Effect of age and maternal antibodies on the systemic and mucosal immune response after neonatal immunization in a porcine model.

abstract：:The nature of the Fc receptors for IgG subclasses displayed on the epithelium of the small intestine in neonatal rats was examined by comparing results gained from 125I-IgG binding studies using isolated enterocyte brush borders, and from experiments where in vivo transmission from the gut to the bloodstream was quant...

journal_title：Immunology

authors： Peppard JV,Jackson LE,Mackenzie NM

更新日期：1985-09-01 00:00:00

abstract：:The results presented in this paper demonstrate that a mouse IgM monoclonal antibody (T-80) recognizes an antigen on cells of the T-lymphocyte lineage of sheep. However, this antibody does not identify all T cells, as 10-20% of thymocytes and some peripheral-blood T cells are negative. T-80- thymocytes reside in the m...

journal_title：Immunology

authors： Miyasaka M,Heron I,Dudler L,Cahill RN,Forni L,Knaak T,Trnka Z

更新日期：1983-07-01 00:00:00

abstract：:The development of improved vaccines and vaccination strategies against Mycobacterium tuberculosis has been hindered by a limited understanding of the immune correlates of anti-tuberculosis protective immunity. Simple measurement of interferon-γ frequency or production per se does not provide adequate prediction of im...

journal_title：Immunology

authors： Kang H,Yuan Q,Ma H,Hu ZD,Han DP,Wu K,Lowrie DB,Fan XY

更新日期：2014-12-01 00:00:00

abstract：:In order to identify and characterize the sheep major histocompatibility complex (MHC) class II molecules, a panel of 19 monoclonal antibodies (mAb) has been raised following immunization of mice with a variety of class II antigen preparations. Antibodies were selected by ELISA using immunopurified sheep class II as a...

journal_title：Immunology

authors： Dutia BM,Hopkins J,Allington MP,Bujdoso R,McConnell I

更新日期：1990-05-01 00:00:00

abstract：:The level of circulating thymic factor (FTS) tested by its action on spleen rosette-forming cells from adult thymectomized mice, has been shown to be stable in young animals. This stability suggests a regulatory mechanism. An approach of this regulation has been attempted by disrupting the FTS level either by neonatal...

journal_title：Immunology

authors： Tubiana N,Dardenne M

更新日期：1979-02-01 00:00:00

abstract：:Pollen grains contain reduced nicotinamide adenine dinucleotide phosphate (NADPH) oxidases and in contact with mucosal surfaces generate superoxide anion (O2*-). In the presence of iron, O2*- may be converted to more reactive oxygen radicals, such as to H2O2 and/or *OH, which may augment antigen-induced airway inflamm...

journal_title：Immunology

authors： Kruzel ML,Bacsi A,Choudhury B,Sur S,Boldogh I

更新日期：2006-10-01 00:00:00

abstract：:Studies in long-term non-progressors (LTNP) have suggested that the quality of the CD8(+) response may involve protective human leucocyte antigen (HLA) class I alleles. However, studies examining the expansion ability of different functional CD8(+) T cells and their association with HLA class I alleles are lacking. LT...

journal_title：Immunology

authors： López M,Peris A,Soriano V,Lozano S,Vicario JL,Rallón NI,Restrepo C,Benito JM

更新日期：2011-11-01 00:00:00

abstract：:Binding of streptococcal antigen was compared between T8+ cells and monocytes (Mo) from DRw6+ and DRw6- subjects. Both T8+ cells and Mo from DRw6- subjects bind streptococcal antigen (SA) specifically and almost entirely at a concentration of 1000 ng per 0.1 ml. However, the DRw6+, T8+ cells bind SA at a concentration...

journal_title：Immunology

authors： Lehner T,Jones T

更新日期：1984-10-01 00:00:00

abstract：:Acute and chronic infusions of a lipophilic analogue of cyclic AP (dibutyryl cyclic AMP) into cannulated afferent lymphatics of popliteal lymph nodes of sheep have reduced the output of both small and blast lymphocytes into efferent lymph and have tended to reduce the volume of efferent lymph flow (collected by chroni...

journal_title：Immunology

authors： Moore TC,Lachmann PJ

更新日期：1982-11-01 00:00:00

abstract：:I have briefly reviewed the factors that motivated me to change my views about the existence and importance of suppressor/regulatory T cells and to devote the majority of my laboratory efforts to this newly revitalized area of immunologic research. I am optimistic that manipulation of regulatory T-cell function will s...

