Abstract：
:The molecular characteristics of a serum IL-2 inhibitor were determined by fractionating active sera from normal and malaria-infected mice, and assaying inhibitory activity in blocking production and expression of IL-2 activity. Using isoelectric focusing and ion exchange chromatography, the activity resolved in a single peak (pI = 6.2). HPLC gel filtration resolved two peaks of activity (50,000 and 25,000 MW) which are probably related. The molecule is precipitated by 50% saturated ammonium sulphate, and is destroyed by heating above 56 degrees or by acidification below pH 4.
journal_name
Immunologyjournal_title
Immunologyauthors
Male D,Lelchuk R,Curry S,Pryce G,Playfair JHsubject
Has Abstractpub_date
1985-09-01 00:00:00pages
119-25issue
1eissn
0019-2805issn
1365-2567journal_volume
56pub_type
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