Studies on delayed hypersensitivity pleural exudates in guinea-pigs. II. The interrelationship of monocytic and lymphocytic cells with respect to migration activity.

abstract：:In mice arthritis model induced by anti-type II collagen (CII) antibodies and lipopolysaccharide (LPS), most of cells that infiltrated into the joint space were neutrophils. To investigate the role of neutrophils in the pathogenesis of arthritis, we depleted the neutrophils in vivo by injection of the antibody against...

journal_title：Immunology

authors： Tanaka D,Kagari T,Doi H,Shimozato T

更新日期：2006-10-01 00:00:00

abstract：:Drug abuse is a global problem of considerable concern to health. One such health concern stems from the fact that many drugs of abuse have immunosuppressive actions and consequently have the potential to increase susceptibility to infectious disease. This article is focused on the impact of the amphetamine derivative...

journal_title：Immunology

authors： Connor TJ

更新日期：2004-04-01 00:00:00

abstract：:The kinetics of anti-paternal alloantibody production in syngeneically and allogeneically mated mice previously immunized with allogenic spleen cells has been investigated. In allogeneically mated females, total and cytotoxic alloantibody levels increased during the final 3 days of pregnancy to reach maximal levels ar...

journal_title：Immunology

authors： Roe R,Bell SC

更新日期：1982-05-01 00:00:00

abstract：:alpha 1-Acid glycoprotein (AG), a serum component elevated during acute inflammation, has been implicated in the suppression of various immunological responses. Pretreatment of lymphoid cells with AG at a concentration commonly found in patients with acute inflammation results in the inhibition of mitogen induced lymp...

journal_title：Immunology

authors： Cheresh DA,Haynes DH,Distasio JA

更新日期：1984-03-01 00:00:00

abstract：:Guinea-pig mitogenic factor(s) were found capable of stimulating both normal T and B cells. Preliminary physicochemical characterization could not dissociate the mitogenic factors for respective cell populations. Furthermore, both immune T and B cells could produce mitogenic factors upon stimulation with antigen in co...

journal_title：Immunology

authors： Bergenstock RW,Cohen S,Yoshida T

更新日期：1981-02-01 00:00:00

abstract：:The expression of adhesion molecules in monocytes of patients with recent onset type I diabetes was analysed. Monocytes were identified as CD14-positive cells by flow cytometry. The percentage of monocytes expression LFA-1 alpha, ICAM-1 and HLA-DR was slightly lower in recent onset type I diabetes (n = 13) compared to...

journal_title：Immunology

authors： Martin S,Rothe H,Tschöpe D,Schwippert B,Kolb H

更新日期：1991-05-01 00:00:00

abstract：:The glucocorticoid-induced tumour necrosis factor receptor family related gene (GITR) has been reported to be expressed on the activated T and CD4(+)CD25(+) regulatory T cells (Treg). Signalling triggered by GITR not only neutralizes the suppressive effect of Treg cells, but also augments activation, proliferation and...

journal_title：Immunology

authors： Lee SK,Choi BK,Kim YH,Kang WJ,Kim KH,Sakaguchi S,Suh JH,Kim TY,Kwon BS

更新日期：2006-12-01 00:00:00

abstract：:Trypanosoma cruzi, the causative agent of Chagas' disease, suppresses immune responses during the acute phase and has been shown to induce multiple cellular alterations in activated human T lymphocytes. However, no information is available regarding the effects of this parasite on human B cells. Using an in vitro cult...

journal_title：Immunology

authors： Kierszenbaum F,Moretti E,Sztein MB

更新日期：1991-10-01 00:00:00

abstract：:The role of Peyer's patches in the local intestinal and serum antibody responses to keyhole limpet haemocyanin (KLH) was studied in rabbits with chronically isolated ileal loops. Four weekly doses of 400 microgram KLH were administered into loops prepared with and without Peyer's patches. Isotype-specific IgA and IgG ...

journal_title：Immunology

authors： Hamilton SR,Keren DF,Yardley JH,Brown G

更新日期：1981-03-01 00:00:00

abstract：:Thoracic duct lymphocytes (TDL) from (AS2 x AS)F1 rats previously injected with human serum albumin (HSA) were transferred to 900 r irradiated syngeneic recipients which were challenged with various doses of soluble HSA (s-HSA). TDL from partially tolerant rats, which were deficient in high avidity B cells, produced a...