journal_title：Immunology

authors： Shevach EM

更新日期：2008-01-01 00:00:00

abstract：:Peripheral blood mononuclear cells (PBMC) from a patient suffering from the hyper IgE syndrome were used to generate phytohaemagglutinin (PHA)-expanded T-cell clones (all CD4+, CD8-, CD23-). A selection of the clones was tested for their ability to help IgE secretion by culturing with normal B cells in the presence of...

journal_title：Immunology

authors： Quint DJ,Bolton EJ,McNamee LA,Solari R,Hissey PH,Champion BR,MacKenzie AR,Zanders ED

更新日期：1989-05-01 00:00:00

abstract：:It is becoming increasingly clear that the T-cell-mediated immune response is important in many diseases. In this study, we used concanavalin A (Con A) -induced hepatitis to investigate the role of CD49a in the molecular and cellular mechanism of the T-cell-mediated immune response. We found that CD49a(-/-) mice had s...

journal_title：Immunology

authors： Chen Y,Peng H,Chen Y,Wei H,Sun R,Tian Z

更新日期：2014-03-01 00:00:00

abstract：:Bacterial superantigens bind to major histocompatibility complex (MHC) class II and subsequently activate both CD4+ and CD8+ T lymphocytes expressing certain T-cell receptor (TCR)-Vbeta chains. In response to superantigen exposure these subsets proliferate, produce large amounts of proinflammatory cytokines and in add...

journal_title：Immunology

authors： Sundstedt A,Grundström S,Dohlsten M

更新日期：1998-09-01 00:00:00

abstract：:Humans and other mammals coexist with a diverse array of microbes colonizing the intestine, termed the microflora. The relationship is symbiotic, with the microbes benefiting from a stable environment and nutrient supply, and the host gaining competitive exclusion of pathogens and continuously maintenance of the gut i...

journal_title：Immunology

authors： Zeuthen LH,Fink LN,Frokiaer H

更新日期：2008-02-01 00:00:00

abstract：:In order to analyse the molecular mechanism of lymphocyte activation defect in MRL/MP-lpr (MRL/1) mice, c-myc proto-oncogene expression was examined in MRL/1 lymph node cells stimulated by various agents. Since a transient increase of c-myc RNA in early hours is required for lymphocyte activation, detection of c-myc m...

journal_title：Immunology

authors： Koizumi T,Nakao Y,Matsui T,Katakami Y,Mihara K,Takahashi R,Maeda S,Sugiyama T,Fujita T

更新日期：1988-05-01 00:00:00

abstract：:We have previously shown that chlorpromazine (CPZ) inhibits tumour necrosis factor (TNF) production and protects against endotoxic shock in mice. In this paper we investigated the effect of pretreatment with CPZ, 4 mg/kg i.p. 30 min before, compared with dexamethasone (DEX; 3 mg/kg) on the induction of other endotoxin...

journal_title：Immunology

authors： Mengozzi M,Fantuzzi G,Faggioni R,Marchant A,Goldman M,Orencole S,Clark BD,Sironi M,Benigni F,Ghezzi P

更新日期：1994-06-01 00:00:00

abstract：:In many species, the rejection of liver allografts is milder than that of other organs. This is especially so in the rat where, without immunosuppressive treatment, liver grafts between certain strain combinations are accepted permanently, whereas skin, heart and renal allografts undergo acute rejection. Reliable surg...

journal_title：Immunology

authors： Kamada N

更新日期：1985-07-01 00:00:00

abstract：:The genes coding for the main molecules involved in the human immune system--immunoglobulins, human leucocyte antigen (HLA) molecules and killer-cell immunoglobulin-like receptors (KIR)--exhibit a very high level of polymorphism that reveals remarkable frequency variation in human populations. 'Genetic marker' (GM) al...

journal_title：Immunology

authors： Sanchez-Mazas A,Fernandez-Viña M,Middleton D,Hollenbach JA,Buhler S,Di D,Rajalingam R,Dugoujon JM,Mack SJ,Thorsby E

更新日期：2011-06-01 00:00:00

abstract：:The properties of IgA and IgG anti-gliadin antibodies from the serum of patients with coeliac disease have been compared. The antibodies were quantified by ELISA using microtitre plates coated with crude gliadin fractions. Their specificity was confirmed by immunoblotting. Heat-treated sera containing IgA antibodies s...

journal_title：Immunology

authors： Stewart WW,Kerr MA

更新日期：1991-08-01 00:00:00

abstract：:We have isolated, characterized and quantified the immunocompetent cells present in the extravascular hepatic compartment at various stages after Plasmodium yoelii malaria infection with sporozoites. Cytological analyses revealed a predominantly lymphoid population. In mice with a primary infection, the predominant ce...

