Abstract：
:A soluble form of Fc epsilon RII/CD23 is spontaneously released from most lymphoblastoid cell lines established by the Epstein-Barr virus (EBV). Such a product was purified on an IgE-Sepharose column and its pyrogenic effect was investigated in rabbits. This preparation induced a monophasic fever in rabbits, with a peak response appearing 75 min after injection. Since IgE was found to be capable of abrogating such an effect, it is suggested that IgE might be involved in the control of the effectiveness of this soluble protein.
journal_name
Immunologyjournal_title
Immunologyauthors
Ghaderi AA,Stanworth DRkeywords:
subject
Has Abstractpub_date
1991-08-01 00:00:00pages
510-1issue
4eissn
0019-2805issn
1365-2567journal_volume
73pub_type
杂志文章相关文献
IMMUNOLOGY文献大全abstract：:The immunological basis for the production of autoantibodies characteristic of systemic lupus erythematosus (SLE) against a wide range of antigens remains obscure. The specificity of (NZB x NZW)F1 (BWF1) or MRL/Mp-lpr/lpr (MRL/lpr) mouse monoclonal antibodies (mAb) was examined by immunofluorescence, immunoblotting an...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1992-12-01 00:00:00
abstract：:The binding of 125I-BSA-anti-BSA immune complexes (IC) formed in the presence of complement (nascent IC) and those that reacted with complement after their formation (preformed IC) to human erythrocytes was studied. The effect of antigen-antibody ratios and serum dilutions on IC binding to red blood cells (RBC) were a...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1988-07-01 00:00:00
abstract：:Human β-defensin 3 (hBD-3) activates antigen-presenting cells through Toll-like receptors (TLRs) 1/2. Several TLR1/2 agonists have been identified but little is known about how they might differentially affect cellular activation. We compared the effects of hBD-3 with those of another TLR1/2 agonist, Pam(3) CSK(4) , i...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1111/j.1365-2567.2011.03475.x
更新日期：2011-10-01 00:00:00
abstract：:DNA breaks play an essential role in germinal centre B cells as intermediates to immunoglobulin class switching, a recombination process initiated by activation-induced cytidine deaminase (AID). Immunoglobulin gene hypermutation is likewise catalysed by AID but is believed to occur via single-strand DNA breaks. When i...
journal_title：Immunology
pub_type： 杂志文章,评审
doi：10.1111/j.1365-2567.2008.03050.x
更新日期：2009-03-01 00:00:00
abstract：:The haemolymph of the colonial ascidian Botrylloides leachii contains two haemagglutinins which have been termed HA-1 and HA-2 respectively. The HA-1 agglutinin is specific for guinea-pig erythrocytes, requires Ca2+ ions for its activity and has an apparent mol. wt. of about 200,000. It can be adsorbed by guinea-pig b...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1981-02-01 00:00:00
abstract：:Vitamin A and its active metabolite retinoic acid are essential for the development and function of many tissues including the immune system. The induction of mucosal homing receptors on T and B cells by mucosal dendritic cells (DC) depends on the presence of vitamin A. Recent studies indicate that also the differenti...
journal_title：Immunology
pub_type： 杂志文章,评审
doi：10.1111/imm.12228
更新日期：2014-05-01 00:00:00
abstract：:T helper type 17 (Th17) cells and regulatory T (Treg) cells are two distinct T-cell subsets with opposite effects on immune functions. While Th17 cells are a key effector in the immune response and play critical roles in the development of autoimmunity and inflammation, Treg cells orchestrate the overall immune respon...
