Abstract:
:B lymphocyte-induced maturation protein-1 (Blimp-1), the transcription factor encoded by the gene Prdm1, plays a number of crucial roles in the adaptive immune system, which result in the maintenance of key effector functions of B- and T-cells. Emerging clinical data, as well as mechanistic evidence from mouse studies, have additionally identified critical functions of Blimp-1 in the maintenance of immune homeostasis by the mononuclear phagocyte (MNP) system. Blimp-1 regulation of gene expression affects various aspects of MNP biology, including developmental programmes such as fate decisions of monocytes entering peripheral tissue, and functional programmes such as activation, antigen presentation and secretion of soluble inflammatory mediators. The highly tissue-, subset- and state-specific regulation of Blimp-1 expression in MNPs suggests that Blimp-1 is a dynamic regulator of immune activation, integrating environmental cues to fine-tune the function of innate cells. In this review, we will discuss the current knowledge regarding Blimp-1 regulation and function in macrophages and dendritic cells.
journal_name
Immunologyjournal_title
Immunologyauthors
Ulmert I,Henriques-Oliveira L,Pereira CF,Lahl Kdoi
10.1111/imm.13249subject
Has Abstractpub_date
2020-12-01 00:00:00pages
303-313issue
4eissn
0019-2805issn
1365-2567journal_volume
161pub_type
杂志文章,评审相关文献
IMMUNOLOGY文献大全abstract::Three-week-old chickens were given sheep erythrocytes or bovine serum albumin intravenously. Seven days later their tears and saliva possessed low levels of antibody to those antigens. Concurrent infection with lentogenic Newcastle disease virus (NDV) caused a significant increase in transuded antibody in those fluids...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1976-07-01 00:00:00
abstract::The members of the tumour necrosis factor (TNF) superfamily of cytokines play important roles in the regulation of various immune-cell functions. Likewise, induction of cell death by apoptosis is indispensable for the normal functioning of the immune system. There are two major pathways of apoptosis induction. The int...
journal_title:Immunology
pub_type: 杂志文章,评审
doi:10.1111/j.1365-2567.2009.03058.x
更新日期:2009-06-01 00:00:00
abstract::Salmonella enterica serovar Typhimurium (S. typhimurium) causes a localized enteric infection and its elimination is dependent on a T helper type 1 immune response. However, the mechanism of the protective immune response against the pathogen in gut-associated lymphoid tissue (GALT) at an early stage of the infection ...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1111/j.1365-2567.2010.03310.x
更新日期:2010-11-01 00:00:00
abstract::Lipoprotein was isolated from tumour cells by sonication and ultracentrifugal flotation on KBr gradients. It contained H-2 antigen detectable by antibody binding and induced a primary or secondary cell-mediated cytotoxic response in vitro which was H-2 specific. In a syngeneic model only a secondary cell-mediated resp...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1979-12-01 00:00:00
abstract::Recent studies employing reverse transription-polymerase chain reaction (RT-PCR) have demonstrated the intrathymic presence of mRNA for various autoantigens, including thyroglobulin (Tg). Deliberations on the mechanisms of central tolerance usually assume that this approach detects intact mRNA transcripts that can be ...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1111/j.1365-2567.2005.02119.x
更新日期:2005-05-01 00:00:00
abstract::Some plasmacytomas produce myeloma proteins with known antibody specificities and the secretion of these proteins by individual tumour cells can be determined using haemolytic plaque assay. After a 3 day culture of mouse plasmacytoma cells in medium containing 10% normal mouse serum, the number of plaques was reduced ...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1980-10-01 00:00:00
abstract::Purified human and murine monocytes can be activated in vitro by human recombinant IL-2 to secrete tumour necrosis factor (TNF). TNF mRNA is detected within 4 h of addition of IL-2. Signal transduction does not appear to require expression of the Tac peptide of the IL-2 receptor. IL-2 does, however, induce Tac mRNA an...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1989-08-01 00:00:00
abstract::The expression of adhesion molecules on vascular endothelial cells determines the pattern of migration and extravasation of leucocytes in inflammation and immunity. Here we show that costimulation with CD40 ligand (CD40L) and interleukin (IL)-4 (or IL-13) gives rise to a unique pattern of adhesion molecule expression ...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1046/j.1365-2567.2000.00061.x
