Abstract:
:The expression of natural cytotoxicity in the gut-associated lymphoid tissue of the rat was investigated. Intra-epithelial lymphocytes (IEL) isolated from the small intestine had a similar frequency of cytotoxic and tumour target binding cells as the spleen. However, cytotoxic activity was low in Peyer's patches and mesenteric lymph node. Cytotoxic IEL exhibited similar target-cell specificity to splenic natural killer (NK) cells, and substantial antibody-dependent cell-mediated cytotoxicity. However, their cytotoxicity and lytic efficiency was not rapidly increased following exposure to interferon and IEL probably contain only a relatively small pool of pre-NK cells. IEL contained approximately 50% of cells with basophilic cytoplasmic granules, compared to approximately 2% of granule-containing mononuclear cells in the spleen. Direct observation using the uptake of acridine orange to detect cytoplasmic granules established that some cytotoxic IEL were granular. However, substantial cytotoxicity was also mediated by non-granular IEL and not all granular IEL which bound to target cells were cytotoxic. Counts of granulated cells in Giemsa-stained preparations of spleen cells and results from single-cell assays using unfractionated splenocytes suggest that the majority of target-binding cells and at least half of the naturally cytotoxic cells must also be non-granular.
journal_name
Immunologyjournal_title
Immunologyauthors
Flexman JP,Shellam GR,Mayrhofer Gsubject
Has Abstractpub_date
1983-04-01 00:00:00pages
733-41issue
4eissn
0019-2805issn
1365-2567journal_volume
48pub_type
杂志文章相关文献
IMMUNOLOGY文献大全abstract::The role of genetic factors associated with the immunoglobulin heavy chain locus (Igh) in the development of benign monoclonal gammapathy (BMG), a benign B-cell proliferative disorder, was investigated in six Igh congenic mouse strains during ageing. The strains used had a C57BL or BALB background: C57BL/6, BALB.Igb a...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1988-09-01 00:00:00
abstract::Adult normal mice and those mice which had been thymectomized, X-irradiated, and reconstituted either with bone marrow cells and thymus cells (TxXBT) or with bone marrow cells along (TxXB), were given varying amounts (0.1-5 mg) of deaggregated soluble bovine serum albumin (sBSA). They were challenged 10 days later wit...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1975-05-01 00:00:00
abstract::Within the lesions of inflammatory myopathies, muscle fibres and invading mononuclear cells express Fas and Fas ligand (FasL), respectively. However, the roles of the Fas/FasL interaction in the pathogenesis of inflammatory myopathies are not fully understood. In the present study, we investigated the roles of proinfl...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1111/j.1365-2567.2008.03039.x
更新日期:2009-09-01 00:00:00
abstract::Fc-gamma receptor III (Fc gamma RIII, CD16) type A is expressed on natural killer cells, on a small subset of peripheral blood monocytes and on mature macrophages. Along with differentiation into macrophages, monocytes will express Fc gamma RIII when cultured with transforming growth factor-beta (TGF-beta). In view of...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1996-01-01 00:00:00
abstract::An investigation was made of the properties of cytotoxic T cells induced by Con A and exposure to LCM virus-infected cells. As a basis for such studies, the optimal conditions for in vitro Con A stimulation of in vivo LCM virus-primed C3H mouse splenocytes were determined. The most potent cytotoxicity was obtained whe...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1979-10-01 00:00:00
abstract::The anti-C6 monoclonal antibody WU 6-4 was shown to be unequivocally native restricted since it neither binds to the terminal complement complex (TCC) nor to C5b6. In addition, it was shown to inhibit TCC formation by interfering with C5b6 generation. Using the pUEX expression system and C6 cDNA the WU 6-4 epitope was...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1995-06-01 00:00:00
abstract::With an increase in the importance of umbilical cord blood (CB) as an alternative source of haematopoietic progenitors for allogenic transplantation, donor lymphocyte infusion (DLI) with donor CB-derived activated CD4(+) T cells in the unrelated CB transplantation setting is expected to be of increased usefulness as a...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1111/j.1365-2567.2009.03122.x
更新日期:2009-11-01 00:00:00
