Abstract：
:A highly purified preparation of mouse B cells showed greatly decreased incorporation of [6-3H]-thymidine when stimulated with pokeweed Pa-1 mitogen or bacterial lipopolysaccharide compared with mouse splenic lymphocytes. This decreased stimulation was restored by the addition of purified T cells, but not macrophages. Nylon-adherent T cells exerted this helper activity only toward complement receptor-positive B cells (CR+B cells). whereas the helper activity of nylon-non-adherent T cells was effective only on complement receptor-negative B cells (CR-B cells). Since the helper activity of nylon-adherent T cells was completely abolished by the treatment with anti-Ia antiserum and complement but that of nylon-non-adherent T cells was not, it was assumed that Ia+T cells were helper cells for CR+B cells and Ia-T cells helper cells for CR-B cells. Moreover, these helper activities of both T-cell subsets were mediated by soluble factors, which were effective just before the onset of DNA synthesis of the corresponding B-cell subpopulations.
journal_name
Immunologyjournal_title
Immunologyauthors
Yokoyama K,Osawa Tsubject
Has Abstractpub_date
1979-12-01 00:00:00pages
789-96issue
4eissn
0019-2805issn
1365-2567journal_volume
38pub_type
杂志文章相关文献
IMMUNOLOGY文献大全abstract：:Humans and other mammals coexist with a diverse array of microbes colonizing the intestine, termed the microflora. The relationship is symbiotic, with the microbes benefiting from a stable environment and nutrient supply, and the host gaining competitive exclusion of pathogens and continuously maintenance of the gut i...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1111/j.1365-2567.2007.02687.x
更新日期：2008-02-01 00:00:00
abstract：:Clonal deletion of T cells capable of recognizing both host-type Mls and donor-type Mls occurred in the peripheral mature T-cell pool in radiation bone marrow chimeras of two H-2-compatible Mls-disparate strain combinations of AKR/J(H-2k,Thy-1.1,Mls-1a) and C3H/He(H-2k,Thy-1.2,Mls-1b). In order to determine further th...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1990-03-01 00:00:00
abstract：:Generation of an effective cellular immune response is key to the successful development of both humoral and cellular immune defences against most pathogens. However, while the type of cellular immune response elicited by any given pathogen is dictated by the entire array of antigens and molecules which comprise that ...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1046/j.1365-2567.1998.00631.x
更新日期：1998-12-01 00:00:00
abstract：:The neonatal Fc receptor, FcRn, plays a central role in immunoglobulin G (IgG) transport across placental barriers. Genetic variations of FcRn-dependent transport across the placenta may influence antibody-mediated pathologies of the fetus and the newborn. Sequencing analysis of 20 unrelated individuals demonstrated n...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1111/j.1365-2567.2006.02408.x
更新日期：2006-09-01 00:00:00
abstract：:The role of T-cell receptor (TCR) gammadelta T cells in the induction of protective TCR alphabeta T cells against infection by the intracellular bacteria Listeria monocytogenes was analysed. We found that depletion of gammadelta T cells by anti-TCR delta monoclonal antibody treatment before intravenous immunization of...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1046/j.1365-2567.1998.00593.x
更新日期：1998-10-01 00:00:00
abstract：:Peripheral blood mononuclear cells (PBMC) from a patient suffering from the hyper IgE syndrome were used to generate phytohaemagglutinin (PHA)-expanded T-cell clones (all CD4+, CD8-, CD23-). A selection of the clones was tested for their ability to help IgE secretion by culturing with normal B cells in the presence of...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1989-05-01 00:00:00
abstract：:Invariant natural killer T (iNKT) cells are an innate population of T cells identified by the expression of an invariant T-cell receptor and reactivity to lipid-based antigens complexed with CD1d. They account for a small percentage of lymphocytes, but are extremely potent and play central roles in immunity to infecti...