更新日期:2000-08-01 00:00:00
abstract::Random-bred TO mice have been selectively bred into two lines on the basis of the relative affinity (KR) of antibody produced to protein antigens, one line producing high and the other low KR antibody. After four generations of selective breeding the difference in KR between the two lines was highly significant (P les...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1975-09-01 00:00:00
abstract::We performed a genomic study combining single-cell mRNA differential display and RNA subtractive hybridization to elucidate CD8 T-cell quiescence/ignorance. By comparing actively maintained quiescent CD8 T cells from liver tumour tumour-infiltrating lymphocytes (TILs) with quiescent T cells at the single-cell level, w...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1111/j.1365-2567.2008.02926.x
更新日期:2009-05-01 00:00:00
abstract::Bovine tuberculosis, which persists as a residual level of infection in many European countries, has implications not only for the economy of farming communities but also for human health. The aim of this study was to identify a common mycobacterial antigen which was recognized in bovine tuberculosis and to characteri...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1046/j.1365-2567.1998.00449.x
更新日期:1998-03-01 00:00:00
abstract::The influence of intact influenza virus and purified detergent solubilized haemagglutinin (HA) subunits from these viruses on human natural killer (NK) cell activity was examined. Effector cells incubated with whole influenza virus for 18 hr initiated the production of alpha interferon which was associated with the en...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1984-08-01 00:00:00
abstract::Marginal zone (MZ) B cells are positioned within the spleen to capture blood-borne antigen and immune complexes and deliver them to follicular dendritic cells in the B-cell follicles. We show that within the spleens of aged mice antigen capture by MZ B cells, and their ability to shuttle between the follicle and MZ, w...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1111/imm.12737
更新日期:2017-07-01 00:00:00
abstract::We investigated the individual CD8+ populations with natural killer (NK) cell markers (NK-type T cell); CD56 single positive (CD56)-T cells, CD56/CD57 double positive (DP)-T cells and CD57 single positive (CD57)-T cells in the peripheral blood. All NK-type T-cell populations expressed CD122 and intermediate levels of ...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1046/j.1365-2567.2003.01575.x
更新日期:2003-02-01 00:00:00
abstract::Studies with gene-deficient and gnotobiotic mice have identified many host and microbial factors that contribute to induced colitis, but information on whether specific factors determine susceptibility under more physiological conditions is lacking. Using wild-type strains that differ in their IgA response but harbor ...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1111/imm.13091
更新日期:2019-09-01 00:00:00
abstract::In our efforts to identify products that might be used for active immunotherapy in human immunodeficiency virus (HIV) infection, we have studied synthetic peptides derived from the CD4 attachment site of gp120. Two peptides have emerged with particularly interesting properties. The first (B138) is linear and spans the...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1992-04-01 00:00:00
abstract::Rabbits immunized with complexes of denatured calf thymus DNA and methylated bovine serum albumin (MBSA) produced only IgM antibodies to denatured DNA, confirming the results of previous studies. In contrast, both IgM and IgG antibodies were induced by MBSA complexes of Trypanosoma brucei DNA. A similar response was o...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1976-05-01 00:00:00
abstract::Accumulating evidence indicates that B cells may undergo sequential rearrangements at the light chain loci, despite already expressing light chain receptors. This phenomenon may occur in the bone marrow and, perhaps, in germinal centers. As immunoglobulin (Ig)kappa light chains usually rearrange before Iglambda light ...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1046/j.1365-2567.2004.01902.x
更新日期:2004-07-01 00:00:00
abstract::Several functional parameters and surface markers were studied serially in rnu/rnu rats and compared to rnu/+ controls. Expressed as a percentage of labelled splenocytes, rnu/rnu animals had decreased W3/13 (P less than 0.01) and W3/25 (P less than 0.01) positive cells. Both W3/13 and W3/25 antigens peaked at Week 16 ...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1985-08-01 00:00:00
