Regulation of allotype expression in heterozygous rabbits. I. Concomitant modulation of cell surface allotypes on peripheral blood lymphocytes from b4b6 rabbits.

abstract：:The role of endogenously mediated fever and exogenous hyperthermia as modulators of immune functions remains poorly understood. It is known that fever is mediated by several cytokines, including interleukin-1 alpha and interleukin-1 beta (IL-1 alpha and IL-1 beta), interleukin-6 (IL-6), tumour necrosis factor-alpha (T...

journal_title：Immunology

authors： Kappel M,Diamant M,Hansen MB,Klokker M,Pedersen BK

更新日期：1991-07-01 00:00:00

abstract：:Bovine tuberculosis, which persists as a residual level of infection in many European countries, has implications not only for the economy of farming communities but also for human health. The aim of this study was to identify a common mycobacterial antigen which was recognized in bovine tuberculosis and to characteri...

journal_title：Immunology

authors： Lightbody KA,Girvin RM,Pollock DA,Mackie DP,Neill SD,Pollock JM

更新日期：1998-03-01 00:00:00

abstract：:Using the fluorescence-activated cell sorter (FACS), the percentages of T and B lymphocytes in the peripheral blood, spleen and lymph nodes of CBA syngeneic and allogeneic pregnancies were determined. At 19 days of syngeneic pregnancy, the level of T cells in the blood had decreased and that of B cells had increased. ...

journal_title：Immunology

authors： Carter J,Newport A,Keeler KD,Dresser DW

更新日期：1983-04-01 00:00:00

abstract：:To assess the role of CD5 and CD28 in the pathogenesis of the decreased cellular immune function in patients with rheumatoid arthritis (RA) we analysed the expression and function of these T-cell surface molecules. The expression of CD5 as well as of CD28 in synovial and peripheral blood T cells was similar to that of...

journal_title：Immunology

authors： Verwilghen J,Corrigall V,Pope RM,Rodrigues R,Panayi GS

更新日期：1993-09-01 00:00:00

abstract：:The interaction of mouse intestinal mast cell proteinase (IMCP) with serine proteinase inhibitors (serpins) in blood was analysed: (i) by examining the capacity of the inhibitors in blood to block the binding of the irreversible serine esterase inhibitor [3H]diisopropyl fluorophosphate (DFP); (ii) by Western blotting....

journal_title：Immunology

authors： Irvine J,Newlands GF,Huntley JF,Miller HR

更新日期：1990-01-01 00:00:00

abstract：:Trypanosoma cruzi, the causative agent of Chagas' disease, is a protozoan parasite that infects humans and other mammals in Central and Latin America. Several alterations of the immune response after infection have been described, such as severe immunosuppression of both cellular and humoral responses and massive poly...

journal_title：Immunology

authors： Da Silva AC,Espinoza AG,Taibi A,Ouaissi A,Minoprio P

更新日期：1998-06-01 00:00:00

abstract：:The anti-C6 monoclonal antibody WU 6-4 was shown to be unequivocally native restricted since it neither binds to the terminal complement complex (TCC) nor to C5b6. In addition, it was shown to inhibit TCC formation by interfering with C5b6 generation. Using the pUEX expression system and C6 cDNA the WU 6-4 epitope was...

journal_title：Immunology

authors： Würzner R,Mewar D,Fernie BA,Hobart MJ,Lachmann PJ

更新日期：1995-06-01 00:00:00

abstract：:Chlamydiae are a major cause of infertility and preventable blindness and there is currently no effective vaccine in humans or rodents against these organisms. We have previously shown that a peptide of 12 amino acids (termed TINKP) from a conserved region of the major outer membrane protein (MOMP) of Chlamydia tracho...

journal_title：Immunology

authors： Knight SC,Iqball S,Woods C,Stagg A,Ward ME,Tuffrey M

更新日期：1995-05-01 00:00:00

abstract：:The expanded CD8+ T-lymphocyte population arising in response to viral infection controls the virus but could also prove damaging to the host unless safely removed at the end of the immune response. Apoptosis provides a mechanism whereby this can be achieved, as apoptotic cells are recognized and engulfed by macrophag...

journal_title：Immunology

authors： Borthwick NJ,Bofill M,Hassan I,Panayiotidis P,Janossy G,Salmon M,Akbar AN

更新日期：1996-08-01 00:00:00

abstract：:In this study we aimed to elucidate the physiological role of gammadelta intraepithelial lymphocytes (IEL) in the mouse intestine. For this purpose, we used T-cell receptor (TCR) Vgamma4/Vdelta5 transgenic mice (KN 6 Tg: BALB/c background, H-2d), and compared the immunological and physiological characteristics of the ...

