Abstract：
:The in vitro frequency and proliferative capacity of B cells and B-cell precursors in old mice was assessed. The mitogenic response to the B-cell mitogens lipopolysaccharide (LPS) and dextran sulphate decline later and at a slower rate than the T-cell response to phytohaemagglutinin and concanavalin A. The response to precursor B-cell mitogen dextran sulphate was not depressed in the bone marrow of aging mice. In addition, the dose response and kinetics of LPS and mercaptoethanol stimulated B-cell colony formation in agar was identical in spleen cells from young and old mice. These results indicate that the intrinsic proliferative capacity of B cells from old mice is normal.
journal_name
Immunologyjournal_title
Immunologyauthors
Duwe AK,Roder JC,Singhal SKsubject
Has Abstractpub_date
1979-06-01 00:00:00pages
293-9issue
2eissn
0019-2805issn
1365-2567journal_volume
37pub_type
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