Schiff base-mediated co-stimulation primes the T-cell-receptor-dependent calcium signalling pathway in CD4 T cells.

abstract：:We have produced a mouse anti-rabbit Ia monoclonal antibody (MAb) that detects an isotypic determinant on all rabbit Ia molecules. This MAb precipitates three polypeptide chains with molecular weights of 28,000, 31,000 and 35,000, corresponding to the Ia beta, Ii and alpha chains, respectively. The anti-Ia MAb inhibit...

journal_title：Immunology

authors： Lobel SA,Knight KL

更新日期：1984-01-01 00:00:00

abstract：:The level of circulating thymic factor (FTS) tested by its action on spleen rosette-forming cells from adult thymectomized mice, has been shown to be stable in young animals. This stability suggests a regulatory mechanism. An approach of this regulation has been attempted by disrupting the FTS level either by neonatal...

journal_title：Immunology

authors： Tubiana N,Dardenne M

更新日期：1979-02-01 00:00:00

abstract：:Oral tolerance promotes a generalized decrease in specific immune responsiveness to proteins previously encountered via the oral route. In addition, parenteral immunization with a tolerated protein also triggers a significant reduction in the primary responsiveness to a second unrelated antigen. This is generally expl...

journal_title：Immunology

authors： Ramos GC,Rodrigues CM,Azevedo GM Jr,Pinho V,Carvalho CR,Vaz NM

更新日期：2009-03-01 00:00:00

abstract：:The Mycobacterium leprae and M. tuberculosis 10,000 MW heat-shock protein homologues of GroES have previously been identified as major immunogens for human T cells. We used synthetic peptides to characterize the determinants recognized by murine T cells. The findings suggest that, despite 90% sequence identity between...

journal_title：Immunology

authors： Chua-Intra B,Ivanyi J,Hills A,Thole J,Moreno C,Vordermeier HM

更新日期：1998-01-01 00:00:00

abstract：:The antibody response in rhino mice, which carry a mutant gene hrrh, to thymus-dependent (TD) or thymus-independent (TI) antigens was compared with that of phenotypically normal littermates. The magnitude of antibody response to TD antigens in rhino mice decreased as they grew up, whereas the antibody response to TI a...

journal_title：Immunology

authors： Takaoki M,Kawaji H

更新日期：1980-05-01 00:00:00

abstract：:The generation of effective immunity requires that antigen-specific T cells are activated, clonally expanded and ultimately eliminated by apoptosis. The involvement of CD95-mediated apoptosis in T-cell elimination is well established, but the conditions which regulate the death pathway under normal circumstances are s...

journal_title：Immunology

authors： Walker LS,McLeod JD,Boulougouris G,Patel YI,Ellwood CN,Hall ND,Sansom DM

更新日期：1999-12-01 00:00:00

abstract：:The defined antigen substrate spheres (DASS) system was employed for analysing reactions between solid state antibody or antigen and soluble immune complexes. Sepharose beads covalently coupled with ovalbumin were used to represent tumour cells and beads coupled with antibody against ovalbumin were used to represent a...

journal_title：Immunology

authors： Matthews N,de Kretser T,Nairn RC

更新日期：1975-06-01 00:00:00

abstract：:Factor B-like activity associated with human peripheral blood lymphocytes was first described by Halbwachs & Lachmann (1976), who employed a functional assay. In this present study, clones of B cells from patients with chronic lymphatic leukaemia (CLL) and lymphoblastoid 'Raji' cells were used. The surface of these ce...

journal_title：Immunology

authors： Woo P,Lachmann PJ

更新日期：1981-11-01 00:00:00

abstract：:Affinity-purified polyclonal anti-double-stranded DNA (anti-dsDNA) antibodies from patients with systemic lupus erythematosus (SLE) exert a cytostatic effect on cultured rat glomerular mesangial cells (MC). The cognate antigens expressed on the surface of MC have been proved to be acidic ribosomal phosphoproteins (P p...

journal_title：Immunology

authors： Sun KH,Liu WT,Tang SJ,Tsai CY,Hsieh SC,Wu TH,Han SH,Yu CL

更新日期：1996-03-01 00:00:00

abstract：:Nod-like receptors are a family of innate immune receptors that link cytosolic sensing of microbial and danger stimuli to the activation of immune responses. Two Nod-like receptor family members, Nod1 and Nod2, recognize bacterial peptidoglycan and activate immune responses via nuclear factor-κB (NF-κB) and mitogen-ac...

