Increased infectivity of stationary-phase promastigotes of Leishmania donovani: correlation with enhanced C3 binding capacity and CR3-mediated attachment to host macrophages.

abstract：:FTY720, a novel immunosuppressant, sequesters circulating mature lymphocytes, especially T cells, within lymph nodes and Peyer's patches by accelerating lymphocyte homing, and thereby causes lymphocyte depletion in the blood. The FTY720-induced acceleration of lymphocyte homing appears to be mediated by lymphocyte hom...

journal_title：Immunology

authors： Yanagawa Y,Masubuchi Y,Chiba K

更新日期：1998-12-01 00:00:00

abstract：:There is increasing evidence that primitive progenitors migrate from the bone marrow (BM) via the peripheral circulation to tissue sites where they undergo in situ differentiation to provide a continued source of effector cells, such as eosinophils, during an allergic inflammatory response. To study mechanisms of prog...

journal_title：Immunology

authors： Sehmi R,Dorman S,Baatjes A,Watson R,Foley R,Ying S,Robinson DS,Kay AB,O'Byrne PM,Denburg JA

更新日期：2003-08-01 00:00:00

abstract：:Thymocytes expressing self-reactive T-cell receptors (TCR) are eliminated in the thymus through a TCR-mediated signal. This cell death signal (negative selection) generates nuclear morphological change and DNA fragmentation in thymocytes. However, the pathway leading to DNA fragmentation of thymocytes following TCR en...

journal_title：Immunology

authors： Nagata T,Kishi H,Liu QL,Matsuda T,Imanaka T,Tsukada K,Kang D,Muraguchi A

更新日期：2002-04-01 00:00:00

abstract：:To assess the role of the macrophage scavenger receptor type A (SRA) in immune activation by CpG DNA, cytokine induction and DNA uptake were tested in vitro and in vivo using SRA knockout (SRA-/-) and wild type (WT) mice. As a source of CpG DNA, Escherichia coli DNA (EC DNA) and a 20-mer phosphorothioate oligodeoxynuc...

journal_title：Immunology

authors： Zhu FG,Reich CF,Pisetsky DS

更新日期：2001-06-01 00:00:00

abstract：:Canine cutaneous histiocytoma is a benign epidermal neoplasm of Langerhans cell origin, which usually displays spontaneous regression. Based on the degree of lymphocytic infiltration, 30 histiocytomas were classified into four groups representing different stages of tumour regression. To elucidate further the mechanis...

journal_title：Immunology

authors： Kaim U,Moritz A,Failing K,Baumgärtner W

更新日期：2006-08-01 00:00:00

abstract：:Gangliosides are known to be actively shed from tumour cell membranes, and increased levels of circulating gangliosides may cause tumour-induced T-lymphocyte immunosuppression in vivo by interfering with the actions of interleukin-2 (IL-2). We have investigated the effect of gangliosides on the interaction of IL-2 wit...

journal_title：Immunology

authors： Chu JW,Sharom FJ

更新日期：1993-05-01 00:00:00

abstract：:Thoracic duct lymphocytes (TDL) from (AS2 x AS)F1 rats previously injected with human serum albumin (HSA) were transferred to 900 r irradiated syngeneic recipients which were challenged with various doses of soluble HSA (s-HSA). TDL from partially tolerant rats, which were deficient in high avidity B cells, produced a...

journal_title：Immunology

authors： Bell EB,Shand FL

更新日期：1977-10-01 00:00:00

abstract：:Cytokines and their receptors represent key targets for therapeutic intervention. Ligands are being used to supplement cell numbers that become depleted as a result of disease (organ failure, infection) or subsequent disease treatments (i.e. chemotherapy). Conversely, the inhibition of target cell binding by cytokines...

journal_title：Immunology

authors： Sivakumar PV,Foster DC,Clegg CH

更新日期：2004-06-01 00:00:00

abstract：:CD4 and CD8 T-cell clones were generated using the Mx9 monoclonal antibody (mAb), which recognizes the V beta 8 T-cell receptor (TcR) gene family. The interaction of these clones with the Mx9 antibody was analysed and all were found to be specifically stimulated to proliferate by plastic-adherent Mx9. In the presence ...

journal_title：Immunology

authors： De Berardinis P,Londei M,Carrel S,Feldmann M

更新日期：1988-07-01 00:00:00

abstract：:Bone-marrow-derived macrophages are divided into two phenotypically and functionally distinct subsets, M1 and M2 macrophages. Recently, it was shown that adoptive transfer of M2-polarized peritoneal macrophages reduced the severity of experimental colitis in mice. However, it is still unclear whether peritoneal macrop...