journal_title：Immunology

authors： Bell EB,Shand FL

更新日期：1977-10-01 00:00:00

abstract：:The expression of natural cytotoxicity in the gut-associated lymphoid tissue of the rat was investigated. Intra-epithelial lymphocytes (IEL) isolated from the small intestine had a similar frequency of cytotoxic and tumour target binding cells as the spleen. However, cytotoxic activity was low in Peyer's patches and m...

journal_title：Immunology

authors： Flexman JP,Shellam GR,Mayrhofer G

更新日期：1983-04-01 00:00:00

abstract：:We have previously reported that the 20-mer peptide p2340 (amino acids 2340-2359), of human thyroglobulin (Tg) has the unique feature that it causes experimental autoimmune thyroiditis (EAT) in mouse strains bearing high-responder (HR) or low-responder (LR) MHC haplotypes in Tg-induced EAT. In this study, we have empl...

journal_title：Immunology

authors： Hatzioannou A,Alevizaki M,Carayanniotis G,Lymberi P

更新日期：2012-03-01 00:00:00

abstract：:The non-specific normal immunosuppressive protein (Nip) has been described in our laboratory and its biological activity was extensively studied. In the present study, further purification analyses of Nip were conducted. Fractionation of Nip by Ultrogel AcA 34 column resulted in peak (I) that displayed Nip activity in...

journal_title：Immunology

authors： Gavison-Goren R,Nelken D

更新日期：1983-08-01 00:00:00

abstract：:Interleukin-2 (IL-2) is a mainstay for current immunotherapeutic protocols but its usefulness in patients is reduced by severe toxicities and because IL-2 facilitates regulatory T (Treg) cell development. IL-21 is a type I cytokine acting as a potent T-cell co-mitogen but less efficient than IL-2 in sustaining T-cell ...

journal_title：Immunology

authors： Battaglia A,Buzzonetti A,Baranello C,Fanelli M,Fossati M,Catzola V,Scambia G,Fattorossi A

更新日期：2013-05-01 00:00:00

abstract：:The role of the monocyte in human cytomegalovirus (HCMV)-induced immunosuppression was examined by assessing the ability of the virus to directly suppress various monocyte accessory cell functions. Both patient-derived and laboratory-adapted strains of HCMV were capable of impairing antigen-presenting functions of pur...

journal_title：Immunology

authors： Buchmeier NA,Cooper NR

更新日期：1989-02-01 00:00:00

abstract：:Human autologous-rosette-forming T cells (Tar cells) have many of the characteristics of post-thymic precursor cells. Thus, they bind to sheep erythrocytes but have neither receptors for the Fc portion of IgG nor for that of IgM. They include a subpopulation that binds peanut agglutinin which suggests that they are im...

journal_title：Immunology

authors： Palacios R,Alarcón-Segovia D,Llorente L,Ruíz-Arguelles A,Díaz-Jouanen E

更新日期：1981-01-01 00:00:00

abstract：:Repetitive stimulation of naïve T cells by immature splenic dendritic cells (DC) can result in the differentiation of T-cell lines with regulatory properties. In the present study we identified a population of DC in the mucosae that exhibit the plasmacytoid phenotype, secrete interferon-alpha (IFN-alpha) following sti...

journal_title：Immunology

authors： Bilsborough J,George TC,Norment A,Viney JL

更新日期：2003-04-01 00:00:00

abstract：:The present study aimed to determine whether the frequency of double positive (DP) thymocytes expressing alphabeta T-cell receptor (TCR) clonotypes at the time of selection regulates peripheral CD4 T-cell compartment size. Scid recipients were inoculated with various ratios of TCR Calpha(0/0) and wild-type bone marrow...

journal_title：Immunology

authors： Reed AJ,Zarrabi Y,Perate AL,Jeganathan A,Naji A,Noorchashm H

更新日期：2005-11-01 00:00:00

abstract：:Experimental protocols have been devised to deliniate the importance of T-cell subsets in immunity to Moloney sarcoma virus-induced tumours using the surface antigens L3T4 and Lyt-2 as markers of helper and cytotoxic cells, respectively. Because the monoclonal antibodies used have been shown to deplete T-cell subsets ...

journal_title：Immunology

authors： Bateman WJ,Jenkinson EJ,Owen JJ

更新日期：1987-07-01 00:00:00

abstract：:Mice, immunized with liposome-associated bovine serum albumin (LSM-BSA), showed a significantly higher BSA-specific plaque-forming cell (PFC) response than did mice injected with fluid BSA (fBSA). Physical association between the liposome carrier and the protein antigen is imperative for potentiating the PFC response,...

