Contribution of intraperitoneal immunization to the local immune response in the respiratory tract of sheep.

abstract：:Long-term bovine lymphocyte cultures were initiated by stimulation with alloantigens and maintained in continuous culture using medium containing recombinant human interleukin-2 (rh IL-2). The development of specific and lectin-dependent killing was monitored following primary alloantigen challenge. Cytolytic activity...

journal_title：Immunology

authors： Carter J,Magnuson NS,Davis WC,Mason PH,Magnuson JA,Talmadge JE,Barr PJ

更新日期：1986-01-01 00:00:00

abstract：:The role of the mouse homocytotropic antibodies in passive cutaneous anaphylaxis reaction was investigated. One class of antibody was heat stable, detected at 2 h but not at 48 h after passive transfer, and belonged to a sublcass of mouse IgG. The other was heat labile, detected at 2 h and 48 h after passive transfer,...

journal_title：Immunology

authors： Lehrer SB

更新日期：1977-04-01 00:00:00

abstract：:Activated T cells, through the production of the receptor activator of NF-kappaB ligand (RANKL) cytokine, have been implicated in the osteoclast development and bone loss that are associated with autoimmune diseases such as rheumatoid arthritis. However, the cellular pathways that regulate the expression of RANKL and ...

journal_title：Immunology

authors： Gendron S,Boisvert M,Chetoui N,Aoudjit F

更新日期：2008-11-01 00:00:00

abstract：:CD27 is a T-cell surface antigen expressed on the majority of peripheral T cells and belongs to a newly defined receptor family including the low-affinity nerve growth factor receptor, tumour necrosis factor (TNF) receptors, the B-cell activation antigen CD40, and the Fas antigen. Although the function of CD27 has not...

journal_title：Immunology

authors： Sugita K,Dasgupta JD,Nojima Y,Agematsu K,Schlossman SF,Morimoto C

更新日期：1993-10-01 00:00:00

abstract：:Members of the tumour necrosis factor receptor superfamily play a key role in B-lymphocyte survival, proliferation, differentiation and programmed cell death. A member of this superfamily, the CD40 molecule plays an important role in the differentiation of B lymphocytes into effector cells and in early activation thro...

journal_title：Immunology

authors： Hirano A,Brown WC,Estes DM

更新日期：1997-02-01 00:00:00

abstract：:A subpopulation of human peripheral blood natural killer (NK) cells, defined by sedimentation at Percoll high buoyant densities (P greater than 1.0635-1.0640 g/ml) and unresponsiveness to interleukin-2 (IL-2), contained two distinct populations based on the intensity of CD16 (FcR gamma III) expression, namely CD16dim ...

journal_title：Immunology

authors： Warren HS,Skipsey LJ

更新日期：1991-01-01 00:00:00

abstract：:The mammalian target of rapamycin (mTOR) pathway is an important integrator of nutrient-sensing signals in all mammalian cells, and acts to coordinate the cell proliferation with the availability of nutrients such as glucose, amino acids and energy (oxygen and ATP). A large part of the immune response depends on the p...

journal_title：Immunology

authors： Cobbold SP

更新日期：2013-12-01 00:00:00

abstract：:Secretory proteins of Mycobacterium tuberculosis are the major immunomodulators of the host immune response. Open reading frame (ORF) Rv2626c, encoding a conserved hypothetical protein eliciting a strong humoral immune response in patients with tuberculosis (TB), was shown to be up-regulated upon infection in mice und...

journal_title：Immunology

authors： Bashir N,Kounsar F,Mukhopadhyay S,Hasnain SE

更新日期：2010-05-01 00:00:00

abstract：:In order to study the precise localization pattern of anti-TNP antibody-forming cells (AFCs) during the early primary immune response against TNP conjugated TD (thymus-dependent) and TI-2 (thymus-independent type-2) antigens, rats received an intravenous injection with either TNP-keyhole limpet haemocyanin (KLH) or wi...

journal_title：Immunology

authors： Claassen E,Kors N,Dijkstra CD,Van Rooijen N

更新日期：1986-03-01 00:00:00

abstract：:Immunization of mice with cognate cancer-derived heat-shock protein (hsp) preparations leads to protection from cancer growth. As hsp used for vaccination or therapy are derived from autologous cancers, questions of pathological autoimmunity are of immense significance for the ongoing translation of this approach to t...

