significant (P les...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1975-09-01 00:00:00
abstract：:Using a cell culture system, age-associated changes in immune activities were investigated in newly developed, short-lived mouse strains. These SAM-P strains of mice (H-2k), which have a remarkably short life span (around 9 months) under conventional breeding conditions, showed an age-associated early decline in sever...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1987-11-01 00:00:00
abstract：:To investigate the effect of carbohydrate on activation of the alternative pathway of complement by IgA immune complexes, aglycosylated monoclonal IgA was made biosynthetically in the presence of tunicamycin. When immune complexes were incubated with normal human serum (NHS), the aglycosylated IgA immune complexes cau...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1994-01-01 00:00:00
abstract：:Experimental protocols have been devised to deliniate the importance of T-cell subsets in immunity to Moloney sarcoma virus-induced tumours using the surface antigens L3T4 and Lyt-2 as markers of helper and cytotoxic cells, respectively. Because the monoclonal antibodies used have been shown to deplete T-cell subsets ...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1987-07-01 00:00:00
abstract：:Human plasma kallikrein can replace factor D for the activation of the alternative pathway C3 convertase of human complement. The factor B cleavage patterns by factor D and kallikrein are indistinguishable. The ability of kallikrein to cleave factor B is influenced by the magnesium ion concentration and the C3b concen...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1982-03-01 00:00:00
abstract：:Forssman antiserum produced in rabbits immunized with sheep erythrocyte stromata was found to contain an IgG antibody which inhibited both passive anaphylactic sensitization of guinea-pig lung and also histamine-releasing activity of soluble immune complexes. This Forssman antibody did not itself cause histamine rele...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1976-01-01 00:00:00
abstract：:Mice simultaneously injected intravenously and subcutaneously with herpes simplex virus fail to adoptively transfer delayed hypersensitivity (DH) to syngeneic recipients. The transferred lymph node cells also failed to rapidly eliminate infectious herpes from the pinna, despite the presence of cytotoxic T cells in the...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1982-04-01 00:00:00
abstract：:Group 2 innate lymphoid cells (ILC2s) produce a significant amount of interleukin-5 (IL-5), which supports eosinophil responses in various tissues; they also produce IL-13, which induces mucus production and contributes to tissue repair or fibrosis. The ILC2s are activated by alarmins, such as IL-33 released from epit...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1111/imm.12537
更新日期：2016-01-01 00:00:00
abstract：:The gut immune system and its modification by diet have been implicated in the pathogenesis of type 1 diabetes (T1D). Therefore, we investigated gut immune status in non-diabetes-prone LEW.1AR1 and diabetes-prone LEW.1AR1-iddm rats and evaluated the effect of a low antigen, hydrolysed casein (HC)-based diet on gut imm...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1111/imm.12457
更新日期：2015-07-01 00:00:00
abstract：:Tumour necrosis factor-alpha (TNF-alpha) stimulated invasion by mouse T-cell hybridomas and cytotoxic T-lymphocyte clones into rat embryo fibroblast monolayers. The effect on these highly invasive cells was limited: invasion was stimulated maximally to 130% of controls. However, when cells were pretreated with pertuss...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1992-02-01 00:00:00
abstract：:Stimulated T lymphocytes and certain T-cell hybridomas secrete molecules capable of inducing B-lymphocyte proliferation and differentiation. It has been shown recently that one such B-cell stimulatory factor is associated with chondroitin sulphate proteoglycan (CSPG) and was designated T-cell proteoglycan fraction, or...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1988-08-01 00:00:00
abstract：:Mouse lymph node cells cultured with Concanavalin A (Con A) in serum-free medium containing 59Fe-transferrin took up 59Fe more rapidly than cells cultured without Con-A. Uptake of iron commenced rapidly and preceded the onset of DNA synthesis in stimulated cells. Total uptake of transferrin during culture was much low...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1981-06-01 00:00:00
abstract：:The intraperitoneal injection of lipopolysaccharide (LPS) (400 microg/kg body weight) induced the expression of mRNAs of inflammatory cytokines such as interleukin (IL)-1beta, IL-6 and tumour necrosis factor (TNF)-alpha in the submandibular gland (SMG) of C3H/HeN mice but not that of C3H/HeJ mice, a mutant strain for ...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1111/j.1365-2567.2005.02212.x
更新日期：2005-10-01 00:00:00
abstract：:Initial stages of tumour growth are not easily accessible to investigation. Therefore an experimental procedure was developed to mimic tumorigenesis as closely as possible. BALB/c mice received intraperitoneally exponentially increasing numbers of irradiated syngeneic ADJ-PC-5 plasmacytoma cells. The initial injection...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1982-11-01 00:00:00
abstract：:The role of major histocompatibility complex (MHC) and adhesion molecule expression by alveolar epithelium on the modulation of immune responses in the lung is not understood. We have developed efficient methods to isolate, purify and culture human alveolar epithelial cells (type II pneumocytes) in vitro. The expressi...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1995-10-01 00:00:00
abstract：:Cytotoxic T-lymphocytes (CTL) play an important role in the control of human immunodeficiency virus (HIV) and of human cytomegalovirus (HCMV) infection. Following highly active antiretroviral therapy (HAART), most studies have demonstrated a decline in the frequency of HIV-specific CTL. We analysed the effect of HAART...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1111/j.1365-2567.2006.02334.x
更新日期：2006-05-01 00:00:00