journal_title：Immunology

authors： Oishi S,Takano R,Tamura S,Tani S,Iwaizumi M,Hamaya Y,Takagaki K,Nagata T,Seto S,Horii T,Osawa S,Furuta T,Miyajima H,Sugimoto K

更新日期：2016-11-01 00:00:00

abstract：:Free malarial merozoites isolated from in vitro cultures of P. knowlesi and emulsified with Freund's complete (FCA) or incomplete (FIA) adjuvant were used to vaccinate twelve Rhesus monkeys against the uniformly lethal infection caused by P. knowlesi. Initial challenge of six monkeys with the same parasite variant as ...

journal_title：Immunology

authors： Mitchell GH,Butcher GA,Cohen S

更新日期：1975-08-01 00:00:00

abstract：:The activation of macrophages by various stimuli leading to chemotactic migration and phagocytosis is known to be mediated by an increase in intracellular Ca2+ concentration ([Ca2+]i). We measured changes in [Ca2+]i using a Ca2+ imaging method in individual human macrophages differentiated from freshly prepared periph...

journal_title：Immunology

authors： Oshimi Y,Miyazaki S,Oda S

更新日期：1999-10-01 00:00:00

abstract：:Antibody-dependent cellular cytotoxicity (ADCC) and Fc receptor-mediated phagocytosis were determined with human monocytes, monocyte-derived macrophages and activated macrophages, using rabbit IgG-covered sheep red blood cells (EAs) and anti-D-treated human erythrocytes (EAhu) as target cells. Monocyte and macrophage-...

journal_title：Immunology

authors： Rüegg SJ,Jungi TW

更新日期：1988-03-01 00:00:00

abstract：:B-lymphocyte maturation is considered to be independent of the thymus. However, there is circumstantial evidence suggesting that it may be impaired in nude animals that lack the thymus. Our study shows that the proportion of immature B-lymphocyte subsets (CD90(high) IgM(high) and CD90(high) IgM(low)) was significantly...

journal_title：Immunology

authors： Milićević NM,Nohroudi K,Milićević Z,Hedrich HJ,Westermann J

更新日期：2005-11-01 00:00:00

abstract：:The binding of 125I-BSA-anti-BSA immune complexes (IC) formed in the presence of complement (nascent IC) and those that reacted with complement after their formation (preformed IC) to human erythrocytes was studied. The effect of antigen-antibody ratios and serum dilutions on IC binding to red blood cells (RBC) were a...

journal_title：Immunology

authors： Varga L,Thiry E,Füst G

更新日期：1988-07-01 00:00:00

abstract：:Treatment of patients with septic shock using monoclonal antibodies (mAbs) to endotoxin is still controversial. Clinical trials of E5, one of the mAbs directed against the lipid A moiety of lipopolysaccharide (LPS), are currently in progress. The mechanisms of action of this, and other antibodies under clinical evalua...

journal_title：Immunology

authors： Seelen MA,Athanassiou P,Lynn WA,Norsworthy P,Walport MJ,Cohen J,Davies KA

更新日期：1995-04-01 00:00:00

abstract：:A hapten-specific lymphocyte proliferation assay, which measures the in vitro stimulation of DNA synthesis (as assessed by [3H]thymidine incorporation), was used to determine systemic immunization induced by an epicutaneously applied hapten in addition to the more commonly used method which measures ear (or footpad) s...

journal_title：Immunology

authors： Suzuki K,Kanamori S,Takada K,Kawana S

更新日期：2003-04-01 00:00:00

abstract：:The linker protein LAT is expressed mainly in T and natural killer (NK) cells. LAT-deficient mice have an arrest of intrathymic T-cell development at the CD4+ CD8+ stage and lack mature T cells in the periphery. However, no gross abnormality in development and function of the B and NK cells has been described. Here we...

journal_title：Immunology

authors： Oya K,Wang J,Watanabe Y,Koga R,Watanabe T

更新日期：2003-07-01 00:00:00

abstract：:We previously described the processing of antibodies to CD74 (the major histocompatibility complex class II-associated invariant chain, Ii), by B-cell lymphoma cell lines. These cells expressed relatively low levels of Ii on the surface, but the molecules were rapidly internalized and replaced by new molecules, so tha...

journal_title：Immunology

authors： Ong GL,Goldenberg DM,Hansen HJ,Mattes MJ

更新日期：1999-10-01 00:00:00

abstract：:This study has examined the stimuli required for secretion of regulated upon activation, normal T-cell expressed, presumed secreted (RANTES) from T lymphocytes and found that stimuli such as phorbol 12-myristate 13-acetate (PMA), which are unable to support T-cell proliferation and interleukin-2 (IL-2) production, are...