journal_title：Immunology

authors： Jeong YJ,Kang MJ,Lee SJ,Kim CH,Kim JC,Kim TH,Kim DJ,Kim D,Núñez G,Park JH

更新日期：2014-10-01 00:00:00

abstract：:It has been reported that, in early pregnancy in mice, there is an increase in the number of immunoglobulin-secreting cells in the lymph nodes which drain the uterus. This paper describes the results of further investigations provoked by interest in these early changes. Increases in the numbers of immunoglobulin-secre...

journal_title：Immunology

authors： Hancock RJ,Popham AM,Faruki S,Dresser DW

更新日期：1985-06-01 00:00:00

abstract：:T cells do not generally express Fc receptors (FcRs). However, we report here that C8166 cells, a human CD4+ T lymphoblastoid cell line, widely used in research into the human immunodeficiency virus type 1 (HIV-1), expressed CD64 (Fc gamma RI), CD32 (Fc gamma RII), and CD16 (Fc gamma RIII) on the plasma membrane as sh...

journal_title：Immunology

authors： McLain L,Dimmock NJ

更新日期：1997-01-01 00:00:00

abstract：:Using KOLT-2 monoclonal antibody (mAb) recognizing a 44,000 molecular weight (MW) T-cell activation antigen (CD28), we observed the co-expression of KOLT-2 (CD28) antigen and Tac (CD25) antigen, associated with a 55,000 MW chain of the interleukin-2 receptor (IL-2R) complex. IL-2R (p55), on several T-cell lines transf...

journal_title：Immunology

authors： Shindo T,Sugie K,Nakamura K,Tagaya Y,Maeda M,Uchiyama T,Sagawa K,Yokoyama M,Wada H,Hitomi S

更新日期：1990-09-01 00:00:00

abstract：:In general, the majority of bacteria are pre-inflammatory when injected in experimental animals. However, Mycobacterium leprae has no inflammatory effect when injected into mouse footpad, but using the delipidated mycobacteria we observed a mild significant increase in footpad oedema. Other mycobacteria, Mycobacterium...

journal_title：Immunology

authors： Moura AC,Mariano M

更新日期：1996-12-01 00:00:00

abstract：:The shedding and resynthesis of Fc, C3 receptors, and receptors binding SRBC has been studied in normal peripheral lymphocytes, in lymphocytes from CLL patients and in a Raji cell line during 4 h incubation at 37 degrees. During the first part of the incubation, an increased release of receptors was observed. The shed...

journal_title：Immunology

authors： Sármay G,István L,Gergely J

更新日期：1978-02-01 00:00:00

abstract：:Various strains of the murine mycoplasma M. neurolyticum have been shown to induce extensive blast transformation of mouse lymphocytes, comparable in strength to mitogenicity exerted by these mycoplasma species on rat lymphocytes. The data summarized in this report demonstrate that this mitogenic effect is non-specifi...

journal_title：Immunology

authors： Naot Y,Ginsburg H

更新日期：1978-04-01 00:00:00

abstract：:Animal models of rheumatoid arthritis (RA) have provided substantial insights into basic pathogenic mechanisms of chronic inflammatory arthritis and autoimmune disease in general. Of the variety of models reported, collagen-induced arthritis (CIA) has been the most characterized in terms of both its pathogenesis and i...

journal_title：Immunology

authors： Luross JA,Williams NA

更新日期：2001-08-01 00:00:00

abstract：:Invariant natural killer T (iNKT) cells are an innate population of T cells identified by the expression of an invariant T-cell receptor and reactivity to lipid-based antigens complexed with CD1d. They account for a small percentage of lymphocytes, but are extremely potent and play central roles in immunity to infecti...

journal_title：Immunology

authors： O'Keeffe J,Podbielska M,Hogan EL

更新日期：2015-08-01 00:00:00

abstract：:The effects of immune complex infusion on the clearance of antibody (R3/13)-coated and NEM-treated rat erythrocytes by the splenic component of the rat mononuclear phagocyte system (MPS) were investigated. Equivalence complexes of BSA-anti-BSA produced a significant delay in the clearance of the NEM cells (pre-infusio...

journal_title：Immunology

authors： Yousaf N,Howard JC,Williams BD

更新日期：1986-09-01 00:00:00

abstract：:Eosinophil function is regulated by several cytokines, including interleukin-3 (IL-3), IL-5 and granulocyte-macrophage colony-stimulating factor (GM-CSF). Culture of human eosinophils with IL-3 produced a marked, dose-dependent up-regulation of CR3 expression. This was maximal after 1 day in culture and dependent on p...

