Tumour necrosis factor (TNF-alpha) in leishmaniasis. II. TNF-alpha-induced macrophage leishmanicidal activity is mediated by nitric oxide from L-arginine.

abstract：:Therapeutic vaccination using T-cell receptor (TCR) peptides from V genes commonly expressed by potentially pathogenic T cells remains an approach of interest for treatment of multiple sclerosis (MS) and other autoimmune diseases. We developed a trivalent TCR vaccine containing complementarity determining region (CDR)...

journal_title：Immunology

authors： Vandenbark AA,Culbertson NE,Bartholomew RM,Huan J,Agotsch M,LaTocha D,Yadav V,Mass M,Whitham R,Lovera J,Milano J,Theofan G,Chou YK,Offner H,Bourdette DN

更新日期：2008-01-01 00:00:00

abstract：:Tumour-associated macrophages (TAMs) represent a predominant population of inflammatory cells that present in solid tumours. TAMs are mostly characterized as alternatively activated M2-like macrophages and are known to orchestrate nearly all stages of tumour progression. Experimental investigations indicate that TAMs ...

journal_title：Immunology

authors： Tang X,Mo C,Wang Y,Wei D,Xiao H

更新日期：2013-02-01 00:00:00

abstract：:The discovery of host-encoded gene products that sense molecular patterns in infectious microbes, and the demonstration of their role in triggering innate and adaptive immune responses, has been a key milestone in our understanding of immunology. Twenty-three years after Janeway first outlined the fundamental concepts...

journal_title：Immunology

authors： Browne EP

更新日期：2012-08-01 00:00:00

abstract：:Urokinase-type plasminogen activator (u-PA), tumour necrosis factor-alpha (TNF-alpha) and interleukin-1 (IL-1) activities were measured for highly purified human monocytes cultured for 18 hr with recombinant human interleukin-3 (IL-3). IL-3 alone stimulated monocyte u-PA activity, but not TNF-alpha or IL-1 activity. H...

journal_title：Immunology

authors： Hart PH,Whitty GA,Burgess DR,Hamilton JA

更新日期：1990-09-01 00:00:00

abstract：:The relationship between allograft rejection and the response in the one-way mixed leucocyte reaction (MLR) of the WBC of allograft recipients was investigated. The responses of the WBC were assessed prior to skin allografting and subsequent to rejection of the allograft. The optimal MLR response of the WBC from the a...

journal_title：Immunology

authors： Milthorp P,Belanger R,Richter M

更新日期：1979-01-01 00:00:00

abstract：:Young (15-week-old) CBA/Ca mice were injected intravenously with spleen cells from individual young (15-week-old) or old (18-24-month-old) CBA/T6T6 mice. Samples of peripheral blood were taken at monthly intervals and cultured with phytohaemagglutinin (PHA) to stimulate T lymphocytes into mitosis. In the recipients of...

journal_title：Immunology

authors： Wallis VJ,Chaudhuri M,Jacob MC,Valkova BA,Davies AJ

更新日期：1984-12-01 00:00:00

abstract：:Chemically cross-linked C-reactive protein (CRP) oligomers were prepared and characterized, and C1q binding and C activation were investigated. Purified human CRP was polymerized in the presence of both non-cleavable and cleavable cross-linking agents and further separated by Superose 12 analytical FPLC column chromat...

journal_title：Immunology

authors： Jiang H,Lint TF,Gewurz H

更新日期：1991-12-01 00:00:00

abstract：:Natural killer (NK) cells, which can exert early and powerful anti-tumour and anti-viral responses, are important components of the innate immune system. DNAX accessory molecule-1 (DNAM-1) is an activating receptor molecule expressed on the surface of NK cells. Recent findings suggest that DNAM-1 is a critical regulat...

journal_title：Immunology

authors： Xiong P,Sang HW,Zhu M

更新日期：2015-11-01 00:00:00

abstract：:Interleukin-16 (IL-16) acts as a chemoattractant for CD4+ cells, as a modulator of T-cell activation, and plays a key role in asthma. This report describes the cytokine-inducing effects of IL-16 on total peripheral blood mononuclear cells (PBMC) and PBMC subpopulations. While CD4+ T lymphocytes did not secrete cytokin...

journal_title：Immunology

authors： Mathy NL,Scheuer W,Lanzendörfer M,Honold K,Ambrosius D,Norley S,Kurth R

更新日期：2000-05-01 00:00:00

abstract：:A serum factor, believed to be an IgG autoantibody, in certain patients with lepromatous leprosy inhibits the proliferation of mitogen-stimulated lymphocytes. To investigate which stage of the cell cycle was inhibited, we examined the effect of these sera on the kinetics of lymphocyte activation induced by several mit...

