Abstract:
:Animal models of rheumatoid arthritis (RA) have provided substantial insights into basic pathogenic mechanisms of chronic inflammatory arthritis and autoimmune disease in general. Of the variety of models reported, collagen-induced arthritis (CIA) has been the most characterized in terms of both its pathogenesis and its underlying immunological basis. Collagen-induced arthritis has also been the model of choice in terms of testing potential new therapeutic agents for the treatment of human RA. Nevertheless, the complex nature of the balance between T-cell cytokines and the chronic inflammatory processes is only recently becoming clear. This review focuses on these developments, highlighting their implications for our understanding of RA and for the use of CIA as a suitable animal model.
journal_name
Immunologyjournal_title
Immunologyauthors
Luross JA,Williams NAdoi
10.1046/j.1365-2567.2001.01267.xkeywords:
subject
Has Abstractpub_date
2001-08-01 00:00:00pages
407-16issue
4eissn
0019-2805issn
1365-2567pii
imm1267journal_volume
103pub_type
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