No impairment of local intestinal immune response to keyhole limpet haemocyanin in the absence of Peyer's patches.

abstract：:We found in previous experiments that fractionation of non-immune mouse spleen cells on bovine serum albumin density gradients yields two subpopulations of T cells, one of high, the other of low density. Both subopopulations could be stimulated in corporate thymidine by the T cell-specific mitogen concanavalin A (con ...

journal_title：Immunology

authors： Mugraby L,Gery I,Sulitzeanu D

更新日期：1975-03-01 00:00:00

abstract：:This study reports the expression and functional characterization of the rat analogue of the human complement regulatory molecule CD59. We here describe the expression in chinese hamster ovary (CHO) cells of rat CD59 and a modified rat CD59 in which an N-glycosylation site at Asn-16 has been deleted by point mutation....

journal_title：Immunology

authors： Rushmere NK,Tomlinson S,Morgan BP

更新日期：1997-04-01 00:00:00

abstract：:Virus-specific cytotoxic T-cell (Tc) clones can lyse target cells in vitro in the presence of their specific peptide epitopes. The lytic potency of murine influenza nucleoprotein (NP)-specific Tc clones was investigated after observing that target cell killing was reduced in the presence of high (greater than 0.2 micr...

journal_title：Immunology

authors： Pemberton RM,Wraith DC,Askonas BA

更新日期：1990-06-01 00:00:00

abstract：:Free fatty acids (FFA) were tested for their effects on in vitro thymus-dependent (TD) and thymus-independent (TI) immune responses. Murine T cells proliferating in one-way mixed leucocyte reactions (MLR) were extremely sensitive to inhibition by exogenous stearic acid (18:0) but were only moderately affected by oleic...

journal_title：Immunology

authors： Pourbohloul S,Mallett GS,Buttke TM

更新日期：1985-12-01 00:00:00

abstract：:Salmonella enterica serovar Typhimurium (S. typhimurium) causes a localized enteric infection and its elimination is dependent on a T helper type 1 immune response. However, the mechanism of the protective immune response against the pathogen in gut-associated lymphoid tissue (GALT) at an early stage of the infection ...

journal_title：Immunology

authors： Mayuzumi H,Inagaki-Ohara K,Uyttenhove C,Okamoto Y,Matsuzaki G

更新日期：2010-11-01 00:00:00

abstract：:Urokinase-type plasminogen activator (u-PA), tumour necrosis factor-alpha (TNF-alpha) and interleukin-1 (IL-1) activities were measured for highly purified human monocytes cultured for 18 hr with recombinant human interleukin-3 (IL-3). IL-3 alone stimulated monocyte u-PA activity, but not TNF-alpha or IL-1 activity. H...

journal_title：Immunology

authors： Hart PH,Whitty GA,Burgess DR,Hamilton JA

更新日期：1990-09-01 00:00:00

abstract：:An examination was made of the effects of eosinophilia on acute inflammation. Sprague Dawley rats were infected with Trichinella spiralis larvae which resulted in a blood eosinophilia. Groups of rats with the induced eosinophilia, and untreated rats without the eosinophilia, were treated with carrageenan, bradykinin o...

journal_title：Immunology

authors： Popper H,Picher O,Auer H

更新日期：1982-07-01 00:00:00

abstract：:Crry (CR1-related gene/protein) is a rodent complement regulator that inhibits C3 convertases. CD59 is a conserved protein inhibitor active towards C8 and C9. We have previously produced rat Crry as a recombinant soluble (rs) protein in Pichia pastoris. In this study we produced functionally active rat rsCD59 and a ch...

journal_title：Immunology

authors： Quigg RJ,He C,Hack BK,Alexander JJ,Morgan BP

更新日期：2000-01-01 00:00:00

abstract：:The immunosuppressive activity of serum from PVG rats following orthotopic transplantation of DA liver has been examined in vitro. Liver grafts in this combination are never rejected, but induce a state of specific transplantation tolerance in the recipient. Serum from such tolerant animals was able to inhibit prolife...

journal_title：Immunology

authors： Tsurufuji M,Ishiguro K,Shinomiya T,Uchida T,Kamada N

更新日期：1987-08-01 00:00:00

abstract：:While many aspects of memory T-cell immunobiology have been characterized, we suggest that we know only a fraction of the effector functions that CD4 T cells can bring to bear during secondary challenges. Exploring the full impact of memory CD4 T-cell responses is key to the development of improved vaccines against ma...

journal_title：Immunology

authors： McKinstry KK,Strutt TM,Swain SL

更新日期：2010-05-01 00:00:00

abstract：:Among immunological abnormalities present in human immunodeficiency virus type 1 (HIV-1)-infected individuals are dysregulation of cytokine production and CD4 down-regulation in both T-helper cells and monocytes/macrophages. The HIV-1 envelope glycoprotein 120 (gp120) has the ability to induce different cytokines in p...