journal_title：Immunology

authors： Poulton TA,Gallagher A,Beck JS

更新日期：1989-11-01 00:00:00

abstract：:We quantified immunoglobulin E (IgE) on peritoneal mast cells of interleukin-4 (IL-4)-gene knockout (-/-) mice and wild-type (+/+) controls using a cytofluorometric method, and examined the expression of IgE receptors, estimated by quantifying the total binding of IgE on the mast cells of IL-4 (-/-) mice. The mast cel...

journal_title：Immunology

authors： Chen XJ,Lycke N,Enerbäck L

更新日期：1999-04-01 00:00:00

abstract：:Major histocompatibility complex (MHC) class I-specific inhibitory natural killer receptors (iNKRs) are expressed by subsets of T cells but the mechanisms inducing their expression are poorly understood, particularly for killer-cell immunoglobulin-like receptors (KIRs). The iNKRs are virtually absent from the surface ...

journal_title：Immunology

authors： Hermann E,Berthe A,Truyens C,Alonso-Vega C,Parrado R,Torrico F,Carlier Y,Braud VM

更新日期：2010-03-01 00:00:00

abstract：:Primary contact sensitivity (CS) to Ox and non-specific unresponsiveness to other unrelated delayed-type hypersensitivity (DTH) containing CS were induced simultaneously by i.v. administration of oxazolone(Ox)-conjugated spleen cells. The subpopulation of spleen cells which serves as carriers for the induction of prim...

journal_title：Immunology

authors： Nakano Y,Nakano K

更新日期：1985-02-01 00:00:00

abstract：:Resveratrol is a polyphenol that acts on multiple molecular targets important for cell differentiation and activation. Dendritic cells (DCs) are a functionally diverse cell type and represent the most potent antigen-presenting cells of the immune system. In this study, we investigated resveratrol-induced effects on DC...

journal_title：Immunology

authors： Svajger U,Obermajer N,Jeras M

更新日期：2010-04-01 00:00:00

abstract：:Expression of the lymph node homing and CC-chemokine receptor 7 (CCR7), with L-selectin (CD62L), has been shown to divide human memory T cells into two functionally distinct subsets. We generated a polyclonal antibody against murine CCR7 and used this antibody to study CCR7 expression on murine T-cell subsets. Using f...

journal_title：Immunology

authors： Bjorkdahl O,Barber KA,Brett SJ,Daly MG,Plumpton C,Elshourbagy NA,Tite JP,Thomsen LL

更新日期：2003-10-01 00:00:00

abstract：:Humans and other mammals coexist with a diverse array of microbes colonizing the intestine, termed the microflora. The relationship is symbiotic, with the microbes benefiting from a stable environment and nutrient supply, and the host gaining competitive exclusion of pathogens and continuously maintenance of the gut i...

journal_title：Immunology

authors： Zeuthen LH,Fink LN,Frokiaer H

更新日期：2008-02-01 00:00:00

abstract：:A positive association has been observed in Igh allotype "congenic' mice between skin graft rejection and a block to effective T--B co-operation in the development of both IgM and IgG responses to sheep erythrocytes. Mismatch of Igh alone is insufficient for such a block to become apparent since pairs of Igh-allotype ...

journal_title：Immunology

authors： Dresser DW,Popham AM,Hunt R

更新日期：1982-07-01 00:00:00

abstract：:A superantigen (Streptococcus pyogenes mitogen-2; SPM-2) that stimulates human helper T cells bearing unique types of variable domains of T-cell receptor beta-chain (TCR V beta) was isolated from the culture supernatant of S. pyogenes strain T12. The active molecule isolated by diethylaminoethyl (DEAE)-cellulose chrom...

journal_title：Immunology

authors： Rikiishi H,Okamoto S,Sugawara S,Tamura K,Liu ZX,Kumagai K

更新日期：1997-07-01 00:00:00

abstract：:The role of oral-associated lymphoid tissues during induction of oral tolerance still remains elusive. Therefore, the aim was to compare T-cell activation and induction of tolerance to ovalbumin (OVA) presented through either of two routes; deposited into the oral cavity, or the stomach, thereby bypassing the oral cav...

journal_title：Immunology

authors： Bankvall M,Östberg AK,Jontell M,Wold A,Östman S

更新日期：2016-09-01 00:00:00

abstract：:We have used in situ hybridization (ISH) and immunohistochemistry (IHC) to investigate the kinetics of the expression for Fc epsilon RI mRNA (alpha-, beta- and gamma-chains), the alpha-chain protein product, as well as the phenotype of the mRNA- or protein-positive cells in allergen-induced late-phase skin reactions i...