journal_title：Immunology

authors： Ménoret A,Chandawarkar RY,Srivastava PK

更新日期：2000-11-01 00:00:00

abstract：:In the present study we have investigated whether bovine erythrocytes (Eb) specifically sensitized with human polyclonal IgA1 (Eb-IgA1) are able to bind to resident adherent rat peritoneal cells (PM phi). Rat PM phi formed rosettes with Eb-IgA1 at room temperature and at 37 degrees. The formation of these rosettes cou...

journal_title：Immunology

authors： Gorter A,Hiemstra PS,van der Voort EA,van Es LA,Daha MR

更新日期：1988-06-01 00:00:00

abstract：:Hyper-immunoglobulin M (IgM) syndrome (HIGM) is a rare primary immunodeficiency characterized by elevated or normal IgM and absent or markedly decreased amounts of IgG, IgA and IgE. The X-linked form (HIGM1) is the most common type and is caused by mutations in the gene for CD40L, a T-cell surface molecule required fo...

journal_title：Immunology

authors： Van Hoeyveld E,Zhang PX,De Boeck K,Fuleihan R,Bossuyt X

更新日期：2007-04-01 00:00:00

abstract：:Dendritic cells (DC) are the initiators of immune responses and are present in most tissues in vivo. To generate myeloid DC from monocytes (MoDC) in vitro the necessary cytokines are granulocyte-macrophage colony-stimulating factor (GM-CSF) and interleukin-4 (IL-4). Using degenerated primers delineated from other spec...

journal_title：Immunology

authors： Mauel S,Steinbach F,Ludwig H

更新日期：2006-04-01 00:00:00

abstract：:Protein kinase C (PKC) form a key family of enzymes involved in signalling pathways that specifically phosphorylates substrates at serine/threonine residues. Phosphorylation by PKC is important in regulating a variety of cellular events such as cell proliferation and the regulation of gene expression. In the immune sy...

journal_title：Immunology

authors： Lim PS,Sutton CR,Rao S

更新日期：2015-12-01 00:00:00

abstract：:Silica, or silicon dioxide, has been shown to be toxic for macrophages. This is probably because it damages phagolysosomal membranes, allowing lysosomal enzymes to disrupt the cell. Neutrophils also take up particles such as silica and in addition they contain lysosomes. The purpose of this study was to determine whet...

journal_title：Immunology

authors： Zimmerman BT,Canono BP,Campbell PA

更新日期：1986-12-01 00:00:00

abstract：:BALB/c mice develop myasthenic symptoms after immunization with rodent acetylcholine receptor (AChR). After immunization with Torpedo AChR (TAChR), their CD4+ cells become strongly sensitized against a conserved region of the TAChR alpha subunit sequence (residues alpha 304-322), and cross-react vigorously with the ho...

journal_title：Immunology

authors： Karachunski PI,Ostlie N,Conti-Tronconi BM,Bellone M

更新日期：1994-05-01 00:00:00

abstract：:Antibody-dependent cellular cytotoxicity (ADCC) and Fc receptor-mediated phagocytosis were determined with human monocytes, monocyte-derived macrophages and activated macrophages, using rabbit IgG-covered sheep red blood cells (EAs) and anti-D-treated human erythrocytes (EAhu) as target cells. Monocyte and macrophage-...

journal_title：Immunology

authors： Rüegg SJ,Jungi TW

更新日期：1988-03-01 00:00:00

abstract：:Toll-like receptor 2 (TLR2) is a key mediator of the immune response to mycobacterial infections, and mutations in TLR2 have been shown to confer susceptibility to infection with mycobacteria. This study investigated the profiles of cytokines, such as interferon (IFN)-gamma, interleukin (IL)-10, IL-12 and tumour necro...

journal_title：Immunology

authors： Kang TJ,Yeum CE,Kim BC,You EY,Chae GT

更新日期：2004-08-01 00:00:00

abstract：:It is becoming increasingly clear that the T-cell-mediated immune response is important in many diseases. In this study, we used concanavalin A (Con A) -induced hepatitis to investigate the role of CD49a in the molecular and cellular mechanism of the T-cell-mediated immune response. We found that CD49a(-/-) mice had s...

journal_title：Immunology

authors： Chen Y,Peng H,Chen Y,Wei H,Sun R,Tian Z

更新日期：2014-03-01 00:00:00

abstract：:Macrophage activating factor (MAF) is produced by antigen-stimulated lymphocytes and activates macrophages for antimicrobial function. The capacity of individual microbial antigens to evoke and regulate this response has been explored using an affinity purified antigen (TB68) of Mycobacterium tuberculosis in combinati...