journal_title：Immunology

authors： Matsumoto S,Nanno M,Watanabe N,Miyashita M,Amasaki H,Suzuki K,Umesaki Y

更新日期：1999-05-01 00:00:00

abstract：:Mitogen-activated protein/ERK kinase kinase 3 (MEKK3) is a Ser/Thr protein kinase belonging to the MEKK/STE11 subgroup of the MAP3K family. Recently, we found that MEKK3 plays a critical role in interleukin-1 (IL-1) receptor and Toll-like receptor 4 signalling using established primary mouse embryonic fibroblast (MEF)...

journal_title：Immunology

authors： Kim K,Duramad O,Qin XF,Su B

更新日期：2007-02-01 00:00:00

abstract：:Repetitive stimulation of naïve T cells by immature splenic dendritic cells (DC) can result in the differentiation of T-cell lines with regulatory properties. In the present study we identified a population of DC in the mucosae that exhibit the plasmacytoid phenotype, secrete interferon-alpha (IFN-alpha) following sti...

journal_title：Immunology

authors： Bilsborough J,George TC,Norment A,Viney JL

更新日期：2003-04-01 00:00:00

abstract：:The effect on murine immunoglobulin G (IgG) glycosylation of altering IgG production in vivo was assessed in interleukin (IL)-6 transgenic and CD4 knockout mice. C57BL/6 mice carrying the IL-6 transgene showed increased levels of circulating IgG. This was associated with decreased levels of galactose on the IgG oligos...

journal_title：Immunology

authors： Jeddi P,Keusch J,Lydyard PM,Bodman-Smith KB,Chesnutt MS,Wofsy D,Hirota H,Taga T,Delves PJ

更新日期：1999-11-01 00:00:00

abstract：:The effect of long chain and medium chain fatty acid absorption on transport and mitogen-induced blast transformation of lymphocytes in intestinal lymphatics was investigated. Intestinal lymph was collected from mesenteric lymph duct cannulated rats maintained in Bollman's cage. Following the intraduodenal administrat...

journal_title：Immunology

authors： Miura S,Imaeda H,Shiozaki H,Ohkubo N,Tashiro H,Serizawa H,Tsuchiya M,Tso P

更新日期：1993-01-01 00:00:00

abstract：:The intestine immune response in rats following immunization with horseradish peroxidase (HRP) was studied morphologically. Various routes of immunization (intraperitoneal, intravenous, intraenteric and intra-Peyer's patch) were tested. Single injections did not evoke any specific antibody-containing (anti-HRP) cells ...

journal_title：Immunology

authors： Sminia T,Delemarre F,Janse EM

更新日期：1983-09-01 00:00:00

abstract：:Cells subjected to nucleoside incorporation studies using radiolabelled materials may suffer radiation damage that can alter the results. We did scintimetric and cytofluorographic analysis to confirm this and to determine the optimal experimental doses of, and exposure times to, [3H]-TdR, in order to prevent or minimi...

journal_title：Immunology

authors： Ruiz-Arguelles A,Llorente L,Díaz-Jouanen E,Alarcón-Segovia D

更新日期：1981-12-01 00:00:00

abstract：:Mice injected with rat erythrocytes developed anti-erythrocyte autoantibodies which reached a plateau at 4-12 weeks, then gradually declined until at about 24 weeks the majority of mice were negative. In such recovered mice re-challenge with rat erythrocytes produced an accelerated peak of autoantibody and a much more...

journal_title：Immunology

authors： Naysmith JD,Elson CJ,Dallman M,Fletcher E,Ortega-Pierres MG

更新日期：1980-04-01 00:00:00

abstract：:Montelukast is a leukotriene receptor antagonist that is known to prevent allergic rhinitis and asthma. Blocking the Cysteinyl leukotrienes receptor (CysLTR1), one of the primary receptors of leukotrienes, has been demonstrated to be efficacious in ameliorating experimental autoimmune encephalomyelitis (EAE), an anima...

journal_title：Immunology

authors： Han B,Zhang YY,Ye ZQ,Xiao Y,Rasouli J,Wu WC,Ye SM,Guo XY,Zhu L,Rostami A,Wang LB,Zhang Y,Li X

更新日期：2021-01-22 00:00:00

abstract：:Eosinophil recruitment to the airways, including involvement of haemopoietic eosinophil-basophil progenitors (Eo/B-CFU), is primarily regulated by interleukin-5 (IL-5) and eotaxin. In this study, we investigated the haemopoietic mechanisms in upper and lower airway eosinophilic inflammation. Ovalbumin (OVA) sensitized...

journal_title：Immunology

authors： Li J,Saito H,Crawford L,Inman MD,Cyr MM,Denburg JA

更新日期：2005-03-01 00:00:00

abstract：:The investigation of the role of the macrophage in cutaneous leishmaniasis has been prompted by observations of the clinical behaviour of the infection. In contrast to the self-healing oriental sore, chronic leishmaniasis is characterized by persistent lesions and leishmania recidiva by lesions that flare up locally l...