journal_title：Immunology
pub_type： 杂志文章,评审
doi：10.1111/imm.12481
更新日期：2015-08-01 00:00:00
abstract：:The primary immunoglobulin repertoire of chickens is generated not by gene rearrangement but by a subsequent process of gene conversion in proliferating immature B cells within the follicles of a specialized gut-associated lymphoid organ, the bursa of Fabricius. Neonatal infection with infectious bursal disease virus ...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1111/j.1365-2567.2006.02332.x
更新日期：2006-04-01 00:00:00
abstract：:We report that interleukin (IL)-4 and IL-10 can significantly up- or down-regulate CXC chemokine receptor 4 (CXCR4) expression on CD4+ T lymphocytes, respectively. Stromal cell-derived factor-1alpha (SDF-1alpha)-induced CD4+ T-lymphocyte chemotaxis was also correspondingly regulated by IL-4 and IL-10. IL-4 and IL-10 u...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1046/j.1365-2567.2000.00954.x
更新日期：2000-03-01 00:00:00
abstract：:Histamine not only mediates immediate allergic reactions, it also regulates cellular immune responses. H4R is the most recently identified histamine receptor (HR). In the present study, we examined the in vitro effect of histamine and H4R agonists on the responses of human T cells to purified protein derivative from M...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1111/j.1365-2567.2007.02574.x
更新日期：2007-06-01 00:00:00
abstract：:Two herpes simplex virus type 1 (HSV-1) antigens of apparent molecular weight 123,000 and 63,000 which are associated with the viral glycoprotein complex have been identified and purified using virus-specific monoclonal antibodies. Mice immunized with either glycoprotein showed marked resistance to challenge with viru...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1983-06-01 00:00:00
abstract：:The amount and relative affinity of antibodies to tetanus toxoid were measured, following immunization, in patients with chronic or recurrent acute chest infections and in healthy controls. The responding patients and controls produced similar amounts of antibody and, although antibody affinity was higher in the contr...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1985-07-01 00:00:00
abstract：:The expression of natural cytotoxicity in the gut-associated lymphoid tissue of the rat was investigated. Intra-epithelial lymphocytes (IEL) isolated from the small intestine had a similar frequency of cytotoxic and tumour target binding cells as the spleen. However, cytotoxic activity was low in Peyer's patches and m...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1983-04-01 00:00:00
abstract：:The non-precipitating guinea-pig IgG1 and IgG2 antibodies, produced by administration of an excessive dose of hen ovalbumin (OA), were capable of forming only certain soluble complexes having molar ratios of antibody to antigen lower than 1-5:1, which were lower than the minimum ratio of 2-5:1 shown by anti-OA antibod...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1976-07-01 00:00:00
abstract：:Pollen grains contain reduced nicotinamide adenine dinucleotide phosphate (NADPH) oxidases and in contact with mucosal surfaces generate superoxide anion (O2*-). In the presence of iron, O2*- may be converted to more reactive oxygen radicals, such as to H2O2 and/or *OH, which may augment antigen-induced airway inflamm...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1111/j.1365-2567.2006.02417.x
更新日期：2006-10-01 00:00:00
abstract：:Electron microscopic study of the events occurring at the cell membrane during reactive lysis by complement, showed that a foliaceous particle was formed at the C5b-7 stage, that enlarged to a particle with a variable number of arms at the C5b-8 stage. Up to this point, no typical complement lesions were found. At the...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1978-08-01 00:00:00
abstract：:Mycobacterium leprae-specific immunoglobulin G1 (IgG1) antibodies in patients with leprosy show a direct correlation with bacterial load (rho=0.748; P<0002) suggesting that IgG1 B-cell responses may be surrogate markers of disease progression. To investigate if this upregulation was a general feature of IgG1 responses...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1046/j.1365-2567.1999.00740.x
更新日期：1999-04-01 00:00:00
abstract：:Leukosialin or CD43 is a heavily O-glycosylated transmembrane protein expressed on all cells of the haematopoietic cell lineage with the exception of red blood cells and mature B cells. This antigen has been identified in human, mouse and rat with monoclonal antibodies. Although orthologues of many human and rodent le...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1046/j.1365-2567.1999.00604.x
更新日期：1999-01-01 00:00:00
abstract：:We have previously reported that placental macrophages of fetal origin have a decreased ability to present antigen. To clarify the underlying mechanism for this deficiency, we have generated primary fetal macrophage cell lines. Our data show that despite their defective antigen-presenting ability, fetal macrophages do...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1046/j.1365-2567.1997.00369.x
更新日期：1997-12-01 00:00:00
abstract：:Chronic antigenic stimulation leads to gradual accumulation of late-differentiated, antigen-specific, oligoclonal T cells, particularly within the CD8(+) T-cell compartment. They are characterized by critically shortened telomeres, loss of CD28 and/or gain of CD57 expression and are defined as either CD8(+) CD28(-) or...