journal_title：Immunology

authors： Shek PN,Sabiston BH

更新日期：1982-02-01 00:00:00

abstract：:The interference of two simultaneous skin test reactions of intermediate strength has been studied in the guinea-pig, using four different antigens, i.e. ovalbumin, horse cytochrome c, PPD and oxazolone. Skin test reactions were evaluated at 4, 24 and 48 h by measuring three parameters: increase in skin thickness, dia...

journal_title：Immunology

authors： Von Blomberg M,Boerrigter GH,Scheper RJ

更新日期：1978-08-01 00:00:00

abstract：:The subcutaneous (s.c.) injection of sheep red blood cells (SRBC) without adjuvant into mice preferentially induced delayed hypersensitivity (DH) reaction, as measured by footpad swelling, while intraperitoneal (i.p.) measured by the haemagglutinin test. Under these conditions, the properties of the helper activities...

journal_title：Immunology

authors： Tamura SI,Egashira Y

更新日期：1975-05-01 00:00:00

abstract：:Sodium penicillin was conjugated to sheep erythrocytes and optimal quantities, added to a 5% SRBC suspension, were determined for haemagglutination (12-5 mg/ml) and for haemolysis (50 mg/ml) using carp antibodies and carp complement. The epitope density on the BSA molecule was gradually increased, when increasing amou...

journal_title：Immunology

authors： Avtalion RR,Milgrom L

更新日期：1976-10-01 00:00:00

abstract：:The cellular basis of the mechanism of immunological tolerance to human gamma-globulin (H gamma G) induced in foetal and neonatal mice by materno-foetal or materno-neonatal transfer after a single injection of tolerogen (deaggregated H gamma G) into the mothers was investigated using a cell transfer system and assays ...

journal_title：Immunology

authors： Shinka S,Komatsu T,Dohi Y,Amano T

更新日期：1979-05-01 00:00:00

abstract：:Extracorporeal photochemotherapy (ECP) has been shown to be a potent activator of peripheral blood macrophages because it causes a marked release of macrophage-dependent proinflammatory cytokines, and it is therefore currently considered to be a safe and non-toxic immunomodulatory treatment. On this basis we studied t...

journal_title：Immunology

authors： Di Renzo M,Rubegni P,De Aloe G,Paulesu L,Pasqui AL,Andreassi L,Auteri A,Fimiani M

更新日期：1997-09-01 00:00:00

abstract：:We examined the mechanisms of disturbed T-lymphocyte function that occurred during Schistosoma japonicum infection of BALB/c mice from the viewpoint of the interleukin cascade reaction. Each point of the interleukin cascade reaction was examined. First, IL-1 production by adherent peritoneal or spleen cells, as a sour...

journal_title：Immunology

authors： Yamashita T,Watanabe T,Sendo F

更新日期：1987-10-01 00:00:00

abstract：:The CD3-T-cell receptor complex is the clonotypic surface structure by which T lymphocytes recognize foreign antigens and are subsequently activated. Because of the low immunogenicity of the CD3 molecules, anti-CD3 monoclonal antibodies (mAb) are difficult to prepare and have not been available in several species. Fol...

journal_title：Immunology

authors： Yang H,Oura CA,Kirkham PA,Parkhouse RM

更新日期：1996-08-01 00:00:00

abstract：:The isolation and characterization of a new eosinophil-derived protein, eosinophil protein X (EPX) is here described. The purified EPX is a highly basic glycoprotein and shows one band on sodium dodecyl sulphate polyacrylamide gel electrophoresis and on agarose electrophoresis. The molecular weight of the unreduced pr...

journal_title：Immunology

authors： Peterson CG,Venge P

更新日期：1983-09-01 00:00:00

abstract：:Five of twenty-three patients with paraproteinaemia (two IgM, three IgG) have been shown to exhibit marked classical pathway complement activation. The mechanisms of hypocomplementaemia proposed for the five patients are cryoglobulinaemia in one and in vivo immunoglobulin aggregation in the other four. Three further p...

journal_title：Immunology

authors： Naish PF,Collins C,Barratt J

更新日期：1977-10-01 00:00:00

abstract：:Group 2 innate lymphoid cells (ILC2s) are an important component of the innate immune system that execute important effector functions at barrier surfaces, such as lung and skin. Like T helper type 2 cells, ILC2s are able to release high amounts of type 2 cytokines that are essential in inducing allergic inflammation ...

journal_title：Immunology

authors： Lei A,He Y,Yang Q,Li X,Li R

更新日期：2020-09-01 00:00:00