Abstract：
:Purified human and murine monocytes can be activated in vitro by human recombinant IL-2 to secrete tumour necrosis factor (TNF). TNF mRNA is detected within 4 h of addition of IL-2. Signal transduction does not appear to require expression of the Tac peptide of the IL-2 receptor. IL-2 does, however, induce Tac mRNA and Tac peptide expression on peripheral blood monocytes (PBM). In addition to these in vitro studies, PBM retrieved from IL-2-treated cancer patients and mice have been shown to have a greatly increased capacity for TNF production. These studies identify a pathway for macrophage activation by IL-2 both in vitro and in vivo. They also suggest a mechanism for some of the immunoregulatory and toxic effects of IL-2 based immunotherapy regimens.
journal_name
Immunologyjournal_title
Immunologyauthors
Economou JS,McBride WH,Essner R,Rhoades K,Golub S,Holmes EC,Morton DLsubject
Has Abstractpub_date
1989-08-01 00:00:00pages
514-9issue
4eissn
0019-2805issn
1365-2567journal_volume
67pub_type
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