abstract::The major site of B-cell genesis in the sheep is the ileal Peyer's patch (PP). The B cells in the ileal PP undergo both extensive proliferation and massive death in association with an ongoing diversification of the immunoglobulin repertoire by somatic hypermutation. Most, if not all, the B-cell death in the ileal PP ...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1995-03-01 00:00:00
abstract::LacZ (Gal)-reactive immune cells were transferred into athymic nu/nu mice inoculated with Gal-expressing syngeneic tumour cells (ESbL-Gal) in order to study tumour-protective T-cell memory. This transfer prevented tumour outgrowth in recipients and resulted in the persistence of a high frequency of Gal-specific CD8(+)...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1111/j.1365-2567.2005.02163.x
更新日期:2005-07-01 00:00:00
abstract::We quantified immunoglobulin E (IgE) on peritoneal mast cells of interleukin-4 (IL-4)-gene knockout (-/-) mice and wild-type (+/+) controls using a cytofluorometric method, and examined the expression of IgE receptors, estimated by quantifying the total binding of IgE on the mast cells of IL-4 (-/-) mice. The mast cel...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1046/j.1365-2567.1999.00727.x
更新日期:1999-04-01 00:00:00
abstract::Burkholderia pseudomallei is the causative agent of melioidosis, an infectious disease with high incidence and mortality in South East Asia and northern Australia. To date there is no protective vaccine and antibiotic treatment is prolonged and not always effective. Most people living in endemic areas have been expose...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1111/imm.12709
更新日期:2017-05-01 00:00:00
abstract::Four specific interleukin-2 (IL-2) surface binding proteins can be detected by covalent cross-linking of [125I]IL-2 to rat spleen cells that have been activated with various stimuli including concanavalin A (Con A), phytohaemagglutinin (PHA), calcium ionophore, and phorbol dibutyrate (PDB) with or without calcium iono...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1992-11-01 00:00:00
abstract::The level of circulating thymic factor (FTS) tested by its action on spleen rosette-forming cells from adult thymectomized mice, has been shown to be stable in young animals. This stability suggests a regulatory mechanism. An approach of this regulation has been attempted by disrupting the FTS level either by neonatal...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1979-02-01 00:00:00
abstract::In the rat strain combination of DA into PVG, an orthotopic liver graft has the ability to abrogate an existing state of sensitization against donor (DA) antigens. Fifty-four percent of PVG rats sensitized against DA by skin grafting accepted a DA liver graft permanently, and about half of these became systemically to...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1985-05-01 00:00:00
abstract::Immunoregulatory CD4(-) CD8(-) (double-negative; DN) T cells exhibit a unique antigen-specific mode of suppression, yet the ontogeny of DN T cells remains enigmatic. We have recently shown that 3A9 T-cell receptor (TCR) transgenic mice bear a high proportion of immunoregulatory 3A9 DN T cells, facilitating their stud...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1111/imm.12064
更新日期:2013-05-01 00:00:00
abstract::Interleukin-6 (IL-6) is an important B-cell growth and differentiation factor. IL-6 treatment of the human lymphoblastoid cell line, SKW6.4, leads to increased IgM production. We have previously shown that IL-6 induces activation of JAK1 and JAK2 in human B cell lines. A chimeric IL-6 receptor, comprised of the intrac...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1111/j.1365-2567.1997.00350.x
更新日期:1997-03-01 00:00:00
abstract::Anti-human milk fat globule membrane monoclonal antibodies HMFG-1 and HMFG-2 recognize epitopes within the protein core of human polymorphic epithelial mucin (PEM). These have been identified as PDTR and DTR, respectively. Using the solid phase synthesis of immobilized tetrameric peptides, we have systematically inves...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1991-08-01 00:00:00
abstract::The MHC class I and II antigen processing and presentation pathways display peptides to circulating CD8+ cytotoxic and CD4+ helper T cells respectively to enable pathogens and transformed cells to be identified. Once detected, T cells become activated and either directly kill the infected / transformed cells (CD8+ cyt...