journal_title：Immunology

authors： Ying S,Barata LT,Meng Q,Grant JA,Barkans J,Durham SR,Kay AB

更新日期：1998-02-01 00:00:00

abstract：:Factor B-like activity associated with human peripheral blood lymphocytes was first described by Halbwachs & Lachmann (1976), who employed a functional assay. In this present study, clones of B cells from patients with chronic lymphatic leukaemia (CLL) and lymphoblastoid 'Raji' cells were used. The surface of these ce...

journal_title：Immunology

authors： Woo P,Lachmann PJ

更新日期：1981-11-01 00:00:00

abstract：:The intestinal lamina propria (LP) contains antigen-presenting cells with features of dendritic cells and macrophages, collectively referred to as mononuclear phagocytes (MNPs). Association of MNPs with the epithelium is thought to play an important role in multiple facets of intestinal immunity including imprinting M...

journal_title：Immunology

authors： McDonald KG,Wheeler LW,McDole JR,Joerger S,Gustafsson JK,Kulkarni DH,Knoop KA,Williams IR,Miller MJ,Newberry RD

更新日期：2017-12-01 00:00:00

abstract：:Adoptive transfer of anti-Listeria resistance by Listeria-immune spleen T cells was markedly reduced by pretreatment of the cells with monoclonal anti-Lyt 2.2 and complement (Lyt 2+C); pretreatment of cells with monoclonal anti-L3T4 and complement (L3T4+C) had a lesser effect on their ability to transfer resistance. L...

journal_title：Immunology

authors： Czuprynski CJ,Brown JF

更新日期：1987-02-01 00:00:00

abstract：:The process by which naive T cells become activated, differentiate into effector cells and ultimately generate long-lived memory cells is dependent upon a number of factors, including the costimulatory signals received by the T cell. To best understand the multiple events involved, it is important to understand the po...

journal_title：Immunology

authors： Kohlmeier JE,Chan MA,Benedict SH

更新日期：2006-08-01 00:00:00

abstract：:In an attempt to produce monoclonal antibodies against human large granular lymphocytes (LGL), the effector cells of natural killer (NK) and killer (K) activity, a monoclonal IgM antibody (VEP10) has been obtained. This antibody is reactive by indirect membrane immunofluorescence (IMF) with 14.7 +/- 8.5% peripheral bl...

journal_title：Immunology

authors： Rumpold H,Kraft D,Obexer G,Böck G,Möschl P

更新日期：1983-06-01 00:00:00

abstract：:The concentration of CXCL12/SDF-1 in the bloodstream is tightly regulated, given its central role in leucocyte and stem/progenitor cell egress from bone marrow and recruitment to sites of inflammation or injury. The mechanism responsible for this regulation is unknown. Here we show that both genetic deletion and pharm...

journal_title：Immunology

authors： Berahovich RD,Zabel BA,Lewén S,Walters MJ,Ebsworth K,Wang Y,Jaen JC,Schall TJ

更新日期：2014-01-01 00:00:00

abstract：:A neutral protease with a molecular weight of about 14,00 was separated at acid pH from rabbit neutrophils and then partially purified by elution on DEAE-Sephadex, CM-Sephadex and Sephadex G-75 in that order. This enzyme was inactivated by diisopropyl fluorophosphate (DFP), phenylmethyl sulphonylfluoride (PMSF), soybe...

journal_title：Immunology

authors： Ishida M,Honda M,Hayashi H

更新日期：1978-07-01 00:00:00

abstract：:The effect of different macrophage populations and supernatants derived from these macrophages on Con-A induced lymphocyte activation in macrophage depleted lymph node cells has been investigated. All macrophage populations tested were able to restore the lymphocytic response to Con A. Macrophages of different origin ...

journal_title：Immunology

authors： Knop J

更新日期：1980-10-01 00:00:00

abstract：:Among peripheral T cells, the expression of CD4 and CD8 is almost mutually exclusive. However, here we show, using flow cytometric analysis, that ex vivo approximately 6% of rat T cells stained for both CD4 and CD8. These double positive cells were also detected by confocal microscopy. Only around 50% of double positi...

journal_title：Immunology

authors： Kenny E,Mason D,Pombo A,Ramírez F

更新日期：2000-10-01 00:00:00

abstract：:Tumour necrosis factor-alpha (TNF-alpha) stimulated invasion by mouse T-cell hybridomas and cytotoxic T-lymphocyte clones into rat embryo fibroblast monolayers. The effect on these highly invasive cells was limited: invasion was stimulated maximally to 130% of controls. However, when cells were pretreated with pertuss...

journal_title：Immunology

authors： La Rivière G,Klein Gebbinck JW,Schipper CA,Roos E

更新日期：1992-02-01 00:00:00