The genetic and immunopathological processes underlying collagen-induced arthritis.

Abstract:

:Animal models of rheumatoid arthritis (RA) have provided substantial insights into basic pathogenic mechanisms of chronic inflammatory arthritis and autoimmune disease in general. Of the variety of models reported, collagen-induced arthritis (CIA) has been the most characterized in terms of both its pathogenesis and its underlying immunological basis. Collagen-induced arthritis has also been the model of choice in terms of testing potential new therapeutic agents for the treatment of human RA. Nevertheless, the complex nature of the balance between T-cell cytokines and the chronic inflammatory processes is only recently becoming clear. This review focuses on these developments, highlighting their implications for our understanding of RA and for the use of CIA as a suitable animal model.

journal_name

Immunology

journal_title

Immunology

authors

Luross JA,Williams NA

doi

10.1046/j.1365-2567.2001.01267.x

keywords:

subject

Has Abstract

pub_date

2001-08-01 00:00:00

pages

407-16

issue

4

eissn

0019-2805

issn

1365-2567

pii

imm1267

journal_volume

103

pub_type

杂志文章,评审
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    authors: Holt PG,Vines J,Britten D

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    authors: Ali-Khan Z

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  • A Role For Mitochondria In Antigen Processing And Presentation.

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