journal_title：Immunology
pub_type： 杂志文章,评审
doi：10.1111/imm.12994
更新日期：2018-12-01 00:00:00
abstract：:CD4 and CD8 T-cell clones were generated using the Mx9 monoclonal antibody (mAb), which recognizes the V beta 8 T-cell receptor (TcR) gene family. The interaction of these clones with the Mx9 antibody was analysed and all were found to be specifically stimulated to proliferate by plastic-adherent Mx9. In the presence ...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1988-07-01 00:00:00
abstract：:Random-bred TO mice have been selectively bred into two lines on the basis of the relative affinity (KR) of antibody produced to protein antigens, one line producing high and the other low KR antibody. After four generations of selective breeding the difference in KR between the two lines was highly significant (P les...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1975-09-01 00:00:00
abstract：:The localization of Thy-1, MRC OX 2 and Ia antigens as defined by monoclonal antibodies MRC OX 7, MRC OX 2 and MRC OX 6 was determined by an indirect immunoperoxidase technique on cryostat sections of rat ovaries. Thy-1 antigen was present significantly in the theca interna of growing antral follicles. Developing corp...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1983-03-01 00:00:00
abstract：:Chemically cross-linked C-reactive protein (CRP) oligomers were prepared and characterized, and C1q binding and C activation were investigated. Purified human CRP was polymerized in the presence of both non-cleavable and cleavable cross-linking agents and further separated by Superose 12 analytical FPLC column chromat...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1991-12-01 00:00:00
abstract：:Endodontic infections are polymicrobial infections resulting in bone destruction and tooth loss. The host response to these infections is complex, including both innate and adaptive mechanisms. Osteopontin (OPN), a secreted, integrin-binding protein, functions in the regulation of immune responses and enhancement of l...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1111/j.1365-2567.2009.03159.x
更新日期：2010-01-01 00:00:00
abstract：:We have previously demonstrated that intranasal (i.n.) administration of the major encephalitogenic peptide, Ac1-9 of myelin basic protein (MBP), inhibited T-cell responsiveness in vitro and induced tolerance in the H-2u mouse model of experimental autoimmune encephalomyelitis (EAE). The peptide analogue Ac1-9[4Y] wit...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1046/j.1365-2567.1999.00795.x
更新日期：1999-06-01 00:00:00
abstract：:It is increasingly becoming clear that various immune cells are infected by the very pathogens that they are supposed to attack. Although many mechanisms for microbial entry exist, it appears that a common route of entry shared by certain bacteria, viruses and parasites involves cellular lipid-rich microdomains someti...
journal_title：Immunology
pub_type： 杂志文章,评审
doi：10.1046/j.1365-2567.2001.01173.x
更新日期：2001-01-01 00:00:00
abstract：:It is believed that self-reactive forbidden T-cell clones are generated by 'failure' of the pathway of T-cell differentiation in the thymus, if it is disturbed. We examined how such forbidden clones are generated under immunosuppressive conditions. Mice were treated with an injection of deoxyspergualin, FK506, or cycl...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1046/j.1365-2567.1997.00222.x
更新日期：1997-05-01 00:00:00
abstract：:In order to explore the role of glutathione in cell-mediated cytotoxicity, we have examined the effect of the sulphydryl-reactive and glutathione-depleting agent 2-cyclohexene-1-one on antibody-dependent cellular cytotoxicity, spontaneous cell-mediated cytotoxicity, and cell-mediated lympholysis by human peripheral bl...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1986-04-01 00:00:00
abstract：:Lipoprotein lipase (LPL) is the key enzyme in the metabolism of triglyceride-rich lipoproteins. The patterns of LPL mRNA expression and secretion of the enzyme have not yet been established in natural killer (NK) cells. We show in the present communication that CD3- CD16+ cells (NK cells) transcribe LPL mRNA, express ...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1994-10-01 00:00:00
abstract：:Thymocytes incubated with either ATP or GTP exhibit a brief period of enhanced DNA synthesis in contrast to the prolonged period of enhanced synthesis observed when thymocytes were incubated with concanavalin A. The cells responding to nucleotides represent a sub-population of theta antigen-bearing T cells comprising ...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1981-03-01 00:00:00
