Abstract:
:We have developed a thyroglobulin-specific haemolytic plaque assay and investigated potential sites of autoantibody synthesis in good and poor responder strains of rats immunized with thyroglobulin and in rats subjected to thymectomy and sub-lethal irradiation which subsequently develop thyroiditis spontaneously. The bone marrow appears to be the most important site of thyroglobulin antibody synthesis in all groups, but spleen and cervical lymph nodes are also involved. No thyroglobulin plaque-forming cells could be found in the thyroid. These results imply widespread involvement of the humoral immune system in organ-specific autoimmune processes.
journal_name
Immunologyjournal_title
Immunologyauthors
Weetman AP,McGregor AM,Rennie DP,Hall Rsubject
Has Abstractpub_date
1982-06-01 00:00:00pages
465-72issue
2eissn
0019-2805issn
1365-2567journal_volume
46pub_type
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