In vitro macrophage chemotactic generation from serum immunoglobulin G by neutrophil neutral seryl protease.

abstract：:Systemic lupus erythematosus (SLE) is an autoimmune chronic inflammatory disease of unknown etiology, although genetic and environmental factors appear to contribute to its pathogenesis. Specifically, infectious processes are associated with SLE onset and exacerbation. However, we are far from a complete understanding...

journal_title：Immunology

authors： Illescas-Montes R,Corona-Castro CC,Melguizo-Rodríguez L,Ruiz C,Costela-Ruiz VJ

更新日期：2019-11-01 00:00:00

abstract：:Langerhans' cells (LC) cultured for 1-3 days lose their ability to process native protein antigens but acquire the ability to stimulate resting T cells as assessed in an allogeneic mixed lymphocyte response (MLR). Lymph-borne dendritic cells (L-DC) are physiologically involved in the transport of antigens to lymph nod...

journal_title：Immunology

authors： Liu LM,MacPherson GG

更新日期：1995-02-01 00:00:00

abstract：:HIV infection is associated with increased representation of T cells bearing an activated, memory (CD45RO+) phenotype. Although administration of antiretroviral agents and interleukin-2 (IL-2) augment depleted CD4+ T-cell numbers, such therapies have been preferentially beneficial for CD45RO+ T cells. Interleukin-15 (...

journal_title：Immunology

authors： Naora H,Gougeon M

更新日期：1999-06-01 00:00:00

abstract：:Lymphoid cells in decidualized uterine endometrium in early human pregnancy may be essential for successful implantation and placentation. Endometrial granulocytes are prominent in early pregnancy decidua and express some T-cell associated surface antigens (CD2+, CD7+), but little is known of their function. We report...

journal_title：Immunology

authors： Ritson A,Bulmer JN

更新日期：1987-10-01 00:00:00

abstract：:Cells expressing indoleamine 2,3-dioxygenase (IDO), an enzyme which catabolizes tryptophan, prevent T-cell proliferation in vitro, suppress maternal antifetal immunity during pregnancy and inhibit T-cell-mediated responses to tumour-associated antigens. To examine the mechanistic basis of these phenomena we activated ...

journal_title：Immunology

authors： Lee GK,Park HJ,Macleod M,Chandler P,Munn DH,Mellor AL

更新日期：2002-12-01 00:00:00

abstract：:Formation of osteoclasts and consequent joint destruction are hallmarks of rheumatoid arthritis (RA). Here we show that LIGHT, a member of the tumour necrosis factor (TNF) superfamily, induced the differentiation into tartrate-resistant acid phosphatase (TRAP)-positive multinucleated cells (MNCs) of CD14(+) monocytes ...

journal_title：Immunology

authors： Ishida S,Yamane S,Nakano S,Yanagimoto T,Hanamoto Y,Maeda-Tanimura M,Toyosaki-Maeda T,Ishizaki J,Matsuo Y,Fukui N,Itoh T,Ochi T,Suzuki R

更新日期：2009-09-01 00:00:00

abstract：:Different genetic mutations have been described in complement component C7 deficiency, a molecular defect clinically associated with an increased susceptibility to neisserial recurrent infections. In this work we report the genetic basis of C7 deficiency in two different Spanish families (family 1 and family 2). In fa...

journal_title：Immunology

authors： Barroso S,Sánchez B,Alvarez AJ,López-Trascasa M,Lanuza A,Luque R,Wichmann I,Núñez-Roldán A

更新日期：2004-12-01 00:00:00

abstract：:In understanding the regulation of the specific immune response to Salmonella typhimurium, the role of a surface major component (porins) was studied. In this study we demonstrate that purified porins are able to induce a different response to that induced by the porins present on the S. typhimurium cell surface. Pori...

journal_title：Immunology

authors： Galdiero M,De Martino L,Marcatili A,Nuzzo I,Vitiello M,Cipollaro de l'Ero G

更新日期：1998-05-01 00:00:00

abstract：:The induction of T-cell growth by the T-cell antigen receptor (TcR) is dependent on a co-ordinated process of phosphorylation and dephosphorylation of intracellular proteins. An intermediary in this signalling pathway is the serine kinase, p42 mitogen-activated protein kinase (p42MAPK), also known as microtubule-assoc...

journal_title：Immunology

authors： Amaral MC,Casillas AM,Nel AE

更新日期：1993-05-01 00:00:00

abstract：:Antibody-dependent cellular cytotoxicity (ADCC) and Fc receptor-mediated phagocytosis were determined with human monocytes, monocyte-derived macrophages and activated macrophages, using rabbit IgG-covered sheep red blood cells (EAs) and anti-D-treated human erythrocytes (EAhu) as target cells. Monocyte and macrophage-...

