Abstract：
:The L2C leukaemia is a B-lymphocytic neoplasm of strain 2 guinea-pigs, maintained by passaging in vivo. It synthesizes mu and lambda immunoglobulin chains. These combines to form monomeric (7S) IgM molecules which are inserted into the plasma membranes. From here they are shed as monomeric IgM and as a species of higher molecular weight which has not been further defined. The synthesis of lambda chain is in excess of that required for the IgM molecule, the surplus being exported directly from the cell without any intervening phase in the plasma membrane. Quantitative estimates of synthetic rates and pool sizes for these immunoglobulin species are presented.
journal_name
Immunologyjournal_title
Immunologyauthors
Hough DW,Chapple JC,Stevenson FK,Stevenson GTsubject
Has Abstractpub_date
1978-05-01 00:00:00pages
889-99issue
5eissn
0019-2805issn
1365-2567journal_volume
34pub_type
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