abstract::The effect of E. coli lipopolysaccharide (LPS) on the induction of both hapten-specific immunity and tolerance was studied in an in vivo system utilizing putative T-cell dependent (TD) or T-cell independent (TI) challenge antigens. The administration of LPS 1 day prior to challenge preempted the response of C3D2 mice ...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1979-11-01 00:00:00
abstract::High-density human B lymphocytes were prepared from tonsillar mononuclear cells by depletion of adherent cells and T lymphocytes, followed by discontinuous density gradient centrifugation. The B cells were analysed for the levels of expression of the CD25 (Tac) antigen marker by flow cytometry following culture with a...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1990-01-01 00:00:00
abstract::Oral tolerance promotes a generalized decrease in specific immune responsiveness to proteins previously encountered via the oral route. In addition, parenteral immunization with a tolerated protein also triggers a significant reduction in the primary responsiveness to a second unrelated antigen. This is generally expl...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1111/j.1365-2567.2008.02901.x
更新日期:2009-03-01 00:00:00
abstract::The aim of this study was to characterize the epitope specificity and the idiotype(s) of gp330-specific autoantibodies in active Heymann nephritis (HN). To study this, two monoclonal autoantibodies (mAb), 3D9B and 5B8C, derived from Lewis rats with HN, were generated. These antibodies bound to different epitopes on th...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1990-07-01 00:00:00
abstract::The suppression of immune responsiveness to heterologous antigenic stimulation during concurrent infection with Nematospiroides dubius was reproduced using soluble antigens derived from adult parasites. Immunosuppression appeared to be selective in that the administration of equivalent quantities of an irrelevant hete...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1984-04-01 00:00:00
abstract::Membrane attack complexes of complement occur around thyroid follicles in Graves' disease and Hashimoto's thyroiditis. The lytic potential of such complexes is controlled by membrane-bound and fluid phase regulators and we have investigated the role of these in autoimmune thyroid disease. By immunohistochemical staini...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1994-04-01 00:00:00
abstract::The humoral and mucosal immune responses to oral immunization with xenogeneic antibodies were studied using an animal model in which female rabbits were fed daily doses of the MOPC-315 murine IgA antibody, and were mated during the course of the feeding programme. Serum and colostrum samples were assayed for the prese...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1991-08-01 00:00:00
abstract::The IgG and IgA subclass distribution of anti-carbohydrate antibodies in normal and immunodeficient donors was investigated. In normal donors, the specific anti-dextran antibodies were mainly of the IgG2 and IgA2 subclass, although substantial amounts of antibodies could also be of the IgG1 subclass. In children, IgG1...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1985-04-01 00:00:00
abstract::Over the last few years, natural killer (NK) cells have been shown to express major histocompatibility complex (MHC) molecules recognizing receptors that are thought to function primarily as negative signalling receptors. Much attention has been focused on the NK cell receptors CD158a (EB6) and CD158b (GI 183), which ...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1046/j.1365-2567.1997.00374.x
更新日期:1997-12-01 00:00:00
abstract::Among their diverse roles as transcriptional regulators during development and cell fate specification, the RUNX transcription factors are best known for the parts they play in haematopoiesis. RUNX proteins are expressed throughout all haematopoietic lineages, being necessary for the emergence of the first haematopoie...
journal_title:Immunology
pub_type: 杂志文章,评审
doi:10.1111/imm.12535
更新日期:2015-12-01 00:00:00
abstract::We and others have established an important role for phosphoinositide-3 kinase gamma (PI3Kgamma) in the chemotactic responses of macrophages and neutrophils. The involvement of this lipid kinase in allergic inflammatory responses is, however, yet to be fully determined. Here we compare wild-type (WT) and PI3Kgamma(-/-...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1111/j.1365-2567.2008.02908.x
更新日期:2009-03-01 00:00:00