journal_title：Immunology

authors： Rüegg SJ,Jungi TW

更新日期：1988-03-01 00:00:00

abstract：:Haptoglobin (Hp), a major acute-phase plasma protein, has been found in arthritic synovial fluid (SF). However, the function and structural modifications of Hp in arthritic SF are unknown. To investigate in vivo generation of modified Hp associated with inflammatory disease, we examined a new Hp isoform in SF from pat...

journal_title：Immunology

authors： Park HJ,Oh MK,Kim NH,Cho ML,Kim IS

更新日期：2013-09-01 00:00:00

abstract：:In this study we aimed to elucidate the physiological role of gammadelta intraepithelial lymphocytes (IEL) in the mouse intestine. For this purpose, we used T-cell receptor (TCR) Vgamma4/Vdelta5 transgenic mice (KN 6 Tg: BALB/c background, H-2d), and compared the immunological and physiological characteristics of the ...

journal_title：Immunology

authors： Matsumoto S,Nanno M,Watanabe N,Miyashita M,Amasaki H,Suzuki K,Umesaki Y

更新日期：1999-05-01 00:00:00

abstract：:Ly-49A is a member of the Ly-49 family of mouse natural killer cell receptors that inhibit cytotoxicity upon recognition of their ligands, the major histocompatibility complex (MHC) class I molecules, on the target cell surface. Although Ly-49A has an immunoreceptor tyrosine-based inhibition motif (ITIM) in its cytopl...

journal_title：Immunology

authors： Motoda K,Takata M,Kiura K,Nakamura I,Harada M

更新日期：2000-07-01 00:00:00

abstract：:Nod-like receptors are a family of innate immune receptors that link cytosolic sensing of microbial and danger stimuli to the activation of immune responses. Two Nod-like receptor family members, Nod1 and Nod2, recognize bacterial peptidoglycan and activate immune responses via nuclear factor-κB (NF-κB) and mitogen-ac...

journal_title：Immunology

authors： Jeong YJ,Kang MJ,Lee SJ,Kim CH,Kim JC,Kim TH,Kim DJ,Kim D,Núñez G,Park JH

更新日期：2014-10-01 00:00:00

abstract：:Initial separation and concentration of Clq from fresh, normal equine serum was accomplished by precipitation in 0.02 M acetate buffer, pH 5.5, at 4 degrees for 24 h. The re-dissolved precipitate was clarified by centrifugation at 80,000 g for 1 h and then dialysed against Tris-HCl buffer (0.05 M, pH 8.0) containing 1...

journal_title：Immunology

authors： McDonald TL,Burger D

更新日期：1979-07-01 00:00:00

abstract：:Anti-Gal is the most abundant natural antibody in humans, constituting ~ 1% of immunoglobulins. Anti-Gal is naturally produced also in apes and Old World monkeys. The ligand of anti-Gal is a carbohydrate antigen called the 'α-gal epitope' with the structure Galα1-3Galβ1-4GlcNAc-R. The α-gal epitope is present as a maj...

journal_title：Immunology

authors： Galili U

更新日期：2013-09-01 00:00:00

abstract：:Bone marrow cells from mice were cultured in vitro in the presence of interleukin-3 (IL-3). After 2 weeks, the majority of the cells differentiated towards mast cells as judged by morphological and biochemical criteria. When populations of 99% IL-3-dependent mast cells (IL-3 MC) were tested for their anti-tumour activ...

journal_title：Immunology

authors： Ghiara P,Boraschi D,Villa L,Scapigliati G,Taddei C,Tagliabue A

更新日期：1985-06-01 00:00:00

abstract：:B lymphocyte-induced maturation protein-1 (Blimp-1), the transcription factor encoded by the gene Prdm1, plays a number of crucial roles in the adaptive immune system, which result in the maintenance of key effector functions of B- and T-cells. Emerging clinical data, as well as mechanistic evidence from mouse studies...

journal_title：Immunology

authors： Ulmert I,Henriques-Oliveira L,Pereira CF,Lahl K

更新日期：2020-12-01 00:00:00

abstract：:Mice injected with rat erythrocytes developed anti-erythrocyte autoantibodies which reached a plateau at 4-12 weeks, then gradually declined until at about 24 weeks the majority of mice were negative. In such recovered mice re-challenge with rat erythrocytes produced an accelerated peak of autoantibody and a much more...

journal_title：Immunology

authors： Naysmith JD,Elson CJ,Dallman M,Fletcher E,Ortega-Pierres MG

更新日期：1980-04-01 00:00:00

abstract：:Functionally defined mouse Lyt-1 and Lyt-2 cell sets were selected from peripheral lymph nodes by cytotoxic elimination with anti-Lyt monoclonal antibodies. The selected populations were labelled with 51Cr or [3H]-adenosine and traced in syngeneic recipients at 1, 24, 45 and 65 hr after intravenous injection. Recovere...