journal_title：Immunology

authors： Karsten V,Gordon S,Kirn A,Herbein G

更新日期：1996-05-01 00:00:00

abstract：:The immunological basis for the production of autoantibodies characteristic of systemic lupus erythematosus (SLE) against a wide range of antigens remains obscure. The specificity of (NZB x NZW)F1 (BWF1) or MRL/Mp-lpr/lpr (MRL/lpr) mouse monoclonal antibodies (mAb) was examined by immunofluorescence, immunoblotting an...

journal_title：Immunology

authors： Bronze-da-Rocha E,Machado C,Staines NA,Sunkel CE

更新日期：1992-12-01 00:00:00

abstract：:Toll-like receptors (TLR) are sentinel receptors capable of recognizing pathogen-associated molecule patterns (PAMP) such as lipopolysaccharide (LPS) and CpG-containing oligonucleotides (CpG ODN). TLR2 and TLR4 are major receptors for Gram-positive and Gram-negative bacterial cell wall components, respectively. TLR9 i...

journal_title：Immunology

authors： An H,Yu Y,Zhang M,Xu H,Qi R,Yan X,Liu S,Wang W,Guo Z,Guo J,Qin Z,Cao X

更新日期：2002-05-01 00:00:00

abstract：:Adoptive transfer of T-cells is a promising therapy for many cancers. To enhance tumour recognition by T-cells, chimeric antigen receptors (CARs) consisting of signalling domains fused to receptors that recognize tumour-associated antigens can be expressed in T-cells. While CAR T-cells have shown clinical success for ...

journal_title：Immunology

authors： Parriott G,Deal K,Crean S,Richardson E,Nylen E,Barber A

更新日期：2020-07-01 00:00:00

abstract：:Haptenated murine Langerhans' cells (LCs) have been reported to induce contact sensitivity when injected via the subcutaneous, intraperitoneal and, in some instances, the intravenous route. Similar studies were undertaken to elucidate the role of the LC in the induction of contact sensitivity in the guinea-pig. The su...

journal_title：Immunology

authors： Baker D,Parker D,Healey DG,Turk JL

更新日期：1987-12-01 00:00:00

abstract：:Four specific interleukin-2 (IL-2) surface binding proteins can be detected by covalent cross-linking of [125I]IL-2 to rat spleen cells that have been activated with various stimuli including concanavalin A (Con A), phytohaemagglutinin (PHA), calcium ionophore, and phorbol dibutyrate (PDB) with or without calcium iono...

journal_title：Immunology

authors： Chopra RK,Carroll MP,May WS,Bhatia SK,Margolick JB,Nagel JE,Adler WH

更新日期：1992-11-01 00:00:00

abstract：:A highly purified preparation of mouse B cells showed greatly decreased incorporation of [6-3H]-thymidine when stimulated with pokeweed Pa-1 mitogen or bacterial lipopolysaccharide compared with mouse splenic lymphocytes. This decreased stimulation was restored by the addition of purified T cells, but not macrophages....

journal_title：Immunology

authors： Yokoyama K,Osawa T

更新日期：1979-12-01 00:00:00

abstract：:The induction of T-cell growth by the T-cell antigen receptor (TcR) is dependent on a co-ordinated process of phosphorylation and dephosphorylation of intracellular proteins. An intermediary in this signalling pathway is the serine kinase, p42 mitogen-activated protein kinase (p42MAPK), also known as microtubule-assoc...

journal_title：Immunology

authors： Amaral MC,Casillas AM,Nel AE

更新日期：1993-05-01 00:00:00

abstract：:Previous studies in our laboratory have shown that bone-marrow-derived mast cells (BMMC) could present immunogenic peptides, from soluble antigens endocytosed through fluid phase, only if they were subjected to a 48-hr treatment with interleukin-4 (IL-4) and granulocyte-macrophage colony-stimulating factor (GM-CSF). I...

journal_title：Immunology

authors： Tkaczyk C,Villa I,Peronet R,David B,Mécheri S

更新日期：1999-06-01 00:00:00

abstract：:The influence of the synthetic corticosteroid dexamethasone sodium phosphate (DEXA) upon mouse B cells was studied. This was done by in vivo treatment of mice with a single or multiple injection of DEXA, and by culturing murine spleen cells and bone marrow cells in vitro in the presence of different concentrations of ...

journal_title：Immunology

authors： Sabbele NR,Van Oudenaren A,Hooijkaas H,Benner R

更新日期：1987-10-01 00:00:00

abstract：:with AgB-primed B or T cells and injected into syngeneic X-irradiated recipients. Anti-THF and anti-Eid purified by an AgB-specific T suppressor factor (TSF) affi-gel adsorbent retain their ability to specifically initiate [3H]-thymidine incorporation of AgB-primed T cells. The data indicate that both anti-THF and ant...

