Abstract:
:The level of circulating thymic factor (FTS) tested by its action on spleen rosette-forming cells from adult thymectomized mice, has been shown to be stable in young animals. This stability suggests a regulatory mechanism. An approach of this regulation has been attempted by disrupting the FTS level either by neonatal thymus grafting in adult normal and thymectomized animals, or by injections of synthetic thymic factor into normal, thymectomized mice, grafted or ungrafted. In all cases, after an initial increase over the normal value, FTS levels returned close to the previous range, indicating the existence of some homeostatic mechanism of FTS secretion.
journal_name
Immunologyjournal_title
Immunologyauthors
Tubiana N,Dardenne Msubject
Has Abstractpub_date
1979-02-01 00:00:00pages
207-13issue
2eissn
0019-2805issn
1365-2567journal_volume
36pub_type
杂志文章相关文献
IMMUNOLOGY文献大全abstract::Chloroquine treatment of antigen-presenting cells (APC) was explored as a tool to investigate the processing pathway for major histocompatibility complex (MHC) class II-restricted presentation of the endogenous secreted hen egg lysozyme (HEL) and transmembrane measles virus haemagglutinin (HA). A 72-hr pretreatment of...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1993-12-01 00:00:00
abstract::Human cells are relatively resistant to lysis by the homologous complement system. Here we describe the mechanism of action of a recently discovered and widely distributed 18,000-20,000 molecular weight (MW) membrane glycoprotein (CD59), which appears to act as a major protective element against complement-mediated ly...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1990-09-01 00:00:00
abstract::The mechanisms of action and the nature of the co-operating cells (CC) controlling human T-lymphocyte-colony formation were investigated. Media conditioned by PHA-stimulated blood mononuclear cells (MC) were tested for their capacity to induce T-colony formation in the effluent cell population, obtained after anti (Fa...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1982-02-01 00:00:00
abstract::Urokinase-type plasminogen activator (u-PA), tumour necrosis factor-alpha (TNF-alpha) and interleukin-1 (IL-1) activities were measured for highly purified human monocytes cultured for 18 hr with recombinant human interleukin-3 (IL-3). IL-3 alone stimulated monocyte u-PA activity, but not TNF-alpha or IL-1 activity. H...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1990-09-01 00:00:00
abstract::A technique is reported here for the quantitative extraction of live cells from the lung interstitium; it involves the incubation of slices of perfused lung in a mixture containing optimal concentrations of collagenase, DNAse, and fetal calf serum, followed by the simultaneous recovery and fractionation of cells relea...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1985-01-01 00:00:00
abstract::In the study described here, the effect of human tears and purified lactoferrin was investigated on the deposition of complement components on solid-phase bound immune complexes. After incubating immune complexes with fresh normal human serum, the deposition of complement components (C3, C4 and C5) was measured with a...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1985-03-01 00:00:00
abstract::The secondary humoral response evoked in W/Fu rats by the weakly immunogenic soluble Gross cell surface antigen (GCSAa) extracted from the syngeneic (C58NT)D lymphoma can be enhanced when GCSAa is presented in liposomes, and this requires the antigen to be strongly associated with the phospholipid bilayers. In order t...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1986-07-01 00:00:00
abstract::A superantigen (Streptococcus pyogenes mitogen-2; SPM-2) that stimulates human helper T cells bearing unique types of variable domains of T-cell receptor beta-chain (TCR V beta) was isolated from the culture supernatant of S. pyogenes strain T12. The active molecule isolated by diethylaminoethyl (DEAE)-cellulose chrom...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1046/j.1365-2567.1997.00277.x
更新日期:1997-07-01 00:00:00
abstract::We undertook a search for cytokine-inducible molecules present on brain endothelium and which are involved in the control of lymphocyte adhesion. We screened 39 monoclonal antibodies (mAb) against rat brain endothelium in vitro, and identified five recognizing cytokine-inducible molecules. None of the 39 antibodies bl...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1995-03-01 00:00:00
abstract::The cytokine interleukin-12 (IL-12) is essential for resistance to Trypanosoma cruzi infection because it stimulates the synthesis of interferon-gamma (IFN-gamma), a major activator of the parasiticidal effect of macrophages. A less studied property of IL-12 is its ability to amplify the proliferation of T or natural ...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1046/j.1365-2567.2001.01311.x
更新日期:2001-11-01 00:00:00
abstract::We have produced a mouse anti-rabbit Ia monoclonal antibody (MAb) that detects an isotypic determinant on all rabbit Ia molecules. This MAb precipitates three polypeptide chains with molecular weights of 28,000, 31,000 and 35,000, corresponding to the Ia beta, Ii and alpha chains, respectively. The anti-Ia MAb inhibit...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1984-01-01 00:00:00
abstract::It has been reported that, in early pregnancy in mice, there is an increase in the number of immunoglobulin-secreting cells in the lymph nodes which drain the uterus. This paper describes the results of further investigations provoked by interest in these early changes. Increases in the numbers of immunoglobulin-secre...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1985-06-01 00:00:00
abstract::The migration of leucocytes into tissues is a process mediated by leucocyte endothelial interactions, in which adhesion receptors play a crucial role. Recently, it was found that 80-90% of T cells in inflammatory skin diseases were reactive to the monoclonal antibody (mAb) HECA-452+ in contrast to inflamed non-cutaneo...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1994-03-01 00:00:00
abstract::We hypothesized that the addition of polymer to the surface of liposome/DNA complexes may potentially enhance in vivo delivery of plasmid DNA to antigen-presenting cells and thereby facilitate enhanced immune responses to encoded protein. BALB/c mice were immunized subcutaneously or intramuscularly three times with a ...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1046/j.1365-2567.2002.01448.x