journal_title：Immunology

authors： Matthews R,Scoging A,Rees AD

更新日期：1985-01-01 00:00:00

abstract：:Five of twenty-three patients with paraproteinaemia (two IgM, three IgG) have been shown to exhibit marked classical pathway complement activation. The mechanisms of hypocomplementaemia proposed for the five patients are cryoglobulinaemia in one and in vivo immunoglobulin aggregation in the other four. Three further p...

journal_title：Immunology

authors： Naish PF,Collins C,Barratt J

更新日期：1977-10-01 00:00:00

abstract：:Spleen cells from LAF1 mice primed with photo-oxidized antigen B exhibit helper T-cell activity when assayed in an adoptive transfer system with spleen cells from mice primed with timothy pollen extract and treated with anti-thy 1.2 serum and complement. These helper cells, when placed in culture with antigen B, secre...

journal_title：Immunology

authors： Brandt CJ,Deppe LB,Malley A

更新日期：1981-10-01 00:00:00

abstract：:The discovery of host-encoded gene products that sense molecular patterns in infectious microbes, and the demonstration of their role in triggering innate and adaptive immune responses, has been a key milestone in our understanding of immunology. Twenty-three years after Janeway first outlined the fundamental concepts...

journal_title：Immunology

authors： Browne EP

更新日期：2012-08-01 00:00:00

abstract：:While many aspects of memory T-cell immunobiology have been characterized, we suggest that we know only a fraction of the effector functions that CD4 T cells can bring to bear during secondary challenges. Exploring the full impact of memory CD4 T-cell responses is key to the development of improved vaccines against ma...

journal_title：Immunology

authors： McKinstry KK,Strutt TM,Swain SL

更新日期：2010-05-01 00:00:00

abstract：:The process by which naive T cells become activated, differentiate into effector cells and ultimately generate long-lived memory cells is dependent upon a number of factors, including the costimulatory signals received by the T cell. To best understand the multiple events involved, it is important to understand the po...

journal_title：Immunology

authors： Kohlmeier JE,Chan MA,Benedict SH

更新日期：2006-08-01 00:00:00

abstract：:In the present study, we have analysed the phenotype of EphB2 and/or EphB3 deficient thymocytes confirming and extending previous studies on the role of this family of molecules in T-cell differentiation. In all mutant thymuses statistically significant reduced cell contents were observed. This reduction of thymic cel...

journal_title：Immunology

authors： Alfaro D,Muñoz JJ,García-Ceca J,Cejalvo T,Jiménez E,Zapata A

更新日期：2008-09-01 00:00:00

abstract：:This study investigates the effect of feeding fermented milks with Lactobacillus casei, Lactobacillus acidophilus and a mixture of both micro-organisms on the specific and non-specific host defence mechanisms in Swiss mice. Animals fed with fermented milk for 8 days (100 micrograms/day) showed an increase in both phag...

journal_title：Immunology

authors： Perdigón G,de Macias ME,Alvarez S,Oliver G,de Ruiz Holgado AP

更新日期：1988-01-01 00:00:00

abstract：:T. brucei infection in mice causes generalized immunosuppression with multiple changes in the cells of the lymphoid tissue. Loss of B cell responsiveness to antigens and mitogens, and the induction of suppressive T-cells and macrophages, have been previously reported (Hudson, Byner, Freeman & Terry, 1976; Corsini, Cla...

journal_title：Immunology

authors： Askonas BA,Corsini AC,Clayton CE,Ogilvie BM

更新日期：1979-02-01 00:00:00

abstract：:Regulatory T (Treg) cells act to suppress activation of the immune system and thereby maintain immunological homeostasis and tolerance to self-antigens. The frequency and suppressing activity of Treg cells in general are high in different malignancies. We wanted to identify the role and regulation of CD4(+)  CD25(+)  ...

journal_title：Immunology

authors： Bhattacharya K,Chandra S,Mandal C

更新日期：2014-05-01 00:00:00

abstract：:The effect of stem cell factor (SCF) on histamine and tumour necrosis factor-alpha (TNF-alpha) release from rat peritoneal mast cells (PMC) was determined and the intracellular pathways involved in the potentiation of histamine secretion were investigated. The effects of SCF (2-100 ng/ml) were examined following both ...

journal_title：Immunology

authors： Lin TJ,Bissonnette EY,Hirsh A,Befus AD

更新日期：1996-10-01 00:00:00