journal_title：Immunology
pub_type： 杂志文章,评审
doi：10.1111/j.1365-2567.2011.03470.x
更新日期：2011-09-01 00:00:00
abstract：:The interaction between living groups A, C and G streptococci and IgG Fc was studied using human IgG, IgG Fc and IgG Fc-intermediate (Fci) fragments, chemically modified human IgG and fragment D of staphylococcal protein A (SPA). Diethylpyrocarbonate modification of His or N-acetylimidazole modification of Tyr of huma...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1987-12-01 00:00:00
abstract：:The specific recognition of the acetylcholine receptor and its alpha-subunit by T cells derived from patients with myasthenia gravis or mice with experimental autoimmune myasthenia gravis raises the question of the role of autoreactive T cells in the myasthenic process. Sequences of the acetylcholine receptor alpha-su...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1990-04-01 00:00:00
abstract：:Gene ablation studies in mice indicate that lymphotoxin (LT)alpha, LTbeta and LTbetaR are essential for the genesis of lymph nodes (LN), normal structural development of peripheral lymphoid tissues and the differentiation of natural killer (NK) cells. LTbetaR binds to the heterotrimeric cytokines LTalpha1beta2 and LIG...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1046/j.1365-2567.2003.01586.x
更新日期：2003-03-01 00:00:00
abstract：:Stimulated T lymphocytes and certain T-cell hybridomas secrete molecules capable of inducing B-lymphocyte proliferation and differentiation. It has been shown recently that one such B-cell stimulatory factor is associated with chondroitin sulphate proteoglycan (CSPG) and was designated T-cell proteoglycan fraction, or...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1988-08-01 00:00:00
abstract：:Following immunization with various lambda Bence-Jones proteins, over 100 hybridomas were established. A majority of the monoclonal antibodies (McAb) produced were demonstrated to recognize epitopes common to all lambda chains or unique to the immunogen. Twenty-nine McAb exhibited profiles of 'restricted' reactivity. ...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1986-11-01 00:00:00
abstract：:Microbial adjuvants are essential for the development of T-cell-dependent antibody production, recall T-cell proliferation and interferon-gamma production following immunization with protein antigens. Using an adoptive transfer approach, we showed that the adjuvant lipopolysaccharide enhanced the frequency of cells pr...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1111/j.1365-2567.2007.02620.x
更新日期：2007-09-01 00:00:00
abstract：:Using monoclonal antibodies (mAb) characterized at the last International Workshop on Human Leucocyte Antigens, we examined the expression of CDw75 antigens (beta-galactoside alpha 2,6-sialyltransferase) on normal peripheral blood cells and on cells from patients with B-cell chronic lymphocytic leukaemia (CLL). The mA...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1991-10-01 00:00:00
abstract：:Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by chronic, synovial inflammation affecting multiple joints, finally leading to extra-articular lesions for which limited effective treatment options are currently available. Interleukin-34 (IL-34), recently discovered as the second colony-stimul...
journal_title：Immunology
pub_type： 杂志文章,评审
doi：10.1111/imm.12660
更新日期：2016-12-01 00:00:00
abstract：:The class distribution of 4193 monoclonal gammopathies (MG), detected over approximately 10 years in western France (WF), was compared to that established by a compilation of twenty-seven series from the literature. Several points emerged from this study: the incidence of the light chain MG (4.8%) was slightly lower t...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1985-11-01 00:00:00
abstract：:Successful elimination of the hepatitis C virus (HCV) during acute infection has been linked to strong HCV-specific in vitro T-cell proliferation, whereas T cells from patients with chronic hepatitis C respond only weakly to HCV antigens. Lipid-coupled peptides are immunostimulants, which might provide a basis for nov...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1046/j.1365-2567.2001.01209.x
更新日期：2001-04-01 00:00:00
