Caspase-3-dependent phagocyte death during systemic Salmonella enterica serovar Typhimurium infection of mice.

Abstract:

:Growth of Salmonella enterica in mammalian tissues results from continuous spread of bacteria to new host cells. Our previous work indicated that infective S. enterica are liberated from host cells via stochastic necrotic burst independently of intracellular bacterial numbers. Here we report that liver phagocytes can undergo apoptotic caspase-3-mediated cell death in vivo, with apoptosis being a rare event, more prevalent in heavily infected cells. The density-dependent apoptotic cell death is likely to constitute an alternative mechanism of bacterial spread as part of a bet-hedging strategy, ensuring an ongoing protective intracellular environment in which some bacteria can grow and persist.

journal_name

Immunology

journal_title

Immunology

authors

Grant AJ,Sheppard M,Deardon R,Brown SP,Foster G,Bryant CE,Maskell DJ,Mastroeni P

doi

10.1111/j.1365-2567.2008.02814.x

subject

Has Abstract

pub_date

2008-09-01 00:00:00

pages

28-37

issue

1

eissn

0019-2805

issn

1365-2567

pii

IMM2814

journal_volume

125

pub_type

杂志文章