journal_title：Immunology

authors： Hartnell A,Kay AB,Wardlaw AJ

更新日期：1992-12-01 00:00:00

abstract：:Immunoglobulin G4 (IgG4) antibodies have been known for some time to be functionally monovalent. Recently, the structural basis for this monovalency has been elucidated: the in vivo exchange of IgG half-molecules (one H-plus one L-chain) among IgG4. This process results in bispecific antibodies that in most situations...

journal_title：Immunology

authors： Aalberse RC,Schuurman J

更新日期：2002-01-01 00:00:00

abstract：:The fluorescence-activated cell sorter and a rosette-depletion technique were used to separate rat spleen lymphocytes and BCG-activated lymphocytes into subpopulations with and without the antigens defined by W3/13, W3/23 and OX8 monoclonal antibodies. The resultant populations were then tested for natural killer (NK)...

journal_title：Immunology

authors： Cantrell DA,Robins RA,Brooks CG,Baldwin RW

更新日期：1982-01-01 00:00:00

abstract：:Synthesis of interferon (IFN)-gamma by natural killer (NK) cells is an important pro-inflammatory event with interleukin (IL)-12 and IL-18 playing major inductive roles. However, other temporal events are likely to regulate such processes and as prostaglandin E2 (PGE2) is ubiquitous during inflammation this study test...

journal_title：Immunology

authors： Walker W,Rotondo D

更新日期：2004-03-01 00:00:00

abstract：:Vitamin A and its active metabolite retinoic acid are essential for the development and function of many tissues including the immune system. The induction of mucosal homing receptors on T and B cells by mucosal dendritic cells (DC) depends on the presence of vitamin A. Recent studies indicate that also the differenti...

journal_title：Immunology

authors： Beijer MR,Kraal G,den Haan JM

更新日期：2014-05-01 00:00:00

abstract：:The activation of macrophages by various stimuli leading to chemotactic migration and phagocytosis is known to be mediated by an increase in intracellular Ca2+ concentration ([Ca2+]i). We measured changes in [Ca2+]i using a Ca2+ imaging method in individual human macrophages differentiated from freshly prepared periph...

journal_title：Immunology

authors： Oshimi Y,Miyazaki S,Oda S

更新日期：1999-10-01 00:00:00

abstract：:The Ager assay was adapted to a porcine lymphocyte-rat high endothelial cell (HEC) system. Using this in vitro assay, the role of porcine CD44 in lymphocyte binding to HEC was examined. The results show that the presence of soluble CD44 molecules did not inhibit the binding of porcine lymphocytes to the cultured rat H...

journal_title：Immunology

authors： Yang H,Binns RM

更新日期：1993-07-01 00:00:00

abstract：:CD27 is a T-cell surface antigen expressed on the majority of peripheral T cells and belongs to a newly defined receptor family including the low-affinity nerve growth factor receptor, tumour necrosis factor (TNF) receptors, the B-cell activation antigen CD40, and the Fas antigen. Although the function of CD27 has not...

journal_title：Immunology

authors： Sugita K,Dasgupta JD,Nojima Y,Agematsu K,Schlossman SF,Morimoto C

更新日期：1993-10-01 00:00:00

abstract：:Adoptive transfer of anti-Listeria resistance by Listeria-immune spleen T cells was markedly reduced by pretreatment of the cells with monoclonal anti-Lyt 2.2 and complement (Lyt 2+C); pretreatment of cells with monoclonal anti-L3T4 and complement (L3T4+C) had a lesser effect on their ability to transfer resistance. L...

journal_title：Immunology

authors： Czuprynski CJ,Brown JF

更新日期：1987-02-01 00:00:00

abstract：:Pollen grains contain reduced nicotinamide adenine dinucleotide phosphate (NADPH) oxidases and in contact with mucosal surfaces generate superoxide anion (O2*-). In the presence of iron, O2*- may be converted to more reactive oxygen radicals, such as to H2O2 and/or *OH, which may augment antigen-induced airway inflamm...

journal_title：Immunology

authors： Kruzel ML,Bacsi A,Choudhury B,Sur S,Boldogh I

更新日期：2006-10-01 00:00:00

abstract：:The role of gut-derived CD4+ T cells in clearance of Pseudomonas aeruginosa from the lung was studied by cell transfer experiments. Mesenteric lymph node cells from unimmunized rats, or rats orally immunized with either killed P. aeruginosa or Helicobacter pylori, were transferred to naive rats which were subsequently...

journal_title：Immunology

authors： Dunkley ML,Clancy RL,Cripps AW

更新日期：1994-11-01 00:00:00