journal_title：Immunology

authors： Farah FS,Samra SA,Nuwayri-Salti N

更新日期：1975-10-01 00:00:00

abstract：:Group 2 innate lymphoid cells (ILC2s) are an important component of the innate immune system that execute important effector functions at barrier surfaces, such as lung and skin. Like T helper type 2 cells, ILC2s are able to release high amounts of type 2 cytokines that are essential in inducing allergic inflammation ...

journal_title：Immunology

authors： Lei A,He Y,Yang Q,Li X,Li R

更新日期：2020-09-01 00:00:00

abstract：:Apoptosis of macrophages infected with pathogenic mycobacteria is an alternative host defence capable of removing the environment supporting bacterial growth. In this work the influence of virulence and bacterial load on apoptosis of alveolar macrophages during the initial phase of infection by Mycobacterium bovis was...

journal_title：Immunology

authors： Rodrigues MF,Barsante MM,Alves CC,Souza MA,Ferreira AP,Amarante-Mendes GP,Teixeira HC

更新日期：2009-09-01 00:00:00

abstract：:Bile acids (BAs) play important roles not only in lipid metabolism, but also in signal transduction. TGR5, a transmembrane receptor of BAs, is an immunomodulative factor, but its detailed mechanism remains unclear. Here, we aimed to delineate how BAs operate in immunological responses via the TGR5 pathway in human mon...

journal_title：Immunology

authors： Yoneno K,Hisamatsu T,Shimamura K,Kamada N,Ichikawa R,Kitazume MT,Mori M,Uo M,Namikawa Y,Matsuoka K,Sato T,Koganei K,Sugita A,Kanai T,Hibi T

更新日期：2013-05-01 00:00:00

abstract：:The class distribution of 4193 monoclonal gammopathies (MG), detected over approximately 10 years in western France (WF), was compared to that established by a compilation of twenty-seven series from the literature. Several points emerged from this study: the incidence of the light chain MG (4.8%) was slightly lower t...

journal_title：Immunology

authors： Hurez D,Youinou P,Gombert J,Preud'Homme JL

更新日期：1985-11-01 00:00:00

abstract：:This study investigates the effect of feeding fermented milks with Lactobacillus casei, Lactobacillus acidophilus and a mixture of both micro-organisms on the specific and non-specific host defence mechanisms in Swiss mice. Animals fed with fermented milk for 8 days (100 micrograms/day) showed an increase in both phag...

journal_title：Immunology

authors： Perdigón G,de Macias ME,Alvarez S,Oliver G,de Ruiz Holgado AP

更新日期：1988-01-01 00:00:00

abstract：:Guinea-pigs immunized with homogenates of unfed larvae and nymphs of the tick Rhipicephalus appendiculatus developed significant levels of protective immunity to infestation with adults of this species. The mean engorged weight of female ticks feeding on immunized animals (181.96 +/- 05.63 mg and 170.11 +/- 11.54 mg) ...

journal_title：Immunology

authors： Varma MG,Heller-Haupt A,Trinder PK,Langi AO

更新日期：1990-09-01 00:00:00

abstract：:Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by chronic, synovial inflammation affecting multiple joints, finally leading to extra-articular lesions for which limited effective treatment options are currently available. Interleukin-34 (IL-34), recently discovered as the second colony-stimul...

journal_title：Immunology

authors： Zhou RP,Wu XS,Xie YY,Dai BB,Hu W,Ge JF,Chen FH

更新日期：2016-12-01 00:00:00

abstract：:Histamine not only mediates immediate allergic reactions, it also regulates cellular immune responses. H4R is the most recently identified histamine receptor (HR). In the present study, we examined the in vitro effect of histamine and H4R agonists on the responses of human T cells to purified protein derivative from M...

journal_title：Immunology

authors： Sugata Y,Okano M,Fujiwara T,Matsumoto R,Hattori H,Yamamoto M,Nishibori M,Nishizaki K

更新日期：2007-06-01 00:00:00

abstract：:This paper uses B-lymphocyte cloning methods to quantify the effects of anti-mu chain antibody on immature and mature B cells. Nude mouse spleen lymphocytes were incubated with various concentrations of sheep anti-mouse mu chain antibody for times varying from 10 min to 24 h. They were then washed and plated in the ag...

journal_title：Immunology

authors： Nossal GJ,Pike BL,Battye FL

更新日期：1979-05-01 00:00:00

abstract：:We examined the mechanisms of disturbed T-lymphocyte function that occurred during Schistosoma japonicum infection of BALB/c mice from the viewpoint of the interleukin cascade reaction. Each point of the interleukin cascade reaction was examined. First, IL-1 production by adherent peritoneal or spleen cells, as a sour...

journal_title：Immunology

authors： Yamashita T,Watanabe T,Sendo F

更新日期：1987-10-01 00:00:00