abstract：:Neutrophil migration inhibition factor from T lymphocytes (NIF-T) is produced in response to mitogens as the result of cellular interactions between T and B lymphocytes. The requirement for B-cell alloantigen in this interaction process was indicated by (1) collaboration between peripheral blood T cells with various B...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1980-04-01 00:00:00
abstract：:Neuropeptides can influence immune effector cell function at both systemic and mucosal immune sites. We examined the ability of substance P (SP) to modulate the natural killer (NK) activity of intestinal intraepithelial leucocytes (IEL). Yac-1 killing by IEL but not splenic cells was increased after either 18 hr prein...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1990-10-01 00:00:00
abstract：:A suppressive B-cell factor (SBF)-producing hybridoma termed TS-4.44 was established by fusion of B cells which possessed receptors for the Fc portion of IgG (FcR gamma + B cells) and thymidine kinase defective fibroblasts, 3T3-4E cells. The biological properties of hybridoma-produced SBF (Hyb-SBF) are almost the same...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1983-12-01 00:00:00
abstract：:Virus-specific cytotoxic T-cell (Tc) clones can lyse target cells in vitro in the presence of their specific peptide epitopes. The lytic potency of murine influenza nucleoprotein (NP)-specific Tc clones was investigated after observing that target cell killing was reduced in the presence of high (greater than 0.2 micr...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1990-06-01 00:00:00
abstract：:Studies with gene-deficient and gnotobiotic mice have identified many host and microbial factors that contribute to induced colitis, but information on whether specific factors determine susceptibility under more physiological conditions is lacking. Using wild-type strains that differ in their IgA response but harbor ...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1111/imm.13091
更新日期：2019-09-01 00:00:00
abstract：:In addition to macromolecular interactions that provide co-stimulation during antigen-presenting cell (APC) and CD4+ T-cell conjugation, covalent chemical events between specialized ligands have been implicated in T-cell co-stimulation. These take the form of transient Schiff base formation between carbonyls and amine...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1046/j.1365-2567.2001.01290.x
更新日期：2001-09-01 00:00:00
abstract：:We have previously presented indirect evidence that both specific immunosuppression and lymphocyte mitogenicity induced in mice by p36, a proteinaceous factor of virulence produced by porcine monocytes infected by African swine fever virus, were consistent with a Th2-driven response. Here we show: (1) Interleukin-4 (I...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1046/j.1365-2567.1999.00629.x
更新日期：1999-03-01 00:00:00
abstract：:The rat popliteal lymph node was studied from 1 hr to 8 days after the footpad injection of either sheep erythrocytes or syngeneic rat erythrocytes. The following were measured relative to the contralateral (unstimulated) lymph node: (i) blood flow; (ii) lymph node weight; (iii) influx of lymphocytes from the blood; (...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1981-09-01 00:00:00
abstract：:The endogenous cannabinoid system plays an important role in regulating the immune system. Modulation of endogenous cannabinoids represents an attractive alternative for the treatment of inflammatory disorders. This study investigated the effects of URB597, a selective inhibitor of fatty acid amide hydrolase (FAAH), t...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1111/j.1365-2567.2008.02838.x
更新日期：2008-10-01 00:00:00
abstract：:The intestinal lamina propria (LP) contains antigen-presenting cells with features of dendritic cells and macrophages, collectively referred to as mononuclear phagocytes (MNPs). Association of MNPs with the epithelium is thought to play an important role in multiple facets of intestinal immunity including imprinting M...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1111/imm.12801
更新日期：2017-12-01 00:00:00
abstract：:We have shown that human endothelial cells (EC) are protected against complement-mediated injury by the inducible expression of decay-accelerating factor (DAF). To understand further the importance of DAF regulation, we characterized EC DAF expression on murine EC in vitro and in vivo using a model of glomerulonephrit...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1046/j.1365-2567.2003.01733.x
更新日期：2003-10-01 00:00:00
abstract：:Experimental protocols have been devised to deliniate the importance of T-cell subsets in immunity to Moloney sarcoma virus-induced tumours using the surface antigens L3T4 and Lyt-2 as markers of helper and cytotoxic cells, respectively. Because the monoclonal antibodies used have been shown to deplete T-cell subsets ...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1987-07-01 00:00:00