journal_title：Immunology

authors： Malley A,Brandt CJ,Deppe LB

更新日期：1982-02-01 00:00:00

abstract：:Allergic diseases are frequently exacerbated between midnight and early morning, suggesting a role for the biological clock. Mast cells (MC) and eosinophils are the main effector cells of allergic diseases and some MC-specific or eosinophil-specific markers, such as tryptase or eosinophil cationic protein, exhibit cir...

journal_title：Immunology

authors： Baumann A,Gönnenwein S,Bischoff SC,Sherman H,Chapnik N,Froy O,Lorentz A

更新日期：2013-12-01 00:00:00

abstract：:The effect on murine immunoglobulin G (IgG) glycosylation of altering IgG production in vivo was assessed in interleukin (IL)-6 transgenic and CD4 knockout mice. C57BL/6 mice carrying the IL-6 transgene showed increased levels of circulating IgG. This was associated with decreased levels of galactose on the IgG oligos...

journal_title：Immunology

authors： Jeddi P,Keusch J,Lydyard PM,Bodman-Smith KB,Chesnutt MS,Wofsy D,Hirota H,Taga T,Delves PJ

更新日期：1999-11-01 00:00:00

abstract：:The glucocorticoid-induced tumour necrosis factor receptor family related gene (GITR) has been reported to be expressed on the activated T and CD4(+)CD25(+) regulatory T cells (Treg). Signalling triggered by GITR not only neutralizes the suppressive effect of Treg cells, but also augments activation, proliferation and...

journal_title：Immunology

authors： Lee SK,Choi BK,Kim YH,Kang WJ,Kim KH,Sakaguchi S,Suh JH,Kim TY,Kwon BS

更新日期：2006-12-01 00:00:00

abstract：:In an attempt to produce monoclonal antibodies against human large granular lymphocytes (LGL), the effector cells of natural killer (NK) and killer (K) activity, a monoclonal IgM antibody (VEP10) has been obtained. This antibody is reactive by indirect membrane immunofluorescence (IMF) with 14.7 +/- 8.5% peripheral bl...

journal_title：Immunology

authors： Rumpold H,Kraft D,Obexer G,Böck G,Möschl P

更新日期：1983-06-01 00:00:00

abstract：:Vitamins A and E and select flavonoids in the family of catechins are well-defined small molecules that, if proven to possess immunomodulatory properties, hold promise as vaccine adjuvants and various therapies. In an effort to determine the in vivo immunomodulatory properties of these molecules, we found that althoug...

journal_title：Immunology

authors： Patel S,Akalkotkar A,Bivona JJ 3rd,Lee JY,Park YK,Yu M,Colpitts SL,Vajdy M

更新日期：2016-08-01 00:00:00

abstract：:Stimulation of human polymorphonuclear leucocytes (PMN) with phagocytosable particles [yeast-IgG (Y-IgG)], lipopolysaccharide (LPS), tumour necrosis factor (TNF) or formyl-methionyl-leucyl-phenyl-alanine (FMLP) results in an increase of the interleukin-8 (IL-8) mRNA accumulation and a subsequent release of the protein...

journal_title：Immunology

authors： Cassatella MA,Guasparri I,Ceska M,Bazzoni F,Rossi F

更新日期：1993-02-01 00:00:00

abstract：:Immunoregulatory CD4(-)  CD8(-) (double-negative; DN) T cells exhibit a unique antigen-specific mode of suppression, yet the ontogeny of DN T cells remains enigmatic. We have recently shown that 3A9 T-cell receptor (TCR) transgenic mice bear a high proportion of immunoregulatory 3A9 DN T cells, facilitating their stud...

journal_title：Immunology

authors： Dugas V,Chabot-Roy G,Beauchamp C,Guimont-Desrochers F,Hillhouse EE,Liston A,Lesage S

更新日期：2013-05-01 00:00:00

abstract：:The capacity of the immune system to respond efficiently to new antigens depends upon a continuous source of naive CD4+ T cells. Such cells exit from the thymus and join the recirculated T-cell pool. Factors present at the sites of naive CD4+ T-cell circulation must be responsible for their survival, since upon remova...

journal_title：Immunology

authors： Webb LM,Foxwell BM,Feldmann M

更新日期：1999-11-01 00:00:00

abstract：:Dengue virus (DENV) infection causes dengue fever, dengue haemorrhagic fever, or dengue shock syndrome. Mast cells have been speculated to play a role in DENV disease although their precise roles are unclear. In this study, we used mast cell-deficient Kit(W-sh/W-sh) mice to investigate the involvement of mast cells af...

journal_title：Immunology

authors： Chu YT,Wan SW,Anderson R,Lin YS

更新日期：2015-09-01 00:00:00