journal_title:Immunology
pub_type: 杂志文章,评审
doi:10.1111/imm.12675
更新日期:2017-01-01 00:00:00
abstract::A superantigen (Streptococcus pyogenes mitogen-2; SPM-2) that stimulates human helper T cells bearing unique types of variable domains of T-cell receptor beta-chain (TCR V beta) was isolated from the culture supernatant of S. pyogenes strain T12. The active molecule isolated by diethylaminoethyl (DEAE)-cellulose chrom...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1046/j.1365-2567.1997.00277.x
更新日期:1997-07-01 00:00:00
abstract::Urokinase-type plasminogen activator (u-PA), tumour necrosis factor-alpha (TNF-alpha) and interleukin-1 (IL-1) activities were measured for highly purified human monocytes cultured for 18 hr with recombinant human interleukin-3 (IL-3). IL-3 alone stimulated monocyte u-PA activity, but not TNF-alpha or IL-1 activity. H...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1990-09-01 00:00:00
abstract::In comparison to primary immune responses after lung immunization, the level of antigen-specific antibody and the number of cells producing specific antibody are significantly increased after challenging the lungs with antigen. The response of immune memory cells in the lung to an antigen challenge could be responsibl...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1111/j.1365-2567.1996.tb00004.x
更新日期:1996-06-01 00:00:00
abstract::Incubation of sensitized mononuclear cells from patients with schistosomiasis with specific antigen containing a suspension of viable Schistosoma haematobium ova resulted in the release of a soluble factor which was chemotactic for eosinophils. Production of this substance was detectable at 24 h and demonstrated peak ...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1980-12-01 00:00:00
abstract::The balance between pro- and anti-inflammatory cytokines has been implicated in the pathogenesis of infectious and auto-immune diseases, and its modulation has been proposed as a potential therapeutic target. The results reported in the present study show that modulators of the renin-angiotensin system, such as the an...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1046/j.1365-2567.1998.00524.x
更新日期:1998-07-01 00:00:00
abstract::Apolipoprotein-E (apoE) is expressed at high levels by macrophages. In addition to its role in lipid transport, macrophage-derived apoE plays an important role in immunoregulation. Previous studies have identified macrophage subpopulations that differ substantially in their ability to synthesize specific cytokines and...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1111/j.1365-2567.2004.01972.x
更新日期:2004-11-01 00:00:00
abstract::The effector CD8(+) T cells recognize major histocompatibility complex (MHC) class I binding altered self-peptides expressed in tumour cells. Although the requirement for CD4(+) T helper type 1 (Th1) cells in regulating CD8(+) T cells has been documented, their target epitopes and functional impact in antitumour respo...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1111/j.1365-2567.2005.02262.x
更新日期:2006-01-01 00:00:00
abstract::Serum antibodies to glucosyltransferase (GTF) of Streptococcus mutans serotype c were assayed sequentially by means of an enzyme inhibition radio-assay in twenty-six Rhesus monkeys immunized with S. mutans. Pre-immune and control sera had a GTP-enhancing effect which was shown also by albumin and non-immune immunoglob...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1976-05-01 00:00:00
abstract::Syngeneic (CB20) thymus and spleen T cells transferred to SCID mice, and shown to be present by flow cytometric analysis and functional by their ability to reject third-party skin grafts, do not lead to a detectable failure of syngeneic or allogeneic pregnancy. Unless the small number of B cells contaminating the T-ce...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1990-11-01 00:00:00
abstract::The aim of this study was to characterize the epitope specificity and the idiotype(s) of gp330-specific autoantibodies in active Heymann nephritis (HN). To study this, two monoclonal autoantibodies (mAb), 3D9B and 5B8C, derived from Lewis rats with HN, were generated. These antibodies bound to different epitopes on th...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1990-07-01 00:00:00
abstract::Oral administration of a protein antigen generates a serum factor that induces tolerance when transferred into naïve recipients. This serum factor has been described in rats as consisting of exosome-like structures or tolerosomes, which express major histocompatibility complex class II molecules (MHCII) and mediate an...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1111/j.1365-2567.2005.02245.x
更新日期:2005-12-01 00:00:00
abstract::CD4 and CD8 T-cell clones were generated using the Mx9 monoclonal antibody (mAb), which recognizes the V beta 8 T-cell receptor (TcR) gene family. The interaction of these clones with the Mx9 antibody was analysed and all were found to be specifically stimulated to proliferate by plastic-adherent Mx9. In the presence ...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1988-07-01 00:00:00