journal_title：Immunology

authors： Carroll AM,de Sousa M

更新日期：1984-06-01 00:00:00

abstract：:Immunopotentiation has been demonstrated when Klebsiella O3 lipopolysaccharide (KO3 LPS), which possesses a linear mannan as the O-specific side chain, was injected subcutaneously into endotoxin resistant C3H/HeJ mice together with soluble protein antigens. The LPS exhibited significantly positive adjuvant effects on ...

journal_title：Immunology

authors： Ohta M,Kido N,Nakashima I,Kato N

更新日期：1985-11-01 00:00:00

abstract：:In the autologous Theileria mixed leucocyte reaction (MLR), irradiated Theileria parva-infected cells induce proliferative responses in autologous peripheral blood mononuclear leucocytes (PBM), irrespective of the immune status of the donor animal. In this paper we have analysed the cellular basis of this response in ...

journal_title：Immunology

authors： Goddeeris BM,Morrison WI

更新日期：1987-01-01 00:00:00

abstract：:This paper uses B-lymphocyte cloning methods to quantify the effects of anti-mu chain antibody on immature and mature B cells. Nude mouse spleen lymphocytes were incubated with various concentrations of sheep anti-mouse mu chain antibody for times varying from 10 min to 24 h. They were then washed and plated in the ag...

journal_title：Immunology

authors： Nossal GJ,Pike BL,Battye FL

更新日期：1979-05-01 00:00:00

abstract：:The humoral and mucosal immune responses to oral immunization with xenogeneic antibodies were studied using an animal model in which female rabbits were fed daily doses of the MOPC-315 murine IgA antibody, and were mated during the course of the feeding programme. Serum and colostrum samples were assayed for the prese...

journal_title：Immunology

authors： Collins AM,Roberton DM,Hosking CS,Flannery GR

更新日期：1991-08-01 00:00:00

abstract：:Natural cell-mediated cytotoxicity is mediated by a family of effector cells that express cytolytic activities distinct from those generally attributed to B cells, T cells and macrophages; it includes both natural killer (NK) and natural cytotoxic (NC) activities. There is now convincing evidence to show that NC activ...

journal_title：Immunology

authors： Patek PQ,Lin Y

更新日期：1989-08-01 00:00:00

abstract：:Designing peptide-based vaccines for therapeutic applications in cancer immunotherapy requires detailed knowledge of the interactions between the antigenic peptide and major histocompatibility complex (MHC) in addition to that between the peptide-MHC complex and the T-cell receptor. Past efforts to immunize with high-...

journal_title：Immunology

authors： Lazoura E,Lodding J,Farrugia W,Ramsland PA,Stevens J,Wilson IA,Pietersz GA,Apostolopoulos V

更新日期：2006-11-01 00:00:00

abstract：:Membrane sialoglycoprotein (GP) of mouse erythrocytes were incorporated into artificial membranes of liposomes which also contained DNP-aminocaproylphosphatidylethanolamine hapten. The liposomes were tested for their potential to modulate the anti-hapten antibody response in mice as a plausible model of haptenated iso...

journal_title：Immunology

authors： Hitsumoto Y,Hineno T,Utsumi S

更新日期：1984-12-01 00:00:00

abstract：:A common factor existing among autoimmune target antigens was sought in association with their developmental expression during organogenesis. Autoimmunity against a certain organ was experimentally induced in rats by deliberate immunization with whole tissue extract of the respective organ. Histopathological changes i...

journal_title：Immunology

authors： Akashi T,Eishi Y

更新日期：1991-11-01 00:00:00

abstract：:Cytokines are the most important inducers of T helper (Th) cell differentiation. Interleukin-12 (IL-12) and interferon-alpha (IFN-alpha) are responsible for human Th1-cell differentiation, while IL-4 is the critical cytokine promoting Th2-cell development. These two subsets of cells co-ordinate immunological responses...

journal_title：Immunology

authors： Aho TL,Lund RJ,Ylikoski EK,Matikainen S,Lahesmaa R,Koskinen PJ

更新日期：2005-09-01 00:00:00

abstract：:Interaction between CD27 and its ligand CD70 provides a second signal for T-cell proliferation and tumour necrosis factor-alpha (TNF-alpha) production. Whereas CD27 is broadly expressed during T-cell development, expression of CD70 in vivo is restricted. To determine when CD27 CD70 interactions can occur in immune rea...

journal_title：Immunology

authors： Lens SM,Baars PA,Hooibrink B,van Oers MH,van Lier RA

更新日期：1997-01-01 00:00:00