Abstract：
:Anti-human milk fat globule membrane monoclonal antibodies HMFG-1 and HMFG-2 recognize epitopes within the protein core of human polymorphic epithelial mucin (PEM). These have been identified as PDTR and DTR, respectively. Using the solid phase synthesis of immobilized tetrameric peptides, we have systematically investigated the contribution of each amino acid in the immune recognition of the PDTR domain by the antibodies HMFG-1 and HMFG-2. The findings obtained have been interpreted with respect to the presence of, and requirements for elements of secondary structure, which have been identified in this region of the PEM protein core.
journal_name
Immunologyjournal_title
Immunologyauthors
Briggs S,Price MR,Tendler SJsubject
Has Abstractpub_date
1991-08-01 00:00:00pages
505-7issue
4eissn
0019-2805issn
1365-2567journal_volume
73pub_type
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