更新日期:2002-07-01 00:00:00
abstract::The contribution of B7 molecules to the induction and maintenance of the T-cell response to the human pathogenic fungus Cryptococcus neoformans was investigated. T-cell activation by C. neoformans was regulated by B7 molecules. This costimulatory signal was necessary for initiation and maintenance of the T-cell respon...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1046/j.1365-2567.1999.00853.x
更新日期:1999-09-01 00:00:00
abstract::Infection of susceptible mice with murine cytomegalovirus (MCMV) induces persistent inflammation, and the production of autoantibodies reactive with large numbers of proteins from all major organs. However the roles of polyclonal B-cell activation, autoreactive T-helper cells and host-virus cross-reactions in these ph...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1993-01-01 00:00:00
abstract::Attempts were made to break the tolerance of lymph node B cells to deaggregated human gamma globulin. Using allotype-congenic mice, lymph node cells from virgin or tolerant (5 mg) CBA/Igb donors were transferred tonormal CBA/Iga recipients and the proportion of responding donor B cells estimated 1 and 13 days later. T...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1977-11-01 00:00:00
abstract::We examined whether protein-calorie (PC) and vitamin A (VA) deficiencies altered the intestinal localization of mesenteric lymph node (MLN) lymphoblasts using an adoptive lymphocyte transfer method. MLN cells from donor rats were labelled in vitro with [125I]-deoxyuridine and injected i.v. into various recipients. Twe...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1982-01-01 00:00:00
abstract::The kinetics of ingestion and degradation of guinea-pig IgG2-containing soluble immune complexes by guinea-pig macrophages and neutrophils have been compared and aspects of the biochemical control of these events in neutrophils have been investigated using a selection of inhibitors. Differences were observed between t...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1985-04-01 00:00:00
abstract::The in vitro frequency and proliferative capacity of B cells and B-cell precursors in old mice was assessed. The mitogenic response to the B-cell mitogens lipopolysaccharide (LPS) and dextran sulphate decline later and at a slower rate than the T-cell response to phytohaemagglutinin and concanavalin A. The response to...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1979-06-01 00:00:00
abstract::We have shown that human endothelial cells (EC) are protected against complement-mediated injury by the inducible expression of decay-accelerating factor (DAF). To understand further the importance of DAF regulation, we characterized EC DAF expression on murine EC in vitro and in vivo using a model of glomerulonephrit...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1046/j.1365-2567.2003.01733.x
更新日期:2003-10-01 00:00:00
abstract::The purpose of this study was to investigate the effect of cyclophosphamide (CY) and 6-mercaptopurine (6-MP) on the production of the two IgG antibody subclasses in guinea-pigs. Following the intradermal application of dinitrophenylated bovine gamma globulin (DNP20-BGG) emulsified in Freund's incomplete adjuvant (FIA)...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1981-09-01 00:00:00
abstract::The induction of proliferation of murine splenocytes by lipopolysaccharide (LPS) of Shigella dysenteriae type 1 and its polysaccharide (PS) and lipid A fractions was investigated. The LPS-induced proliferation reached a maximum at a concentration of 30 ng/ml. The PS and lipid A induced proliferation of murine splenocy...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1995-02-01 00:00:00
abstract::Both lipopolysaccharide (LPS) and phorbol 12-myristate 13-acetate (PMA) impeded monocyte to macrophage differentiation with respect to typical phenotypic modulation and certain phagocyte-related processes. The down-regulation of the porcine monocyte marker SWC1, and up-regulation of the SWC9 macrophage marker were ret...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1046/j.1365-2567.2001.01266.x
更新日期:2001-08-01 00:00:00
abstract::Polystyrene surfaces coated with proteins at alkaline pH were found to be useful to investigate the stimulation of neutrophils independently of phagocytosis. Human neutrophils, when exposed to appropriate stimuli, release superoxide anion (O2-). We have measured superoxide dismutase-inhibitable cytochrome c reduction ...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1978-10-01 00:00:00
abstract::Co-expression of EP2 and EP3 subtypes of prostaglandin E2 (PGE2) receptors (R) by U937 human monocytic cells permitted comparative studies of desensitization of each subtype. Specific binding of [3H]PGE2 to membranes of U937 cells showed a Kd of 2.9 +/- 0.3 nM (mean +/- SEM) and a Bmax of 40.5 +/- 1.0 fmol/mg protein,...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1995-12-01 00:00:00
abstract::Studies have demonstrated that the anti-tumour effect of natural killer (NK) cells is successful for patients with several cancers. Although interleukin-32 (IL-32) is endogenously expressed in NK cells, cytolytic function of NK cells against cancer cells has not been fully demonstrated. In the present study, we found ...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1111/j.1365-2567.2011.03513.x
更新日期:2012-01-01 00:00:00
abstract::Lymphocytes are heterogeneous with respect to their life-span. Typical B cells, bearing on their membranes immunoglobulin receptors, easily detectable by immunofluorescence, belong mainly to the long-lived population: this can be observed using combined autoradiography and immunofluorescence. However, when primed mice...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1975-05-01 00:00:00
abstract::It has recently been shown that factors in addition to interleukin-2 (IL-2) are required for the proliferation or differentiation of at least some murine T-cell lines. We have previously shown that conditioned medium from human mononuclear cells stimulated with phorbol ester and staphylococcal enterotoxin A is superio...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1986-09-01 00:00:00
abstract::Various methods for measuring monocyte numbers and function in human blood are compared. The assays used were: phagocytosis of antibody-sensitized sheep red cells; staining for diffuse non-specific esterase activity; capacity to adhere to polystyrene and ability to lyse human A1 red cells sensitized with allogeneic an...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1977-12-01 00:00:00