journal_title：Immunology

authors： Faure P,Marussig M,Goossens P,Miltgen F,Mazier D

更新日期：1994-08-01 00:00:00

abstract：:This study demonstrated that the greater infectivity of stationary-phase promastigotes of Leishmania donovani is related to increased complement fixation on the parasite surface, resulting in increased binding to host mononuclear phagocytes (MPs) via complement type 3 receptors (CR3). The in vivo infectivity of log- a...

journal_title：Immunology

authors： Wozencraft AO,Blackwell JM

更新日期：1987-04-01 00:00:00

abstract：:Fas ligand (FasL) expression induces apoptosis of activated T cells and has been suggested as a strategy to inhibit graft rejection. Unfortunately, the use of FasL to confer 'immune privilege' in this setting has been hampered by the finding that it may also provoke a destructive granulocytic response. While the Fas/F...

journal_title：Immunology

authors： Dupont PJ,Warrens AN

更新日期：2007-01-01 00:00:00

abstract：:A soluble form of Fc epsilon RII/CD23 is spontaneously released from most lymphoblastoid cell lines established by the Epstein-Barr virus (EBV). Such a product was purified on an IgE-Sepharose column and its pyrogenic effect was investigated in rabbits. This preparation induced a monophasic fever in rabbits, with a pe...

journal_title：Immunology

authors： Ghaderi AA,Stanworth DR

更新日期：1991-08-01 00:00:00

abstract：:Class switch recombination (CSR) is a T-cell-dependent mechanism regulating isotype switching in activated mature B cells. Recently we showed that T-cell-independent CSRs occur spontaneously during B lymphopoiesis, but such cells are negatively selected by Fas signalling. In immunoglobulin mu-deficient mice, lack of F...

journal_title：Immunology

authors： Seagal J,Melamed D

更新日期：2004-06-01 00:00:00

abstract：:DNA breaks play an essential role in germinal centre B cells as intermediates to immunoglobulin class switching, a recombination process initiated by activation-induced cytidine deaminase (AID). Immunoglobulin gene hypermutation is likewise catalysed by AID but is believed to occur via single-strand DNA breaks. When i...

journal_title：Immunology

authors： Casellas R,Yamane A,Kovalchuk AL,Potter M

更新日期：2009-03-01 00:00:00

abstract：:Sodium penicillin was conjugated to sheep erythrocytes and optimal quantities, added to a 5% SRBC suspension, were determined for haemagglutination (12-5 mg/ml) and for haemolysis (50 mg/ml) using carp antibodies and carp complement. The epitope density on the BSA molecule was gradually increased, when increasing amou...

journal_title：Immunology

authors： Avtalion RR,Milgrom L

更新日期：1976-10-01 00:00:00

abstract：:Electron microscopic study of the events occurring at the cell membrane during reactive lysis by complement, showed that a foliaceous particle was formed at the C5b-7 stage, that enlarged to a particle with a variable number of arms at the C5b-8 stage. Up to this point, no typical complement lesions were found. At the...

journal_title：Immunology

authors： Dourmashkin RR

更新日期：1978-08-01 00:00:00

abstract：:It is now well accepted that sex hormones have immunoregulatory activity and may prevent exacerbations in multiple sclerosis during pregnancy. Our previous studies demonstrated that oestrogen (17β-oestradiol; E(2) ) protection against experimental autoimmune encephalomyelitis (EAE) is mediated mainly through oestrogen...

journal_title：Immunology

authors： Bodhankar S,Vandenbark AA,Offner H

更新日期：2012-12-01 00:00:00

abstract：:Allergic diseases are frequently exacerbated between midnight and early morning, suggesting a role for the biological clock. Mast cells (MC) and eosinophils are the main effector cells of allergic diseases and some MC-specific or eosinophil-specific markers, such as tryptase or eosinophil cationic protein, exhibit cir...

journal_title：Immunology

authors： Baumann A,Gönnenwein S,Bischoff SC,Sherman H,Chapnik N,Froy O,Lorentz A

更新日期：2013-12-01 00:00:00

abstract：:Lymphocyte activation requires signal transduction mediated by reversible phosphorylation. Changing profiles of phosphorylated intermediates relate to the progressive series of transduction pathways in cells moving from G0 to G1, and thereafter through the cell cycle. We have previously shown that transient inhibition...

journal_title：Immunology

authors： Richards FM,Milner J,Metcalfe S

更新日期：1992-08-01 00:00:00