Neonatal thymus grafts. I. Studies on the regulation of the level of circulating thymic factor (FTS).

Abstract:

:The level of circulating thymic factor (FTS) tested by its action on spleen rosette-forming cells from adult thymectomized mice, has been shown to be stable in young animals. This stability suggests a regulatory mechanism. An approach of this regulation has been attempted by disrupting the FTS level either by neonatal thymus grafting in adult normal and thymectomized animals, or by injections of synthetic thymic factor into normal, thymectomized mice, grafted or ungrafted. In all cases, after an initial increase over the normal value, FTS levels returned close to the previous range, indicating the existence of some homeostatic mechanism of FTS secretion.

journal_name

Immunology

journal_title

Immunology

authors

Tubiana N,Dardenne M

subject

Has Abstract

pub_date

1979-02-01 00:00:00

pages

207-13

issue

2

eissn

0019-2805

issn

1365-2567

journal_volume

36

pub_type

杂志文章