journal_title：Immunology

authors： Sotsios Y,Blair PJ,Westwick J,Ward SG

更新日期：2000-09-01 00:00:00

abstract：:T-cell mediated immunity (CMI) is crucial for protection against genital chlamydial infection in mice. To define the underlying molecular mechanism for this protection, several T-cell clones generated against the Chlamydia trachomatis agent of mouse pneumonitis (MoPn) were analysed in an in vitro model of the mucosal ...

journal_title：Immunology

authors： Igietseme JU

更新日期：1996-01-01 00:00:00

abstract：:Fifteen sera of patients with visceral leishmaniasis were investigated for the occurrence of autoantibodies. They were found in high incidence and titre, and with specificity to the intermediate filament (INFIL) proteins vimentin (12 out of 15 with a titre higher than 1:10) and keratin (9 out of 15 with a titre higher...

journal_title：Immunology

authors： Böhme MW,Evans DA,Miles MA,Holborow EJ

更新日期：1986-12-01 00:00:00

abstract：:The L2C leukaemia is a B-lymphocytic neoplasm of strain 2 guinea-pigs, maintained by passaging in vivo. It synthesizes mu and lambda immunoglobulin chains. These combines to form monomeric (7S) IgM molecules which are inserted into the plasma membranes. From here they are shed as monomeric IgM and as a species of high...

journal_title：Immunology

authors： Hough DW,Chapple JC,Stevenson FK,Stevenson GT

更新日期：1978-05-01 00:00:00

abstract：:T cells play a key role in the pathogenesis of type 1 diabetes, and targeting the CD3 component of the T-cell receptor complex provides one therapeutic approach. Anti-CD3 treatment can reverse overt disease in spontaneously diabetic non-obese diabetic mice, an effect proposed to, at least in part, be caused by a selec...

journal_title：Immunology

authors： Wallberg M,Recino A,Phillips J,Howie D,Vienne M,Paluch C,Azuma M,Wong FS,Waldmann H,Cooke A

更新日期：2017-06-01 00:00:00

abstract：:Adult normal mice and those mice which had been thymectomized, X-irradiated, and reconstituted either with bone marrow cells and thymus cells (TxXBT) or with bone marrow cells along (TxXB), were given varying amounts (0.1-5 mg) of deaggregated soluble bovine serum albumin (sBSA). They were challenged 10 days later wit...

journal_title：Immunology

authors： Muramatsu S,Amagai T,Katura Y

更新日期：1975-05-01 00:00:00

abstract：:This paper describes experiments undertaken to determine more uniform conditions for the generation of cytotoxic lymphokine--'lymphotoxin' (LT) in differently stimulated rat lymphocyte cultures, and to compare the sensitivity of different test systems for detecting rat LT activity in vitro. Wistar rat lymphoid cells w...

journal_title：Immunology

authors： Ryzewska AG,Darbrowska BK

更新日期：1976-11-01 00:00:00

abstract：:B lymphocyte-induced maturation protein-1 (Blimp-1), the transcription factor encoded by the gene Prdm1, plays a number of crucial roles in the adaptive immune system, which result in the maintenance of key effector functions of B- and T-cells. Emerging clinical data, as well as mechanistic evidence from mouse studies...

journal_title：Immunology

authors： Ulmert I,Henriques-Oliveira L,Pereira CF,Lahl K

更新日期：2020-12-01 00:00:00

abstract：:The non-obese diabetic (NOD) mouse is an animal model for insulin-dependent diabetes that has many similarities to the human disease. NOD mice transgenic for the Ea gene, allowing expression of the E molecule, are protected from diabetes and rarely develop insulitis. An Ea transgene mutated in the promoter region, (De...

journal_title：Immunology

authors： Brenden N,Böhme J

更新日期：1998-09-01 00:00:00

abstract：:The response of peripheral blood mononuclear cells to pokeweed mitogen (PWM) stimulation was investigated with combined light (LM) and scanning electron microscopy (SEM). The DNA content of the nucleus of a cell (measured by fluorescence) was compared directly with the diameter and morphological features (by SEM). It ...

journal_title：Immunology

authors： Wouters CH,van der Weij JP,Koper GJ,Daems WT,de Vries E,Ploem JS

更新日期：1986-05-01 00:00:00

abstract：:Ly-49A is a member of the Ly-49 family of mouse natural killer cell receptors that inhibit cytotoxicity upon recognition of their ligands, the major histocompatibility complex (MHC) class I molecules, on the target cell surface. Although Ly-49A has an immunoreceptor tyrosine-based inhibition motif (ITIM) in its cytopl...

journal_title：Immunology

authors： Motoda K,Takata M,Kiura K,Nakamura I,Harada M

更新日期：2000-07-01 00:00:00